| Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2009: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2008: ¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
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| Research Abstract |
We explored the mechanisms underlying the IL-21-mediated suppression of IgE-based allergic responses. We also examined whether nano DDS is useful for therapeutic application for allergic diseases. Analyses of dose-response and administration methodology revealed that IL-21 may suppress allergic responses not only by inhibiting IgE class switch recombination but also by affecting other pathways. Then we asked whether IL-21 directly acts on mast cells. IL-21 signal suppresses degranulation of mast cell, while proliferation of mast cell precursors may be inhibited by Id2 transcriptional repressor. Meanwhile, nano DDS was also useful for desensitization procedures and significantly reduced IgE level while suppressing allergic responses. The present study may lead to a novel therapeutic strategy against allergic disorders.
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