A retrospective cohort study to evaluate the impact of dual infection of HGV and HTLV-1 on the maternal infection of HTLV-1

• Project/Area Number: 20390186
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Nagasaki University
• Principal Investigator: YAMAMOTO Taro Nagasaki University, 熱帯医学研究所, 教授 (70304970)
• Co-Investigator(Kenkyū-buntansha): ICHIKAWA Tatsuki 長崎大学, 大学病院, 助教 (80346949) ; KATAMINE Shigeru 長崎大学, 学長 (40161062) ; 矢野 公士 国立国際医療センター, 国府病院, 医長 (60360856)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000); Fiscal Year 2010: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2009: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000); Fiscal Year 2008: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
• Keywords: 疫学 / 感染症疫学

Research Abstract

This study has been to evaluate, with retrospective cohort, the impact of dual infection of HTLV-1 and Hepatitis G virus on maternal to child infection of HTLV-1, main transmission route of which is maternal infection, let alone horizontal transmission through blood and sexual contact. By the time of the last year, we established RT-PCR enable to detect hepatitis G virus. As a consequence, we obtained the result that infection rate of HGV was 0.8 percents. On the other hand, we also have gotten the result that there have been two subgroups of HTLV-1 existing in Japan, and those were divided around 20 to 40 thousand years ago.

Research Products

• [Journal Article] Successful pegylated interferon alpha2a monotherapy for hepatitis Cvirus infection in a transplanted patient who relapsed after the precedingcourse. (2011)
  • Author(s): Ichikawa T, Taura N, Miyaaki H, Matsuzaki M, Eguchi S, Takatsuki M, Kanematsu T, Nakao K.
  • Journal Title: Transpl Infect Dis
  • Peer Reviewed
• [Journal Article] Epidemiological Evidence that Simian T-lymphotropic Virus Type1 in Macaca fuscata has an Alternative Transmission Route to Maternal Infection. (2010)
  • Author(s): Eguchi K, Ohsawa, Fuse M(kiyono), Suzuki J, Kurokawa K, Yamamoto T.
  • Journal Title: AIDS Research and Human Retroviruses. 27(2) Pages: 113-114
  • Peer Reviewed
• [Journal Article] Educational intervention for preventing blood-borne infection among medical students in China. (2010)
  • Author(s): Zhang Z, Yamamoto T, Wu X, Moji K, Cai X, Kuroiwa C.
  • Journal Title: Journal of Hospital Infection. 75(1) Pages: 47-51
  • Peer Reviewed
• [Journal Article] Epidemiological Evidence that Simian T-lymphotropic Virus Type 1 in Macaca fuscata has an Alternative transmission Route to Maternal Infection. (2010)
  • Author(s): Eguchi K, Ohsawa K, Fuse M, Suzuki J, Kurokawa K, Yamamoto T.
  • Journal Title: AIDS Research and Human Retroviruses. Volume: 27(2) Pages: 113-114
  • Peer Reviewed
• [Journal Article] The role of climate variability in the spread of malaria in Bangladeshi highland. (2010)
  • Author(s): Haque U, Hashizume M, Glass GE, Dewan A, Overgaard HJ, Yamamoto T.
  • Journal Title: PLoS ONE. Volume: 5(12)
  • NAID: 120006984821
  • Peer Reviewed
• [Journal Article] International contribution Made by Universities and Medical Schools in Japan (2010)
  • Author(s): Yamamoto T.
  • Journal Title: Japan Medical Association Journal. Volume: 53(3) Pages: 1-2
  • Peer Reviewed
• [Journal Article] Educational intervention for preventing blood-borne infection among medical students in China. (2010)
  • Author(s): Zhang Z, Yamamoto T, Wu X, Moji K, Cai X, Kuroiwa C.
  • Journal Title: Journal of Hospital Infection.
  • Peer Reviewed
• [Journal Article] Effect of an oral branched chain amino acid-enriched snack in cirrhotic patients with sleep disturbance. (2010)
  • Author(s): Ichikawa T, Naota T, Miyaaki H, Miuma S, Isomoto H, Takeshima F, Nakao K.
  • Journal Title: Hepatol Res. Volume: 40(10) Pages: 971-978
  • NAID: 10027821149
  • Peer Reviewed
• [Journal Article] Macrophage-dominant sialademitis in human T-cell leukemia virus type I-associated myelopathy after living-donor liver transplantation. (2010)
  • Author(s): Nakamura H, Ichikawa T, Nakamura T, Kawakami A, Iwamoto N, Matsuzaki T, Miyaaki H, Eguchi S, Hayashi T, Nakao K, Kanematsu T, Eguchi K.
