Identification of gene targets for molecular diagnosis and therapeutics in hematopoietic malignancies based on advanced genomics

• Project/Area Number: 20390266
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hematology
• Research Institution: The University of Tokyo
• Principal Investigator: OGAWA Seishi The University of Tokyo, 医学部附属病院, 特任准教授 (60292900)
• Co-Investigator(Kenkyū-buntansha): 半下石 明 東京大学, 医学部附属病院, 特任講師 (20344450) ; 熊野 恵城 東京大学, 医学部附属病院, 助教 (90396721) ; 山本 豪 東京大学, 医学部附属病院, 助教 (70396753)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000); Fiscal Year 2010: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2009: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2008: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
• Keywords: ゲノミクス / 分子標的 / 造血器腫瘍 / 遺伝子診断 / ゲノム異常 / SNPアレイ / リシーケンス / MDS / ゲノム解析 / 遺伝子変異 / ATL / HTLV-1 / CD2 / CD28 / BCL11B

Research Abstract

Hematopoietic neoplasms are caused by genetic alterations and as such, it is essential to identify the spectrum of genetic changes incriminated in the neoplastic processes for the development of novel diagnostics and therapeutics. In this study, we performed comprehensive genetic analyses of more than 2,000 hematopoietic neoplasms using high-density SNP arrays. Though the high-throughput analysis we identified a number of genetic changes that are relevant to the pathogenesis of hematopoietic neoplasms, including mutations of c-CBL and IDH1/2 in myelodysplastic syndromes, and inactivating mutation/deletion of A20 in non-Hodgkin lymphoma. Combined with subsequent functional studies on these mutations, our finding provide an important insight into the molecular pathogenesis of hemaopoietic malignancies.

Research Products

• [Journal Article] A nonsense mutation of IDH1 in myelodysplastic syndromes and related disorders. (2011)
  • Author(s): Yoshida K, Sanada M, Kato M, Kawahata R, Matsubara A, Takita J, Shih LY, Mori H, Koeffler HP, Ogawa S.
  • Journal Title: Leukemia. 25 Pages: 184-186
  • Peer Reviewed
• [Journal Article] IDH1 and IDH2 mutations are rare in pediatric myeloid malignancies. (2011)
  • Author(s): Oki K, Takita J, Hiwatari M, Nishimura R, Sanada M, Okubo J, Adachi M, Sotomatsu M, Kikuchi A, Igarashi T, Hayashi Y, Ogawa S.
  • Journal Title: Leukemia. 25 Pages: 382-384
  • Peer Reviewed
• [Journal Article] Oncogenic mutations of ALK in neuroblastoma. (2011)
  • Author(s): Ogawa S, Takita J, Sanada M, Hayashi Y.
  • Journal Title: Cancer Sci. 102 Pages: 302-308
  • NAID: 10029289653
  • Peer Reviewed
• [Journal Article] A nonsense mutation of IDH1 in myelodysplastic syndromes and related disorders. (2011)
  • Author(s): 吉田健一, ら
  • Journal Title: Leukemia. Volume: 25 Pages: 184-186
  • Peer Reviewed
• [Journal Article] IDH1 and IDH2 mutations are rare in pediatric myeloid malign ancies. (2011)
  • Author(s): 大木健太郎, ら
  • Journal Title: Leukemia Volume: 25 Pages: 382-389
  • Peer Reviewed
• [Journal Article] Therapy of relapsed leukemia after allogeneic hematopoietic cell transplantation with T cells specific for minor histocompatibility antigens. (2010)
  • Author(s): Warren EH, Fujii N, Akatsuka Y, Chaney CN, Mito JK, Loeb KR, Gooley TA, Brown ML, Koo KK, Rosinski KV, Ogawa S, Matsubara A, Appelbaum FR, Riddell SR.
