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Experimental organ transplantation: Application of the drug-induced immune tolerance-

Research Project

Project/Area Number 20390371
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionKyushu University

Principal Investigator

TOMITA Yukihiro  Kyushu University, 医学研究院, 研究員 (90180174)

Co-Investigator(Kenkyū-buntansha) 吉開 泰信  九州大学, 生体防御医学研究所, 教授 (90158402)
山田 久方  九州大学, 生体防御医学研究所, 准教授 (20363369)
中島 淳博  九州大学, 大学病院, 助教 (10260704)
清水 一郎  九州大学, 大学病院, 医員 (70444841)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2010: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2009: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2008: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Keywordsキメリズム / サイクロフォスファミド / 免疫寛容誘導 / 免疫寛容
Research Abstract

Cyclophosphamide (CP)-induced tolerance is a mixed chimerism-based tolerance induction protocol. Recently, we reported that invariant natural killer T (iNKT) cells were essential for the tolerance induction in this system. In this study, we evaluated the roles of the cytokines produced by iNKT cells.
iNKT cells were required in the initial phase of the induction of chimerism. Our results indicated that known major cytokines produced by iNKT cells were dispensable for the regulatory function of iNKT cells.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (11 results)

All 2010 2009 2008

All Journal Article (6 results) (of which Peer Reviewed: 3 results) Presentation (5 results)

  • [Journal Article] Antibody-Mediated T-cell reduction or increased levels of chimerism overcome resistance to cyclophosph amide-induced tolerance in NKT-deficient mice2010

    • Author(s)
      T.Onzuka, Y.Tomita, S.Okano, I.Shimizu, H.Yamada, Y.Yoshikal, R.Tominaga
    • Journal Title

      Scand J Immunol 72

      Pages: 106-117

    • Related Report
      2010 Final Research Report
  • [Journal Article] Effects of Toll-like receptor agonist on the induction of mixed chimerism in cyclophosphamide-induced tolerance2009

    • Author(s)
      T.Onzuka, Y.Tomita, S.Okano, I.Shimizu, H.Yamada, Y.Yoshikai, R.Tominaga
    • Journal Title

      Scand J Immunol 70

      Pages: 423-430

    • Related Report
      2010 Final Research Report
  • [Journal Article] Effects of lipopolysaccharide on the induction of mixed chimerism in cyclophosphamide-induced tolerance2009

    • Author(s)
      Onzuka, T.
    • Journal Title

      Scand J Immunol 70

      Pages: 423-430

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of the cytokine profiles produced by iNKT cells in the initial phase of cyclophosphamide-induced tolerance2008

    • Author(s)
      Onzuka T, Tomita Y, Shimizu I, Okano S, Yamada H, Yoshikai Y, Tominaga R
    • Journal Title

      Transplantatian 86(9)

      Pages: 1301-1310

    • Related Report
      2010 Final Research Report
  • [Journal Article] Role of the cytokine profiles produced by iNKT cells in the initial phase of eyelophosphamide-induced tolerance2008

    • Author(s)
      Onzuka T. Tomita Y
    • Journal Title

      Transplantation 86

      Pages: 1301-1310

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pivotal fole of the natural killer T cell for the induction of mixed chimerism in the thvmus2008

    • Author(s)
      Onzuka T, Tomita Y
    • Journal Title

      Am J Transplant Sup 8

      Pages: 481-481

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Pivotal fole of the natural killer T cell for the induction of mixed chimerism in the thymus (Poster)2008

    • Author(s)
      Onzuka T, Tomita Y
    • Organizer
      American Transplant Congress 2008
    • Place of Presentation
      Tronto
    • Year and Date
      2008-06-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] Pivotal fole of the natural killer T cell for the induction of mixed chimerism in the thymus2008

    • Author(s)
      恩塚龍士, 富田幸裕, 清水一郎, 富永隆治
    • Organizer
      American Transplant Congress 2008(Poster)
    • Related Report
      2010 Final Research Report
  • [Presentation] Requirement of INKT cells for the maintenance of mixed chimerism in cyclophosphamide-induced tolerance2008

    • Author(s)
      恩塚龍士, 富田幸裕, 清水一郎, 密永隆治
    • Organizer
      XXII International Congress of The Transplantation Society(一般演題)
    • Related Report
      2010 Final Research Report
  • [Presentation] Pivotal role of the natural killer cell for the induction of mixed chimerism in the thymus2008

    • Author(s)
      恩塚龍士, 富田幸裕, 清水一郎, 密永隆治
    • Organizer
      XXII International Congress of The Transplantatlon Society(一般演題)
    • Related Report
      2010 Final Research Report
  • [Presentation] Cyclophosphamide誘導性免疫寛容系敗血症モデルにおける寛容誘導阻害効果の検討2008

    • Author(s)
      恩塚龍士、富田幸裕、神尾明君、前田武俊、馬場啓徳、清水一郎、富永隆治
    • Organizer
      第105回日本循環器学会九州地方会(一般演題)
    • Related Report
      2010 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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