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A new strategy for antibody-therapy against infectious diseases and bacterial terrorism using lymphocyte-chip

Research Project

Project/Area Number 20390286
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Infectious disease medicine
Research InstitutionUniversity of Toyama

Principal Investigator

MURAGUCHI Atsushi  University of Toyama, 大学院・医学薬学研究部, 教授 (20174287)

Co-Investigator(Kenkyū-buntansha) KISHI Hiroyuki  富山大学, 大学院・医学薬学研究部, 准教授 (60186210)
OZAWA Tatsuhiko  富山大学, 大学院・医学薬学研究部, 助教 (10432105)
KITAJIMA Isao  富山大学, 大学院・医学薬学研究部, 教授 (50214797)
NIKAIDO Toshio  富山大学, 大学院・医学薬学研究部, 教授 (50180568)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2010: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2009: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2008: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Keywordsリンパ球チップ / 抗体医療 / 抗体遺伝子 / 抗体産生細胞 / リコンビナント抗体 / インフルエンザウイルス / B型肝炎ウイルス / 中和抗体 / 抗体医薬 / 感染症 / 抗体工学 / ヒト抗体 / 新興感染症
Research Abstract

We developed ISAAC (Immunospot assay for antibody-secreting cell) method that can detect antibody-secreting cells in a microwell using murine system. We then succeeded in generating high-quality human monoclonal antibodies for hepatitis B virus and influenza virus from vaccinated healthy volunteers using the ISAAC method in a very short time ; within one week. We further developed an in vitro assay system to examine the HBV-neutralizing activity of human anti-HBs antibodies and clarified the relationship between neutralizing activity of human mAbs and epitopes of HBs antigen.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (76 results)

All 2011 2010 2009 2008

All Journal Article (29 results) (of which Peer Reviewed: 29 results) Presentation (47 results)

  • [Journal Article] Aberrant CaMKII activity is associated with abnormal dendoric spine morphology in ATRX mutant mouse brain.2011

    • Author(s)
      Shioda N., et al
    • Journal Title

      J Neurosci

      Volume: 31 Pages: 346-358

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Generation of TRAIL-receptor 1-specific human monoclonal Ab by a combination of immunospot array assay on a chip and human Ab-producing mice.2010

    • Author(s)
      Jin A., Ozawa T., Tajiri K., Lin Z., Obata T., Ishida I., Kishi H., Muraguchi A.
    • Journal Title

      Eur.J.Immunol. 40

      Pages: 3591-3593

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of the epitope and neutralizing capacity of human monoclonal antibodies induced by hepatitis B vaccine.2010

    • Author(s)
      Tajiri K., Ozawa T., Jin A., Tokimitsu Y., Minemura M., Kishi H., Sugiyama T., Muraguchi A.
    • Journal Title

      Antiviral.Res. 87

      Pages: 40-49

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Post-translational modification of TRAIL receptor type 1 on various tumor cells and the susceptibility of tumors to TRAIL-induced apoptosis.2010

    • Author(s)
      Lin Z., Jin A., Ozawa T., Tajiri K., Obata T., Ishida I., Jin F., Kishi H., Muraguchi A.
    • Journal Title

      Biochem.Biophys.Res.Commun. 395

      Pages: 251-257

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Generation of TRAIL-receptor 1-specific human monoclonal Ab by a combination of immunospot array assay on a chip and human Ab-producing mice.2010

    • Author(s)
      Jin A., et al
    • Journal Title

      Eur.J.Immunol.

      Volume: 40 Pages: 3591-3593

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of the epitope and neutralizing capacity of human monoclonal antibodies induced by hepatitis B vaccine.2010

    • Author(s)
      Tajiri K., et al
    • Journal Title

      Antiviral.Res.

      Volume: 87 Pages: 40-49

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Post-translational modification of TRAIL receptor type 1 on various tumor cells and the susceptibility of tumors to TRAIL-induced apoptosis.2010

    • Author(s)
      Lin Z., et al
    • Journal Title

      Biochem.Biophys.Res.Commun.

      Volume: 395 Pages: 251-257

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulatory role of leukocyte common antigen-related molecule (LAR) in thymocyte differentiation.2010

    • Author(s)
      Kondo S., et al
    • Journal Title

      Eur.J.Immunol.

