Development of new biomarkers in breast cancer by glycomic profile analyses

• Project/Area Number: 20390347
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General surgery
• Research Institution: Nagoya City University
• Principal Investigator: YAMASHITA Hiroko Nagoya City University, 大学院・医学研究科, 准教授 (70332947)
• Co-Investigator(Kenkyū-buntansha): TOYAMA Tatsuya 名古屋市立大学, 大学院・医学研究科, 准教授 (30315882) ; SUGIURA Hiroshi 名古屋市立大学, 大学院・医学研究科, 研究員 (20381882) ; NISHIMURA Shinichiro 北海道大学, 先端生命科学研究院, 教授 (00183898)
• Co-Investigator(Renkei-kenkyūsha): NISHIMURA Shinichiro 北海道大学, 先端生命科学研究院, 教授 (00183898)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2008: ¥15,470,000 (Direct Cost: ¥11,900,000、Indirect Cost: ¥3,570,000)
• Keywords: 乳癌 / 糖鎖解析 / バイオマーカー

Research Abstract

Serum glycomic profiles were compared between breast cancer patients and controls. No glycans showed different concentrations between these two groups. We found that the combination of 24 glycans might be a prognostic marker for breast cancer.

Research Products

• [Journal Article] Estrogen receptor-positive breast cancer in Japanese women : trends in incidence, characteristics, and prognosis. (2010)
  • Author(s): Yamashita H, Toyama T, Sugiura H, et al.
  • Journal Title: Ann Oncol (online)
  • Peer Reviewed
• [Journal Article] Current research topics in endocrine therapy for breast cancer. (2008)
  • Author(s): Yamashita H.
  • Journal Title: Int J Clin Oncol 13 Pages: 380-383
  • NAID: 10023919365
• [Presentation] Estrogen receptor-positive breast cancer in Japanese women : trends in incidence, characteristics, and prognosis. (2010)
  • Author(s): Yamashita H, Toyama T, Sugiura H, et al.
  • Organizer: The 33th Annual San Antonio Breast Cancer Symposium
  • Place of Presentation: San Antonio, USA
• [Book] Current research on estrogen receptor a inbreast cancer "Current Research in Cancer3" (2009)
  • Author(s): Yamashita H, Toyama T, Sugiura H, et al.
  • Publisher: RESARCH MEDIA
• [Remarks] ホームページ等
  • URL: http://www.med.nagoya-cu.ac.jp/mammal.dir/index.html