  • Journal Title: Blood. 115 Pages: 3869-3878
  • Peer Reviewed
• [Journal Article] Relapse of leukemia with loss of mismatched HLA resulting from uniparental disomy after haploidentical hematopoietic stem cell transplantation. (2010)
  • Author(s): Villalobos IB, Takahashi Y, Akatsuka Y, Muramatsu H, Nishio N, Hama A, Yagasaki H, Saji H, Kato M, Ogawa S, Kojima S.
  • Journal Title: Blood. 115 Pages: 3158-3161
  • Peer Reviewed
• [Journal Article] Prevalence and prognostic impact of allelic imbalances associated with leukemic transformation of Philadelphia chromosome-negative myeloproliferative neoplasms. (2010)
  • Author(s): Thoennissen NH, Krug UO, Lee DH, Kawamata N, Iwanski GB, Lasho T, Weiss T, Nowak D, Koren-Michowitz M, Kato M, Sanada M, Shih LY, Nagler A, Raynaud SD, Muller-Tidow C, Mesa R, Haferlach T, Gilliland DG, Tefferi A, Ogawa S, Koeffler HP.
  • Journal Title: Blood. 115 Pages: 2882-2890
  • Peer Reviewed
• [Journal Article] Prognostic significance of genetic alterations detected by high-density single nucleotide polymorphism array in gastric cancer. (2010)
  • Author(s): Tada M, Kanai F, Tanaka Y, Sanada M, Nannya Y, Tateishi K, Ohta M, Asaoka Y, Seto M, Imazeki F, Yoshida H, Ogawa S, Yokosuka O, Omata M.
  • Journal Title: Cancer Sci. 101 Pages: 1261-1269
  • NAID: 10026592643
  • Peer Reviewed
• [Journal Article] CBL mutations in juvenile myelomonocytic leukemia and pediatric myelodysplastic syndrome. (2010)
  • Author(s): Shiba N, Kato M, Park MJ, Sanada M, Ito E, Fukushima K, Sako M, Arakawa H, Ogawa S, Hayashi Y.
  • Journal Title: Leukemia. 24 Pages: 1090-1092
  • Peer Reviewed
• [Journal Article] Variation in CDKN2A at 9p21.3 influences childhood acute lymphoblastic leukemia risk. (2010)
  • Author(s): Sherborne AL, Hosking FJ, Prasad RB, Kumar R, Koehler R, Vijayakrishnan J, Papaemmanuil E, Bartram CR, Stanulla M, Schrappe M, Gast A, Dobbins SE, Ma Y, Sheridan E, Taylor M, Kinsey SE, Lightfoot T, Roman E, Irving JA, Allan JM, Moorman AV, Harrison CJ, Tomlinson IP, Richards S, Zimmermann M, Szalai C, Semsei AF, Erdelyi DJ, Krajinovic M, Sinnett D, Healy J, Neira AG, Kawamata N, Ogawa S, Koeffler HP, Hemminki K, Greaves M, Houlston RS.
  • Journal Title: Nat Genet. 42 Pages: 492-494
  • Peer Reviewed
• [Journal Article] Genomic profiling of adult acute lymphoblastic leukemia by single nucleotide polymorphism oligonucleotide microarray and comparison to pediatric acute lymphoblastic leukemia. (2010)
  • Author(s): Okamoto R, Ogawa S, Nowak D, Kawamata N, Akagi T, Kato M, Sanada M, Weiss T, Haferlach C, Dugas M, Ruckert C, Haferlach T, Koeffler HP.
  • Journal Title: Haematologica. 95 Pages: 1481-1488
  • Peer Reviewed
• [Journal Article] Deregulated Intracellular Signaling by Mutated c-CBL in Myeloid Neoplasms. (2010)
  • Author(s): Ogawa S, Shih LY, Suzuki T, Otsu M, Nakauchi H, Koeffler HP, Sanada M.
  • Journal Title: Clin Cancer Res. 16 Pages: 3825-3831
  • Peer Reviewed
• [Journal Article] Gain-of-function c-CBL mutations associated with uniparental disomy of 11q in myeloid neoplasms. (2010)
  • Author(s): Ogawa S, Sanada M, Shih LY, Suzuki T, Otsu M, Nakauchi H, Koeffler HP.
