Adiponectin prevents atherosclerosis by accelerating reverse cholesterol transport and HDL synthesis
Project/Area Number |
20390256
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Metabolomics
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Research Institution | Osaka University |
Principal Investigator |
YAMASHITA Shizuya Osaka University, 医学系研究科, 准教授 (60243242)
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Co-Investigator(Kenkyū-buntansha) |
OHAMA Tohru 大阪大学, 保健センター, 助教 (20467583)
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Project Period (FY) |
2008 – 2010
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Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2010: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2009: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2008: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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Keywords | アデイポネクチン / HDLコレステロール / アポ蛋白A-I / アポ蛋白B-100 / COUP-TF2 / アディポネクチン / HDL / 粥状動脈硬化 / ABCA1 / メタボリックシンドローム / コレステロール逆転送系 / ApoA-1 / 脂質排泄 / コレステロール逆転送 / ABCG1 |
Research Abstract |
High density lipoproteins (HDL) are known to prevent from development of atherosclerosis and the reduction of HDL is one of the risk factors for coronary heart disease. HDL and their component, apolipoprotein (Apo) A-I, take up cholesterol from atherosclerotic plaques and transport it back to the liver, a system called "reverse cholesterol transport (RCT)". Both ApoA-I and ATP-binding cassette transporter A1 (ABCA1) are the rate-limiting factors that generate HDL in the liver. We for the first time identified adiponectin (APN) from adipocytes that inhibits the development of atherosclerosis. We found a positive correlation between plasma high density lipoprotein-cholesterol (HDL-C) and APN concentrations in humans. We have shown that APN accelerates RCT by increasing the hepatic expression of ApoA-I and ABCA1, using HepG2 cells. In contrast, APN reduced the expression of ApoB100 mRNA and secretion of ApoB100 into the medium. We elucidated the importance of COUP-TF2, one of the nuclear receptors, a new regulator of lipoprotein metabolism, that may prevent atherosclerosis by increasing HDL synthesis by enhancing ApoA-I and ABCA1 and by reducing ApoB100 (VLDL) secretion.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] Adiponectin prevents atherosclerosis by increasing cholesterol efflux from macrophages.2008
Author(s)
Tsubakio-Yamamoto K, Matsuura F, Koseki M, Oku H, Sandoval JC, Inagaki M, Nakatani K, Nakaoka H, Kawase R, Yuasa-Kawase M, Masuda D, Ohama T, Maeda N, Nakagawa-Toyama Y, Ishigami M, Nishida M, Kihara S, Shimomura I, Yamashita S
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Journal Title
Biochem Biophys Res Commun 375(3)
Pages: 390-394
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[Presentation] Adiponectin might prevent atherosclerosis by COUP-TF2-dependent pathway.2010
Author(s)
Yamamoto K, Yamashita S, Ohama T, Masuda D, Sandoval JC, Inagaki M, Nakatani K, Kawase M, Kawase R, Nakaoka H, Toyama Y, Nishida M, Ishigami M, Kihara S, Shimomura I, Komuro I
Organizer
第74回日本循環器学会
Place of Presentation
京都国際会議場
Year and Date
2010-03-07
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[Presentation] Adiponectin enhances de novo hepatic HDL synthesis through LXR alpha-and COUP-TFII-dependent pathways.2010
Author(s)
Ohama T, Yamamoto K, Masuda D, Sandoval JC, Inagaki M, Nakatani K, Kawase M, Kawase R, Nakaoka H, Toyama Y, Nishida M, Ishigami M, Kihara S, Shimomura I, Yamashita S, Komuro I
Organizer
第74回日本循環器学会
Place of Presentation
京都国際会議場
Year and Date
2010-03-07
Related Report
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[Presentation] Adiponectin enhances apo-A1-mediated cholesterol efflux from macrophages through ABCA1-dependent pathway.2009
Author(s)
Ohama T, Tshibakio-Yamamoto K, Sandoval JC, Inagaki M, Nakatani K, Masuda D, Nakagawa-Toyama Y, Nishida M, Ishigami M, Kihara S, Shimomura I, Yamashita S
Organizer
第41回日本動脈硬化学会総会学術集会
Place of Presentation
海峡メッセ下関、山口
Year and Date
2009-07-18
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[Presentation] Role of adiponectine in the pathogenesis of dyslipidemia in the metabolic syndrome.2009
Author(s)
Ohama T, Yamamoto K, Kawase R, Nakaoka H, Nakatani K, Inagaki M, Sandoval JC, Masuda D, Toyama Y, Nishida M, Ishigami M, Shimomura I, Yamashita S
Organizer
第73回日本循環器学会総会・学術集会
Place of Presentation
大阪国際会議場
Year and Date
2009-03-20
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[Presentation] Adiponectin enhances de novo hepatic HDL synthesis through LXR alpha-and COUP-TFII-dependent pathways.2009
Author(s)
Tsubakio-Yamamoto K, Yamashita S, Ohama T, Masuda D, Sandoval JC, Inagaki M, Nakatani K, Yuasa-Kawase M, Kawase R, Nakaoka H, Nakagawa-Toyama Y, Nishida M, Ishigami M, Kihara S, Shimomura I, Komuro I
Organizer
82^<nd> American Heart Association Annual Scientific Meeting
Place of Presentation
Orlando, FL, USA
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[Presentation] Role of adiponectin in the atheroprotective system via HDL-cholesterol.2009
Author(s)
Ohama T, Yamamoto K, Nakatani K, Inagaki M, Sandoval JC, Masuda D, Toyama Y, Nishida M, Ishigami M, Yamashita S
Organizer
15th International Symposium on Atherosclerosis
Place of Presentation
Boston, MA, USA
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[Presentation] Adiponectin deficiency suppresses ABCA1 expression and apoA-I synthesis in the liver.2008
Author(s)
Matsuura F, Oku H, Koseki M, Sandoval JC, Yuasa-Kawase M, Tsubakio-Yamamoto K, Masuda D, Maeda N, Ohama T, Ishigami M, Nishida M, Hirano K, Kihara S, Hori M, Shimomura I, Yamashita S
Organizer
77th Congress of European Atherosclerosis Society
Place of Presentation
Istanbul Lutfi Kindar Convention & Exhibition Centre
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