Disturbance of innate immune system in alcoholic sudden death and organ damage

• Project/Area Number: 20390196
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Legal medicine
• Research Institution: Sapporo Medical University
• Principal Investigator: MATSUMOTO Hiroshi 札幌医科大学, 医学部, 教授 (60263092)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000); Fiscal Year 2010: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2009: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2008: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
• Keywords: アルコール / Myd88 / TLR / 自然免疫 / 急死 / 壊死 / シグナリング / 大腿骨頭壊死 / 頭部外傷死 / トランスクリプトミクス / TLR4

Research Abstract

This study found that the transcription factor IRF7 and its-induced IFNalpha plays a crucial role in the alcohol-related death, traumatic brain injury under alcohol consumption, and osteonecrosis of the femoral head

Research Products

• [Journal Article] アルコールの基礎知識 (2011)
  • Author(s): 松本博志
  • Journal Title: 日本アルコール・薬物医学会雑誌 Volume: 46 Pages: 135-140
  • NAID: 10027808133
• [Journal Article] 交通被害者と飲酒 (2011)
  • Author(s): 松本博志
  • Journal Title: 日本アルコール・薬物医学会雑誌 Volume: 46 Pages: 141-146
  • NAID: 10027808104
• [Journal Article] 交通被害者と飲酒 (2011)
  • Author(s): 松本博志
  • Journal Title: 日本アルコール薬物医学会雑誌 Volume: 46 Pages: 140-145
  • NAID: 10027808104
  • Peer Reviewed
• [Journal Article] アルコールの基礎知識 (2011)
  • Author(s): 松本博志
  • Journal Title: 日本アルコール薬物医学会雑誌 Volume: 46 Pages: 146-156
  • NAID: 10027808133
  • Peer Reviewed
• [Journal Article] 脳挫傷後の脳浮腫増大にアルコールはglutathione系を介して関与する (2010)
  • Author(s): 片田竜一, 西谷陽子, 水尾圭祐, 渡邊智, 松本博志
  • Journal Title: アルコールと医学生物学 Volume: 28 Pages: 55-58
  • Peer Reviewed
• [Journal Article] Prior ethanol injection promotes brain edema after traumatic brain injury : evidence for poor prognosis for intoxicated patients (2009)
  • Author(s): Katada R, Nishitani Y, Honmou O, Okazaki S, Houkin K, Matsumoto H
  • Journal Title: J Neurotrauma Volume: 26 Pages: 2015-2025
• [Journal Article] Femoral head osteonecrosis can be caused by disruption of the systemic immune response via the toll-like receptor 4 signalling pathway (2009)
  • Author(s): Okazaki S, Nishitani Y, Nagoya S, Kaya M, Yamashita T, Matsumoto H
  • Journal Title: Rheumatology Volume: 48 Pages: 227-232
• [Journal Article] Femoral head osteonecrosis can be caused by disruption of the systemic immune response via the toll-like receptor 4 signalling pathway (2009)
  • Author(s): Okazaki, et al.
  • Journal Title: Rheumatology 48 Pages: 227-232
  • Peer Reviewed
• [Journal Article] アルコールの脳挫傷後脳浮腫に及ぼす影響 (2009)
  • Author(s): 片田竜一ら
  • Journal Title: アルコール医学生物学 28 Pages: 66-69
  • Peer Reviewed
• [Journal Article] Ethanol-induced JNK activation is suppressed via active Akt in hepatocytes. (2008)
  • Author(s): Nishitani, et al.
  • Journal Title: Jpn J Alcohol & Drug Dependence 43 Pages: 35-43
  • Peer Reviewed
• [Journal Article] Expression of aquaporin-4 augments cytotoxic brain edema after traumatic brain injury during acute ethanol exposure
  • Author(s): Katada R, Nishitani Y, Honmou O, Mizuo K, Okazaki S, Tateda K, Watanabe S, Matsumoto H
  • Journal Title: Am J Pathol Volume: (in press)
• [Journal Article] High risk of osteonecrosis of the femoral head in autoimmune disease patients showing no immediate increase in hepatic enzyme under steroid therapy