  • Journal Title: Cell Cycle. 9
  • Peer Reviewed
• [Journal Article] SNP array analysis of tyrosine kinase inhibitor-resistant chronic myeloid leukemia identifies heterogeneous secondary genomic alterations. (2010)
  • Author(s): Nowak D, Ogawa S, Muschen M, Kato M, Kawamata N, Meixel A, Nowak V, Kim HS, Kang S, Paquette R, Chang MS, Thoenissen NH, Mossner M, Hofmann WK, Kohlmann A, Weiss T, Haferlach T, Haferlach C, Koeffler HP.
  • Journal Title: Blood. 115 Pages: 1049-1053
  • Peer Reviewed
• [Journal Article] Hes1 immortalizes committed progenitors and plays a role in blast crisis transition in chronic myelogenous leukemia. (2010)
  • Author(s): Nakahara F, Sakata-Yanagimoto M, Komeno Y, Kato N, Uchida T, Haraguchi K, Kumano K, Harada Y, Harada H, Kitaura J, Ogawa S, Kurokawa M, Kitamura T, Chiba S.
  • Journal Title: Blood. 115 Pages: 2872-2881
  • Peer Reviewed
• [Journal Article] Impact of highly conserved HLA haplotype on acute graft-versus-host disease. (2010)
  • Author(s): Morishima S, Ogawa S, Matsubara A, Kawase T, Nannya Y, Kashiwase K, Satake M, Saji H, Inoko H, Kato S, Kodera Y, Sasazuki T, Morishima Y.
  • Journal Title: Blood. 115 Pages: 4664-4670
  • Peer Reviewed
• [Journal Article] The correlation pattern of acquired copy number changes in 164 ETV6/RUNX1-positive childhood acute lymphoblastic leukemias. (2010)
  • Author(s): Lilljebjorn H, Soneson C, Andersson A, Heldrup J, Behrendtz M, Kawamata N, Ogawa S, Koeffler HP, Mitelman F, Johansson B, Fontes M, Fioretos T.
  • Journal Title: Hum Mol Genet. 19 Pages: 3150-3158
  • Peer Reviewed
• [Journal Article] Gastric cancer cell line Hs746T harbors a splice site mutation of c-Met causing juxtamembrane domain deletion. (2010)
  • Author(s): Asaoka Y, Tada M, Ikenoue T, Seto M, Imai M, Miyabayashi K, Yamamoto K, Yamamoto S, Kudo Y, Mohri D, Isomura Y, Ijichi H, Tateishi K, Kanai F, Ogawa S, Omata M, Koike K.
  • Journal Title: Biochem Biophys Res Commun. 394 Pages: 1042-1046
  • Peer Reviewed
• [Journal Article] Prevalence and prognostic impact of allelic imbalances associated with leukemic transformation of Philadelphia chromosom e-negative myeloproliferative neoplasms. (2010)
  • Author(s): Thoennissen NH, ら
  • Journal Title: Blood Volume: 115 Pages: 2882-2890
  • Peer Reviewed
• [Journal Article] Derivation of functional mature neutrophils from human embryonic stem cells. (2009)
  • Author(s): Yokoyama Y, Suzuki T, Sakata-Yanagimoto M, Kumano K, Higashi K, Takato T, Kurokawa M, Ogawa S, Chiba S.
  • Journal Title: Blood. 113 Pages: 6584-6592
  • NAID: 120007131544
  • Peer Reviewed
• [Journal Article] High-resolution genomic copy number profiling of glioblastoma multiforme by single nucleotide polymorphism DNA microarray. (2009)
  • Author(s): Yin D, Ogawa S, Kawamata N, Tunici P, Finocchiaro G, Eoli M, Ruckert C, Huynh T, Liu G, Kato M, Sanada M, Jauch A, Dugas M, Black KL, Koeffler HP.
