• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Disturbance of innate immune system in alcoholic sudden death and organ damage

Research Project

Project/Area Number 20390196
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Legal medicine
Research InstitutionSapporo Medical University

Principal Investigator

MATSUMOTO Hiroshi  札幌医科大学, 医学部, 教授 (60263092)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2010: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2009: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2008: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
Keywordsアルコール / Myd88 / TLR / 自然免疫 / 急死 / 壊死 / シグナリング / 大腿骨頭壊死 / 頭部外傷死 / トランスクリプトミクス / TLR4
Research Abstract

This study found that the transcription factor IRF7 and its-induced IFNalpha plays a crucial role in the alcohol-related death, traumatic brain injury under alcohol consumption, and osteonecrosis of the femoral head

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (36 results)

All 2011 2010 2009 2008 Other

All Journal Article (12 results) (of which Peer Reviewed: 6 results) Presentation (21 results) Book (2 results) Remarks (1 results)

  • [Journal Article] アルコールの基礎知識2011

    • Author(s)
      松本博志
    • Journal Title

      日本アルコール・薬物医学会雑誌

      Volume: 46 Pages: 135-140

    • NAID

      10027808133

    • Related Report
      2010 Final Research Report
  • [Journal Article] 交通被害者と飲酒2011

    • Author(s)
      松本博志
    • Journal Title

      日本アルコール・薬物医学会雑誌

      Volume: 46 Pages: 141-146

    • NAID

      10027808104

    • Related Report
      2010 Final Research Report
  • [Journal Article] 交通被害者と飲酒2011

    • Author(s)
      松本博志
    • Journal Title

      日本アルコール薬物医学会雑誌

      Volume: 46 Pages: 140-145

    • NAID

      10027808104

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] アルコールの基礎知識2011

    • Author(s)
      松本博志
    • Journal Title

      日本アルコール薬物医学会雑誌

      Volume: 46 Pages: 146-156

    • NAID

      10027808133

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 脳挫傷後の脳浮腫増大にアルコールはglutathione系を介して関与する2010

    • Author(s)
      片田竜一, 西谷陽子, 水尾圭祐, 渡邊智, 松本博志
    • Journal Title

      アルコールと医学生物学

      Volume: 28 Pages: 55-58

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prior ethanol injection promotes brain edema after traumatic brain injury : evidence for poor prognosis for intoxicated patients2009

    • Author(s)
      Katada R, Nishitani Y, Honmou O, Okazaki S, Houkin K, Matsumoto H
    • Journal Title

      J Neurotrauma

      Volume: 26 Pages: 2015-2025

    • Related Report
      2010 Final Research Report
  • [Journal Article] Femoral head osteonecrosis can be caused by disruption of the systemic immune response via the toll-like receptor 4 signalling pathway2009

    • Author(s)
      Okazaki S, Nishitani Y, Nagoya S, Kaya M, Yamashita T, Matsumoto H
    • Journal Title

      Rheumatology

      Volume: 48 Pages: 227-232

    • Related Report
      2010 Final Research Report
  • [Journal Article] Femoral head osteonecrosis can be caused by disruption of the systemic immune response via the toll-like receptor 4 signalling pathway2009

    • Author(s)
      Okazaki, et al.
    • Journal Title

      Rheumatology 48

      Pages: 227-232

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] アルコールの脳挫傷後脳浮腫に及ぼす影響2009

    • Author(s)
      片田竜一ら
    • Journal Title

      アルコール医学生物学 28

      Pages: 66-69

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ethanol-induced JNK activation is suppressed via active Akt in hepatocytes.2008

    • Author(s)
      Nishitani, et al.
    • Journal Title

      Jpn J Alcohol & Drug Dependence 43

      Pages: 35-43

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of aquaporin-4 augments cytotoxic brain edema after traumatic brain injury during acute ethanol exposure

    • Author(s)
      Katada R, Nishitani Y, Honmou O, Mizuo K, Okazaki S, Tateda K, Watanabe S, Matsumoto H
    • Journal Title

      Am J Pathol

      Volume: (in press)

    • Related Report
      2010 Final Research Report
  • [Journal Article] High risk of osteonecrosis of the femoral head in autoimmune disease patients showing no immediate increase in hepatic enzyme under steroid therapy

    • Author(s)
      Okazaki S, Nagoya S, Yamamoto M, Tateda K, Takahashi H, Yamashita T, Matsumoto H
    • Journal Title