      Volume: 40 Pages: 1296-1302

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Venous thromboembolism after spinal surgery : Changes of the fibrin monomer complex and D-dimer level during the perioperative period.2010

    • Author(s)
      Yoshioka K., et al
    • Journal Title

      Journal of Neurosurgery.Spine

      Volume: 13 Pages: 594-599

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reduced expression of the ATRX gene, a chromatin-remodeling factor, causes hippocampal dysfunction in mice.2010

    • Author(s)
      Nogami T., et al
    • Journal Title

      HIPPOCAMPUS

      Volume: 21巻

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A role for IL-17 in induction of an inflammation at the fetomaternal interface in preterm labour.2010

    • Author(s)
      Ito M., et al
    • Journal Title

      J Reprod Immunol

      Volume: 84 Pages: 75-85

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cyclin A2 confers cisplatin resistance to endometrial carcinoma cells via up-regulation of an Akt-binding protein, periplakin.2010

    • Author(s)
      Suzuki A., et al
    • Journal Title

      J Cell Mol Med

      Volume: 14 Pages: 2305-2317

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A role for IL-17 in induction of an inflammation at the fetomaternal interface in preterm labour,2010

    • Author(s)
      Ito M, et al.
    • Journal Title

      J Reprod Immunol 84

      Pages: 75-85

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A rapid and efficient single-cell manipulation method for screening antigen-specific antibody-secreting cells from human peripheral blood.2009

    • Author(s)
      Jin A.-S., Ozawa T., Tajiri K., Obata T., Kondo S., Kinoshita K., Kadowaki S., Takahashi K., Sugiyama T., Kishi H., Muraguchi A.
    • Journal Title

      Nat.Med. 15

      Pages: 1088-1092

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of antigen-specific B cells by concurrent monitoring of intracellular Ca^<2+> mobilization and antigen binding with microwell array chip system equipped with a CCD imager.2009

    • Author(s)
      Kinoshita K., Ozawa T., Tajiri K., Kadowaki S., Kishi H., Muraguchi A.
    • Journal Title

      Cytometry Part A 75A

      Pages: 682-687

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] SFMAC : A novel method for analyzing multiple parameters on lymphocytes with a single fluorophore in cell-microarray system.2009

    • Author(s)
      Tajiri K., Kishi H., Ozawa T., Sugiyama T., Muraguchi A.
    • Journal Title

      Cytometry Part A 75A

      Pages: 282-288

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] MAC-CCD system : a novel lymphocyte microwell-array chip system equipped with CCD scanner to generate human monoclonal antibodies against influenza virus.2009

    • Author(s)
      Ozawa T., Kinoshita K., Kadowaki S., Tajiri K., Kondo S., Honda R., Ikemoto M., Piao L.-X., Morisato A., Fukurotani K., Kishi H., Muraguchi A.
    • Journal Title

      Lab on a Chip 9

      Pages: 158-163

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A rapid and efficient single-cell manipulation method for screening antigen-specific antibody-secreting cells from human peripheral blood.2009

    • Author(s)
      Jin A.-S., et al
    • Journal Title

      Nature Medicine 15

      Pages: 1088-1092

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of antigen-specific B cells by concurrent monitoring of intracellular Ca^<2+> mobilization and antigen binding with microwell array chip system equipped with a CCD imager.2009

    • Author(s)
      Kinoshita K., et al
    • Journal Title

      Cytometry Part A 75A

      Pages: 682-687

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of autophagic cell death and radiosensitization by the pharmacological inhibition of nuclear factor-kappa B activation in human glioma cell lines.2009

    • Author(s)
      Tsuoi Y, et al.
    • Journal Title

      J.Neurosurg. 110

      Pages: 594-604

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MAC-CCD system : a novel lymphocyte microwell-array chip system equipped with CCD scanner to generate human monoclonal antibodies against influenza virus2009

    • Author(s)
      Ozawa T., et al
    • Journal Title

      Lab on a Chip 9

      Pages: 158-163

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] SFMAC : A novel method for analyzing multiple parameters on lymphocytes with a single fluorophore in cell-microarray system2009

