Cell selective particle therapy for malignant brain tumor

• Project/Area Number: 20390379
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: University of Tsukuba
• Principal Investigator: MATSUMURA Akira 筑波大学, 医学医療系, 教授 (90241819)
• Co-Investigator(Kenkyū-buntansha): YAMAMOTO Tetsuya 筑波大学, 医学医療系, 講師 (30375505) ; KUMADA Hiroaki 筑波大学, 医学医療系, 准教授 (30354913) ; NAKAI Kei 筑波大学, 医学医療系, 講師 (50436284) ; ISOBE Tomonori 筑波大学, 医学医療系, 准教授 (70383643) ; NARIAI Tadashi 東京医科歯科大学, 医学部附属病院, 講師 (00228090)
• Project Period (FY): 2008 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000); Fiscal Year 2011: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2009: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2008: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
• Keywords: 中性子捕捉療法 / BNCT / グリオーマ / PET / 中性子 / ホウ素 / 脳腫瘍

Research Abstract

We started BNCT for newly diagnosed glioblastoma and recurrent malignant brain tumor with the new protocol. In Newly diagnosed glioblastoma case, progression free survival was 13 month, and overall survival was 21month.In recurrent malignant brain tumor case, we perform BNCT for 2 cases. Recurrent glioblastoma case revealed radiation necrosis and skin necrosis but tumor was stable during 2 years of follow up period. Malignant meningioma case is recurrence free during 2 years of follow up period.

Research Products

• [Journal Article] Multistep Lattice-Voxel method utilizing lattice function for Monte-Carlo treatment planning with pixel based voxel model (2011)
  • Author(s): Kumada H, Saito K, Nakamura T, Sakae T, Sakurai H, Matsumura A, Ono K.
  • Journal Title: Appl Radiat Isot Volume: 69 Issue: 12 Pages: 1866-1869
  • DOI: 10.1016/j.apradiso.2011.03.023
  • NAID: 120007137344
  • Peer Reviewed
• [Journal Article] Boron neutron capture therapy combined with fractionated photon irradiation for glioblastoma : a recursive partitioning analysis of BNCT patients (2011)
  • Author(s): Nakai K, Yamamoto T, Aiyama H, Takada T, Yoshida F, Kageji T, Kumada H, Isobe T, Endo K, Matsuda M, Tsurubuchi T, Shibata Y, Takano S, Mizumoto M, Tsuboi K, Matsumura A
  • Journal Title: Appl Radiat Isot Volume: 69 Issue: 12 Pages: 1790-1792
  • DOI: 10.1016/j.apradiso.2011.03.049
  • Peer Reviewed
• [Journal Article] A clinical trial protocol for second line treatment of malignant brain tumors with BNCT at University of Tsukuba (2011)
  • Author(s): Aiyama H, Nakai K, Yamamoto T, Nariai T, Kumada H, Ishikawa E, Isobe T, Endo K, Takada T, Yoshida F, Shibata Y, Matsumura A
  • Journal Title: Appl Radiat Isot Volume: 69 Issue: 12 Pages: 1819-1822
  • DOI: 10.1016/j.apradiso.2011.04.031
  • Peer Reviewed
• [Journal Article] the status of Tsukuba BNCT trial : BPA-based boron neutron capture therapy combined with X-ray irradiation (2011)
  • Author(s): Yamamoto T, Nakai K, Nariai T, Kumada H, Okumura T, Mizumoto M, Tsuboi K, Zaboronok A, Ishikawa E, Aiyama H, Endo K, Takada T, Yoshida F, Shibata Y, Matsumura A
  • Journal Title: Appl Radiat Isot Volume: 69 Issue: 12 Pages: 1817-1818
  • DOI: 10.1016/j.apradiso.2011.02.013
  • Peer Reviewed
• [Journal Article] Prognostic factors in glioblastoma multiforme patients receiving high-dose particle radiotherapy or conventional radiotherapy (2011)
  • Author(s): Matsuda M, Yamamoto T, Ishikawa E, Nakai K, Zaboronok A, Takano S, Matsumura A
  • Journal Title: Br J Radiol Volume: 84 Issue: special_issue_1 Pages: 54-60
  • DOI: 10.1259/bjr/29022270
  • NAID: 120007137315
  • Peer Reviewed
• [Journal Article] Applicationof the multi-model Monte-Carlo treatment planning system combined with PHITS to proton radiotherapy (2011)
  • Author(s): Kumada H, Sakae T, Saito K, Isobe T, Hashimoto T, Sakurai H
  • Journal Title: Prog Nucl Sci Technol Volume: 2 Pages: 213-218
  • Peer Reviewed
• [Journal Article] Application of the multi-model Monte-Carlo treatment planning system combined with PHITS to proton radiotherapy (2011)
  • Author(s): Kumada H, Sakae T, Saito K, Isobe T, Hashimoto T, Sakurai H
  • Journal Title: Prog Nucl Sci Technol Volume: 2 Pages: 213-218
  • Peer Reviewed
• [Journal Article] BNCT and other emerging treatments for malignant glioma (2010)
  • Author(s): Matsumura A, et al.
