Investigation of the mechanism underlying the effect of high-fat diet and adiponectin on colorectal carcinogenesis
Project/Area Number |
20390212
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Gastroenterology
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Research Institution | Yokohama City University |
Principal Investigator |
NAKAJIMA Atsushi Yokohama City University, 附属病院, 教授 (30326037)
|
Co-Investigator(Kenkyū-buntansha) |
ABE Yasunobu 横浜市立大学, 医学部, 助教 (10347312)
INAMORI Masahiko 横浜市立大学, 附属病院, 助教 (10381477)
TAKAHASHI Hirokazu 横浜市立大学, 附属病院, 助教 (70438159)
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Project Period (FY) |
2008 – 2010
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Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2010: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2009: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2008: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
|
Keywords | アディポネクチン / 大腸がん / 化学発がん予防 / 高脂肪食 / 発癌機序 |
Research Abstract |
We clarified that the suppressive effect of adiponectin on colon carcinogenesis under high-fat diet condition is mediated by AMPK using mouse carcinogenesis model, and then demonstrated the chemopreventive effect of Metformin, AMPK activator, on human subject.
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Report
(4 results)
Research Products
(252 results)
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[Journal Article] Leptin acts as a growth factor for colorectal tumours at stages subsequent to tumour initiation in murine colon carcinogenesis.2011
Author(s)
Endo H, Hosono K, Uchiyama T, Sakai E, Sugiyama M, Takahashi H, Nakajima N, Wada K, Takeda K, Nakagama H, Nakajima A.
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Journal Title
Gut. (Epub ahead of print)
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[Journal Article] Leptin receptor is involved in STAT3 activation in human colorectal adenoma.2010
Author(s)
Uchiyama T, Takahashi H, Sugiyama M, Sakai E, Hosono K, Endo H, Yoneda K, Yoneda M, Inamori M, Nagashima Y, Inayama Y, Wada K, Nakajima A.
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Journal Title
Cancer Science. 102(2)
Pages: 367-372
NAID
Related Report
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[Journal Article] Metformin suppresses colorectal aberrant crypt foci in a short-term clinical trial.2010
Author(s)
Hosono K, Endo H, Takahashi H, Sugiyama M, Sakai E, Uchiyama T, Suzuki K, Iida H, Sakamoto Y, Yoneda K, Koide T, Tokoro C, Abe Y, Inamori M, Nakagama H, Nakajima A.
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Journal Title
Cancer Prev Res (Phila). 3(9)
Pages: 1077-1083
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[Journal Article] Molecular Mechanisms Linking Adiponectin Receptor Signalling and Cancer.2010
Author(s)
Nakajima A, Endo H, Yoneda K, Fujisawa T, Sugiyama M, Hosono K, Nozaki Y, Takahashi H, Fujita K, Yoneda M, Inamori M, Shimamura T, Kobayashi N, Kirikoshi H, Kubota K, Saito S, Wada K, Nakagama H
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Journal Title
The Open Obesity Journal. 2
Pages: 43-49
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[Journal Article] Metformin suppresses azoxymethane-induced colorectal aberrant crypt foci by activating AMP-activated protein kinase.2010
Author(s)
Hosono K, Endo H, Takahashi H, Sugiyama M, Uchiyama T, Suzuki K, Nozaki Y, Yoneda K, Fujita K, Yoneda M, Inamori M, Tomatsu A, Chihara T, Shimpo K, Nakagama H, Nakajima A.
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Journal Title
Molecular Carcinogenesis. 49(7)
Pages: 662-671
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[Journal Article] Involvement of JNK pathway in the promotion of the early stage of colorectal carcinogenesis under high-fat dietary conditions.2009
Author(s)
Endo H, Hosono K, Fujisawa T, Takahashi H, Sugiyama M, Yoneda K, Nozaki Y, Fujita K, Yoneda M, Inamori M, Wada K, Nakagama H, Nakajima A.
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Journal Title
Gut. 58(12)
Pages: 1637-1643
Related Report
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[Journal Article] Adiponectin inhibits colorectal cancer cell growth through the AMPK/mTOR pathway.2009
Author(s)
Sugiyama M, Takahashi H, Hosono K, Endo H, Kato S, Yoneda k, Nozaki Y, Fujita K, Yoneda M, Wada K, Nakagama H, Nakajima A.