  • Journal Title: Transplant Proc. Volume: 42(7) Pages: 2797-2799
  • Peer Reviewed
• [Journal Article] Educational intervention for preventing blood-borne infection among medical students in China. (2010)
  • Author(s): Zhang Z, Yamamoto T, Wu X, Moji K, Cai X, Kuroiwa C.
  • Journal Title: Journal of Hospital Infection. (in press)
• [Journal Article] AIDS/STD Epidemics among Cross-Border Floating Populations in South China. (2009)
  • Author(s): Cai G, L.S, Kang J, Zhang Z, Yamamoto T, Zhang K, Moji K.
  • Journal Title: Joutnsl of International Health. 24(3) Pages: 236-236
  • Peer Reviewed
• [Journal Article] A Further Insight into the Origin of Human T-Lymphotropic Virus Type1(HTLV-1) in Japan, Based on the Genotyping of ABCC11. (2009)
  • Author(s): Oshima K, Fujii H, Eguchi K, Otani M, Matsuo T, Kondo S, Yoshimura K, Yamamoto T.
  • Journal Title: Tropical Medicine and Healthe. Pages: 121-123
  • NAID: 10025715307
  • Peer Reviewed
• [Journal Article] Usefulness of Highly Active Antiretroviral Therapy on Health-Related Quality of Life of Adult Recipients in Tanzania. (2009)
  • Author(s): Magafu M, Moji K, Lgumvor EU, Hashizume M, Mizota T, Komazawa O, Cai G, Yamamoto T.
  • Journal Title: AIDS PATIENT CARE and STDs. Pages: 563-570
  • Peer Reviewed
• [Journal Article] Human T-Lymphotropic Virus Type1(HTLV-1) Genetic Typing in Kakeroma Island, an Island at the Crossroads of the Ryukyuans and Wajin in Japan, Providing Further Insights into the Origin of the Virus in Japan. (2009)
  • Author(s): Eguchi K, Fujii H, Otani M, Oshima K, Matsuo T, Yamamoto T.
  • Journal Title: Journal of Medical Virology. Pages: 1450-1456
  • Peer Reviewed
• [Journal Article] Assessment of a questionnaire used for an AIDS-related KABP survey among physicians in China. (2009)
  • Author(s): Cai G, Kang J, Shen L, Min X, Wu Z, Rou K, Yamamoto T, Moji K.
  • Journal Title: Information. Pages: 721-730
  • Peer Reviewed
• [Journal Article] A Further Insight into the Origin of Human T-Lymphotropic Virus Type 1(HTLV-1)in Japan, Based on the Genotyping of ABCC11. (2009)
  • Author(s): Oshima K, Fujii H, Eguchi K, Otani M, Matsuo T, Kondo S, Yoshiura K, Yamamoto T.
  • Journal Title: Tropical Medicine and Health. 37(3) Pages: 121-123
  • NAID: 10025715307
  • Peer Reviewed
• [Journal Article] Usefulness of Highly Active Antiretroviral Therapy on Health-Related Quality of Life of Adult Recipients in Tanzania. (2009)
  • Author(s): Magafu M, Moji K, Lgumvor EU, Hashizume M, Mizota T, Komazawa O, Cai G, Yamamoto T.
  • Journal Title: AIDS PATIENT CARE and STDs. 23(7) Pages: 563-570
  • Peer Reviewed
• [Journal Article] Effect of communal piped water supply on water use pattern and the transmission of schistosomiasis haematobia in an endemic area of Kenya. (2009)
  • Author(s): Abe M, Muhoho ND, Sunahara T, Moji K, Yamamoto T, Aoki Y.
  • Journal Title: Tropical Medicine and Health. 37(2) Pages: 43-53
  • Peer Reviewed
• [Journal Article] Human T-Lymphotropic Virus Type 1(HTLV-1)Genetic Typing in Kakeroma Island, an Island at the Crossroads of the Ryukyuans and Wajin in Japan, Providing Further Insights into the Origin of the Virus in Japan. (2009)
  • Author(s): Eguchi K, Fujii H, Otani M, Oshima K, Matsuo T, Yamamoto T.
  • Journal Title: Journal of Medical Virology 81 Pages: 1450-1456
  • Peer Reviewed
• [Journal Article] Risk Factors for Malaria Infection among Ethnic Minorities in Binh Phuoc, Vietnam. (2009)
  • Author(s): Abe T, Honda S, Nakazawa S, Tuong TD, Thieu NQ, Hung LX, Thuan LK, Moji K, Takagi M, Yamamoto T.
