Pediatric hematological disorder caused by in utero facors

• Project/Area Number: 20390302
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Embryonic/Neonatal medicine
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: MIZUTANI Shuuki Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 教授 (60126175)
• Co-Investigator(Kenkyū-buntansha): 高木 正稔 東京医科歯科大学, 講師 (10406267)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2009: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000); Fiscal Year 2008: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
• Keywords: ATM / BCR / ABL / CML / γδT細胞 / LOH / DNA damage / BCR/ABL1 / 胎児 / Phクローン / NIMA / 免疫学的寛容 / 母体環境 / TopoII阻害剤 / 染色体転座 / 造血幹細胞 / 白血病

Research Abstract

Genetic and environmental factors on the fetus were studied for the possible causative mechanism of childhood leukemia. As the experimental model etoposide was injected into pregnant mice and DNA damage response was monitored in mononuclear cells in fetal liver and bone marrow of the mother. As the result DNA damage was much more extensive in fetal liver than the corresponding mother's bone marrow. Oncogenic effect by active oncogene was analyzed in ATM+/+ and ATM+/- mice. As the result haploinsufficiency of ATM was shown to cause higher frequency of leukemia than wild type background. This was the first evidence to demonstrate the biological effect of haploinsufficiency of ATM in vivo.

Research Products

• [Journal Article] Attenuation of p53 accumulation after irradiation in cells with C465T polymorphism. (2010)
  • Author(s): Sato M, Takagi M, Mizutani S
  • Journal Title: J Med Dent Sci. 57 Pages: 139-145
• [Journal Article] Autoimmune Lymphoproliferative Syndrome Like Disease With Somatic KRAS Mutation. (2010)
  • Author(s): Takagi M, Mizutani S, et al.
  • Journal Title: Blood Nov 9(Epub ahead of print.)
• [Journal Article] DNA lesions induced by replication stress trigger mitotic aberration and tetraploidy development. (2010)
  • Author(s): Ichijima Y, Mizutani S, et al.
  • Journal Title: PLoS One. 5(1)
• [Journal Article] Autoimmune phenomena in Noonan syndrome ; a possible link with RALD. (2010)
  • Author(s): Mizutani S, Takagi M.
  • Journal Title: Blood.e-letter.
• [Journal Article] ARF suppresses tumor angiogenesis through translational control of VEGFA mRNA. (2010)
  • Author(s): Kawagishi H, Tagaki M, Mizutani S, etal.
  • Journal Title: Cancer Res Volume: 70 Pages: 4749-4758
  • Peer Reviewed
• [Journal Article] Autoimmune lymphoproliferative syndrome-like disease with somatic KRAS mutation. (2010)
  • Author(s): Takagi M, Mizutani S, et al.
  • Journal Title: Blood Volume: 117 Pages: 2887-2890
  • Peer Reviewed
• [Journal Article] ATM modulates the loading of recombination proteins onto a chromosomal translocation breakpoint hotspot. (2010)
  • Author(s): Sun J, Mizutani S, et al.
  • Journal Title: PLoS One. Volume: 5 Pages: 13554-13554
  • NAID: 130007000400
  • Peer Reviewed
• [Journal Article] Attenuation of p53 accumulation after irradiation in cells with C465T polymorphism. (2010)
  • Author(s): Sato M, Takagi M, Mizutani S.
  • Journal Title: J Med Dent Sci. Volume: 57 Pages: 139-145
  • Peer Reviewed
• [Journal Article] Autopsy study of cerebellar degeneration in siblings with ataxia-telangiectasia-like disorder. (2010)
  • Author(s): Oba D, Hayashi M, Minamitani M, Hamano S, Uchisaka N, Kikuchi A, Kishimoto H, Takagi M, Morio T, Mizutani S.
  • Journal Title: Acta Neuropathol. Volume: 119 Pages: 513-520
  • Peer Reviewed
• [Journal Article] Pharmacokinetic monitoring is still required for intravenous busulfan in SCT for small children International (2010)
  • Author(s): Nagasawa M, Noriko Mitsuiki, Toshiaki Ono, Masatoshi Takagi, Hiromi Oda, Masato Yasuhara, Shuki Mizutani
  • Journal Title: Journal of Hematology Volume: 91 Pages: 728-730
  • Peer Reviewed
• [Journal Article] Pharmacokinetic monitoring is still required for intravenous busulfan in SCT for small children. (2010)
  • Author(s): Nagasawa M, Mitsuiki N, Ono T, Takagi M, Oda H, Yasuhara M, Mizutani S.