  • Journal Title: Mol Cancer Res. 7 Pages: 665-677
  • Peer Reviewed
• [Journal Article] Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms. (2009)
  • Author(s): Sanada M, Suzuki T, Shih LY, Otsu M, Kato M, Yamazaki S, Tamura A, Honda H, Sakata-Yanagimoto M, Kumano K, Oda H, Yamagata T, Takita J, Gotoh N, Nakazaki K, Kawamata N, Onodera M, Nobuyoshi M, Hayashi Y, Harada H, Kurokawa M, Chiba S, Mori H, Ozawa K, Omine M, Hirai H, Nakauchi H, Koeffler HP, Ogawa S.
  • Journal Title: Nature. 460 Pages: 904-908
  • Peer Reviewed
• [Journal Article] Molecular allelokaryotyping of T-cell prolymphocytic leukemia cells with high density single nucleotide polymorphism arrays identifies novel common genomic lesions and acquired uniparental disomy. (2009)
  • Author(s): Nowak D, Le Toriellec E, Stern MH, Kawamata N, Akagi T, Dyer MJ, Hofmann WK, Ogawa S, Koeffler HP.
  • Journal Title: Haematologica. 94 Pages: 518-527
  • Peer Reviewed
• [Journal Article] Gain-of-function mutations and copy number increases of Notch2 in diffuse large B-cell lymphoma. (2009)
  • Author(s): Lee SY, Kumano K, Nakazaki K, Sanada M, Matsumoto A, Yamamoto G, Nannya Y, Suzuki R, Ota S, Ota Y, Izutsu K, Sakata-Yanagimoto M, Hangaishi A, Yagita H, Fukayama M, Seto M, Kurokawa M, Ogawa S, Chiba S.
  • Journal Title: Cancer Sci. 100 Pages: 920-926
  • NAID: 10025145854
  • Peer Reviewed
• [Journal Article] HLA mismatch combinations associated with decreased risk of relapse: implications for the molecular mechanism. (2009)
  • Author(s): Kawase T, Matsuo K, Kashiwase K, Inoko H, Saji H, Ogawa S, Kato S, Sasazuki T, Kodera Y, Morishima Y.
  • Journal Title: Blood. 113 Pages: 2851-2858
  • Peer Reviewed
• [Journal Article] Double minute chromosomes containing MYB gene and NUP214-ABL1 fusion gene in T-cell leukemia detected by single nucleotide polymorphism DNA microarray and fluorescence in situ hybridization. (2009)
  • Author(s): Kawamata N, Zhang L, Ogawa S, Nannya Y, Dashti A, Lu D, Lim S, Schreck R, Koeffler HP.
  • Journal Title: Leuk Res. 33 Pages: 569-571
  • Peer Reviewed
• [Journal Article] Molecular allelokaryotyping of relapsed pediatric acute lymphoblastic leukemia. (2009)
  • Author(s): Kawamata N, Ogawa S, Seeger K, Kirschner-Schwabe R, Huynh T, Chen J, Megrabian N, Harbott J, Zimmermann M, Henze G, Schrappe M, Bartram CR, Koeffler HP.
  • Journal Title: Int J Oncol. 34 Pages: 1603-1612
  • Peer Reviewed
• [Journal Article] Identified hidden genomic changes in mantle cell lymphoma using high-resolution single nucleotide polymorphism genomic array. (2009)
  • Author(s): Kawamata N, Ogawa S, Gueller S, Ross SH, Huynh T, Chen J, Chang A, Nabavi-Nouis S, Megrabian N, Siebert R, Martinez-Climent JA, Koeffler HP.
  • Journal Title: Exp Hematol. 37 Pages: 937-946
  • Peer Reviewed
• [Journal Article] Hepatoblastoma in a patient with sotos syndrome. (2009)
  • Author(s): Kato M, Takita J, Takahashi K, Mimaki M, Chen Y, Koh K, Ida K, Oka A, Mizuguchi M, Ogawa S, Igarashi T.
