Role of breakfast in food-induced entrainment of mouse circadian clock

• Project/Area Number: 20390065
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Environmental physiology (including Physical medicine and Nutritional physiology)
• Research Institution: Waseda University
• Principal Investigator: SHIBATA Shigenobu Waseda University, 理工学術院, 教授 (10162629)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000); Fiscal Year 2010: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2009: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2008: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
• Keywords: 体内時計 / 食事同調 / インスリン / 朝日 / 肝臓 / 代謝 / 栄養 / 時間栄養学 / 時計遺伝子 / 朝食 / 絶食

Research Abstract

Circadian clock is entrained by light as well as by fixed feeding. In this project we asked which mealtime is key for entrainment, and what kind of food is good entrainment. Breakfast (feeding after long-long starvation) rather than other mealtimes could entrain the liver clock. Among nutrients of food, easily digestible cornstarch had stronger entraining force through high insulin secretion. The preset results suggest us digestible starch for breakfast is good maintenance of circadian rhythm.

Research Products

• [Journal Article] Refeeding after fasting elicits insulin-dependent regulation of Per2 and Rev-erba with shifts in the liver clock. (2011)
  • Author(s): Yu Tahara,Makiko Otsuka, Yuta Fuse, Akiko Hirao, Shigenobu Shibata
  • Journal Title: J Biological Rhythms (in press)
  • Peer Reviewed
• [Journal Article] The circadian clock gene Period2 regulates a time of day-dependent variation in cutanenous anaphylactic reaction Journal of Allergy and Clinical (2011)
  • Author(s): Yuki Nakamura; Daisuke Harama; Naomi Shimokawa; Mutsuko Hara; Rhuyo Suzuki, Yu Tahara; Kayoko Ishimaru; Rhohei Katoh; Ko Okumura; Hideoki Ogawa; Shigenobu Shibata; Atsuhito Nakao
  • Journal Title: Immunology (in press)
  • Peer Reviewed
• [Journal Article] Attenuated food anticipatory activity and abnormal circadian locomotor rhythms in Rgs16 knockdown mice PLoS One (2011)
  • Author(s): Naoto Hayasaka, Kazuyuki Aoki, Saori Kinoshita, Shoutaroh Yamaguchi, John K. Wakefield, Sachiyo Tsuji-Kawahara, Kazumasa Horikawa, Hiroshi Ikegami, Shigeharu Wakana, Takamichi Murakami, Ram Ramabhadran, Masaaki Miyazawa, Shigenobu Shibata
  • Journal Title: (in press)
  • Peer Reviewed
• [Journal Article] the Freshmen in Dietetic Courses Study II group. The midpoint of sleep is associated with dietary intake and dietary behavior among young Japanese women. (2011)
  • Author(s): Sato-Mito N, Sasaki S, Murakami K, Okubo H, Takahashi Y, Shibata S, Yamada K, Sato K
  • Journal Title: Sleep Med. 12(3) Pages: 289-294
  • Peer Reviewed
• [Journal Article] 体内時計と疾患と治療 (2011)
  • Author(s): 柴田重信
  • Journal Title: ファルマシア、日本薬学会 (印刷中)
  • Peer Reviewed
• [Journal Article] 体内時計と食・栄養科学 (2011)
  • Author(s): 柴田重信
  • Journal Title: 食品工業 54 Pages: 46-53
• [Journal Article] 時間栄養学とはなにか (2011)
  • Author(s): 柴田重信、平尾彰子
  • Journal Title: 日本薬理学雑誌、金芳堂 137 Pages: 109-114
  • NAID: 10029417255
• [Journal Article] Time of day and nutrients in feeding govern daily expression rhythms of the gene for sterol regulatory element-binding protein (SREBP)-1 in the mouse liver. (2010)
  • Author(s): Matsumoto E, Ishihara A, Tamai S, Nemoto A, Iwase K, Hiwasa T, Shibata S, Takiguchi M.