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Journal Title
Int J Oncol. 34(2)
Pages: 339-344
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[Journal Article] Involvement of JNK pathway in the promotion of the early stage of colorectal carcinogenesis under high-fat dietary conditions2009
Author(s)
Endo H, Hosono K, Fujisawa T, Takahashi H, Sugiyama M, Yoneda K, Nozaki Y, Fujita K, Yoneda M, Inamori M, Wada K, Nakagama H, Nakajima A.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Identification of Cystatin SN as a novel tumor marker for colorectal cancer2009
Author(s)
Yoneda K, Iida H, Endo H, Hosono K, Akiyama T, Takahashi H, Inamori M, Abe Y, Yoneda M, Fujita K, Kato S, Nozaki Y, Ichikawa Y, Uozaki H, Fukayama M, Shimamura T, Kodama T, Aburatani H, Miyazawa C, Ishii K, Hosomi N, Sagara M, Takahashi M, Ike H, Saito H, Kusakabe A, Nakajima A
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Journal Title
Int J Oncol 35
Pages: 33-40
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Peer Reviewed
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[Journal Article] Adiponectin inhibits colorectal cancer cell growth through the AMPK/mTOR pathway2009
Author(s)
Sugiyama M, Takahashi H, Hosono K, Endo H, Kato S, Yoneda K, Nozaki Y, Fujita K, Yoneda M, Wada K, Nakagama H, Nakajima A
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Journal Title
Int J Oncol 34
Pages: 339-44
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Peer Reviewed
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[Journal Article] Correlation of the plasma level of insulin-like growth factor-1 with the number of aberrant crypt foci in male individuals2009
Author(s)
Takahashi H, Takayama T, Hosono K, Yoneda K, Endo H, Nozaki Y, Fujita K, Yoneda M, Inamori M, Abe Y, Kobayashi N, Kirikoshi H, Kubota K, Saito S, Nakagama H, Nakajima A.
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Journal Title
Mol Med Rep. 2
Pages: 339-343
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[Journal Article] Association of visceral fat accumulation and plasma adiponectin with rectal dysplastic aberrant crypt foci in a clinical population2009
Author(s)
Takahashi H, Takayama T, Yoneda K, Endo H, Iida H, Sugiyama M, Fujita K, Yoneda M, Inamori M, Abe Y, Saito S, Wada K, Nakagama H, Nakajima A.
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Journal Title
Cancer Sci. 100
Pages: 29-32
NAID
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[Journal Article] Adiponectin Suppresses Colorectal Carcinogenesis under the High-fat Diet Condition.2008
Author(s)
Fujisawa T, Endo H, Tomimoto A, Sugiyama M, Takahashi H, Saito S, Inamori M, Nakajima N, Watanabe M, Kubota N, Yamauchi T, Kadowaki T, Wada K, Nakagama H, Nakajima A.
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Journal Title
Gut 57(11)
Pages: 1531-1538
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[Journal Article] Metformin suppresses intestinal polyp growth in ApcMin/+mice.2008
Author(s)
Tomimoto A, Endo H, Sugiyama M, Fujisawa T, Hosono K, Takahashi H, Nakajima N, Nagashima Y, Wada K, Nakagama H, Nakajima A.
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Journal Title
Cancer Science 99(11)
Pages: 2136-2141
NAID
Related Report
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[Journal Article] Effectiveness of antlplatelet drugs on experimental non-alcoholic fatty liver disease.2008
Author(s)
Fujita K, Nozaki Y, Yoneda M, Wada K, Endo H, Mawatari H, Takahashi H, Inamori M, Abe Y, Kobayashi N, Kirikoshi H, Kubota K, Saito S, Nakajima A.
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Journal Title
Gut 57(11)
Pages: 1583-91
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Peer Reviewed
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[Journal Article] Tumorous arteriovenous malformation in the jejunum missed by capsule endoscopy.2008
Author(s)
Endo H, Matsuhashi N, Inamori M, Ohya T, Yanagawa T, Asayama M, Hisatomi K, Teratani T, Fujita K, Yoneda M, Nakajima A.
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Journal Title
Gastrointestinal Endoscopy 68(4)
Pages: 773-4
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Peer Reviewed
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[Journal Article] Gastric ulcer following a thrombotic aneurism of the splenic artery.2008
Author(s)
Suzuki K, Takahashi H, Fujisawa N, Sekino Y, Akimoto K, Tomimoto A, Saito K, Yoneda M, Inamori M, Abe Y, Kirikoshi H, Kobayashi N, Kubota K, Saito S, Koyama S, Nakajima A
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[Journal Article] Tumor fragment impacted at the major duodenal papi11a causing obstructive jaundice in a patient with hepatocellular carcinoma (HCC).2008
Author(s)
Kobayashi N, Kirikoshl H, Higurashi T, Iida H, Mawatari H, Endo H, Nozaki Y, Yoneda K, Akiyaraa T, Fujita K, Yoneda M, Takahashi H, Abe Y, Inamori M, Kubota K, Saito S, Ueno N, Nakajima A.