  • Journal Title: Int JHematol. Volume: 91 Pages: 728-30
  • NAID: 10026402408
  • Peer Reviewed
• [Journal Article] T ranscription-dependent activation of ataxia telangiectasia-mutated prevents DNA-dependent protein kinase-mediated cell death in response to topoisomerase Ipoison. (2010)
  • Author(s): Sakasai R, Teraoka H, Takagi M, Tibbetts RS.
  • Journal Title: JBiol Chem. Volume: 285 Pages: 15201-15208
  • Peer Reviewed
• [Journal Article] DNA lesions induced by replication stress trigger mitotic aberration and tetraploidy development. (2010)
  • Author(s): Ichijima Y, Yoshioka K, Yoshioka Y, Shinohe K, Fujimori H, Unno J, Takagi M, Goto H, Inagaki M, Mizutani S, Teraoka H.
  • Journal Title: PLoS One. Volume: 5 Pages: 8821-8821
• [Journal Article] Autoimmune phenomena in Noonan syndrome; a possible link with RALD. (2010)
  • Author(s): Mizutani S, Takagi M.
  • Journal Title: Blood. Volume: (e-letter)
  • Peer Reviewed
• [Journal Article] 小児白血病の発生要因一環境と遺伝をめぐる研究の進歩一 (2010)
  • Author(s): 水谷修紀
  • Journal Title: 小児科臨床 Volume: 63 Pages: 7-14
• [Journal Article] 小児白血病の発生要因をめぐる研究の進歩一「究極の原因は何か」をめぐる諸問題一 (2010)
  • Author(s): 水谷修紀
  • Journal Title: 東京都医師会雑誌 Volume: 63 Pages: 11-15
• [Journal Article] 急性リンパ性白血病の治療後に皮膚限局型ランゲルハンス組織球症を発症した1例 (2010)
  • Author(s): 満生紀子, 梶原道子, 長澤正之, 森尾友宏, 水谷修紀
  • Journal Title: 日本小児血液学会雑誌 Volume: 24 Pages: 93-96
  • NAID: 10026419365
• [Journal Article] Immunologically silent cancer clone transmission from mother to offspring. (2009)
  • Author(s): Isoda T, Mizutani S, et al.
  • Journal Title: Proc.Natl.Acad.Sci.USA. 106(42) Pages: 17882-17885
• [Journal Article] Phenotypic Variations between Affected Siblings with Ataxia-Telangiectasia : Ataxia-Telangiectasia in Japan. (2009)
  • Author(s): Morio T, Mizutani S, et al.
  • Journal Title: Int.J.Hematol. 90 Pages: 455-462
• [Journal Article] Two brothers with ataxia-telangiectasia. like disorder with lung adenocarcinoma. (2009)
  • Author(s): Uchisaka N, Mizutani S, et al.
  • Journal Title: J.Pediatr. 155 Pages: 435-438
• [Journal Article] Rapid diagnosis of ataxia-telangiectasia by flow cytometric monitoring of DNA damage-dependent ATM phosphorylation. (2009)
  • Author(s): Honda M, Takagi M, Chessa L, Morio T, Mizutani S
  • Journal Title: Leukemia. 23 Pages: 409-414
• [Journal Article] 毛細血管拡張性運動失調 (2009)
  • Author(s): 水谷修紀
  • Journal Title: 日本臨床(別冊) 新領域別症候群(10)呼吸器症候群第2版(日本臨床社) Pages: 669-672
• [Journal Article] Rapid diagnosis of ataxia-telangiectasia by flow cytometric monitoring of DNA damage-dependent ATM phosphorylation. (2009)
  • Author(s): Honda M, Mizuatni S., et al.
  • Journal Title: Leukemia 23 Pages: 409-414
  • Peer Reviewed
• [Journal Article] Phenotypic variations between affected siblings with ataxia-telangiectasia : ataxia-telangiectasia in Japan. (2009)
  • Author(s): Morio T, Mizutani S., et al.
  • Journal Title: Int J Hematol 90, 455-62 (2009) 90 Pages: 455-462
  • Peer Reviewed
• [Journal Article] Immunologically silent cancer clone transmission from mother to offspring. (2009)
  • Author(s): Isoda T, Mizutani S., et al.