  • Author(s): Okazaki S, Nagoya S, Yamamoto M, Tateda K, Takahashi H, Yamashita T, Matsumoto H
  • Journal Title: Rheumatol Int Volume: (in press)
• [Presentation] 脂肪酸はラット肝細胞においてアルコール負荷時のERストレスを増悪する (2010)
  • Author(s): 横山佳浩、柏木智則、岡崎俊一郎、舘田健児、片田竜一、水尾圭祐、渡邊智、松本博志
  • Organizer: 第30回アルコール医学生物学研究会学術集会
  • Place of Presentation: 久留米翠香園ホテル(久留米市)
  • Year and Date: 2010-11-26
• [Presentation] LPS負荷後のアルコール投与はデスシグナリングを活性化させる (2010)
  • Author(s): 蕨玲子、岡崎俊一郎、片田竜一、水尾圭祐、舘田健児、渡邊智、浅井康文、松本博志
  • Organizer: 第30回アルコール医学生物学研究会学術集会
  • Place of Presentation: 久留米翠香園ホテル(久留米市)
  • Year and Date: 2010-11-26
• [Presentation] アルコール性肝障害におけるXBP1の役割 (2010)
  • Author(s): 柏木智則、岡崎俊一郎、舘田健児、横山佳浩、片田竜一、水尾圭祐、渡邊智、松本博志
  • Organizer: 第30回アルコール医学生物学研究会学術集会
  • Place of Presentation: 久留米翠香園ホテル(久留米市)
  • Year and Date: 2010-11-26
• [Presentation] ステロイド誘発大腿骨頭壊死症の発生要因としての肝臓機能 (2010)
  • Author(s): 岡崎俊一郎, 名越智, 山本元久, 館田健児, 高橋裕樹, 山下敏彦, 松本博志
  • Organizer: 第30回アルコール医学生物学研究会学術集会
  • Place of Presentation: 久留米翠香園ホテル(久留米市)
  • Year and Date: 2010-11-26
• [Presentation] Aquaporin-4がアルコール摂取における脳挫傷後脳浮腫増悪に及ぼす影響 (2010)
  • Author(s): 片田竜一、水尾圭祐、岡崎俊一郎、舘田健児、渡邊智、松本博志
  • Organizer: 第30回アルコール医学生物学研究会学術集会
  • Place of Presentation: 久留米翠香園ホテル(久留米市)
  • Year and Date: 2010-11-26
• [Presentation] アルコールによる脳挫傷後脳浮腫増大に及ぼすAquaporin-4の役割 (2010)
  • Author(s): 片田竜一、水尾圭祐、岡崎俊一郎、舘田健児、渡邊智、松本博志
  • Organizer: 平成22年度アルコール・薬物依存関連学会合同学術総会(第45回日本アルコール・薬物医学会)
  • Place of Presentation: リーガロイヤルホテル小倉(北九州市)
  • Year and Date: 2010-10-07
• [Presentation] The effects of AQP4 on augmentation of rat brain edema after traumatic brain injury under ethanol injection (2010)
  • Author(s): Katada R, Mizuo K, Okazaki S, Watanabe S, Matsumoto H
  • Organizer: 2010 ISBRA World Congress
  • Place of Presentation: パリ、フランス国
  • Year and Date: 2010-09-16
• [Presentation] Role of IFN-γ and IL-17 in the pathogenesis of steroid and ethanol-induced osteonecrosis of femoral head (2010)
  • Author(s): K Tateda, S Okazaki, S Watanebe, R Katada, K Mizuo, S Nagoya, T Yamashita, H Matsumoto
  • Organizer: 2010 ISBRA World Congress
  • Place of Presentation: パリ、フランス国
  • Year and Date: 2010-09-16
• [Presentation] EFFECT OF SLEEPING ON ETHANOL ELIMINATION KINETICS IN HUMANS (2010)
  • Author(s): Matsumoto H, Ishiza A, Shimizu J, Katada R, Mizuo K, Tanaka M, Higuchi S
  • Organizer: 2010 ISBRA World Congress
  • Place of Presentation: パリ、フランス国
  • Year and Date: 2010-09-15
• [Presentation] Acute ethanol administration changes in the expression of microRNAs in mouse brain (2010)
  • Author(s): Mizuo ; Y.Nishitani ; R.Katada ; S.Okazaki ; K.Tateda ; S.Watanabe ; H.Matsumoto
  • Organizer: 2010 ISBRA World Congress
  • Place of Presentation: パリ、フランス国
  • Year and Date: 2010-09-14
• [Presentation] Aquaporin-4 affects brain edema after brain contusion under ethanol consumption (2010)
  • Author(s): Katada R, Mizuo K, Okazaki S, Tateda K, Watanabe S, Matsumoto H
  • Organizer: Neuro2010
  • Place of Presentation: 神戸国際会議場(神戸市)
  • Year and Date: 2010-09-04
• [Presentation] Role of IL-17 in the pathogenesis of steroid-induced osteonecrosis of femoral head (2010)
  • Author(s): K Tateda, S Okazaki, S Watanebe, R Katada, K Mizuo, S Nagoya, T Yamashita, H Matsumoto
  • Organizer: 14th International Congress of Immunology
  • Place of Presentation: 神戸国際会議場(神戸市)
  • Year and Date: 2010-08-24