  • Journal Title: Southeast Asian Journal of Tropical Medicine and Public Health 40 Pages: 18-29
  • Peer Reviewed
• [Journal Article] Assessment of a questionnaire used for an AIDS-related KABP survey among physicians in China. (2009)
  • Author(s): Guoxi CAI, Jun KANG, Ling SHEN, Xiangdong MIN, Zhunyou WU, Keming ROU, Taro YAMAMOTO, Kazuhiko MOJI.
  • Journal Title: Information (in press)
  • Peer Reviewed
• [Journal Article] Study of liver-targeted regulatory T cells in hepatitis B and C virus in chronically infected patients. (2009)
  • Author(s): Miyaaki H, Zhou H, Ichikawa T, Nakao K, Shibata H, Takeshita S, Akiyama M, Ozawa E, Miuma S, Eguchi K
  • Journal Title: Liver Int 29(5) Pages: 702-707
  • Peer Reviewed
• [Journal Article] Long-term increase in liver volume after Denver peritoneovenous shunt : report of two cases. (2009)
  • Author(s): Miyaaki H, Murakami E, Ichikawa T, Nakao K, Takeshita S, Shibata H, Ozawa E, Akiyama M, Miuma S, Fujimoto M, Kuroki T, Tajima Y, Kanematsu T, Eguchi K
  • Journal Title: Liver Int 29(5) Pages: 774-775
  • Peer Reviewed
• [Journal Article] Actual therapeutic efficacy of pre-transplant treatment on hepatocellular carcinoma and its impact on survival after salvage living donor liver transplantation. (2009)
  • Author(s): Eguchi S, Hidaka M, Tomonaga T, Miyazaki K, Inokuma T, Takatsuki M, Okudaira S, Yamanouchi K, Miyaaki H, Ichikawa T, Tajima Y, Kanematsu T
  • Journal Title: J Gastroenterol 44(6) Pages: 624-629
  • NAID: 10025175794
  • Peer Reviewed
• [Journal Article] Interferon-α-induced mTOR activation is an anti-hepatitis C virus signal via the phosphatidylinositol 3-kinase-Akt-independent pathway. (2009)
  • Author(s): Matsumoto A, Ichikawa T, Nakao K, Miyaaki H, Hirano K, Fujimoto M, Akiyama M, Miuma S, Ozawa E, Shibata H, Takeshita S, Yamasaki H, Ikeda M, Kato N, Eguchi K
  • Journal Title: J Gastroenterol 44(8) Pages: 856-863
  • Peer Reviewed
• [Journal Article] Predictive value of suppressor of cytokine signal 3(SOCS3)in the outcome of interferon therapy in chronic hepatitis C. (2009)
  • Author(s): Miyaaki H, Ichikawa T, Nakao K, Matsuzaki T, Muraoka T, Honda T, Takeshita S, Shibata H, Ozawa E, Akiyama M, Miuma S, Eguchi K
  • Journal Title: Hepatol Res 39(3) Pages: 850-855
  • NAID: 10025861842
  • Peer Reviewed
• [Journal Article] Hepatitis C virus kinetics during the first phase of pegylated interferon-α-2b with ribavirin therapy in patients with living donor liver transplantation. (2009)
  • Author(s): Ichikawa T, Nakao K, Miyaaki H, Eguchi S, Takatsuki M, Fujimoto M, Akiyama M, Miuma S, Ozawa E, Shibata H, Takeshita S, Kanematsu T, Eguchi K
  • Journal Title: Hepatol Res 39(9) Pages: 856-864
  • NAID: 10025861871
  • Peer Reviewed
• [Journal Article] The significance of enzyme immunoassay for the assessment of hepatitis Bvirus core-related antigen following liver transplantation. (2009)
  • Author(s): Fujimoto M, Ichikawa T, Nakao K, Miyaaki H, Shibata H, Eguchi S, Takatsuki M, Nagaoka S, Yatsuhashi H, Kanematsu T, Eguchi K
  • Journal Title: Intern Med 48(18) Pages: 1577-1583
  • NAID: 130000122067
  • Peer Reviewed
• [Journal Article] Induction of late-onset spontaneous autoimmune thyroiditis by a single low-dose irradiation in thyroiditis-prone non-obese diabetic-H2(h4)mice. (2009)
  • Author(s): Nagayama Y, Ichikawa T, Saitoh O, Abiru N
  • Journal Title: J Radiat Res 50(6) Pages: 573-577
  • NAID: 10025913203
  • Peer Reviewed