  • Journal Title: Proc Natl Acad Sci USA. 106 Pages: 17882-17885
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): 水谷修紀
  • Journal Title: 毛細血管拡張性運動失調.日本臨床(別冊)新領域別症候群(10)呼吸器症候群第2版(日本臨床社) Pages: 669-672
• [Journal Article] Soluble TWEAK is markedly elevated in hemophagocytic lymphohistiocytosis. (2008)
  • Author(s): Nagasawa M, Mizutani S., et al
  • Journal Title: Am J Hematol. 83(3) Pages: 222-225
  • Peer Reviewed
• [Journal Article] Oxidative stress in neurodegeneration in dentatorubral -pallidoluysian atrophy. (2008)
  • Author(s): Miyata R, Mizutani S., et al.
  • Journal Title: J Neurol Sci. 264(1 -2) Pages: 133-139
  • Peer Reviewed
• [Journal Article] Caffeine yields aneuploidy through asymmetrical cell division caused by misalignment of chromosomes. (2008)
  • Author(s): Katsuki Y, Mizutani S, et al
  • Journal Title: Cancer Sci. 99 Pages: 1539-45
  • Peer Reviewed
• [Presentation] 造血幹細胞移植における新規「DIC・微小血管障害の臨床スコア」作成とその有効性・有用性の後方視的検討 (2010)
  • Author(s): 長澤正之, 大川哲平, 遠藤明史, 満生紀子, 青木由貴, 小野敏明, 磯田健志, 富澤大輔, 高木正稔, 梶原道子, 森尾友宏, 水谷修紀
  • Organizer: 第52回日本小児血液学会
  • Place of Presentation: 大阪
  • Year and Date: 2010-12-18
• [Presentation] Immunologically sflent cancer clone transmission from mother to offspring (2010)
  • Author(s): 磯田健志
  • Organizer: プレナリーセッション日本小児血液学会賞授賞口演 第52回日本小児血液学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-12-17
• [Presentation] Regulation of DNA damage response network and clinico-pathological features in childhood genetic diseases. (2010)
  • Author(s): Mizutani S.
  • Organizer: 第33回分子生物学会年会第83回日本生化学会大会合同大会シンポジウム
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-10
• [Presentation] ATM regulate adipocyte differentiation. (2010)
  • Author(s): 烏野初萌, 高木正稔, 杉本昌隆, 安田章夫, 水谷修紀
  • Organizer: 第33回分子生物学会年会第83回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-09
• [Presentation] ATM regulates cell differentiation. (2010)
  • Author(s): Masatoshi Takagi, Hatsume Uno, Takeshi Isoda, Masataka Sugimoto, Akio Yasuda, Shuki Mizutani.
  • Organizer: 第33回分子生物学会年会第83回日本生化学会大会合同大会ワークショップ
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-09
• [Presentation] 非定型抗酸菌と結核菌群による播種性全身感染症を呈した外胚葉形成不全免疫不全症候群の1例 (2010)
  • Author(s): 大川哲平, 遠藤明史, 小野敏明, 富澤大輔, 高木正稔, 梶原道子, 長澤正之, 森尾友宏, 水谷修紀
  • Organizer: 第42回日本小児感染症学会
  • Place of Presentation: 仙台
  • Year and Date: 2010-11-27
• [Presentation] 診断時よりBCG感染によると思われる全身性の紅斑を認め、移植後発熱が遷延したX連鎖性重症複合免疫不全症の2例 (2010)
  • Author(s): 小野敏明, 大川哲平, 遠藤明史, 満生紀子, 富澤大輔, 今井雅子, 高木正稔, 梶原道子, 長澤正之, 森尾友宏, 水谷修紀
  • Organizer: 第42回日本小児感染症学会
  • Place of Presentation: 仙台
  • Year and Date: 2010-11-27
• [Presentation] 乳児MLL再構成陽性ALLの階層性の解析 (2010)
  • Author(s): 青木由貴, 石川文彦, 水谷修紀
  • Organizer: 厚生労働省がん研究開発費班会議(主任研究者水谷修紀)
  • Place of Presentation: 名古屋
  • Year and Date: 2010-11-12
• [Presentation] RAS associated ALPS like disease. (2010)
  • Author(s): 高木正稔
  • Organizer: 関東甲越免疫不全症研究会
  • Place of Presentation: 東京
  • Year and Date: 2010-10-23
• [Presentation] 応答機構と白血病 (2010)
  • Author(s): 高木正稔
  • Organizer: 第53回日本放射線影響学会大会シンポジウム
  • Place of Presentation: 京都