  • Journal Title: J Pediatr. 155 Pages: 937-939
  • Peer Reviewed
• [Journal Article] Frequent inactivation of A20 in B-cell lymphomas. (2009)
  • Author(s): Kato M, Sanada M, Kato I, Sato Y, Takita J, Takeuchi K, Niwa A, Chen Y, Nakazaki K, Nomoto J, Asakura Y, Muto S, Tamura A, Iio M, Akatsuka Y, Hayashi Y, Mori H, Igarashi T, Kurokawa M, Chiba S, Mori S, Ishikawa Y, Okamoto K, Tobinai K, Nakagama H, Nakahata T, Yoshino T, Kobayashi Y, Ogawa S.
  • Journal Title: Nature. 459 Pages: 712-716
  • NAID: 40019064821
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• [Journal Article] HapMap scanning of novel human minor histocompatibility antigens. (2009)
  • Author(s): Kamei M, Nannya Y, Torikai H, Kawase T, Taura K, Inamoto Y, Takahashi T, Yazaki M, Morishima S, Tsujimura K, Miyamura K, Ito T, Togari H, Riddell SR, Kodera Y, Morishima Y, Kuzushima K, Ogawa S, Akatsuka Y.
  • Journal Title: Blood. 113 Pages: 5041-5048
  • Peer Reviewed
• [Journal Article] Notch activation induces the generation of functional NK cells from human cord blood CD34-positive cells devoid of IL-15. (2009)
  • Author(s): Haraguchi K, Suzuki T, Koyama N, Kumano K, Nakahara F, Matsumoto A, Yokoyama Y, Sakata-Yanagimoto M, Masuda S, Takahashi T, Kamijo A, Takahashi K, Takanashi M, Okuyama Y, Yasutomo K, Sakano S, Yagita H, Kurokawa M, Ogawa S, Chiba S.
  • Journal Title: J Immunol. 182 Pages: 6168-6178
  • Peer Reviewed
• [Journal Article] Single nucleotide polymorphism genomic arrays analysis of t(8;21) acute myeloid leukemia cells. (2009)
  • Author(s): Akagi T, Shih LY, Ogawa S, Gerss J, Moore SR, Schreck R, Kawamata N, Liang DC, Sanada M, Nannya Y, Deneberg S, Zachariadis V, Nordgren A, Song JH, Dugas M, Lehmann S, Koeffler HP.
  • Journal Title: Haematologica. 94 Pages: 1301-1306
  • NAID: 120001643240
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• [Journal Article] Hidden abnormalities and novel classification of t(15;17) acute promyelocytic leukemia (APL) based on genomic alterations. (2009)
  • Author(s): Akagi T, Shih LY, Kato M, Kawamata N, Yamamoto G, Sanada M, Okamoto R, Miller CW, Liang DC, Ogawa S, Koeffler HP.
  • Journal Title: Blood. 113 Pages: 1741-1748
  • NAID: 120001249804
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• [Journal Article] Chromosomal abnormalities and novel disease-related regions in progression from Barrett's esophagus to esophageal adenocarcinoma. (2009)
  • Author(s): Akagi T, Ito T, Kato M, Jin Z, Cheng Y, Kan T, Yamamoto G, Olaru A, Kawamata N, Boult J, Soukiasian HJ, Miller CW, Ogawa S, Meltzer SJ, Koeffler HP.
  • Journal Title: Int J Cancer. 125 Pages: 2349-2359
  • Peer Reviewed
• [Journal Article] Oncogenic mutations of ALK kinase in neuroblastoma (2009)
  • Author(s): 真田昌, et al.
  • Journal Title: Nature 460 Pages: 904-908
  • Peer Reviewed
• [Journal Article] Frequent inactivation of A20 in B-cell lymphomas (2009)
  • Author(s): 加藤元博, et al.
  • Journal Title: Natur 459 Pages: 712-6
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• [Journal Article] Hidden abnormalities and novel classification of t(15;17)acute promyelocytic leukemia(APL)based on genomic alterations (2009)
  • Author(s): Akagi, T., et al.