• [Journal Article] T helper type 17 immune response plays an indispensable role for development of iodine-induced autoimmune thyroiditis in nonobese diabetic-H2h4 mice. (2009)
  • Author(s): Horie I, Abiru N, Nagayama Y, Kuriya G, Saitoh O, Ichikawa T, Iwakura Y, Eguchi K
  • Journal Title: Endocrinology 150(11) Pages: 5135-5142
  • NAID: 120006983712
  • Peer Reviewed
• [Journal Article] The level of fasting serum insulin, but not adiponectin, is associated with the prognosis of early stage hepatocellular carcinoma. (2009)
  • Author(s): Miuma S, Ichikawa T, Taura N, Shibata H, Takeshita S, Akiyama M, Motoyoshi Y, Ozawa E, Fujimoto M, Kawashimo H, Miyaaki H, Eguchi K, Nakao K
  • Journal Title: Oncol Rep 22(6) Pages: 1415-1424
  • NAID: 120006984584
  • Peer Reviewed
• [Journal Article] Relationship between Regulatory T Cells and the Combination of Pegylated Interferon and Ribavirin for the Treatment of Chronic Hepatitis Type C. (2009)
  • Author(s): Akiyama M, Ichikawa T, Miyaaki H, Motoyoshi Y, Takeshita S, Ozawa E, Miuma S, Shibata H, Taura N, Nakao K
  • Journal Title: Intervirology 53(3) Pages: 154-160
  • Peer Reviewed
• [Journal Article] Serum BAFF and APRIL levels in patients with PBC. (2009)
  • Author(s): Migita K, Ilyassova B, Kovzel EF, Nersesov A, Abiru S, Maeda Y, Komori A, Ito M, Yano K, Yatsuhashi H, Shimoda S, Ishibashi H, Nakamura M.
  • Journal Title: Clin Immunol 134(2) Pages: 217-225
  • Peer Reviewed
• [Journal Article] Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C. (2009)
  • Author(s): Tanaka Y, Nishida N, Sugiyama M, Kurosaki M, Matsuura K, Sakamoto N, Nakagawa M, Korenaga M, Hino K, Hige S, Ito Y, Mita E, Tanaka E, Mochida S, Murawaki Y, Honda M, Sakai A, Hiasa Y, Nishiguchi S, Koike A, Sakaida I, Imamura M, Ito K, Yano K, Masaki N, Sugauchi F, Izumi N, Tokunaga K, Mizokami M.
  • Journal Title: Nat Genet 41(10) Pages: 1105-9
  • Peer Reviewed
• [Journal Article] Changing Epidemiology of Acute Hepatitis in Japan-Outbreaks of hepatitis E-. (2009)
  • Author(s): Yano K.
  • Journal Title: The 6th Korea-Japan Liver Symposium(KJLS), Kyong ju, Korea, 2009.07.19. Pages: 33-38
  • Peer Reviewed
• [Journal Article] Plasticity of intrahepatic biliary epithelial cells ; an alternative paradigm? (2009)
  • Author(s): Komori A, Fujiwara S, Aiba Y, Nakamura M, Yano K, Fujioka H, MIgita K, Ishibashi H.
  • Journal Title: International Symposium of Viral Hepatitis Research The Memorial Symposium for Professor Whan Kook Chung, Seoul, 2009.04.11. Pages: 38-38
  • Peer Reviewed
• [Journal Article] Analysis of Predicting factors for HBeAg-Ab seroconversion in chronichepatitis B patients. (2009)
  • Author(s): Sung-Kwan B, Yatsuhashi H, Yano K, Hamada R, Nakao R, Hashimoto S, Nishikawa A, Tateyama M, Motoyoshi Y, Nagaoka S, Taura N, Yanagi K, Abiru S, Ishibashi H.
  • Journal Title: International Symposium of Viral Hepatitis Research The Memorial Symposium for Professor Whan Kook Chung, Seoul, 2009.04.11. Pages: 20-20
  • Peer Reviewed
• [Journal Article] Emerging Infection of Hepatitis Viruses : Hepatitis E in Industrialized Countries. (2009)
  • Author(s): Yano K, Tamada Y, Yatsuhashi H, Komori A, Sung-Kwan B, Ishibashi H, Mishiro S, Mizokami M.
  • Journal Title: International Symposium of Viral Hepatitis Research The Memorial Symposium for Professor Whan Kook Chung, Seoul, 2009.04.11. Pages: 36-36
  • Peer Reviewed
• [Journal Article] 【ここが知りたいウイルス性肝炎への抗ウイルス療法の問題点と将来展望】B型肝炎急性肝炎への核酸アナログ投与の適応と中止基準. (2009)
  • Author(s): 八橋弘, 矢野公士, 長岡進矢, 阿比留正剛.
