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Investigation of the genes associated with bone mineral density by high-density SNP chip analysis in a large cohort study

Research Project

Project/Area Number 20390264
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Endocrinology
Research InstitutionKyushu University

Principal Investigator

TAKAYANAGI Ryoichi  九州大学, 大学院・医学研究院, 教授 (30154917)

Co-Investigator(Renkei-kenkyūsha) OHNAKA Keizo  九州大学, 大学院・医学研究院, 講師 (30325518)
YAMAMOTO Ken  九州大学, 生体防御医学研究所, 准教授 (60274528)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2010: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Keywords骨密度 / 遺伝子多型 / 骨粗鬆症 / コホート / 内科 / ゲノム / 老化 / 遺伝子 / 全ゲノム相関解析
Research Abstract

To explore candidate g:enes associated with bone mineral density(BMD) of Japanese women, we performed a genome-wide association study(GWAS) in a large community-based cohort. The study subjects were postmenopausal women without taking any drugs, having any diseases or gynecological history. The GWAS and the following analyses uncovered several candidate genes to be associated with BMD in Japanese women.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (23 results)

All 2011 2010 2009 2008

All Journal Article (16 results) (of which Peer Reviewed: 16 results) Presentation (6 results) Book (1 results)

  • [Journal Article] Clinical and experimental evidence for oxidative stress as an exacerbating factor of diabetes mellitus2011

    • Author(s)
      Takayanagi R, Inoguchi T, Ohnaka K.
    • Journal Title

      J Clin Biochem Nutr

      Volume: 48(1) Pages: 72-77

    • NAID

      130004879235

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Raloxifene induces nucleolar translocation of the estrogen receptor2010

    • Author(s)
      Gushima M, Kawate H, Ohnaka K, Nomura M, Takayanagi R.
    • Journal Title

      Mol Cell Endocrinol

      Volume: 319(1-2) Pages: 14-22

    • Related Report
      2010 Annual Research Report 2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Alendronate improves QOL of postmenopausal women with osteoporosis2010

    • Author(s)
      Kawate H, Ohnaka K, Adachi M, Kono S, Ikematsu H, Matsuo H, Higuchi K, Takayama T, Takayanagi R.
    • Journal Title

      Clin Interv Aging

      Volume: 5 Pages: 123-131

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inverse associations of serum bilirubin with C-reactive protein, glycated he moglobin, and prevalence of diabetes mellitus in middle-aged and elderly Japanese men and women2010

    • Author(s)
      Ohnaka K, Kono S, Inoguchi T, Yin G, Morita M, Adachi M, Kawate H, Takayanagi R.
    • Journal Title

      Diabetes Res Clin Pract

      Volume: 88(1) Pages: 103-110

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Blood pressure and hypertension are associated with 7 loci in the Japanese population2010

    • Author(s)
      Takeuchi F, Isono M, Katsuya T, Yamamoto K, Yokota M, Sugiyama T, Nabika T, Fujioka A, Ohnaka K, Asano H, Yamori Y, Yamaguchi S, Kobayashi S, Takayanagi R, Ogihara T, Kato N.
    • Journal Title

      Circulation

      Volume: 121(21) Pages: 2302-2309

    • Related Report
      2010 Annual Research Report 2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inverse associations of serum bilirubin with C-reactive protein, glycated hemoglobin, and prevalence of diabetes mellitus in middle-aged and elderly Japanese men and women2010

    • Author(s)
      Ohnaka K, et al.
    • Journal Title

      Diabetes Res Clin Pract

      Volume: 88(1) Pages: 103-110

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of single nucleotide polymorphisms in secreted frizzled-related protein 1 gene with bone mineral density in Japanese women2009

    • Author(s)
      Ohnaka K, Yamamoto K, Nakamura K, Adachi M, Kawate H, Kono S, Takayanagi R.
    • Journal Title

      Geriatr Gerontrol Int

      Volume: 9(3) Pages: 304-309

    • NAID

      10025638117

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 福岡骨粗鬆症コホート研究2009

    • Author(s)
      大中佳三日本人の骨密度関連遺伝子の網羅的解析
    • Journal Title

      日本老年医学会雑誌

      Volume: 46(2) Pages: 114-116

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] アンドロゲン、エストロゲンと骨代謝マーカー2009

    • Author(s)
      大中佳三、高柳涼一
    • Journal Title

      CLINICAL CALCIUM

      Volume: 19(8) Pages: 1118-1124

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association of single nucleotide polymorphisms in secreted frizzled-related protein 1 gene with bone mineral density in Japanese women2009