    • Author(s)
      Tajiri K., et al
    • Journal Title

      Cytometry Part A 75A

      Pages: 282-288

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The direct excitatory effect of IL-1β on cerebellar Purkinje cell2009

    • Author(s)
      Motoki K., et al
    • Journal Title

      Biochem. Biophys. Res. Commun. 379

      Pages: 665-668

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of autophagic cell death and radiosensitization by the pharmacological inhibition of nuclear factor-kappa B actication in human glioma cell lines2009

    • Author(s)
      Tsuboi Y., et al
    • Journal Title

      J. Neurosurg 110

      Pages: 594-604

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comprehensive analysis of the functional TCR repertoire at the single-cell level2008

    • Author(s)
      Ozawa T., et al
    • Journal Title

      Biochem. Biophys. Res. Commun. 367

      Pages: 820-825

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of different statins on endothelial nitric oxide synthase and AKT phosphorylation in endothelial cells2008

    • Author(s)
      Wang J., et al
    • Journal Title

      International Journal of Cardiology 127

      Pages: 33-39

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Changes of the soluble fibrin monomer complex level in the perioperative period of hip replacement surgery2008

    • Author(s)
      Misaki T., et al
    • Journal Title

      J. Orthop. Sci. 13

      Pages: 419-424

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of laminin isoforms in human amnion2008

    • Author(s)
      Takashima S., et al
    • Journal Title

      Tissue and Cell 40

      Pages: 75-81

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of RhoA enhances peritoneal dissemination. RhoA suppression with Lovastatin may be useful for ovarian cancer2008

    • Author(s)
      Horiuchi A., et al
    • Journal Title

      Cancer Sci. 99

      Pages: 2532-2539

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Characterization of human anti-influenza M2 antibody obtained from peripheral blood of vaccinated volunteer.2011

    • Author(s)
      Muraguchi A., Ozawa T., Jin A., Tajiri K., Takemoto M., Okuda T., Shiraki K., Kishi H.
    • Organizer
      Keystone Symposia
    • Place of Presentation
      Keystone, USA.
    • Related Report
      2010 Final Research Report
  • [Presentation] Characterization of human anti-influenza M2 antibody obtained from peripheral blood of vaccinated volunteer.2011

    • Author(s)
      Muraguchi A., et al
    • Organizer
      Keystone Symposia
    • Place of Presentation
      Keystone, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Enhancement of TRAIL-induced apoptosis with novel TRAIL-Receptor 1 specific human mAbs generated by Immunos of array assay on a chip.2011

    • Author(s)
      Jin A., et al
    • Organizer
      Keystone Symposia
    • Place of Presentation
      Keystone, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Nuclear factor-kappa B activity correlates with metabolic syndrome-related biomerkers in patients with essential hypertension.2010

    • Author(s)
      Harada K., et al
    • Organizer
      2010 AACC (American Association for Clinical Chemistry)
    • Place of Presentation
      Anaheim, CA, USA
    • Year and Date
      2010-07-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] Anti-inflammatory effect of pitavastatin on NF-kaoppa B activated by TNF-alfa through Rho kinase pathway in breast cancer cells.2010

    • Author(s)
      Kitajima I
    • Organizer
      Keystone Symposia 2010 NF-kappa B in inflammation and Disease
    • Place of Presentation
      Santa Fe, USA
    • Year and Date
      2010-01-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] Isolation and characterization of a fully human monoclonal antibody against extracellular domain of matrix protein 2 of influenza A virus.2010

    • Author(s)
      Ozawa T., Jin A., Tajiri K., Takemoto M., Okuda T., Shiraki K., Kishi H., Muraguchi A.
    • Organizer
      Cold Spring Harbor Conferences Asia
    • Place of Presentation
      Suzhou, China.
    • Related Report
      2010 Final Research Report
  • [Presentation] Enhancement of TRAIL-induced apoptosis with novel TRAIL-receptor 1 specific human mAbs generated by Immunospot array assay on a chip.2010