  • Journal Title: 肝・胆・膵 58(5) Pages: 601-608
  • Peer Reviewed
• [Journal Article] 【外科医が知っておくべきウイルス肝炎の最新治療】D, E型肝炎、その他のウイルス肝炎のupdate. (2009)
  • Author(s): 矢野公士.
  • Journal Title: 外科 71(4) Pages: 360-365
  • Peer Reviewed
• [Journal Article] ウイルス性急性肝炎の診断のポイントと盲点. (2009)
  • Author(s): 矢野公士.
  • Journal Title: Medical Practice 26(8) Pages: 1411-1411
  • Peer Reviewed
• [Journal Article] A型肝炎 臨床. (2009)
  • Author(s): 矢野公士.
  • Journal Title: 臨床とウイルス 37(4) Pages: 291-295
  • NAID: 10025630650
  • Peer Reviewed
• [Journal Article] Prevalence of hepatitis C virus and its genotypes among a cohort of drug users in Kenya. (2008)
  • Author(s): Musa T., Yano K., et al.
  • Journal Title: East Afr. Med. J. 85 Pages: 318-325
  • Peer Reviewed
• [Journal Article] わが国における急性肝炎の動向 (2008)
  • Author(s): 矢野公士, 八橋弘
  • Journal Title: 臨床と研究 85 Pages: 941-946
• [Presentation] TB control activities in conflict-ridden lturi in Democratic Republic of Congo. (2010)
  • Author(s): JP Malemba, J Okumura, JM Mpapa, R Mbumba, T Yamamoto, JP Kabuayi, A Ndongosieme.
  • Organizer: The 41st World Conference on Lung Health of the International Union Against.
  • Place of Presentation: Berlin Germany
• [Presentation] TB control activities in conflict-ridden area : Through a case of Ituri in Democratic Republic of Congo. (2010)
  • Author(s): Junko Okumura ,Malemba Tshibuyi JP, Mpapa JM, Mbunmba NR, Kabuayi Nyengele JP, Ndongosieme Okumu A, Taro Yamamoto.
  • Organizer: The 10th Asia Pacific Conference on Disaster Medicine(第10回アジア・太平洋災害医学会)
  • Place of Presentation: 札幌プリンスホテル
• [Presentation] A Light shed on The Enigma Surrounding HTLV-1 Epidemic in Japan. (2010)
  • Author(s): Yamamoto T.
  • Organizer: 1st World Congress of Virus and Infections-2010
  • Place of Presentation: 釜山(韓国)
• [Presentation] 中国におけるハイリスク集団を対象とするエイズ予防問題について (2009)
  • Author(s): Zhuo Z, Cai G, Shen L, Yamamoto T.
  • Organizer: 第50回日本熱帯医学会大会
  • Place of Presentation: 沖縄コンベンションセンター
• [Presentation] 東アジアにおける成人T細胞白血病ウイルス1型(HTLV-1)の空間的広がりと系統分化～HTLV-1がいつ、どこから日本に来て、どのように広まったのか～ (2009)
  • Author(s): 江口克之, 藤井秀文, 大島謙吾, 大谷正史, 松尾敏明, 渡邉俊樹, 山本太郎
  • Organizer: 第50回日本熱帯医学会大会
  • Place of Presentation: 沖縄コンベンションセンター
• [Presentation] Roles of growth hormone, insulin-like growth factor 1 and insulin-like growth factor-binding protein 3 in the development of non-alcoholic fatty liver disease (2009)
  • Author(s): Ichikawa T, Miyaaki H, Taura N, Nakao K
  • Organizer: Special Conference on NAFLD/NASH and Related Metabolic Disease
  • Place of Presentation: Bologna, Italy
• [Presentation] How are micrornas working in esophageal squamous cell carcinoma? (2009)
  • Author(s): Matsushima K, Isomoto H, Inoue N, Norimura D, Nakashima Y, Yamaguchi N, Ohnita K, Ichikawa T, Takeshima F, Nakao K
  • Organizer: GASTRO 2009 UEGW/WCOG
  • Place of Presentation: Michael Farthing/Juan-R Maragelada London, United Kingdom
• [Remarks] ホームページ等
  • URL: http://www.tm.nagasaki-u.ac.jp/newrect/
• [Remarks]
  • URL: http://www.tm.nagasaki-u.ac.jp/newrect/japanese/member/yamamoto.html
• [Remarks]
  • URL: http://www.tm.nagasaki-u.ac.jp/newrect/Japanese/member/yamamoto.html