Development of hybrid domino reactions via multi-chemical species and the synthetic application
| Project/Area Number |
20390008
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Chemical pharmacy
|
|---|
| Research Institution | Kobe Pharmaceutical University |
|---|
Principal Investigator |
NAITO Takeaki Kobe Pharmaceutical University, 薬学部, 教授 (00068339)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MIYATA Okiko 神戸薬科大学, 薬学部, 教授 (90102110)
UEDA Masafumi 神戸薬科大学, 薬学部, 講師 (00340935)
MIYABE Hideto 兵庫医療大学, 薬学部, 教授 (10289035)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2010: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2009: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2008: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
|
|---|
| Keywords | ラジカル種 / イオン種 / ドミノ反応 / オキシムエーテル / 環境重視型反応 / ラジカル / イオン / テオン / カキシムエーテル |
|---|
| Research Abstract |
Hybrid-type domino radical reactions of conjugated imine as a conjugated p-system were newly developed via the route involving various types of chemical species such as radical, ion, and organometallic species. Efficient synthetic methodology for highly functionalized products was developed via environmentally benign oxidation and radical-ionic domino reaction both of which proceeded via trapping the intermediates by atmospheric oxygen and appropriate electrophiles. Particularly, we were able to isolate unexpected reaction intermediates and thus succeeded in the development of powerful synthetic methods for various types of versatile and potential compounds by only one-manipulation.
|
Report
(4 results)
Research Products
(30 results)
