Tracking the intracellular dynamics of HIV-1 proteins
Project/Area Number |
20390136
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Virology
|
Research Institution | National Institute of Infectious Diseases |
Principal Investigator |
RYO Akihide National Institute of Infectious Diseases, 医学研究科, 教授 (20363814)
|
Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Naoki 国立感染症研究所, エイズ研究センター, センター長 (00094053)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2010: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2009: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2008: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
|
Keywords | ヒト免疫不全ウイルス / エイズ / 宿主因子 / 細胞内輸送 / レトロウイルス / 翻訳後修飾 / タンパク質輸送 / 細胞 / HIV |
Research Abstract |
Human immunodeficiency virus type 1 (HIV-1) utilizes the macromolecular machinery of the infected host cell to produce progeny virus. We have identified suppressor of cytokine signaling 1 (SOCS1) as a host factor that positively regulates the intracellular trafficking and stability of HIV-1 Gag. SOCS1 can directly bind to Gag and enhance its stability and trafficking, resulting in the efficient production of HIV-1 particles. We found also that SOCS1 can enhance the ubiqtuitintion of Gag and facilitate its interaction with microtubule network. These findings will be useful for developing a new anti-HIV therapy.
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Report
(4 results)
Research Products
(79 results)
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[Journal Article] A distinct role for Pin1 in the induction and maintenance of pluripotency.2011
Author(s)
Nishi M, Akutsu H, Masui S, Kondo A, Nagashima Y, Kimura H, Perrem K, Shigeri Y, Toyoda M, Okayama A, Hirano H, Umezawa A, Yamamoto N, Lee SW, Ryo A.
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Journal Title
J Biol Chem 286(13)
Pages: 11593-11603
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[Journal Article] Postinfection passive transfer of KD-247 protects against simian/human immunodeficiency virus-induced CD4+ T-cell loss in macaque lymphoid tissue.2009
Author(s)
Murakami T, Eda Y, Nakasone T, Ami Y, Someya K, Yoshino N, Kaizu M, Izumi Y, Matsui H, Shinohara K, Yamamoto N, Honda M.
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Journal Title
AIDS. 23(12)
Pages: 1485-1494
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[Journal Article] The novel CXCR4 antagonist KRH-3955 is an orally bioavailable and extremely potent inhibitor of human immunodeficiency virus type 1 infection : comparative studies with AMD3100.2009
Author(s)
Murakami T, Kumakura S, Yamazaki T, Tanaka R, Hamatake M, Okuma K, Huang W, Toma J, Komano J, Yanaka M, Tanaka Y, Yamamoto N.
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Journal Title
Antimicrob Agents Chemother. 53(7)
Pages: 2940-2948
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[Journal Article] Follicular dendritic cells activate HIV-1 replication in monocytes/macrophages through a juxtacrine mechanism mediated by P-selectin glycoprotein ligand 1.2009
Author(s)
Ohba K, Ryo A, Dewan MZ, Nishi M, Naito T, Qi X, Inagaki Y, Nagashima Y, Tanaka Y, Okamoto T, Terashima K, Yamamoto N.
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Journal Title
J Immunol. 183(1)
Pages: 524-532
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[Journal Article] Identification of the P-TEFb complex-interacting domain of Brd4 as an inhibitor of HIV-1 replication by functional cDNA library screening in MT-4 cells.2008
Author(s)
Urano E, Kariya Y, Futahashi Y, Ichikawa R, Hamatake M, Fukazawa H, Morikawa Y, Yoshida T, Koyanagi Y, Yamamoto N, Komano J.
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Journal Title
FEBS Lett. 582(29)
Pages: 4053-4058
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[Journal Article] Loss of Atg16L1, an autophagy regulator, enhances endotoxin-induced IL-1β production Nature2008
Author(s)
Saitoh T, Fujita N, Jang MH, Uematsu S, Yang BG, Satoh T, Omori H, Noda T, Yamamoto N, Komatsu M, Tanaka K, Kawai T, Tsujimura T, Takeuchi O, Yoshimori T, Akira S.
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Journal Title
Related Report
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[Journal Article] Overexpressed NF-kappaB-inducing kinase contributes to the tumorigenesis of adult T-cell leukemia and Hodgkin Reed-Sternberg cells.2008
Author(s)
Saitoh Y, Yamamoto N, Dewan MZ, Sugimoto H, Martinez Bruyn VJ, Iwasaki Y, Matsubara K, Qi X, Saitoh T, Imoto I, Inazawa J, Utsunomiya A, Watanabe T, Masuda T, Yamamoto N, Yamaoka S.
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Journal Title
Blood. 111(10)
Pages: 5118-5129
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