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Journal Title
Gastrointestinal Endoscopy 68(5)
Pages: 999-1000
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Peer Reviewed
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[Journal Article] Differentiating Sclerosing Cholangitis Caused by Autoimmune Pancreatitis and Primary Sclerosing Cholangitis According to Endoscopic Duodenal Papillary Features.2008
Author(s)
Kubota K, Kato S, Akiyama T, Yoneda M, Fujita K, Ogawa M, Inamori M, Kobayashi N, Saito S, Kakuta Y, Ohshiro H, Nakajima A.
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Journal Title
Gastrointestinal Endoscopy 68(6)
Pages: 1204-1208
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Peer Reviewed
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[Journal Article] Inhibition of Peroxisome Proliferator-Actlvated Receptor Gamma Activity Suppresses Pancreatic Cancer Cell Motility.2008
Author(s)
Nakajima A, Tomimoto A, Fujita K, Sugiyama M, Takahashi H, Ikeda I, Hosono K, Endo H, Yoneda K, Iida H, Inamori M, Kubota K, Saito S, Nakajima N, Wada K, Nagashima Y, Nakagama H.
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Journal Title
Cancer Science 99(10)
Pages: 1892-900
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Peer Reviewed
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[Journal Article] Metformin suppresses intestinal polyp growth in ApcMin/+ mice.2008
Author(s)
Tomimoto A, Endo H, Sugiyama M, Fujisawa T, Hosono K, Takahashi H, Nakajima N, Nagashima Y, Wada K, Nakagama H, Nakajima A.
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Journal Title
Cancer Science 99(11)
Pages: 2136-41
NAID
Related Report
Peer Reviewed
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[Journal Article] Rebleeding rate after interventional therapy directed by capsule endoscopy in patients with obscure gastrointestinal bleeding.2008
Author(s)
Endo H, Matsuhashi N, Inamori M, Akimoto K, Ohya T, Yanagawa T, Asayama M, Hisatomi K, Teratani T, Fujita K, Yoneda M, Nakajlma A.
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Journal Title
BMC Gastroenterol 8(1)
Pages: 12-12
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[Journal Article] Collagenous colitis in Japanese woman : successful treatment by mesalazine.2008
Author(s)
Suzuki K, Kawabe T, Takahashi H, Nakao S, Suzuki A, Inamori M, Iida H, Endo H, Akiyama T, Fujita K, Yoneda M, Abe Y, Kobayashi N, Kubota K, Oshiro H, Nakajima A.
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Journal Title
Digestion 77(3-4)
Pages: 155-156
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Peer Reviewed
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[Journal Article] Ulcerative colitis with positivity for proteinase 3-antineutrophil cytoplasmic antibody.2008
Author(s)
Suzuki K, Nakao S, Suzuki A, Inamori M, Iida H, Endo H, Akiyama T, Yoneda K, Fujita K, Takahashi H, Yoneda M, Abe Y, Kobayashi N, Kubota K, Saito S, Nakajima A.
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Journal Title
Digestion 77(3-4)
Pages: 157-158
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Peer Reviewed
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[Journal Article] Association between PPARGCIA polymorphisms and the occurrence of nonalcoholic fatty liver disease (NAFLD).2008
Author(s)
Yoneda M, Hotta K, Nozakl Y, Endo H, Uchiyama T, Mawatari H, Iida H, Kato K, Hosono K, Fujita K, Yoneda K, Takahashi H, Kirikoshi H, Kobayashi N, Inamori M, Abe Y, Kubota K, Saito S, Maeyama S, Wada K, Nakajima A.
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Journal Title
BMC Gastroenterology 8
Pages: 27-27
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Peer Reviewed
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[Journal Article] Severe large-intestine involvement in adult-onset Henoch-Schonlien purpura : Successful treatment with factor XIII concentrate.2008
Author(s)
Hosono K, Endo H, Inamori M, Mawatari H, Iida H, Nozaki Y, Yoneda K, Akiyama T, Fujita K, Yoneda M, Takahashi H, Abe Y, Kirikoshi H, Kobayashi N, Kubota K, Saito S, Nakajima A.
