|Budget Amount *help
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2010: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2009: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2008: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
This study focused on the drug transporters expressed in the blood-brain barrier, and aimed at developing quantitative evaluation method of the impact of such drug transporters. In vivo studies using knockout mice elucidated that drugs that are actively extruded by ABC transporters, Mrp4, P-gp and Bcrp at the blood-brain barrier, and thereby, showing limited penetration into the central nervous system. This study also elucidated drugs that are removed by Oat3 from the central nervous system. In conjunction with Mrp4, Oat3 forms efficient directional transport across the blood-brain barrier. This study also found some transporter substrates applicable to PET study.