| Project/Area Number |
20390197
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | University of Toyama |
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Principal Investigator |
MATSUMOTO Kinzo University of Toyama, 和漢医薬学総合研究所, 教授 (10114654)
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| Co-Investigator(Kenkyū-buntansha) |
TSUNEYAMA Koichi 富山大学, 大学院・医学薬学研究部(医学), 准教授 (10293341)
TANAKA Ken 富山大学, 和漢医薬学総合研究所, 准教授 (60418689)
MURAKAMI Yukihisa 富山大学, 和漢医薬学総合研究所, 助教 (00377269)
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| Co-Investigator(Renkei-kenkyūsha) |
SIBAHARA Naotoshi 富山大学, 和漢医薬学総合研究所, 教授 (10272907)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2010: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2009: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2008: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
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| Keywords | 認知症モデル / 漢方薬 / メディエータ / 脳虚血 / 加齢 / dementia model / Kampo medicine / vascular endothelial growth factor / neuroplasticity / aging / platelet derived growth factor / ischemia / mediator(s) / anti-dementia drug / emotional disoders / Senescence-accelerated mouse |
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| Research Abstract |
In this study, we have demonstrated the anti-dementia effects of chotosan, yokukansan, and kangenkaryu using animal models of cognitive deficits. We have also suggested that vascular endothelial growth factor and platelet-derived growth factors, as well as facilitation of central cholinergic systems and neuroplasticity systems, are involved in the action of these crude drugs. The present findings that VEGF/PDGF and their receptors are co-localized with NMDA-type glutamate receptors in the cerebral cortical neurons allowed us to infer that VEGF/PDGF may act as endogenous factors that mediate the anti-dementia effects of chotosan, kangen-karyu, and yokukansan.
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