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Journal Title
Digestion 78(1)
Pages: 9-9
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Peer Reviewed
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[Journal Article] Plasma Pentraxin3 is a Novel Marker for Nonalcoholic Steatohepatitis (NASH).2008
Author(s)
Yoneda M, Uchiyama T, Kato S, Endo H, Fujita K, Yoneda K, Mawatari H, Iida H, Takahashi H, Klrikoshi H, Inamori M, Nozaki Y, Kobayashi N, Kubota K, Saito s, Maeyama S, Sagara M, Aburatani H, Kodama T, Nakajima A.
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Journal Title
BMC Gastroenterol 8
Pages: 53-53
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[Journal Article] Alcohol consumption is associated with an increased risk of erosive esophagitis and Barrett's epithelium in Japanese men.2008
Author(s)
Akiyama T, Inamorl M, Iida H, Mawatari H, Endo H, Hosono K, Yoneda K, Fujita K, Yoneda M, Takahashi H, Goto A, Abe Y, Kobayashi N, Kubota K, Saito S, Nakajima A.
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Journal Title
BMC Gastroenterol 8(1)
Pages: 58-58
NAID
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Peer Reviewed
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[Journal Article] Levovist ultrasonography imaging in intracystic hemorrhage of simple liver cyst.2008
Author(s)
Akiyama T, Inamori M, Saito S, Takahashi H, Yoneda M, Fujita K, Fujisawa T, Abe Y, Kirikoshi H, Kubota K, Ueda M, Tanaka K, Togo S, Ueno N, Shimada H, Nakajima A
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Journal Title
World J Gastroenterol 14(5)
Pages: 805-7
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Peer Reviewed
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[Journal Article] Acute appendicitis associated with Peutz-Jeghers-type hamartoma of the appendix.2008
Author(s)
Iida H, Inamori M, Sekino Y, Endo H, Aklyama T, Fujita K, Takahashi H, Yoneda M, Kobayashi N, Abe Y, Kirikoshi H, Kubota K, Saito S, Oshiro H, Rino Y, Nakajma A.
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Journal Title
Dig Dls Sci 53(10)
Pages: 2832-3
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[Journal Article] Characterization of K-ras Gene Mutations in Association with Mucinous Hypersecretion in Intraductal Papillary-Mucinous Neoplasms.2008
Author(s)
Kobayashi N, Inamori M, Fujita K, Fujisawa T, Fujisawa N, Takahashi H, Yoneda M, Abe Y, Kawamura H, Shimamura T, Kirikoshl H, Kubota K, Sakaguchi T, Saito S, Saubermann LJ, Nakajima A.
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Journal Title
J Hepatobiliary Pancreat Surg 15(2)
Pages: 169-77
NAID
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[Journal Article] Usefulness of multidetector computed tomography for detection of the obstructive point in a patient with ileus.2008
Author(s)
Sakai E, Takahashi H, Inamori M, Endo H, Akiyama T, Akimoto K, Mawatari H, Nozaki Y, Fujita K, Yoneda M, Goto A, Abe Y, Kobayashi N, Kubota K, Saito S, Nakajima A.
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Journal Title
Dig Dis Sci 53(12)
Pages: 3264-3264
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[Journal Article] Colonic metastasis from hepatocellular carcinoma : manifested by gastrointestinal bleeding.2008
Author(s)
Nozaki Y, Kobayashi N, Shimamura T, Akiyama T, Inamori M, Iida H, Endo H, Fujita K, Yoneda M, Takahashi H, Abe Y, Kirikoshi H, Kubota K, Saito S, Nakajima A.
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Journal Title
Dig Dis Sci 53(12)
Pages: 3265-6
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[Journal Article] Antiphospholipid syndrome manifested by gastrointesitinal bleeding : Can we overlook endoscopically-revealed small lesions?2008
Author(s)
Nakao S, Akimoto K, Inamori M, Suzuki A, Suzuki K, Iida H, Endo H, Akiyama T, Fujita K, Yoneda M, Takahashi H, Abe Y, Kobayashi N, Kubota K, Yamanaka S, Nakajima A.
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Journal Title
Digestion 77(3-4)
Pages: 139-140
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Peer Reviewed
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[Journal Article] Ingesting 500 ml of Polyethylene Glycol Solution During Capsule Endoscopy Improves the Image Quality and Completion Rate to the Cecum.2008
Author(s)
Endo H, Kondo Y, Inamori M, Ohya TR, Yanagawa T, Asayama M, Hisatomi K, Teratani T, Yoneda M, Nakajima A, Matsuhashi N.