  • Journal Title: J Biol Chem. 285(43) Pages: 33028-33036
  • Peer Reviewed
• [Journal Article] The role of GABAergic neuron on NMDA- and SP-induced phase delays in the suprachiasmatic nucleus neuronal activity rhythm in vitro. (2010)
  • Author(s): Hamada T, Shibata S.
  • Journal Title: Neurosci Lett. 468 Pages: 344-347
  • Peer Reviewed
• [Journal Article] Effects of medial hypothalamic lesions on feeding-induced entrainment of locomotor activity and liver Per2 expression in Per2::luc mice. (2010)
  • Author(s): Tahara Y, Hirao A, Moriya T, Kudo T, Shibata S.
  • Journal Title: J Biol Rhythms. 25 Pages: 9-18
  • Peer Reviewed
• [Journal Article] Time-dependent inhibitory effect of lipopolysaccharide injection on Per1 and Per2 gene expression in the mouse heart and liver. (2010)
  • Author(s): Yamamura Y, Yano I, Kudo T, Shibata S.
  • Journal Title: Chronobiol Int. 27 Pages: 213-232
  • Peer Reviewed
• [Journal Article] Combination of starvation interval and food volume determines the phase of liver circadian rhythm in Per2::Luc knock-in mice under two meals per day feeding. (2010)
  • Author(s): Hirao A, Nagahama H, Tsuboi T, Hirao M, Tahara Y, Shibata S.
  • Journal Title: Am J Physiol Gastrointest Liver Physiol. 299(5)
  • Peer Reviewed
• [Journal Article] 時計遺伝子と栄養 (2010)
  • Author(s): 平尾彰子、柴田重信
  • Journal Title: 脳21、金芳堂 第13巻 Pages: 396-401
• [Journal Article] 生体リズムを調整する太陽光と食事 (2010)
  • Author(s): 堀川和政、柴田重信
  • Journal Title: 循環器内科(科学評論社) Vol.68 Pages: 422-427
• [Journal Article] 子供の体内時計と遺伝 (2010)
  • Author(s): 田原優、柴田重信
  • Journal Title: 乳幼児医学・心理学研究 vol.89 Pages: 89-96
• [Journal Article] 生体時計 (2010)
  • Author(s): 柴田重信
  • Journal Title: 睡眠関連病態、小児科臨床ピクシス(神山潤)、中山書店 Pages: 6-9
• [Journal Article] The adjustment and manipulation of biological rhythms by light, nutrition, and abused drugs. (2010)
  • Author(s): Shibata S, Tahara Y, Hirao A.
  • Journal Title: Adv Drug Deliv Rev. 62(9-10)(Review) Pages: 918-927
  • Peer Reviewed
• [Journal Article] Restricted feeding-induced entrainment of activity rhythm and peripheral clock rhythm (2010)
  • Author(s): Shibata S, Hirao A, Tahara Yu.
  • Journal Title: Sleep and Biological Rhythms 8(review) Pages: 18-27
  • Peer Reviewed
• [Journal Article] Time of day and nutrients in feeding govern daily expression rhythms of the gene for sterol regulatory element-binding protein (SREBP)-1 in the mouse liver. (2010)
  • Author(s): Matsumoto E, Hiwasa T, Shibata S, Takiguchi M.
  • Journal Title: Journal of Biological Chemistry Volume: 285 Pages: 33028-33036
  • Peer Reviewed
• [Journal Article] Combination of starvation interval and food volume determines the phase of liver circadian rhythm in Per2 :: Luc knock-in mice under two meals per day feeding. (2010)
  • Author(s): Hirao A, Nagahama H, Tsuboi T, Hirao N, Tahara Y, Shibata S.
  • Journal Title: Am J physiol Gastrointest Liver Physiol. Volume: 299
  • Peer Reviewed
• [Journal Article] The adjustment and manipulation of biological rhythms by light, nutrition, and abused drugs. (2010)
  • Author(s): Shibata S, Tahara Y, Hirao A.
  • Journal Title: Adv Drug Deliv Rev. Volume: 62 Pages: 918-927
  • Peer Reviewed
• [Journal Article] Restricted feeding-induced entrainment of activity rhythm and peripheral clock rhythm (2010)
  • Author(s): Shigenobu SHIBATA, Akiko HIRAO, Yu TAHARA
  • Journal Title: Sleep and Biological Rhythms 8 Pages: 18-27
  • Peer Reviewed
• [Journal Article] Effects of medial hypothalamic lesions on feeding-induced entrainment of locomotor activity and liver Per2 expression in Per2 : luc mice (2010)
  • Author(s): Tahara Y, Hirao A, Moriya T, Kudo T, Shibata S.
  • Journal Title: J.Biological Rhythms 25 Pages: 9-18
  • Peer Reviewed
• [Journal Article] 概日リズム評価法 (2010)
  • Author(s): 田原優, 柴田重信
  • Journal Title: 実践行動薬理学 Pages: 27-35
• [Journal Article] 「生体時計」、睡眠関連病態 (2010)
  • Author(s): 柴田重信
  • Journal Title: 小児科臨床ピクシス 14 Pages: 6-9
• [Journal Article] Critical review of a report that restoration of Bmal1 expression in the dorsomedial hypothalamus is su ffioient to restore circadian food anticipatory rhythms in Bmali-/-mice (2009)
  • Author(s): Mistlberger R, Escobar C, Kalsbeek A, Landry G, Pevet P, Shibata
  • Journal Title: J. Circadian Rhythms (In press)
  • Peer Reviewed
• [Presentation] 時間栄養学～体内時計と食事のリズム～ (2011)
  • Author(s): 柴田重信
  • Organizer: 多摩区栄養士研修会
  • Place of Presentation: 多摩市民会館、川崎市
  • Year and Date: 2011-02-08
• [Presentation] 生活リズムと体内時計 (2011)
  • Author(s): 柴田重信
  • Organizer: 第9回糖尿病市民セミナー・東京「くらしの中の糖尿病」よみうりホール
  • Place of Presentation: 東京
  • Year and Date: 2011-02-06
• [Presentation] 時計遺伝子と食餌リズム (2011)
  • Author(s): 柴田重信
  • Organizer: 第13回脂質・栄養シンポジューム
  • Place of Presentation: 花王ホール、東京
  • Year and Date: 2011-01-29
• [Presentation] からだとこころの健康の実践:時間栄養学の考え方 (2010)
  • Author(s): 柴田重信
  • Organizer: 早稲田大学教育総合研究所教育最前線講演会シリーズXI現代生活の「時計」と「休息」
  • Place of Presentation: 早稲田大学
  • Year and Date: 2010-12-11
• [Presentation] 子どもの脳の発達に不可欠な睡眠とそのリズム (2010)
  • Author(s): 柴田重信
  • Organizer: 第2回神戸市民講座
  • Place of Presentation: 神戸
  • Year and Date: 2010-10-16
• [Presentation] エイジングとアンチエイジングに対する体内時計の関わり (2010)
  • Author(s): 柴田重信
  • Organizer: 私立大学戦略的基盤形成研究支援事業第2回学術講演会-エイジングに伴う生体機能変化とアンチエイジング戦略
  • Place of Presentation: 近畿大学
  • Year and Date: 2010-06-05
• [Presentation] 時計遺伝子と時間栄養学 (2010)
  • Author(s): 柴田重信
  • Organizer: 茨城県栄養士会総会
  • Place of Presentation: 水戸市(特別講演)
