A novel anti-fibrotic therapy for scirrhous gastric cancer.

• Project/Area Number: 20390211
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Sapporo Medical University
• Principal Investigator: TAKIMOTO Rishu Sapporo Medical University, 医学部, 講師 (10336399)
• Co-Investigator(Kenkyū-buntansha): SATO Yasushi 札幌医科大学, 医学部, 講師 (80343383) ; TAKADA Koichi 札幌医科大学, 医学部, 助教 (90398321)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000); Fiscal Year 2010: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2009: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2008: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
• Keywords: 癌 / 線維化 / 内科 / スキルス胃癌 / 抗線維化 / 抗がん剤 / 治療 / 後線維化

Research Abstract

A novel anti-fibrotic therapy for scirrhous gastric cancer.

Research Products

• [Journal Article] Argon plasma coagulation treatment of hemorrhagic radiation proctopathy : the optimal settings for application and long-term outcome. et al. (2011)
  • Author(s): Sato Y, Takimoto R
  • Journal Title: Gastrointest Endosc. 73(3) Pages: 543-549
  • Peer Reviewed
• [Journal Article] Endoscopic findings of enteropathy-type T-cell lymphoma by double-balloon enteroscopy and capsule endoscopy. et al. (2010)
  • Author(s): Sato Y, Takimoto R
  • Journal Title: Dig Endosc. 22(3) Pages: 243-245
  • Peer Reviewed
• [Journal Article] Pure red cell aplasia associated with Good's syndrome accompanied by decreased stem cell factor production in the bone marrow. et al. (2010)
  • Author(s): Kuribayashi K, Takimoto R
  • Journal Title: Intern Med. 49(5) Pages: 377-82
  • Peer Reviewed
• [Journal Article] Phase II study of S-1, docetaxel and cisplatin combination chemotherapy in patients with unresectable metastatic gastric cancer. et al. (2010)
  • Author(s): Sato Y, Takimoto R
  • Journal Title: Cancer Chemother Pharmacol. 66(4) Pages: 721-728
  • Peer Reviewed
• [Journal Article] Phase II study of S-1, docetaxel and cisplatin combination chemotherapy in patients with unresectable metastatic gastric cancer. (2010)
  • Author(s): Sato Y, Takimoto R., et al.
  • Journal Title: Cancer Chemother Pharmacol. Volume: 66 Pages: 721-728
  • Peer Reviewed
• [Journal Article] Suppressive effect of sulindac on branch duct-intraductal papillary mucinous neopIasms. et al. (2009)
  • Author(s): Hayashi T, Takimoto R
  • Journal Title: J Gastroenterol. 44(9) Pages: 964-975
  • Peer Reviewed
• [Journal Article] Drug resistance is dramatically restored by hedgehog inhibitors in CD34+ leukemic cells. et al. (2009)
  • Author(s): Kobune M, Takimoto R
  • Journal Title: Cancer Sci. 100(5) Pages: 948-955
  • Peer Reviewed
• [Journal Article] Phase II study of S-1, docetaxel and cisplatin combination chemotherapy in patients with unresectable metastatic gastric cancer (2009)
  • Author(s): Sato Y, Takimoto R, et al.
  • Journal Title: Cancer Chemother Pharmacol.
  • Peer Reviewed
• [Journal Article] Suppressive effect of sulindac on branch duct-intraductal papillary mucinoun neoplasms (2009)
  • Author(s): Hayashi T, Takimoto R, et al.
  • Journal Title: J Gastroenterol. 44 Pages: 964-75
  • Peer Reviewed
• [Journal Article] Drug resistance is dramatically restored by hedgehog inhibitors in CD34+ leukemic cells (2009)
  • Author(s): Kobune M, Takimoto R, et al.
  • Journal Title: Cancer Sci. 100(5) Pages: 948-55
  • Peer Reviewed
• [Journal Article] Treatment of hepatocellular carcinoma by AdAFPep/rep, AdAFPep/p53, and 5-fluorouracil in mice. et al. (2008)
  • Author(s): Sagawa T, Takimoto R
  • Journal Title: Hepatology. 48(3) Pages: 828-40
  • Peer Reviewed
• [Journal Article] Apoptos is supercedes necrosis in mitochondrial DNA-depleted Jurkat cells by cleavage of receptor-interacting protein and inhibition of Iysosomal cathepsin. et al. (2008)
  • Author(s): Sato T, Takimoto R
  • Journal Title: J Immunol. 181(1) Pages: 197-207
  • Peer Reviewed