  • Year and Date: 2010-10-20
• [Presentation] 造血幹細胞移植後の生着前凝固異常に対してリコンビナント・トロンボモジュリンを使用した3例 (2010)
  • Author(s): 足洗美穂, 大川哲平, 遠藤明史, 満生紀子, 青木由貴, 小野敏明, 磯田健志, 富澤大輔, 高木正稔, 梶原道子, 長澤正之, 森尾友宏, 水谷修紀
  • Organizer: 第16回小児H-SCT研究会
  • Place of Presentation: 東京
  • Year and Date: 2010-10-08
• [Presentation] 造血幹細胞移植後の生着前凝固障害に対してリコンビナント・トロンボモジュリンを使用した3例 (2010)
  • Author(s): 大川哲平, 遠藤明史, 満生紀子, 青木由貴, 小野敏明, 磯田健志, 富澤大輔, 高木正稔, 梶原道子, 長澤正之, 森尾友宏, 水谷修紀
  • Organizer: 第16回小児H-SCT研究会
  • Place of Presentation: 東京
  • Year and Date: 2010-10-08
• [Presentation] 緑膿菌菌血症および深在性真菌感染症に対して顆粒球輸血を行ったFanconi貧血の1例 (2010)
  • Author(s): 堀越愛那, 小野敏明, 富澤大輔, 梶原道子, 長澤正之, 高木正稔, 森尾友宏, 水谷修紀
  • Organizer: 第12回小児医療セミナー
  • Place of Presentation: 東京
  • Year and Date: 2010-09-18
• [Presentation] RICによる非血縁者間骨髄移植を行った先天性角化異常症の臨床経過 (2010)
  • Author(s): 大川哲平, 満生紀子, 遠藤明史, 小野敏明, 磯田健志, 富澤大輔, 高木正稔梶原道子, 長澤正之, 森尾友宏, 水谷修紀
  • Organizer: 第7回JPLSG研究会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-06-20
• [Presentation] MYH9-ALK : Anaplastic large cell lymphomaにおける稀なALK融合遺伝子の同定 (2010)
  • Author(s): 津山直子, 冨樫由紀, 倉田盛人, 波多野郷子, 青木由貴, 小野敏明, 磯田健志, 高木正稔, 水谷修紀, 北川昌伸, 竹内賢吾
  • Organizer: 第50回日本リンパ網内系学会総会
  • Place of Presentation: 新潟
  • Year and Date: 2010-06-18
• [Presentation] 母体から子へ白血病細胞が移行した機序の解明 (2010)
  • Author(s): 磯田健志, 満生紀子, 青木由貴, 富澤大輔, 高木正稔, 長澤正之, 森尾友宏, 落合央, 滝智彦, 佐治博夫, 水谷修紀
  • Organizer: 東京医科歯科大学医師会賞授賞口演
  • Place of Presentation: 東京
  • Year and Date: 2010-06-16
• [Presentation] 2歳時に急性巨核芽球性白血病を発症後、6年後にB前駆細胞型急性リンパ性白血病を発症したダウン症候群の1例 (2010)
  • Author(s): 秋山めぐみ, 遠藤明史, 富澤大輔, 大川哲平, 高木正稔, 小野敏明, 長澤正之, 森尾友宏, 水谷修紀, 梶原道子
  • Organizer: 第575回日本小児科学会東京都地方会
  • Place of Presentation: 東京医科歯科大学
  • Year and Date: 2010-06-12
• [Presentation] 2歳時に急性巨核芽球性白血病を発症後、6年後にB前駆細胞型急性リンパ性白血病を発症したダウン症候群の1例 (2010)
  • Author(s): 遠藤明史, 富澤大輔, 大川哲平, 小野敏明, 高木正稔, 梶原道子, 長澤正之, 森尾友宏, 水谷修紀
  • Organizer: 日本小児科学会東京都地方会
  • Place of Presentation: 東京
  • Year and Date: 2010-06-12
• [Presentation] たかがこども, されどこども-発がん研究をめぐる環境, 遺伝胎児の視点- (2010)
  • Author(s): 水谷修紀
  • Organizer: ソニー(株)本社にて講演
  • Place of Presentation: 東京
  • Year and Date: 2010-06-11
• [Presentation] 母体から子へ白血病細胞が移行した機序の解明 (2010)
  • Author(s): 磯田健志, 満生紀子, 青木由貴, 富澤大輔, 高木正稔, 長澤正之, 森尾友宏, 落合央, 滝智彦, 佐治博夫, 水谷修紀
  • Organizer: 東京医科歯科大学小児科同窓会口演
  • Place of Presentation: 東京
  • Year and Date: 2010-06-05
• [Presentation] リンパ節腫脹、肝脾腫、自己抗体を産生し、KRAS体細胞変異をみとめた乳児例 (2010)
  • Author(s): 満生紀子, 高木正稔, 遠藤明史, 小野敏明, 梶原道子, 長澤正之, 森尾友宏, 水谷修紀
  • Organizer: 第112回小児血液腫瘍懇話会
  • Place of Presentation: 東京
  • Year and Date: 2010-05-21
• [Presentation] p190型BCR-ABL白血病における母子間転移と非遺伝性HLA(NIMA)欠損 (2010)
  • Author(s): 磯田健志, 満生紀子, 青木由貴, 富澤大輔, 高木正稔, 長澤正之, 森尾友宏, 落合央, 滝智彦, 佐治博夫, 水谷修紀
  • Organizer: 第7回北関東小児がんセミナー
  • Place of Presentation: 群馬
  • Year and Date: 2010-05-15
• [Presentation] Early phase administration of hematopoietic stem cell transplantation to prevent early relapse for infants with acute lymphoblastic leukemia and MLL gene rearrangement ; a report from the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG) trial MLL03. (2010)
  • Author(s): Koh K, Mizutani S, et al.