  • Journal Title: Proceedings of 14th International congress on neutron capture therapy Pages: 3-3
• [Journal Article] Boron neutron capture therapy combined with fractionated photon irradiation for glioblastoma (2010)
  • Author(s): Nakai K, et al.
  • Journal Title: Proceedings of 14th International congress on neutron capture therapy Pages: 19-19
• [Journal Article] Feasibility of Boron Neutron Capture Therapy for malignant spinal tumors (2009)
  • Author(s): Nakai K, Kumada H, Yamamoto T, Tsurubuchi T, Zaboronok A, Matsumura A
  • Journal Title: Appl Radiat Isot Volume: 67 Pages: 43-46
  • Peer Reviewed
• [Journal Article] Current practices and future directions of therapeutic strategy in glioblastoma : survival benefit and indication of BNCT (2009)
  • Author(s): Matsumura A, et al
  • Journal Title: Appl Radiat Isot Volume: 67 Pages: 12-14
  • Peer Reviewed
• [Journal Article] Boron neutron capture therapy for newly diagnosed glioblastoma (2009)
  • Author(s): Yamamoto T, Nakai K, Kageji T, Kumada H, Endo K, Matsuda M, Shibata Y, Matsumura A
  • Journal Title: Radiother Oncol Volume: 91 Pages: 80-84
  • NAID: 120007138272
  • Peer Reviewed
• [Journal Article] 特集脳腫瘍研究の最前線-遺伝子解析から治療まで.悪性グリオーマに対する粒子線治療. (2009)
  • Author(s): 山本哲哉, 坪井康次
  • Journal Title: BRAIN and NERVE 61 Pages: 855-866
  • Peer Reviewed
• [Journal Article] PET pharmacokinetic analysis to estimate boron concentration in tumor and brain as a guide to plan BNCT for malignant cerebral glioma. (2009)
  • Author(s): Nariai T, Ishiwata K, Kimura Y, Inaji M, Momose T, Yamamoto T, Matsumura A, Ishii K, Ohno K.