    • Author(s)
      Ohnaka K, et al
    • Journal Title

      Geriatr Gerontrol Int 9

      Pages: 304-309

    • NAID

      10025638117

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mitochondrial fission factor Drpl is essential for embryonic development and synapse formation in mice2009

    • Author(s)
      Ishihara N, et al
    • Journal Title

      Nat Cell Biol 11

      Pages: 958-966

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population2009

    • Author(s)
      Takeuchi F, et al
    • Journal Title

      Diabetes 58

      Pages: 1690-1699

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 閉経後のステロイド性骨粗鬆症に対するラロキシフェンとビスフォスフォネートの臨床効果の比較2008

    • Author(s)
      高柳涼一、大中佳三
    • Journal Title

      Osteoporosis Japan

      Volume: 16(4) Pages: 298-301

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dietary patterns and A1C in Japanese men and women.2008

    • Author(s)
      Nanri A, et al.
    • Journal Title

      Diabetes Care 31

      Pages: 1568-1573

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dietary patterns and C-reactive protein in Japanese men and women.2008

    • Author(s)
      Nanri A, et al.
    • Journal Title

      Am J Clin Nut 87

      Pages: 1488-1496

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adipose tissue-derived and bone marrow-derived mesenchymal cells develop into different lineage of steroidogenic cells by forced expression of steroidogenic factor 1.2008

    • Author(s)
      Gondo S, et al.
    • Journal Title

      Endocrinology 149

      Pages: 4717-4725

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Clinical and experimental evidence for oxidative stress as an exacerbating factor of diabetes mellitus2011

    • Author(s)
      Ryoichi Takayanagi, Toyoshi Inoguchi, Keizo Ohnaka
    • Organizer
      International Symposium on Free Radical Research
    • Place of Presentation
      Contribution to Medicine, Kyoto
    • Year and Date
      2011-01-22
    • Related Report
      2010 Final Research Report
  • [Presentation] Clinical and experimental evidence for oxidative stress as an exacerbating factor of diabetes mellitus2011

    • Author(s)
      Takayanagi R, et al.
    • Organizer
      International Symposium on Free Radical Research : Contribution to Medicine
    • Place of Presentation
      Kyoto
    • Year and Date
      2011-01-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 九州大学福岡コホートの展望2011

    • Author(s)
      古野純典、高柳涼一、大中佳三
    • Organizer
      第21回日本疫学会学術集会
    • Year and Date
      2011-01-21
    • Related Report
      2010 Final Research Report
  • [Presentation] シンポジウム「酸化ストレスと抗酸化システム」-「ビリルビンの抗酸化作用と生活習慣病」2009

    • Author(s)
      大中佳三
    • Organizer
      第63回日本栄養・食糧学会大会
    • Place of Presentation
      長崎
    • Year and Date
      2009-05-20
    • Related Report
      2010 Final Research Report
  • [Presentation] Wntシグナル関連遺伝子の一塩基多型(SNPs)と骨密度の相関解析2008

    • Author(s)
      大中佳三、河手久弥、高柳涼一
    • Organizer
      第25回日本骨代謝学会
    • Place of Presentation
      大阪
    • Year and Date
      2008-10-29
    • Related Report
      2010 Final Research Report
  • [Presentation] 日本人の骨密度関連遺伝子の網羅的解析(高密度SNP):福岡骨粗鬆症コホート研究2008

    • Author(s)
      大中佳三
    • Organizer
      第50回日本老年医学会学術総会-シンポジウム「骨粗鬆症と変形性関節症:研究と診療の最前線」
    • Place of Presentation
      千葉
    • Year and Date
      2008-06-21
    • Related Report
      2010 Final Research Report
  • [Book] 副甲状腺疾患-新老年学第3版2010

    • Author(s)
      大中佳三
    • Publisher
      東京大学出版会
    • Related Report
      2010 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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