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Journal Title
Dig Dis Sci 53(12)
Pages: 3201-5
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[Journal Article] Variations in the FTO gene are associated with severe obesity in the Japanese.2008
Author(s)
Hotta K, Nakata Y, Matsuo T, Kamohara S, Kotani K, Komatsu R, Itoh N, Mineo I, Wada J, Masuzaki H, Yoneda M, Nakajima A, Miyazaki S, Tokunaga K, Kawamoto M, Funahashi T, Hamaguchi K, Yamada K, Hanafusa T, Oikawa S, Yoshimatsu H, Nakao K, Sakata T, Matsuzawa Y, Tanaka K, Kamatani N, Nakamura Y.
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Journal Title
J Hum Genet 53(6)
Pages: 546-53
NAID
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[Journal Article] Effective treatment for advanced hepatocellular carcinoma with portal venous invasion using a combination ther any of intra-arterial 5-fluorouracil and subcutaneous pegylated-interferon-alpha-2b.2008
Author(s)
Mawatari H, Kirikoshi H, Yoneda M, Higurashi T, Fujita K, Saito S, Inamori M, Takahashi H, Abe Y, Kubota K, Nakajima A.
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Journal Title
Hepato-Gastroenterology 55(86-87
Pages: 1776-7
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Peer Reviewed
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[Journal Article] Sugimori K, Matuo K, Kazunaga T, Shimada H. Clinicopath ological study of resected cases with primary carcinoma of the cystic duct.2008
Author(s)
Kubota K, Kakuta Y, Inayama Y, Yoneda M, Abe Y, Inamori M, Kirikoshi H, Saito S, Nakajima A
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Journal Title
Hepato-Gastroenterology 55(85)
Pages: 1174-8
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[Journal Article] EDUCATION AND IMAGING Gastrointestinal : Intestinal spirochetosis.2008
Author(s)
Tsuzawa K, Fujisawa N, Sekino Y, Suzuki K, Saito K, Koyama S, Tanaka M, Wada A, Inamori M, Kubota K, Nakajima A. O
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Journal Title
J Gastroenterol Hepatol 23(7 Pt1)
Pages: 116-116
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Peer Reviewed
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[Journal Article] Gastric surgery is not a risk factor for the development or progression of Barrett's epithelium.2008
Author(s)
Akiyama T, Inamori M, Akimoto K, Iida H, Mawatari H, Endo H, Nozaki Y, Yoneda K, Ikeda T, Sakamoto Y, Fujita K, Yoneda M, Takahashi H, Goto A, Hirokawa S, Abe Y, Kirikoshi H, Kobayashi N, Kubota K, Saito S, Rino Y, Nakajima A.
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Journal Title
Hepato-Gastroenterology 55(86-87)
Pages: 1899-904
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Peer Reviewed
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[Journal Article] Nitric oxide plays a crucial role in the development/progression of nonalcoholic steathepatitis (NASH)in the chollne deficient, 1-amino acid-deficient (CDAA)diet-fed rat model. [Epub a head of print]2008
Author(s)
Fujita K, Nozaki Y, Yoneda M, Wada K, Takahashi H, Kirikoshi H, Inamori M, Saito s, Iwasakl T, Terauchi Y, Maeyama S, Nakajima A.
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Journal Title
Alcohol Clin Exp Res (印刷中)
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[Journal Article] Expression of Adiponectin receptors, AdipoR1 and AdipoR2, in normal colon epithelium and colon cancer tissue.2008
Author(s)
Yoneda K, Tomimoto A, Endo H, Iida H, Sugiyama M, Takahashi H, Nozaki Y, Fujita K, Yoneda M, Inamori M, Nakajima N, Wada K, Nagashlma Y, Nakagama H, Nakajima A.
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Journal Title
Oncology Reports 20(3)
Pages: 479-83
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[Journal Article] Adenosequamous carcinoma of pancreas associated with Humoral Hypercalcemia of Malignancy (HHM).2008
Author(s)
Kobayashi N, Higurashi T, Iida H, Mawatari H, Endo H, Nozaki Y, Tomimoto A, Yoneda K, Akiyama T, Fujita K, Takahashi H, Yoneda M, Abe Y, Kirikoshi H, Kubota K, Saito S, Ueno N, Nakajima A, Yamanaka S, Inayama Y.
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Journal Title
J Hepatobiliary Pancreat Surg 15(5)
Pages: 531-5
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[Journal Article] Education and Imaging. Gastrointestinal : Ascaris lumbricoidosis manifested by gastrointesitinal bleeding.2008
Author(s)
Suzuki A, Yabushita Y, Takahashi H, Inamori M, Nakao S, Suzuki K, Iida H, Endo H, Akiyama T, Ikeda T, Sakamoto Y, Fujita K, Yoneda M, Goto A, Abe Y, Kirikoshi H, Kobayashi N, Kubota K, Saito S, Nakajima A.