  • Organizer: 52^<nd> Annual Meeting of the American Society of Hematology
  • Place of Presentation: Orlando, USA
• [Presentation] PP-102-32-Impaired CD4 and CD8 Effector Function and Decreased Memory T-cell Populations in ICOS-deficient Patients. (2010)
  • Author(s): Morio T, Terada N, Nanki T, Miyasaka N, Kobata T, Matsumoto K, Azuma M, Mizutani S.
  • Organizer: 14th International Congress of Immunology 2010.
  • Place of Presentation: Kobe in Japan.
• [Presentation] PP-059-37-Functional analysis of Fas-mediated activation signaling pathways in Tcells. (2010)
  • Author(s): Shin M J, Shim J, Lee J, Chae W, LeeH, Morio T, Park J H, Chang E, Lee S.
  • Organizer: 14th International Congress of Immunology 2010.
  • Place of Presentation: Kobe in Japan.
• [Presentation] WS/PP-034-04-Btk controls ROS production and apoptosis in human neutrophil. (2010)
  • Author(s): Honda F, Ikeda Y, Takahashi I N, Lee S, Mizutani S, Morio T.
  • Organizer: 14th International Congress of Immunology 2010
  • Place of Presentation: Kobe in Japan.
• [Presentation] ATM regulates adiopocyte differentiation. (2010)
  • Author(s): Masatoshi Takagi, Hatsume Uno, Masataka Sugimoto, Akio Yasuda, Shuki Mizutani.
  • Organizer: ATW2010
  • Place of Presentation: USA.Los Angels.
• [Presentation] Early phase administration of hematopoietic stem cell transplantation to prevent early relapse for infants with acute lymphoblastic leukemia and MLL gene rearrangement ; areport from the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG) trialMLL03. (2010)
  • Author(s): Koh K, Tomizawa D, Moriya Saito A, Watanabe T, Ogawa A, Sato T, Hirayama M, Takahashi Y, Saikawa Y, Miyamura T, Kato K, Sugita K, Sato T, Taki T, Mizutani S, Tsurusawa M, Horibe K, Ishii E.
  • Organizer: 52nd Annual Meeting of the American Society of Hematology
  • Place of Presentation: Orlando, USA
• [Presentation] 日本における先天性免疫不全症に対する膀帯血移植成績 (2010)
  • Author(s): 森尾友宏, 富澤大輔, 梶原道子, 水谷修紀, 熱田由子, 加藤剛二, 原寿郎, 加藤俊一
  • Organizer: 第113回日本小児科学会学術集会
  • Place of Presentation: 盛岡
• [Presentation] リンパ節腫脹、肝脾腫、自己抗体を産生し、KRAS体細胞変異をみとめた乳児例 (2010)
  • Author(s): 満生紀子, 高木正稔, 遠藤明史, 小野敏明, 梶原道子, 長澤正之, 森尾友宏, 水谷修紀
  • Organizer: 第113回日本小児科学会学術集会
  • Place of Presentation: 盛岡
• [Presentation] KRAS変異を持つALPS様疾患の1例-is there any sequentiality between ALPS andJMML?- (2010)
  • Author(s): 高木正稔, 満生紀子, 遠藤明史, 小野敏明, 梶原道子, 長澤正之, 森尾友宏, 水谷修紀, 小池健一
  • Organizer: 第17回小児再生不良性貧血治療研究会 第15回小児MDS治療研究会
  • Place of Presentation: 名古屋
• [Presentation] In vivo study of human MLL-rearranged acute lymphoblastic leukemia. (2010)
  • Author(s): Yuki Aoki, Yoriko Saito, NahokoSuzuki, Akiko Sone, Mariko Tomizawa, Yuho Najima, Shinsuke Takagi, Satoshi Tanaka, Leonard D.Shultz, Shuki Mizutani, Fumihiko Ishikawa.