      Rheumatol Int

      Volume: (in press)

    • Related Report
      2010 Final Research Report
  • [Presentation] 脂肪酸はラット肝細胞においてアルコール負荷時のERストレスを増悪する2010

    • Author(s)
      横山佳浩、柏木智則、岡崎俊一郎、舘田健児、片田竜一、水尾圭祐、渡邊智、松本博志
    • Organizer
      第30回アルコール医学生物学研究会学術集会
    • Place of Presentation
      久留米翠香園ホテル(久留米市)
    • Year and Date
      2010-11-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] LPS負荷後のアルコール投与はデスシグナリングを活性化させる2010

    • Author(s)
      蕨玲子、岡崎俊一郎、片田竜一、水尾圭祐、舘田健児、渡邊智、浅井康文、松本博志
    • Organizer
      第30回アルコール医学生物学研究会学術集会
    • Place of Presentation
      久留米翠香園ホテル(久留米市)
    • Year and Date
      2010-11-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] アルコール性肝障害におけるXBP1の役割2010

    • Author(s)
      柏木智則、岡崎俊一郎、舘田健児、横山佳浩、片田竜一、水尾圭祐、渡邊智、松本博志
    • Organizer
      第30回アルコール医学生物学研究会学術集会
    • Place of Presentation
      久留米翠香園ホテル(久留米市)
    • Year and Date
      2010-11-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] ステロイド誘発大腿骨頭壊死症の発生要因としての肝臓機能2010

    • Author(s)
      岡崎俊一郎, 名越智, 山本元久, 館田健児, 高橋裕樹, 山下敏彦, 松本博志
    • Organizer
      第30回アルコール医学生物学研究会学術集会
    • Place of Presentation
      久留米翠香園ホテル(久留米市)
    • Year and Date
      2010-11-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] Aquaporin-4がアルコール摂取における脳挫傷後脳浮腫増悪に及ぼす影響2010

    • Author(s)
      片田竜一、水尾圭祐、岡崎俊一郎、舘田健児、渡邊智、松本博志
    • Organizer
      第30回アルコール医学生物学研究会学術集会
    • Place of Presentation
      久留米翠香園ホテル(久留米市)
    • Year and Date
      2010-11-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] アルコールによる脳挫傷後脳浮腫増大に及ぼすAquaporin-4の役割2010

    • Author(s)
      片田竜一、水尾圭祐、岡崎俊一郎、舘田健児、渡邊智、松本博志
    • Organizer
      平成22年度アルコール・薬物依存関連学会合同学術総会(第45回日本アルコール・薬物医学会)
    • Place of Presentation
      リーガロイヤルホテル小倉(北九州市)
    • Year and Date
      2010-10-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] The effects of AQP4 on augmentation of rat brain edema after traumatic brain injury under ethanol injection2010

    • Author(s)
      Katada R, Mizuo K, Okazaki S, Watanabe S, Matsumoto H
    • Organizer
      2010 ISBRA World Congress
    • Place of Presentation
      パリ、フランス国
    • Year and Date
      2010-09-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Role of IFN-γ and IL-17 in the pathogenesis of steroid and ethanol-induced osteonecrosis of femoral head2010

    • Author(s)
      K Tateda, S Okazaki, S Watanebe, R Katada, K Mizuo, S Nagoya, T Yamashita, H Matsumoto
    • Organizer
      2010 ISBRA World Congress
    • Place of Presentation
      パリ、フランス国
    • Year and Date
      2010-09-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] EFFECT OF SLEEPING ON ETHANOL ELIMINATION KINETICS IN HUMANS2010

    • Author(s)
      Matsumoto H, Ishiza A, Shimizu J, Katada R, Mizuo K, Tanaka M, Higuchi S
    • Organizer
      2010 ISBRA World Congress
    • Place of Presentation
      パリ、フランス国
    • Year and Date
      2010-09-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] Acute ethanol administration changes in the expression of microRNAs in mouse brain2010

    • Author(s)
      Mizuo ; Y.Nishitani ; R.Katada ; S.Okazaki ; K.Tateda ; S.Watanabe ; H.Matsumoto
    • Organizer
      2010 ISBRA World Congress
    • Place of Presentation
      パリ、フランス国
    • Year and Date
      2010-09-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] Aquaporin-4 affects brain edema after brain contusion under ethanol consumption2010

