Molecular Basis of Transport of Virulence Factors in the Pathogenic Protist
Project/Area Number |
20390119
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Parasitology (including Sanitary zoology)
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Research Institution | National Institute of Infectious Diseases |
Principal Investigator |
TOMOYOSH Nozaki National Institute of Infectious Diseases, 寄生動物部, 部長 (60198588)
|
Co-Investigator(Kenkyū-buntansha) |
KUMIKO Tsukui 国立感染症研究所, 寄生動物部, 主任研究官 (00420092)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2010: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2009: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2008: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
|
Keywords | 小胞輸送 / 病原機構 / 感染症 / 寄生虫 / システインプロテアーゼ |
Research Abstract |
We identified and characterized a putative receptor/carrier for cysteine proteases, which is believed to play a pivotal role in pathogenesis of the enteric protozoan parasite Entamoeba histolytica. We also identified the members of cysteine protease genes that are stage-specifically expressed during differentiation.
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Report
(4 results)
Research Products
(106 results)
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[Journal Article] Cytotoxic effect of amide derivatives of trifluoromethionine to the enteric protozoan parasite Entamoeba histolytica.2010
Author(s)
Sato. D., Kobayashi S., Yasui H., Shibata N., Toru T., Yamamoto M., Tokoro G., Ali V., Soga T., Takeuchi T., Suematsu M., Nozaki T.
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Journal Title
Int.J.Antimicrob.Agents. 35
Pages: 56-61
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[Journal Article] Two Atypical L-cysteine-regulated NADPH-dependent oxidoreductases involved in redox maintenance, L-cystine reduction, and metronidazole activation in the enteric protozoon Entamoeba histolytica2010
Author(s)
Jeelani, G., Husain, A., Sato, D., Ali, V., Suematsue, M., Soga, T., Nozaki, T.
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Journal Title
J.Biol.Chem.
Volume: 285
Pages: 26889-26899
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Peer Reviewed
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[Journal Article] Metabolome analysis revealed increase in S-methylcysteine and phosphatidylisopropanolamine synthesis uponL-cysteine deprivation in the anaerobic protozoan parasite Entamoeba histolytica.2010
Author(s)
Husain, A., Sato, D., Jeelani, G., Suematsu, M., Soga, T., Nozaki, T.
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Journal Title
J.Biol.Chem.
Volume: 285
Pages: 39160-39170
Related Report
Peer Reviewed
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[Journal Article] An Entamoeba cysteine peptidase specifically expressed during encystation2008
Author(s)
Ebert, F., Bachmann, A., Nakada-Tsukui, K., Hennings, I., Drescher, B., Nozaki, T., Tannich, E., Bruchhaus, I.
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Journal Title
Parasitol. Int. 57
Pages: 521-524
NAID
Related Report
Peer Reviewed
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[Presentation] Metabolomic analysis during differentiation of enteric protozoan parasite Entamoeba histolytica into the infectious cyst stage.2011
Author(s)
Jeelani, G., Sato, D., Husein, A., Suematsu, M., Soga, T., Nozaki, T.
Organizer
The 45th US-Japan Cooperative Medical Science Program
Place of Presentation
Tokyo
Related Report
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[Presentation] Metabolomic analysis of sulfur containing amino acid metabolism in E.histolytica.2011
Author(s)
Husain, A., Sato, D., Jeelani, G., Mi-ichi, F., Ali, V., Suematsu, M., Soga, T., Nozaki, T.
Organizer
The 45th US-Japan Cooperative Medical Science Program
Place of Presentation
Tokyo
Related Report
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[Presentation] Diversity and significance of vesicular trafficking in Entamoeba histolytica.2010
Author(s)
Saito-Nakano Y., Okada. M., Penuliar G.M., Hanadate Y., Gilchrist C.A., Crasta O., Petri Jr., W.A., Fei Z., Trapaidze Ni., Nozaki T.
Organizer
Amebiasis Workshop 2010, "Molecular Approaches and Clinical Aspects"
Place of Presentation
Montreal
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[Presentation] Molecular Approaches in an Important but Neglected Disease2009
Author(s)
Picazarri, K., Furukawa, A., Sato, D., Nakada-Tsukui, K., Nozaki, T.
Organizer
Autophagy in E. histolytica. XVI Seminario Sobre Amibiasis and EMBO Workshop. Amoebiasis
Place of Presentation
Guanajuato, Mexico
Related Report
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[Presentation] Metabolomic and transcriptomic analysis of sulfur-containing amino acid metabolism in the enteric protozoan parasite Entamoeba histolytica.2008
Author(s)
Husein A., Jeelani G., Bilal A.S.,Sato D., Mi-ichi F., Hishiki T., Gilchrist C.A., Suematsu M., Petri W.A., Jr., Nozaki T.
Organizer
The 8th Awaji International Forum on Infection and Immunity.
Place of Presentation
Awaji
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[Presentation] The mitochondria-related organelle in the anaerobic protist Entamoeba histolytica2008
Author(s)
Mi-ichi, F., Abu, Y. M., Nakada-Tsukui, K., Kawai, S., Nozaki, T.
Organizer
International Symposium : Bacteria made ornangelles made eukaryotic cells
Place of Presentation
Tokyo, Japan
Related Report
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[Presentation] The mitochondria-related organelle in the anaerobic parasitic protozoon Entamoeba histolytica2008
Author(s)
Mi-ichi, F., Abu, Y. M., Nakada-Tsukui, K., Kawai, S., Nozaki, T.
Organizer
International Symposium on Protistology : Evolution and Diversity
Place of Presentation
Tsukuba, Japan
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