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Journal Title
J Gastroenterol Hepatol 23(11)
Pages: 1770-1770
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[Journal Article] Gene Expression Profiling of Nonalcoholic Steatohepatitis (NASH) by Gene Set Enrichment Analysis (GSEA).2008
Author(s)
Yoneda M, Endo H, Mawatari H, Nozaki Y, Fujita K, Akiyama T, Higurashi T, Uchiyama T, Yoneda K, Takahashi H, Kirikoshi H, Inamori M, Abe Y, Kubota K, Saito S, Kobayashi N, Yamaguchi N, Maeyama S, Yamamoto S, Tsutsumi S, Aburatani H, Wada K, Hotta K, Nakajima A.
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Journal Title
Hepatology Research 38(12)
Pages: 1204-12
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[Journal Article] INSIG2 gene rs7566605 polymorphism is associated with severe obesity in the Japanese.2008
Author(s)
Hotta K, Nakamura M, Nakata Y, Matsuo T, Kamohara S, Kotani K, Komatsu R, Itoh N, Mineo I, Wada J, Masuzaki H, Yoneda M, Nakajima A, Miyazaki S, Tokunaga K, Kawamoto M, Funahashi T, Hamaguchi K, Yamada K, Hanafusa T, Oikawa S, Yoshimatsu H, Nakao K, Sakata T, Matsuzawa Y, Tanaka K, Kamatani N, Nakamura N.
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Journal Title
J Hum Genet 53(9)
Pages: 857-62
NAID
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[Journal Article] Aperitif effects on gastric emptying : a crossover study using continuous real time ^<13>C breath test (BreathID system).2008
Author(s)
Inamori, M, Iida H, Endo H, Hosono K, Akiyama T, Yoneda K, Fujita K, Iwasaki H, Takahashi H, Yoneda M, Goto A, Abe Y, Kobayashi N, Kubota K, Nakajima A.
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Journal Title
Dig Dis Sci 54(4)
Pages: 816-8
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[Journal Article] Gastrointestinal : Aneurysmal artery in a gastric ulcer following endoscopic hemostasis.2008
Author(s)
Abe Y, Inamori M, Uchiyama T, Iida H, Akimoto K, Mawatari H, Nozaki Y, Hosono K, Endo H, Akiyama T, Yoneda K, Fujita K, Yoneda M, Takahashi H, Goto A, Kobayashl N, Kirikoshi H, Kubota K, Saito S, Nakajima A.
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Journal Title
J Gastroenterol Hepatol 24(2)
Pages: 323-323
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[Journal Article] Chemotherapeutic treatment of priapism in metastatic rectal cancer.2008
Author(s)
Kitai Y, Takahashi H, Goto A, Iida H, Mawatari H, Fujita K, Yoneda M, Inamori M, Abe Y, Kobayashl N, Kirikoshi H, Kubota K, Saito S, Nakajima A.
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Journal Title
Case Reports in Gastroenterology 2
Pages: 505-508
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[Journal Article] Abdominal Surgery Affects Small Bowel Transit Time and Completeness of Capsule Endoscopy.2008
Author(s)
Endo H, Matsuhashi N, Inamori M, Ohya T, Iida H, Mawatari H, Nozaki Y, Yoneda K, Akiyama T, Fujita K, Takahashi H, Yoneda M, Abe Y, Kobayashi N, Kirikoshi H, Kubota K, Saito S, Nakajima A
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Journal Title
Dig Dis Sci 54(5)
Pages: 1066-70
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[Journal Article] Inhibition of peroxisome proliferator-activated receptorg promotes tumorigenesis through activation of the b-catenin/TCF pathway in the mouse intestine.2008
Author(s)
Fujisawa T, Sugiyama M, Tomimoto A, Wada K, Endo H, Takahashi H, Yoneda K, Yoneda M, Inamori M, Saito S, Terauchi Y, Kadowaki T, Tsuchiya N, Nakagama H, Nakajima A.
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Journal Title
J Parmacological Sci 108(4)
Pages: 535-44
Related Report
Peer Reviewed
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[Journal Article] Education and imaging. Gastrointestinal : mantle cell lymphoma diagnosed by balloon enteroscopy.2008
Author(s)
Yumori A, Okubo H, Takahashi H, Iida H, Mawatari H, Yoneda M, Inamori M, Abe Y, Kobayashi N, Kirikoshi H, Kubota K, Saito S, Nakajima A.
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Journal Title
J Gastroenterol Hepatol 23(10)
Pages: 1623-1623
Related Report
Peer Reviewed
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[Journal Article] Risk Factors for the Progression of Endoscopic Barrett's Epithelium in Japan : A Multivariate Analysis Based on The Prague C & M Criteria. [Epub ahead of print]2008
Author(s)
Akiyama T, Inamori M, Akimoto K, Iida H, Mawatari H, Endo H, Ikeda T, Nozaki Y, Yoneda K, Sakamoto Y, Fujita K, Yoneda M, Takahashi H, Hirokawa S, Goto A, Abe Y, Klrikoshi H, Kobayashi N, Kubota K, Saito S, Nakajima A
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Association of visceral fat accumulation and plasma adiponectin with rectal dysplastic aberrant crypt foci in a clinical population.2008
Author(s)
Takahashi H, Takayama T, Yoneda K, Endo H, Iida H, Sugiyama M, Fujita K, Yoneda M, Inamori M, Abe Y, Saito S, Wada K, Nakagama H, Nakajima A
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Journal Title
Cancer Sci 100(1)
Pages: 29-32
NAID
Related Report
Peer Reviewed
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[Journal Article] Noninvasive assessment of liver fibrosis by measurement of stiffness in patients with nonalcoholic fatty liver disease (NAFLD).2008
Author(s)
Yoneda M, Yoneda M, Mawatari H, Fujita K, Endo H, Iida H, Nozaki Y, Yonemitsu K, Higurashi T, Takahashi H, Kobayashi N, Kirikoshi H, Abe Y, Inamori M, Kubota K, Saito S, Tamano M, Hiraishi H, Maeyama S, Yamaguchi N, Togo S, Nakajima A
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Journal Title
Dig Liver Dis 40(5)
Pages: 371-8
Related Report
Peer Reviewed
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[Presentation] Plasma IGF-1 Is Correlated with Dysplastic Aberrant Crypt Foci in Men2009
Author(s)
高橋宏和, 細野邦広, 遠藤宏樹, 米田恭子, 秋山智之, 稲森正彦, 阿部泰伸, 加藤真吾, 内山崇, 飯田洋, 馬渡弘典, 野崎雄一, 藤田浩司, 米田正人, 小林規俊, 桐越博之, 窪田賢輔, 斉藤聡, 中島淳
Organizer
Digestive Disease Week 2009
Place of Presentation
Chicago, USA
Year and Date
2009-06-03
Related Report
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[Presentation] Aberrant crypt foci の自然史に対する解析2009
Author(s)
高橋宏和, 細野邦広, 遠藤宏樹, 米田恭子, 加藤真吾, 内山崇, 飯田洋, 馬渡弘典, 野崎雄一, 秋山智之, 藤田浩司, 米田正人, 稲森正彦, 阿部泰伸, 小林規俊, 桐越博之, 窪田賢輔, 斉藤聡, 上野規男, 中島淳
Organizer
第77回日本消化器内視鏡学会総会
Place of Presentation
名古屋
Year and Date
2009-05-21
Related Report
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[Presentation] 内蔵脂肪およびアディポサイトカインの大腸発癌に関する解析2009
Author(s)
高橋宏和, 細野邦広, 中島淳, 米田恭子, 遠藤宏樹, 加藤真吾, 内山崇, 飯田洋, 馬渡弘典, 野崎雄一, 秋山智之, 藤田浩司, 米田正人, 稲森正彦, 阿部泰伸, 小林規俊, 桐越博之, 窪田賢輔, 斉藤聡, 上野規男, 中島淳
Organizer
第95回日本消化器病学会総会
Place of Presentation
札幌
Year and Date
2009-05-08
Related Report
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[Presentation] Natural history of human aberrant crypt foci after colorectal polypectomy2009
Author(s)
高橋宏和, 細野邦広, 遠藤宏樹, 米田恭子, 藤田浩司, 米田正人, 稲森正彦, 阿部泰伸, 小林規俊, 桐越博之, 窪田賢輔, 斉藤聡, 中島淳
Organizer
AACR 100^<th> Annual Meeting 2009
Place of Presentation
Denver, Colorado, USA
Year and Date
2009-04-19
Related Report
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[Presentation] The comparison of the trans-arterial cherao-embolization (TACE) monotherapy and the combined TACE with percutaneous local the rapy for Hepatocellular carcinoma (HCC).2008
Author(s)
Kirikoshi H, Saito S, Yoneda M, Fujita K, Mawatari H, Nozaki Y, Uchiyama T, Ikeda T, Hosono K, Akiyama T, Endo H, Yoneda K, Inamori M, Takahashi H, Iida H, Kato S, Abe Y, Kobayashi N, Kubota K, Nakajima A
Organizer
59^<th> Annual Meeting of the American Association for the study of Liver Diseases (AASLD). Poster presentation
Place of Presentation
San Francisco
Year and Date
2008-11-02