  • Journal Title: Blood 113 Pages: 1741-8
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• [Journal Article] Donor killer immunoglobulin-like receptor (KIR) genotype-patient cognate KIR ligand combination and antithymocyte globulin preadministration are critical factors in outcome of HLA-C-KIR ligand-mismatched T cell-replete unrelated bone marrow transplantation. (2008)
  • Author(s): Yabe T, Matsuo K, Hirayasu K, Kashiwase K, Kawamura-Ishii S, Tanaka H, Ogawa A, Takanashi M, Satake M, Nakajima K, Tokunaga K, Inoko H, Saji H, Ogawa S, Juji T, Sasazuki T, Kodera Y, Morishima Y.
  • Journal Title: Biol Blood Marrow Transplant. 14 Pages: 75-87
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• [Journal Article] Genome-wide loss of heterozygosity and uniparental disomy in BRCA1/2-associated ovarian carcinomas. (2008)
  • Author(s): Walsh CS, Ogawa S, Scoles DR, Miller CW, Kawamata N, Narod SA, Koeffler HP, Karlan BY.
  • Journal Title: Clin Cancer Res. 14 Pages: 7645-7651
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• [Journal Article] ERCC5 is a novel biomarker of ovarian cancer prognosis. (2008)
  • Author(s): Walsh CS, Ogawa S, Karahashi H, Scoles DR, Pavelka JC, Tran H, Miller CW, Kawamata N, Ginther C, Dering J, Sanada M, Nannya Y, Slamon DJ, Koeffler HP, Karlan BY.
  • Journal Title: J Clin Oncol. 26 Pages: 2952-2958
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• [Journal Article] Gain of GRHL2 is associated with early recurrence of hepatocellular carcinoma. (2008)
  • Author(s): Tanaka Y, Kanai F, Tada M, Tateishi R, Sanada M, Nannya Y, Ohta M, Asaoka Y, Seto M, Shiina S, Yoshida H, Kawabe T, Yokosuka O, Ogawa S, Omata M.
  • Journal Title: J Hepatol. 49 Pages: 746-757
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• [Journal Article] AML1-Evi-1 specifically transforms hematopoietic stem cells through fusion of the entire Evi-1 sequence to AML1. (2008)
  • Author(s): Takeshita M, Ichikawa M, Nitta E, Goyama S, Asai T, Ogawa S, Chiba S, Kurokawa M.
  • Journal Title: Leukemia
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• [Journal Article] Whole-genome profiling of chromosomal aberrations in hepatoblastoma using high-density single-nucleotide polymorphism genotyping microarrays. (2008)
  • Author(s): Suzuki M, Kato M, Yuyan C, Takita J, Sanada M, Nannya Y, Yamamoto G, Takahashi A, Ikeda H, Kuwano H, Ogawa S, Hayashi Y.
  • Journal Title: Cancer Sci. 99 Pages: 564-570
  • NAID: 10024003876
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• [Journal Article] Characterization of adenocarcinoma of the lung in a familial adenomatous polyposis patient. (2008)
  • Author(s): Shinmura K, Suzuki M, Yamada H, Tao H, Goto M, Kamo T, Nagura K, Kageyama S, Kato M, Ogawa S, Maekawa M, Takamochi K, Suzuki K, Nakamura T, Sugimura H.
  • Journal Title: Pathol Int. 58 Pages: 706-712
  • NAID: 10027378345
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• [Journal Article] Coordinated regulation of transcription factors through Notch2 is an important mediator of mast cell fate. (2008)
  • Author(s): Sakata-Yanagimoto M, Nakagami-Yamaguchi E, Saito T, Kumano K, Yasutomo K, Ogawa S, Kurokawa M, Chiba S.
  • Journal Title: Proc Natl Acad Sci USA. 105 Pages: 7839-7844
  • NAID: 120007138253
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• [Journal Article] Exploration of the genetic basis of GVHD by genetic association studies. (2008)
  • Author(s): Ogawa S, Matsubara A, Onizuka M, Kashiwase K, Sanada M, Kato M, Nannya Y, Akatsuka Y, Satake M, Takita J, Chiba S, Saji H, Maruya E, Inoko H, Morishima Y, Kodera Y, Takehiko S.