    • Author(s)
      Jin A., Ozawa T., Tajiri K., Lin Z., Kishi H., Muraguchi A.
    • Organizer
      Cold Spring Harbor Conferences Asia
    • Place of Presentation
      Suzhou, China.
    • Related Report
      2010 Final Research Report
  • [Presentation] Enhancement of TRAIL-induced apoptosis with novel TRAIL-R1-specific human mAbs generated by immunospot array assay on a chip.2010

    • Author(s)
      Kishi H., Jin A., Ozawa T., Tajiri K., Lin Z., Obata T., Ishida I., Muraguchi A.
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      Kobe.
    • Related Report
      2010 Final Research Report
  • [Presentation] Characterization of human anti-influenza M2 antibody obtained from peripheral blood of vaccinated volunteer.2010

    • Author(s)
      Ozawa T., Jin A., Tajiri K., Shiraki K., Kishi H., Muraguchi A.
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      Kobe.
    • Related Report
      2010 Final Research Report
  • [Presentation] Detection of antigen-specific T-cell response on the single cell-basis with microwell array chip.2010

    • Author(s)
      Kishi H., Tajiri K., Hatakeyama S., Kobayashi E., Horii M., Jin A., Ozawa T., Muraguchi A.
    • Organizer
      4th Measuring Antigen-Specific Immune Response (MASIR) Conference
    • Place of Presentation
      Mykonos, Greece.
    • Related Report
      2010 Final Research Report
  • [Presentation] Detection of antigen-specific T-cell response on the single cell-basis with microwell array chip.2010

    • Author(s)
      Kishi H., et al
    • Organizer
      4th Measuring Antigen- Specific Immune Response (MASIR) Conference
    • Place of Presentation
      Mykonos, Greece
    • Related Report
      2010 Annual Research Report
  • [Presentation] Rapid and efficient cloning and functional evaluation system for antigen- specific T cell receptor obtained from single T-cells.2010

    • Author(s)
      Horii M., et al
    • Organizer
      4th Measuring Antigen-Specific Immune Response (MASIR) Conference
    • Place of Presentation
      Mykonos, Greece
    • Related Report
      2010 Annual Research Report
  • [Presentation] Enhancement of TRAIL-induced apoptosis with novel TRAIL-R1-specific human mAbs generated by immunospot array assay on a chip.2010

    • Author(s)
      Kishi H., et al
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      Kobe
    • Related Report
      2010 Annual Research Report
  • [Presentation] Characterization of human anti-influenza M2 antibody obtained from peripheral blood of vaccinated volunteer.2010

    • Author(s)
      Ozawa T., et al
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      Kobe
    • Related Report
      2010 Annual Research Report
  • [Presentation] The novel method to detect single cytokine-secreting T-cell using a cell-microarray chip.2010

    • Author(s)
      Tajiri K., et al
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      Kobe
    • Related Report
      2010 Annual Research Report
  • [Presentation] Single T cell analysis system for rapid cloning and functional evaluation of antigen-specific T cell receptors.2010

    • Author(s)
      Kobayashi E., et al
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      Kobe
    • Related Report
      2010 Annual Research Report
  • [Presentation] Isolation and characterization of a fully human monoclonal antibody against extracellular domain of matrix protein 2 of influenza A virus.2010

    • Author(s)
      Ozawa T., et al
    • Organizer
      Cold Spring Harbor Conferences Asia
    • Place of Presentation
      Suzhou, China
    • Related Report
      2010 Annual Research Report
  • [Presentation] Enhancement of TRAIL-induced apoptosis with novel TRAIL-receptor 1 specific human mAbs generated by Immunos of arra assay on a chip.2010

    • Author(s)
      Jin A., et al
    • Organizer
      Cold Spring Harbor Conferences Asia
    • Place of Presentation
      Suzhou, China
    • Related Report
      2010 Annual Research Report
  • [Presentation] ユニバーサルワクチンに向けたHBワクチンの作用機序の検討2010

    • Author(s)
      田尻和人, 他
    • Organizer
      第46回肝臓学会総会
    • Place of Presentation
      山形
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒトから単離したインフルエンザM2e特異的抗体の機能解析2010

