| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2010: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2009: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2008: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Research Abstract |
Dendritic cells (DCs) sense virus-or host-derived nucleic acids through Toll-like receptors (TLRs) and produce type I interferons (IFNs), thereby provoking antiviral host defense and causing manifestations of various autoimmune diseases. DCs consist of various subsets, but a serine threonine kinase, IKKα, was found to be a unique molecule involved in TLR-induced type I IFN production in all DC subsets. Importantly, we also found that IKK was important in human DCs as in murine DCs. We plan to further clarify molecular mechanisms for DC subset functions.
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