  • Journal Title: Biol Blood Marrow Transplant. 15 Pages: 39-41
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• [Journal Article] Integrated analysis of copy number alterations and loss of heterozygosity in human pancreatic cancer using a high-resolution, single nucleotide polymorphism array. (2008)
  • Author(s): Lin LJ, Asaoka Y, Tada M, Sanada M, Nannya Y, Tanaka Y, Tateishi K, Ohta M, Seto M, Sasahira N, Kawabe T, Zheng CQ, Kanai F, Ogawa S, Omata M.
  • Journal Title: Oncology. 75 Pages: 102-112
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• [Journal Article] Molecular allelokaryotyping of early-stage, untreated chronic lymphocytic leukemia. (2008)
  • Author(s): Lehmann S, Ogawa S, Raynaud SD, Sanada M, Nannya Y, Ticchioni M, Bastard C, Kawamata N, Koeffler HP.
  • Journal Title: Cancer. 112 Pages: 1296-1305
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• [Journal Article] Both Notch1 and Notch2 contribute to the regulation of melanocyte homeostasis. (2008)
  • Author(s): Kumano K, Masuda S, Sata M, Saito T, Lee SY, Sakata-Yanagimoto M, Tomita T, Iwatsubo T, Natsugari H, Kurokawa M, Ogawa S, Chiba S.
  • Journal Title: Pigment Cell Research
  • Peer Reviewed
• [Journal Article] Identification of human minor histocompatibility antigens based on genetic association with highly parallel genotyping of pooled DNA. (2008)
  • Author(s): Kawase T, Nannya Y, Torikai H, Yamamoto G, Onizuka M, Morishima S, Tsujimura K, Miyamura K, Kodera Y, Morishima Y, Takahashi T, Kuzushima K, Ogawa S, Akatsuka Y.
  • Journal Title: Blood. 111 Pages: 3286-3294
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• [Journal Article] Cloning of genes involved in chromosomal translocations by high-resolution single nucleotide polymorphism genomic microarray. (2008)
  • Author(s): Kawamata N, Ogawa S, Zimmermann M, Niebuhr B, Stocking C, Sanada M, Hemminki K, Yamatomo G, Nannya Y, Koehler R, Flohr T, Miller CW, Harbott J, Ludwig WD, Stanulla M, Schrappe M, Bartram CR, Koeffler HP.
  • Journal Title: Proc Natl Acad Sci USA. 105 Pages: 11921-11926
  • Peer Reviewed
• [Journal Article] Molecular allelokaryotyping of pediatric acute lymphoblastic leukemias by high-resolution single nucleotide polymorphism oligonucleotide genomic microarray. (2008)
  • Author(s): Kawamata N, Ogawa S, Zimmermann M, Kato M, Sanada M, Hemminki K, Yamatomo G, Nannya Y, Koehler R, Flohr T, Miller CW, Harbott J, Ludwig WD, Stanulla M, Schrappe M, Bartram CR, Koeffler HP.
  • Journal Title: Blood. 111 Pages: 776-784
  • Peer Reviewed
• [Journal Article] Genetic profiling of myeloproliferative disorders by single-nucleotide polymorphism oligonucleotide microarray. (2008)
  • Author(s): Kawamata N, Ogawa S, Yamamoto G, Lehmann S, Levine RL, Pikman Y, Nannya Y, Sanada M, Miller CW, Gilliland DG, Koeffler HP.
  • Journal Title: Exp Hematol. 36 Pages: 1471-1479
  • Peer Reviewed
• [Journal Article] Chronic phase of ETV6-ABL1 positive CML responds to imatinib. (2008)
  • Author(s): Kawamata N, Dashti A, Lu D, Miller B, Koeffler HP, Schreck R, Moore S, Ogawa S.