    • Author(s)
      Katada R, Mizuo K, Okazaki S, Tateda K, Watanabe S, Matsumoto H
    • Organizer
      Neuro2010
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Year and Date
      2010-09-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] Role of IL-17 in the pathogenesis of steroid-induced osteonecrosis of femoral head2010

    • Author(s)
      K Tateda, S Okazaki, S Watanebe, R Katada, K Mizuo, S Nagoya, T Yamashita, H Matsumoto
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Year and Date
      2010-08-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] Alcohol-induced proinflammatory disturbance promotes insulin resistance in the NIDDM murine model2010

    • Author(s)
      H.Matsumoto, M.Tanaka, K.Tateda, A.Ishizaka, Y.Nishitani, S.Okazaki, M.Tomoyoshi, R.Katada, K.Mizuo, S.Watanabe
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Year and Date
      2010-08-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] Role of innate immune system in the pathogenesis of alcoholic and nonalcoholic fatty liver disease2010

    • Author(s)
      H MATSUMOTO, M TANAKA, K FUJII, S Okazaki, Y NISHITANI, R KATADA, A ISHIZAKA, K TATADA, K MIZUO, S WATANABE
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Year and Date
      2010-08-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] Ethanol promotes brain edema after TBI : its molecular mechanism.2010

    • Author(s)
      Matsumoto H
    • Organizer
      Symposium "Traumatic Brain Injury" Bit's 1^<st> Annual World Congress of Neuro Talk2010
    • Place of Presentation
      Singapore
    • Year and Date
      2010-06-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] Alcohol consumption promotes insulin resistance via accumulation of proinflammatory responses in the NIDDM murine model2010

    • Author(s)
      H Matsumoto, M Tanaka, K Tateda, A Ishizaka, Y Nishitani, S Okazaki, R Katada, K Mizuo, S Watanabe
    • Organizer
      Experimental Biology 2010
    • Place of Presentation
      Anaheim, U.S.A.
    • Year and Date
      2010-04-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] The defensive effect of nitric oxide on the pathogenesis of steroid-induced femoral head osteonecrosis2010

    • Author(s)
      K Tateda, S Okazaki, S Watanebe, R Katada, K Mizuo, S Nagoya, T Yamashita, H Matsumoto
    • Organizer
      Experimental Biology 2010
    • Place of Presentation
      Anaheim, U.S.A.
    • Year and Date
      2010-04-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] Alcohol consumption promotes insulin resistance via accumulation of proinflammatory responses in the NIDDM murine model2010

    • Author(s)
      Matsumoto H, Tanaka M, Tateda K, Ishizaka A, Nishitani Y, Okazaki S, Katada R, Mizuo K, Watanab S
    • Organizer
      Experimental Biology 2010
    • Place of Presentation
      Anaheim, U. S. A
    • Related Report
      2010 Final Research Report
  • [Presentation] Role of innate immune system of alcoholic liver disease and nonalcoholic fatty liver disease in forensic autopsy2009

    • Author(s)
      Matsumoto H, Tanaka M, Fujii K, Nishitani Y, Katada R, Ishizaka A, Shimizu J, Igarashi A, Hagiwara T, Tateda K, Mizuo K, Watanabe S
    • Organizer
      XXI Congress of the International Academy of Legal Medicine
    • Place of Presentation
      Lisbon, Portugal
    • Related Report
      2010 Final Research Report
  • [Presentation] TLR4-signaling pathway contributes to formation of steatosis in alcoholic and nonalcoholic fatty liver disease : A new therapy for fatty liver disease2008

    • Author(s)
      Matsumoto H, Fujii K, Nishitani Y, Okazaki S, Imabayashi K
    • Organizer
      ISBRA 2008
    • Place of Presentation
      Washington DC
    • Related Report
      2010 Final Research Report
  • [Presentation] TLR4-signaling pathway contributes to formation of steatosis in alcoholic and nonalcoholic fatty liver disease : A new therapy for fatty liver disease.2008

    • Author(s)
      Matsumoto, et al.
    • Organizer
      ISBRA2008
    • Place of Presentation
      Washington, D. C.
    • Related Report
      2008 Annual Research Report
  • [Book] NEW法医学・医事法2008

    • Author(s)
      松本博志
    • Total Pages
      95
    • Publisher
      アルコールの法医学
    • Related Report
      2010 Final Research Report
  • [Book] NEW法医学・医事法2008

    • Author(s)
      松本博志
    • Total Pages
      12
    • Publisher
      南江堂
    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://web.sapmed.ac.jp/legalm/

    • Related Report
      2010 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi