Inhibition of migration of bone marrow-derived fibrocytes : a role of PDGF and development of therapy for pulmonary fibrosis
| Project/Area Number |
20390231
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | The University of Tokushima |
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Principal Investigator |
NISHIOKA Yasuhiko The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 准教授 (70274199)
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| Co-Investigator(Kenkyū-buntansha) |
KAKIUCHI Soji 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 特任准教授 (50380100)
AONO Yoshinori 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (50398004)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000)
Fiscal Year 2010: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
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| Keywords | 肺線維症 / fibrocyte / PDGF / PDGFレセプター / イマチニブ / 肺線維芽細胞 / IGF-1 / bFGF / 肺腺維症 |
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| Research Abstract |
We hypothesized that PDGF might directly contribute to the migration of fibrocytes to the injured lungs, which inhibited by the blocking of PDGF receptor. Both human and murine fibrocytes expressed PDGF receptors・and・. PDGF proteins strongly stimulated the migration of both human and murine fibrocytes, and their migration was blocked by treatment with anti-PDGF receptor antibodies or imatinib in vitro. Furthermore, the number of fibrocytes in the lungs was significantly reduced by administration of anti-PDGFR・antibody and imatinib in bleomycin-induced pulmonary fibrosis in mice. These results suggest that PDGF receptor expressed in circulating fibrocytes contribute to their trafficking into the lungs.
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Report
(4 results)
Research Products
(80 results)
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[Journal Article] Blockade of Thl chemokine receptors ameriolates pulmonary granulomatosis in mice.2011
Author(s)
Kishi J, Nishioka Y, Kuwahara T, Kakiuchi S, Azuma M, Aono Y, Makino H, Kinoshita K, Kishi M, Batmunkh R, Uehara H, Izumi K, Sone S.
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Journal Title
Eur Respir J. 38
Pages: 1-10
Related Report
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[Journal Article] Pirfenidone Clinical Study Group in Japan. Pirfenidone in idiopathic pulmonary fibrosis.2010
Author(s)
Taniguchi H, Ebina M, Kondoh Y, Ogura T, Azuma A, Suga M, Taguchi Y, Takahashi H, Nakata K, Sato A, Takeuchi M, Raghu G, Kudoh S, Nukiwa T
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Journal Title
Eur Respir J. 35
Pages: 821-829
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[Journal Article] Antiallergic and anti-inflammatory effects of a novel I κ B kinase β inhibitor, IMD-0354, in a mouse model of allergic inflammation.2009
Author(s)
Sugita A, Ogawa H, Azuma M, Muto S, Honjo A, Yanagawa H, Nishioka Y, Tani K, Itai A, Sone S.
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Journal Title
Int Arch Allergy Immunol. 148
Pages: 186-198
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[Journal Article] Expression of soluble vascular endothelial growth factor receptor-1 in human monocyte-derived mature dendritic cells contributes to their antiangiogenic property.2009
Author(s)
Kishuku M, Nishioka Y, Abe S, Kishi J, Ogino H, Aono Y, Azuma M, Kinoshita K, Batmunkh R, Makino H, Ranjan P, Minakuchi K, Sone S.
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Journal Title
J Immunol. 183
Pages: 8176-8185
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[Presentation] Antifibrotic effects of APA5 and APB5, blocking antibodies specific for PDGF receptors on bleomycin-induced pulmonary fibrosis in mice.2010
Author(s)
M.Kishi, Y.Nishioka, M.Azuma, Y.Aono, B.Rentsenkhand, R.M.El-Morshedy, K.Kinoshita, J.Kishi, H.Uehara, K.Iaumi, S.Sone
Organizer
105th American thoracic society (ATS)
Place of Presentation
(New Orleans, USA)
Year and Date
2010-05-16
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[Presentation] イマチニブ2008
Author(s)
青野純典, 西岡安彦, 東桃代, 上原久典, 泉啓介, 曽根三郎
Organizer
第48回日本呼吸器学会学術講演会シンポジウム6-間質性肺炎の治療法をめぐる臨床研究の展望-
Place of Presentation
神戸
Year and Date
2008-06-16
Related Report
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[Presentation] 骨髄由来fibrocyteとPDGFシグナル2008
Author(s)
西岡安彦, 青野純典, 東桃代, 木下勝弘, 片岡昌美, 曽根三郎
Organizer
第48回日本呼吸器学会学術講演会シンポジウム4社会のニーズに応える呼吸器学の展開-肺損傷から線維化へのパラダイムとその制御-
Place of Presentation
神戸
Year and Date
2008-06-15
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