    • Author(s)
      小澤龍彦, 他
    • Organizer
      BMB2010(第33回日本分子生物学会年会・第83回日本生化学会大会合同大会)
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] Characterization of amniotic stem cells.2010

    • Author(s)
      Koike C., et al
    • Organizer
      The 8th International Society for Stem Cell Research
    • Place of Presentation
      San Francisco
    • Related Report
      2010 Annual Research Report
  • [Presentation] A rapid and efficient single-cell manipulation method for screening antigen-specific antibody-secreting cells from human peripheral blood.2009

    • Author(s)
      小澤龍彦, 金艾順, 田尻和人, 小幡勤, 近藤佐千子, 木下耕史, 門脇慎一, 高橋和郎, 杉山敏郎, 岸裕幸, 村口篤
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] A rapid and efficient single-cell manipulation method for screening antigen-specific antibody-secreting cells from human peripheral blood.2009

    • Author(s)
      金艾順, 小澤龍彦, 田尻和人, 岸裕幸, 村口篤
    • Organizer
      IBC's 20th Annual International Conference Antibody Engineering
    • Place of Presentation
      San Diego, USA.
    • Related Report
      2010 Final Research Report
  • [Presentation] 単一細胞レベルにおけるB細胞受容体シグナル解析2009

    • Author(s)
      岸裕幸, 小澤龍彦, 田尻和人, 村口篤
    • Organizer
      第39回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Isolation of human anti-influenza M2 antibody from peripheral blood of healthy volunteer.2009

    • Author(s)
      小澤龍彦, 田尻和人, 金艾順, 岸裕幸, 村口篤
    • Organizer
      第39回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] A rapid and efficient single-cell manipulation method for screening antigen-specific antibody-secreting cells from human peripheral blood.2009

    • Author(s)
      金艾順, 小澤龍彦, 田尻和人, 岸裕幸, 村口篤
    • Organizer
      第39回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Extracellular loop domain of small (S)-HBsAg play a major role in preventing the infection of HBV : the result from omprehensive analysis of monoclonal antibodies obtained from S-HBsAg-vaccinated healthy individuals.2009

    • Author(s)
      Tajiri K., Ozawa T., Jin A.-S., Tokimitsu Y., Nakayama Y., Minemura M., Kishi H., Sugiyama T., Muraguchi A.
    • Organizer
      The 8th JSH Single Topic Conference
    • Place of Presentation
      Tokyo.
    • Related Report
      2010 Final Research Report
  • [Presentation] B-cell receptor signal analysis at single cell levels using a microwell-array chip.2009

    • Author(s)
      Kinoshita K., Kishi H., Fukurotani K., Honda R., Ozawa T., Tajiri K., Muraguchi A.
    • Organizer
      Cold Spring Harbor Meeting
    • Place of Presentation
      New York.
    • Related Report
      2010 Final Research Report
  • [Presentation] B-cell receptor signal analysis at single cell levels using a microwell-array chip.2009

    • Author(s)
      Kishi H., et al
    • Organizer
      Cold Spring Harbor Meeting
    • Place of Presentation
      New York
    • Related Report
      2009 Annual Research Report
  • [Presentation] Extracellular loop domain of small (S)-HBsAg play a major role in preventing the infection of HBV : the result from comprehensive analysis of monoclonal antibodies obtained from S-HBsAg-vaccinated healthy individuals.2009

    • Author(s)
      Tajiri K., et al
    • Organizer
      The 8th JSH Single Topic Conference
    • Place of Presentation
      Tokyo
    • Related Report
      2009 Annual Research Report
  • [Presentation] A rapid and efficient single-cell manipulation method for screening antigen-specific antibody-secreting cells from human peripheral blood.2009

    • Author(s)
      Muraguchi A., et al
    • Organizer
      IBC's 20th Annual International Conference Antibody Engineering
    • Place of Presentation
      San Diego
    • Related Report
      2009 Annual Research Report
  • [Presentation] HBワクチンにより得られたモノクローナル抗体のHBV中和活性とエピトープの解析2009

    • Author(s)
      田尻和人, 他
    • Organizer
      第39回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] Microwell arrays for detecting single, antigen-specific B-lineage cells.2008