• [Journal Article] Interaction with human stromal cells enhances CXCR4 expression and engraftment of cord blood Lin(-)CD34(-) cells. et al. (2008)
  • Author(s): Kobune M, Takimoto R
  • Journal Title: Exp Hematol. 36(9) Pages: 1121-1131
  • Peer Reviewed
• [Journal Article] Successful treatment of chronic myeloproliferative disease-unclassifiable (CMPD-U) with no chromosomal abnormalities by imatinib mesylate. et al. (2008)
  • Author(s): Iyama S, Takimoto R
  • Journal Title: Intern Med. 47(8) Pages: 791-794
  • Peer Reviewed
• [Journal Article] Resolution of liver cirrhosis using vitamin A-coupled liposomes to deliver siRNA against a collagen-specific chaperone. et al. (2008)
  • Author(s): Sato Y, Takimoto R
  • Journal Title: Nat Biotechnol. 26(4) Pages: 431-442
  • Peer Reviewed
• [Journal Article] Ex vivo large-scale generation of human red blood cells from cord blood CD34+ cells by co-culturing with macrophages. et al. (2008)
  • Author(s): Fujimi A, Takimoto R
  • Journal Title: Int J Hematol. 87(4) Pages: 339-350
  • Peer Reviewed
• [Journal Article] Aberrant crypt foci as precursors of the dysplasia-carcinoma sequence in patients with ulcerative colitis. et al. (2008)
  • Author(s): Kukitsu T, Takimoto R
  • Journal Title: Clin Cancer Res. 14(1) Pages: 48-54
  • Peer Reviewed
• [Journal Article] Combination therapy of an anticancer drug with the FNIII14 peptide of fibronectin effectively overcomes cell adhesion-mediated drug resistance of acute myelogenous leukemia. et al. (2008)
  • Author(s): Matsunaga T, Takimoto R
  • Journal Title: Leukemia. 22(2) Pages: 353-360
  • Peer Reviewed
• [Journal Article] Adenoviral vector-mediated transfer of the Indian hedgehog gene modulates lymphomyelopoiesis in vivo. et al. (2008)
  • Author(s): Kobune M, Takimoto R
  • Journal Title: Stem Cells. 26(2) Pages: 534-542
  • Peer Reviewed
• [Journal Article] Aberrant crypt foci as precursors of the dysplasia-carcinoma sequence in patients with ulcerativecolitis. (2008)
  • Author(s): Kukitsu T, et al.
  • Journal Title: Clin Cancer Res 14(1) Pages: 48-54
  • Peer Reviewed
• [Journal Article] Combination therapy of an anti-cancer drug with the FNIII14 peptide of fibronectin effectively overcomes cell adhesion mediated-drug resistance of acute myelogenous leukemia. (2008)
  • Author(s): Matsunaga T, et al.
  • Journal Title: Leukemia 22(2) Pages: 353-360
  • Peer Reviewed
• [Journal Article] Adenoviral vector-mediated transfer of the Indian hedgehog gene modulates lymphomyelopoiesis in vivo. (2008)
  • Author(s): Kobune M, et al.
  • Journal Title: Stem Cells 26(2) Pages: 534-542
  • Peer Reviewed
• [Journal Article] Resolution of liver cirrhosis using vitamin A-coupled liposomes to deliver siRNA against a collagen-specific chaperone. (2008)
  • Author(s): Sato Y, et al.
  • Journal Title: Nat Biotechnol 26(4) Pages: 431-442
  • Peer Reviewed
• [Journal Article] Apoptosis supercedes necrosis in mitochondrial DNA-depleted Jurkat cells by cleavage of receptor-interacting protein and inhibition of lysosomal cathepsin. (2008)
  • Author(s): Sato T, et al.
  • Journal Title: J Immunol 181(1) Pages: 197-207
  • Peer Reviewed
• [Journal Article] Treatment of hepatocellular carcinoma by AdAFPep/rep, AdAFPep/p53, and 5-fluorouracil in mice. (2008)
  • Author(s): Sagawa T, et al.
  • Journal Title: Hepatology 48(3) Pages: 828-840
  • Peer Reviewed
• [Journal Article] Interaction with human stromal cells enhances CXCR4 expression and engraftment of cord blood Lin(-)CD34(-)cells. (2008)
  • Author(s): Kobune M, et al.
  • Journal Title: Exp Hematol 36(9) Pages: 1121-1131
  • Peer Reviewed
• [Journal Article] Ex vivo large-scale generation of human red blood cells from cord blood CD34+ cells by co-culturing with macrophages. (2008)
  • Author(s): Fujimi A, et al.
  • Journal Title: Int J Hematol 87(4) Pages: 339-350
  • Peer Reviewed