  • Year and Date: 2010-05-26
• [Presentation] 体内時計研究の基礎から応用 (2010)
  • Author(s): 柴田重信
  • Organizer: 山梨大学セミナー
  • Year and Date: 2010-04-12
• [Presentation] リズム障害の基礎と応用 (2010)
  • Author(s): 柴田重信
  • Organizer: 関東睡眠談話会2010
  • Place of Presentation: 東京
  • Year and Date: 2010-02-27
• [Presentation] 体内時計とメタボリックシンドローム」 (2010)
  • Author(s): 柴田重信
  • Organizer: 126回分泌セミナー
  • Place of Presentation: 朝日生命成人病研究所、東京
  • Year and Date: 2010-02-06
• [Presentation] 体内時計と食・栄養科学 (2010)
  • Author(s): 柴田重信
  • Organizer: シンポジューム、第57回日本食品科学工学会
  • Place of Presentation: 東京農業大学
• [Presentation] リズム障害と生活習慣病 (2010)
  • Author(s): 柴田重信
  • Organizer: シンポジューム、第35回日本睡眠学会
  • Place of Presentation: 名古屋
• [Presentation] 時間栄養学の視点からのマウス体内時計研究 (2010)
  • Author(s): 柴田重信
  • Organizer: 第87回日本生理学会
  • Place of Presentation: シンポジューム盛岡
• [Presentation] Nutrition and Circadian Clock System (2010)
  • Author(s): 柴田重信
  • Organizer: 日本農芸化学会2010
  • Place of Presentation: 東大、東京
• [Presentation] 体内時計を利用した創薬から治療戦略まで、「体内時計オーバ-ビュー」 (2010)
  • Author(s): 柴田重信
  • Organizer: 日本薬学会130年会
  • Place of Presentation: 岡山
• [Presentation] 時間栄養学(時間食理学)とは何か (2010)
  • Author(s): 柴田重信
  • Organizer: 第83回日本薬理学会年会
• [Presentation] 時間薬理学と時間栄養学による新しい治療戦略開拓、「時間栄養学とは何か」 (2010)
  • Author(s): 柴田重信
  • Organizer: 83回日本薬理学会年会
  • Place of Presentation: 大阪
• [Presentation] 末梢臓器の給餌性リズム形成におけるDMHの役割と予知行動の意味 (2008)
  • Author(s): 田原優, 平尾彰子, 平尾美朱帆, 守屋孝洋, 柴田重信
  • Organizer: 第15回日本時間生物学会学術大会
  • Place of Presentation: 岡山市
  • Year and Date: 2008-11-08
• [Presentation] 外界の温度変化が末梢の時計遺伝子発現に与える影響 (2008)
  • Author(s): 堂本隆壮, 井筒裕之, 小岩剛貴, 柴田重信
  • Organizer: 第15回日本時間生物学会学術大会
  • Place of Presentation: 岡山市
  • Year and Date: 2008-11-08
• [Presentation] 給餌によるマウス肝臓時計遺伝子発現リズムに対する量とタイミングの効果 (2008)
  • Author(s): 平尾彰子, 田原優, 平尾美朱帆, 柴田重信
  • Organizer: 第15回日本時間生物学会学術大会
  • Place of Presentation: 岡山市
  • Year and Date: 2008-11-08
• [Book] 「食品の体内時計に対する効果」、体内時計の科学と産業応用 (2011)
  • Author(s): 柴田重信
  • Publisher: CMC出版
• [Book] 「体内時計が栄養・食物摂取に及ぼす効果」、体内時計の科学と産業応用 (2011)
  • Author(s): 平尾彰子、柴田重信
  • Publisher: CMC出版
• [Book] 「体内時計と代謝」時間生物学 (2011)
  • Author(s): 柴田重信
  • Publisher: 化学同人
• [Book] 実践行動薬理学(武田弘志、辻、稔、赤池昭紀)(概日リズム評価法) (2010)
  • Author(s): 田原優、柴田重信
  • Publisher: 金芳堂
  • URL: http://www.eb.waseda.ac.jp/shibata/index.html