Related Report
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[Presentation] Influence of AGTRl polymorphisms in Japanese patients with nonalcoholic fatty liver disease (NAFLD).2008
Author(s)
Yoneda M, Nozaki Y, Hotta K, Mawatari H, Iida H, Uchiyama T, Yoneda K, Endo H, Kato S, Hosono K, Fujita K, Higurashi T, Kirikoshi H, Kubota K, Kobayashi N, Inamori M, Saito S, Nakajima A
Organizer
AASLD 2008 Annual Meeting
Place of Presentation
San Francisco
Year and Date
2008-11-02
Related Report
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[Presentation] Effect of ezetimibe administered in combination with acarbose against the development of nonalcoholic fatty liver disease (N AFLD).2008
Author(s)
Nozaki Y, Fujita K, Yoneda M, Kato S, Uchiyama T, Iida H, Mawatari H, Hosono K, Endo H, Akiyama T, Yoneda K, Takahashi H, Kirikoshi H, Kobayashi N, Abe Y, Inamori M, Kubota K, Saito S, Nakajima A
Organizer
59^<th> Annual Meeting of the American Association for the study of Liver Diseases (AASLD). Poster presentation
Place of Presentation
San Francisco
Year and Date
2008-11-02
Related Report
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[Presentation] Metformin suppresses the oolorectal carcinogenesis via activating AMP protein kinase.2008
Author(s)
Suzuki K, Endo H, Kato S, Uchiyama T, Iida H, Mawatari H, Takahashi H, Yoneda M, Inamori M, Abe Y, Kobayashi N, Kirikoshi H, Kubota K, Saito S, Nakajima A
Organizer
2008 DDW
Place of Presentation
San Diego
Year and Date
2008-05-21
Related Report
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[Presentation] Adiponectin suppresses colorectal carcinogenesis induced by high-fat diet via AMP protein kinase2008
Author(s)
Fujisawa N, Takahashi H, Hosono K, Shinohara Y, Sugiyama M, Endo H, Nozaki Y, Akiyama T, Yoneda K, Fujita K, Yoneda M, Nakajima A
Organizer
2008 DDW
Place of Presentation
San Diego
Year and Date
2008-05-18
Related Report
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[Presentation] Adiponectin suppresses colorectal carcinogenesis induced by high-fat diet via AMP protein kinase.2008
Author(s)
Fujisawa N, Takahashi H, Hosono K, Shinohara Y, Sugiyama M, Endo H, Nozaki Y, Akiyama T, Yoneda K, Fujita K, Yoneda M, Nakajima A
Organizer
2008 DDW
Place of Presentation
San Diego
Year and Date
2008-05-18
Related Report
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[Presentation] Novel diagnostic approach for NASH using [11c] choline dynamic PET imaging2008
Author(s)
Fujita K, Nozaki Y, Yoneda M, Hosono K, Endo H, Takahashi H, Inamori M, Abe Y, Kirikoshi H, Kobayashi N, Kubota K, Saito S, Nakajima A
Organizer
2008 16^<th> UEGW Oral presentation
Place of Presentation
Vienna Austria
Related Report
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[Presentation] Role of inducible nitric oxide synthase in experimental nonalcoholic steatohepatitis (NASH)model.2008
Author(s)
Nozaki Y, Fujita K, Yoneda M, Takahashi H, Kirikoshi H, Abe Y, Kobayashi N, Inamori M, Kubota K, Saito S, Nakajima A
Organizer
16^<th> United European Gastroenterology Week (UEGW) Oral presentation
Place of Presentation
Vienna Austria
Related Report
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[Presentation] Correlation of the plasma level of insulin-like growth factor-l with the number of aberrant crypt foci in men. Poster sessions Lower GI2008
Author(s)
Takahashi H, Hosono K, Endo H, Yoneda K, Mawatari H, Fujita K, Yoneda M, Abe Y, Inamori M, Kobayashi N, Kirikoshi H, Kubota K, Saito S, Nakajima A
Organizer
16^<th> United European Gastroenterology Week (UEGW)
Place of Presentation
Vienna Austria
Related Report
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