| Budget Amount *help |
¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
Fiscal Year 2010: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2009: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2008: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
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| Research Abstract |
Importance of the adjuvant activity of chemicals has become widely recognized in the development of allergies. However, mechanisms underlying the adjuvant activity are largely unknown. Using mouse contact hypersentitivity models, we discovered that the adjuvant activity of phthalate esters is correlated with the ability to activate nociceptive receptors, which are expressed on sensory neurons. We also found that phthalate esters uncovered the skin-sensitizing activity of a food constituent that has low immunogenicity.
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