  • Organizer: Noyori Summer School.
  • Place of Presentation: Aioi
• [Presentation] KRAS変異自己免疫性リンパ球増殖症候群 (2010)
  • Author(s): 高木正稔, 篠田邦大, 満生紀子, 朴今花, 高木真理, 松田和之, 村松秀城, 土居崎小夜子, 長澤正之, 森尾友宏, 小池健一, 小島勢二, 高尾明, 水谷修紀
  • Organizer: 第52回日本小児血液学会・第26回日本小児がん学会総会
  • Place of Presentation: 大阪
• [Presentation] 4人の悪性リンパ腫の家族歴を有する小児濾胞性リンパ腫の1例 (2010)
  • Author(s): 森真理, 篠田邦大, 西澤茉莉, 横山能文, 門井絵美, 大西沙織理, 高木正稔, 高尾明
  • Organizer: 第52回日本小児血液学会・第26回日本小児がん学会総会
  • Place of Presentation: 大阪
• [Presentation] T細胞リンパ腫とAtmハプロ不全～BCRABLトランスジェニックマウスを用いた解析～ (2010)
  • Author(s): 佐藤正樹, 高木正稔, 朴今花, 本田博章, 安田章夫, 水谷修紀
  • Organizer: 第52回日本小児血液学会・第26回日本小児がん学会総会
  • Place of Presentation: 大阪
• [Presentation] 寛解導入療法中にクモ膜化出血を起こした急性リンパ球性白血病の1例 (2010)
  • Author(s): 小野敏明, 大川哲平, 遠藤明史, 富澤大輔, 高木正稔, 梶原道子, 武川麻紀, 前原健寿, 長澤正之, 森尾友宏, 水谷修紀
  • Organizer: 第52回日本小児血液学会・第26回日本小児がん学会総会
  • Place of Presentation: 大阪
• [Presentation] 造血幹細胞移植における「新規DIC・微小血管障害の臨床スコア」作成とその有効性・有用性の後方視的検討 (2010)
  • Author(s): 長澤正之, 大川哲平, 遠藤明史, 満生紀子, 青木由貴, 小野敏明, 磯田健志, 富澤大輔, 高木正稔, 梶原道子, 水谷修紀
  • Organizer: 第52回日本小児血液学会・第26回日本小児がん学会総会
  • Place of Presentation: 大阪
• [Presentation] 2歳時に急性巨核芽球性白血病を発症後、6年後B前駆細胞型急性リンパ性白血病を発症したダウン症女児例 (2010)
  • Author(s): 遠藤明史, 大川哲平, 小野敏明, 磯田健志, 富澤大輔, 高木正稔, 長澤正之, 森尾友宏, 水谷修紀, 梶原道子
  • Organizer: 第52回日本小児血液学会・第26回日本小児がん学会総会
  • Place of Presentation: 大阪
• [Presentation] シクロスポリン1日3回投与で血中濃度を維持した急性リンパ性白血病の1例 (2010)
  • Author(s): 大川哲平, 遠藤明史, 小野敏明, 富澤大輔, 高木正稔, 梶原道子, 長澤正之, 森尾友宏, 水谷修紀
  • Organizer: 第52回日本小児血液学会・第26回日本小児がん学会総会
  • Place of Presentation: 大阪
• [Presentation] DNA Double-Strand Break Formation Induced by Replication Arrest Depend On Artemis. (2009)
  • Author(s): Takagi M, Mizutani S, et al.
  • Organizer: 51th American Society of Hematology Annual meeting 2009.
  • Place of Presentation: New Orleans, USA
• [Presentation] Regulation of Artemis/ATM-related DNA damage response (2008)
  • Author(s): S. Mizutani, et al.
  • Organizer: 国際ATワークショップ
  • Place of Presentation: Kyoto
  • Year and Date: 2008-04-24
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