    • Author(s)
      岸裕幸
    • Organizer
      IBC's 19th Annual International Conference Antibody Engineering
    • Place of Presentation
      San Diego.
    • Related Report
      2010 Final Research Report
  • [Presentation] マイクロウェルアレイチップを用いた抗原特異的T細胞の検出2008

    • Author(s)
      岸裕幸, 田尻和人, 小澤龍彦, 金艾順, 村口篤
    • Organizer
      第38回日本免疫学会総会・学術集会
    • Place of Presentation
      京都
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] Microwell arrays for detecting single, antigen-specific B-lineage cells2008

    • Author(s)
      Kishi H.
    • Organizer
      IBC's 19th Annual International Conference Antibody Engineering
    • Place of Presentation
      San Diego
    • Related Report
      2008 Annual Research Report
  • [Presentation] HBワクチンにより誘導されるHBsAg特異的モノクローナル抗体についての検討2008

    • Author(s)
      田尻 和人, 他
    • Organizer
      第44回日本肝臓学会総会
    • Place of Presentation
      松山
    • Related Report
      2008 Annual Research Report
  • [Presentation] Isolation of human anti-Influenza virus antibodies secreting cells from peripheral blood of Influenza HA-vaccinated healthy volunteer2008

    • Author(s)
      小澤 龍彦, 他
    • Organizer
      第38回日本免疫学会総会・学術集会
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report
  • [Presentation] リンパ球チップを用いた完全ヒト抗体産生マウス(TCマウス)からのヒト抗TRAIL-R1抗体遺伝子取得2008

    • Author(s)
      金 艾順, 他
    • Organizer
      第38回日本免疫学会総会・学術集会
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report
  • [Presentation] Hepatitis B virus-neutralization activity with a panel of human monoclonal antibodies obtained by cell-microarray system2008

    • Author(s)
      田尻 和人, 他
    • Organizer
      第38回日本免疫学会総会・学術集会
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report
  • [Presentation] MAC-CCD systemを用いた細胞内カルシウムの時系列解析とヒトモノクローナルインフルエンザ抗体の単離2008

    • Author(s)
      小澤 龍彦, 他
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Related Report
      2008 Annual Research Report
  • [Presentation] 植物細胞を利用したヒトB型肝炎ウイルス抗体の作製及び機能解析2008

    • Author(s)
      池本 守, 他
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Related Report
      2008 Annual Research Report
  • [Presentation] Role of Nuclear factor-kappa B (NF-κB) in tumor progression2008

    • Author(s)
      Kitajima I.
    • Organizer
      The 1^<st> International traditional Chinese medicine and Interactive Medicine Oncology Forum
    • Place of Presentation
      Shanghai
    • Related Report
      2008 Annual Research Report
  • [Presentation] mRNA and micro RNA expression profile in chondrogenic differentiation regulated by BMP2008

    • Author(s)
      Kitajima I., et al
    • Organizer
      Annual TGF-β meeting Leiden
    • Place of Presentation
      Leiden
    • Related Report
      2008 Annual Research Report
  • [Presentation] Gas 6, a new regulator of chodrogenic differentiation promoted by BMP2008

    • Author(s)
      Kitajima I., et al
    • Organizer
      Annual TGF-β meeting Leiden
    • Place of Presentation
      Leiden
    • Related Report
      2008 Annual Research Report
  • [Presentation] The Potential of Amniotic Membrane2008

    • Author(s)
      Nikaido T.
    • Organizer
      The 2nd Hong Kong International Burns & Wound Healing Symposium
    • Place of Presentation
      Hong Kong
    • Related Report
      2008 Annual Research Report
  • [Presentation] Amnion-Derived Cells for Regenerative Medicine2008

    • Author(s)
      Nikaido T.
    • Organizer
      The 2nd Hong Kong International Burns & Wound Healing Symposium
    • Place of Presentation
      Hong Kong
    • Related Report
      2008 Annual Research Report
  • [Presentation] Application of Amniotic Membrane/Amnion-Derived Cells for Regenerative Medicine2008

    • Author(s)
      Nikaido T.
    • Organizer
      The 5^<th> Chinese Conference on Oncology
    • Place of Presentation
      Shijiazhuang
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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