• [Presentation] Alcohol-induced proinflammatory disturbance promotes insulin resistance in the NIDDM murine model (2010)
  • Author(s): H.Matsumoto, M.Tanaka, K.Tateda, A.Ishizaka, Y.Nishitani, S.Okazaki, M.Tomoyoshi, R.Katada, K.Mizuo, S.Watanabe
  • Organizer: 14th International Congress of Immunology
  • Place of Presentation: 神戸国際会議場(神戸市)
  • Year and Date: 2010-08-23
• [Presentation] Role of innate immune system in the pathogenesis of alcoholic and nonalcoholic fatty liver disease (2010)
  • Author(s): H MATSUMOTO, M TANAKA, K FUJII, S Okazaki, Y NISHITANI, R KATADA, A ISHIZAKA, K TATADA, K MIZUO, S WATANABE
  • Organizer: 14th International Congress of Immunology
  • Place of Presentation: 神戸国際会議場(神戸市)
  • Year and Date: 2010-08-23
• [Presentation] Ethanol promotes brain edema after TBI : its molecular mechanism. (2010)
  • Author(s): Matsumoto H
  • Organizer: Symposium "Traumatic Brain Injury" Bit's 1^<st> Annual World Congress of Neuro Talk2010
  • Place of Presentation: Singapore
  • Year and Date: 2010-06-27
• [Presentation] Alcohol consumption promotes insulin resistance via accumulation of proinflammatory responses in the NIDDM murine model (2010)
  • Author(s): H Matsumoto, M Tanaka, K Tateda, A Ishizaka, Y Nishitani, S Okazaki, R Katada, K Mizuo, S Watanabe
  • Organizer: Experimental Biology 2010
  • Place of Presentation: Anaheim, U.S.A.
  • Year and Date: 2010-04-28
• [Presentation] The defensive effect of nitric oxide on the pathogenesis of steroid-induced femoral head osteonecrosis (2010)
  • Author(s): K Tateda, S Okazaki, S Watanebe, R Katada, K Mizuo, S Nagoya, T Yamashita, H Matsumoto
  • Organizer: Experimental Biology 2010
  • Place of Presentation: Anaheim, U.S.A.
  • Year and Date: 2010-04-28
• [Presentation] Alcohol consumption promotes insulin resistance via accumulation of proinflammatory responses in the NIDDM murine model (2010)
  • Author(s): Matsumoto H, Tanaka M, Tateda K, Ishizaka A, Nishitani Y, Okazaki S, Katada R, Mizuo K, Watanab S
  • Organizer: Experimental Biology 2010
  • Place of Presentation: Anaheim, U. S. A
• [Presentation] Role of innate immune system of alcoholic liver disease and nonalcoholic fatty liver disease in forensic autopsy (2009)
  • Author(s): Matsumoto H, Tanaka M, Fujii K, Nishitani Y, Katada R, Ishizaka A, Shimizu J, Igarashi A, Hagiwara T, Tateda K, Mizuo K, Watanabe S
  • Organizer: XXI Congress of the International Academy of Legal Medicine
  • Place of Presentation: Lisbon, Portugal
• [Presentation] TLR4-signaling pathway contributes to formation of steatosis in alcoholic and nonalcoholic fatty liver disease : A new therapy for fatty liver disease (2008)
  • Author(s): Matsumoto H, Fujii K, Nishitani Y, Okazaki S, Imabayashi K
  • Organizer: ISBRA 2008
  • Place of Presentation: Washington DC
• [Presentation] TLR4-signaling pathway contributes to formation of steatosis in alcoholic and nonalcoholic fatty liver disease : A new therapy for fatty liver disease. (2008)
  • Author(s): Matsumoto, et al.
  • Organizer: ISBRA2008
  • Place of Presentation: Washington, D. C.
• [Book] NEW法医学・医事法 (2008)
  • Author(s): 松本博志
  • Total Pages: 95
  • Publisher: アルコールの法医学
• [Book] NEW法医学・医事法 (2008)
  • Author(s): 松本博志
  • Total Pages: 12
  • Publisher: 南江堂
• [Remarks]
  • URL: http://web.sapmed.ac.jp/legalm/