  • Journal Title: Appl Radiat Isot 67(7-8 Suppl)
  • Peer Reviewed
• [Journal Article] Dose distribution and clinical response of glioblastoma treated with external beam boron neutron capture therapy. (2009)
  • Author(s): Matsuda M, Yamamoto T, Kumada H, Nakai K, Shirakawa M, Tsurubuchi T, Matsumura A
  • Journal Title: Appl Radiat Isot
  • Peer Reviewed
• [Journal Article] Current practices and future directions of therapeutic strategy in glioblastoma : survival benefit and indication of BNCT. (2009)
  • Author(s): Matsumura A, Yamamoto T, Tsurubuchi T, Matsuda M, Shirakawa M, Nakai K, Endo K, Tokuue K, Tsuboi K
  • Journal Title: Appl Radiat Isot 67(7-8 Suppl)
  • Peer Reviewed
• [Journal Article] Feasibility of Boron Neutron Capture Therapy for malignant spinal tumors. (2009)
  • Author(s): Nakai K, Kumada H, Yamamoto T, Tsurubuchi T, Zaboronok A, Matsumura A
  • Journal Title: Appl Radiat Isot 67(7-8 Suppl)
  • Peer Reviewed
• [Journal Article] Boron neutron capture therapy for newly diagnosed glioblastoma. (2009)
  • Author(s): Yamamoto T, Nakai K, Kageji T, Kumada H, Endo K, Matsuda M, Shibata Y, Matsumura A
  • Journal Title: Radiother Oncol 91 Pages: 80-84
  • NAID: 120007138272
  • Peer Reviewed
• [Journal Article] Boron neutron capture therapy for newly diagnosed glioblastoma (2009)
  • Author(s): Yamamoto T, Nakai K, Kageji T, Kumada H, Endo K, Matsuda M, Shibata Y, Matsumura A
  • Journal Title: Radiother Oncol 91 Pages: 80-84
  • NAID: 120007138272
  • Peer Reviewed
• [Journal Article] 膠芽腫に対する中性子捕捉療法 (2008)
  • Author(s): 山本哲哉, 中井啓, 松村明
  • Journal Title: No Shinkei Geka Volume: 36 Pages: 293-302
  • NAID: 120006491219
  • Peer Reviewed
• [Journal Article] 膠芽腫に対する中性子捕捉療法. (2008)
  • Author(s): 山本哲哉, 中井啓, 松村明
  • Journal Title: No Shinkei Geka 36 Pages: 293-302
  • NAID: 120006491219
  • Peer Reviewed
• [Journal Article] Boron neutron capture therapy for glioblastoma. (2008)
  • Author(s): 山本哲哉, 中井啓, 松村明
  • Journal Title: Cancer letters 262 Pages: 143-152
  • NAID: 120006491219
  • Peer Reviewed
• [Journal Article] 膠芽腫に対する中性子捕捉療法 (2008)
  • Author(s): 山本哲哉,中井啓,松村明
  • Journal Title: No Shinkei Geka 36 Pages: 293-302
  • NAID: 120006491219
  • Peer Reviewed
• [Presentation] Boron Neutron Capture Therapy for Glioblastoma (2011)
  • Author(s): Yamamoto T
  • Organizer: 6^<th> Young Researchers BNCT neeting
  • Place of Presentation: Hsunchu, Taiwan
  • Year and Date: 2011-12-05
• [Presentation] New Challenge for Advanced BNCT in university of Tsukuba (2011)
  • Author(s): Kumada H, Matsumura A, Sakurai H, Sakae T, Yoshioka M, Kobayashi H, Matsumoto H, Kiyanagi Y, Shibata T, Nakashima H
  • Organizer: 6^<th> Young Researchers BNCT neeting
  • Place of Presentation: Hsunchu, Taiwan
  • Year and Date: 2011-12-05
• [Presentation] Glioblastomaに対する高線量粒子線治療(BNCT, Proton)を含む新規集学的治療の取り組み。-QOLの維持と治療成績の改善を目指して-. (2011)
  • Author(s): 松村明, 山本哲哉, 中井啓, 熊田博明, 松田眞秀, 遠藤聖, 石川栄一, 高野晋吾, 坪井康次, 櫻井英幸, 村垣善浩
  • Organizer: 第70回日本脳神経外科学会
  • Place of Presentation: 横浜
  • Year and Date: 2011-10-13
• [Presentation] GLioblastomaに対する高線量粒子線治療(BNCT,Proton)を含む新規集学的治療の取り組み。-QOLの維持と治療成績の改善を目指して- (2011)
  • Author(s): 松村明, 山本哲哉, 中井啓, 熊田博明, 松田眞秀, 遠藤聖, 石川栄一, 高野晋吾, 坪井康次, 櫻井英幸, 村垣善浩
  • Organizer: 第70回日本脳神経外科学会
  • Place of Presentation: 横浜
  • Year and Date: 2011-10-13
• [Presentation] 悪性脳腫瘍BNCTにおける最大皮膚線量と術後創傷治癒について (2011)
  • Author(s): 中井啓, 山本哲哉, 高田智也, 熊田博明, 松田真秀, 吉田文代, 遠藤聖, 相山仁, 高野晋吾, 松村明
  • Organizer: 第8日本中性子捕捉療法学会
  • Place of Presentation: 徳島