  • Journal Title: Genes Chromosomes Cancer. 47 Pages: 919-921
  • Peer Reviewed
• [Journal Article] AML1/Runx1 Negatively Regulates Quiescent Hematopoietic Stem Cells in Adult Hematopoiesis. (2008)
  • Author(s): Ichikawa M, Goyama S, Asai T, Kawazu M, Nakagawa M, Takeshita M, Chiba S, Ogawa S, Kurokawa M.
  • Journal Title: J Immunol. 180 Pages: 4402-4408
  • Peer Reviewed
• [Journal Article] Evi-1 is a critical regulator for hematopoietic stem cells and transformed leukemic cells. (2008)
  • Author(s): Goyama S, Yamamoto G, Shimabe M, Sato T, Ichikawa M, Ogawa S, Chiba S, Kurokawa M.
  • Journal Title: Cell Stem Cell. 3 Pages: 207-220
  • Peer Reviewed
• [Journal Article] Oncogenic mutations of ALK kinase in neuroblastoma. (2008)
  • Author(s): Chen Y, Takita J, Choi YL, Kato M, Ohira M, Sanada M, Wang L, Soda M, Kikuchi A, Igarashi T, Nakagawara A, Hayashi Y, Mano H, Ogawa S.
  • Journal Title: Nature. 455 Pages: 971-974
  • Peer Reviewed
• [Journal Article] Frequent genomic abnormalities in acute myeloid leukemia/myelodysplastic syndrome with normal karyotype. (2008)
  • Author(s): Akagi T, Ogawa S, Dugas M, Kawamata N, Yamamoto G, Nannya Y, Sanada M, Miller CW, Yung A, Schnittger S, Haferlach T, Haferlach C, Koeffler HP.
  • Journal Title: Haematologica. 94 Pages: 213-223
  • Peer Reviewed
• [Journal Article] Oncogenic mutations of ALK kinase in neuroblastoma (2008)
  • Author(s): Chen Y, et al.
  • Journal Title: Nature 455 Pages: 971-974
  • Peer Reviewed
• [Journal Article] Cloning of genes involved in chromosomal translocations by high-resolution single nucleotide polymorphism genomic microarray (2008)
  • Author(s): Kawamata N, et al.
  • Journal Title: IProc Natl Acad Sc i U S A 105 Pages: 11921-11926
  • Peer Reviewed
• [Journal Article] Molecular allelokaryotyping of pediatric acute lymphoblastic leukemias by high-resolution single nucleotide poly morphism oligonucleotide genomic microarray (2008)
  • Author(s): Kawamata N, et al.
  • Journal Title: Blood 111 Pages: 776-784
  • Peer Reviewed
• [Journal Article] Notch2 signaling is required for proper mast cell distribution and mucosal immunity in the intestine.
  • Author(s): Sakata-Yanagimoto M, Sakai T, Miyake Y, Saito T, Maruyama M, Morishita Y, Nakagami-Yamaguchi E, Kumano K, Yagita Y, Fukayama M, Ogawa S, Kurokawa M, Yasutomo K, Chiba S.
  • Journal Title: Blood In press
  • NAID: 120007137632
  • Peer Reviewed
• [Presentation] Genetic basis of myelodysplastic syndromes and related disorders (2010)
  • Author(s): 小川誠司
  • Organizer: 第72回日本血液学会総会EHA合同シンポジウム
  • Place of Presentation: パシフィコ横浜会議センター
  • Year and Date: 2010-09-26
• [Presentation] Gain-of-function mutations of c-Cb1 tumor suppressor in MDS and MDS/MPD associated with 11q UPD (2009)
  • Author(s): 真田昌, ら
  • Organizer: the 14th Congress of the European Hematology Association
  • Place of Presentation: ベルリン(ドイツ)
  • Year and Date: 2009-06-05
• [Presentation] 成人T細胞白血病(ATL)における網羅的ゲノム解析 (2008)
  • Author(s): 武藤早紀ら
  • Organizer: 第70回日本血液学会学術集塊
  • Place of Presentation: 京都
  • Year and Date: 2008-10-12
• [Remarks] ホームページ等
  • URL: http://www.genome.umin.jp/