  • Year and Date: 2011-09-16
• [Presentation] 動物実験によるホウ素中性子捕捉療法の新規応用・適応拡大に関する検討 (2011)
  • Author(s): 橋本和幸、松村明
  • Organizer: 第6回先進原子力科学技術に関する連携重点研究討論会
  • Place of Presentation: 東海(招待講演)
  • Year and Date: 2011-08-24
• [Presentation] High Dose Boron Neutron Capture Therapy (Alpha Particle Therapy) For Newly Diagnosed Glioblastoma (2011)
  • Author(s): Matsumura A, Yamamoto T, Nakai k, Takano S, Kumada H, Tsuboi K, Sakurai H
  • Organizer: Brain Tumor
  • Place of Presentation: Berlin
  • Year and Date: 2011-06-16
• [Presentation] High Dose Boron Neutron Capture Therapy (Alpha Particle Therapy)For Newly Diagnosed Glioblastoma (2011)
  • Author(s): Matsumura A, Yamamoto T, Nakai k, Takano S, Kumada H, Tsuboi K, Sakurai H
  • Organizer: Brain Tumor
  • Place of Presentation: Berlin(ドイツ)
  • Year and Date: 2011-06-16
• [Presentation] 中性子捕捉療法・陽子線による脳神経外科領域の粒子線治療 (2011)
  • Author(s): 松村明
  • Organizer: 第22回新お茶の水セミナー
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2011-05-28
• [Presentation] ホウ素中性子捕捉療法<BNCT>によるがん治療 (2011)
  • Author(s): 松村明
  • Organizer: 第68回「加速器科学研究会」
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2011-04-28
• [Presentation] BNCT and other emerging treatments for malignant glioma (2010)
  • Author(s): Matsumura A, et al
  • Organizer: 14th International congress on neutron capture therapy
  • Place of Presentation: Buenos Aires, Argentina
  • Year and Date: 2010-10-30
• [Presentation] BNCT and other emerging treatments for malignant glioma. (2010)
  • Author(s): Matsumura A, Yamamoto T, Ishikawa E, Nakai K, Endo K, Takano S, Shibata Y
  • Organizer: 14th International congress on neutron capture therapy
  • Place of Presentation: Buenos Aires, Argentina
  • Year and Date: 2010-10-30
• [Presentation] BNCT and other emerging treatments for malignant glioma (2010)
  • Author(s): Matsumura A, et al.
  • Organizer: 14th International congress on neutron capture therapy
  • Place of Presentation: Buenos Aires (Argentina)
  • Year and Date: 2010-10-30
• [Presentation] Boron neutron capture therapy combined with fractionated photon irradiation for glioblastoma (2010)
  • Author(s): Nakai K, Yamamoto T, Kageji T, Kumada H, Endo K, Matsuda M, Tsurubuchi T, Shibata Y, Takano S, Matsumura A
  • Organizer: 14th International congress on neutron capture therapy
  • Place of Presentation: Buenos Aires, Argentina
  • Year and Date: 2010-10-28
• [Presentation] The status of Tsukuba BNCT trial : boron neutron capture therapy for recurrent glioma and malignant brain tumor (2010)
  • Author(s): Aiyama, H. K. Nakai, T. Yamamoto, T. Nariai, H. Kumada, E. Ishikawa, K. Endo, T. Takada, F. Yoshida, Y. Shibata, A. Matsumura
  • Organizer: 14th International congress on neutron capture therapy
  • Place of Presentation: Buenos Aires, Argentina
  • Year and Date: 2010-10-27
• [Presentation] The status of Tsukuba BNCT trial : BPA-based boron neutron capture therapy combined with X-ray irradiation (2010)
  • Author(s): Yamamoto T, Nakai K, Nariai T, Kumada H, Okumura T, Miszumoto M, Tuboi K, Zaboronok A, Ishikawa E, Aiyama H, Endo K, Takada T, Yoshida F, Shibata Y, Matsumura A
  • Organizer: 14th International congress on neutron capture therapy
  • Place of Presentation: Buenos Aires, Argentina
  • Year and Date: 2010-10-26
• [Presentation] Clinical Results of BNCT for glioblastoma at JRR-4 and future direction of BNCT in Japan (2009)
  • Author(s): Matsumura A, et al.
  • Organizer: International Conference "Nuclear Power for the people" jointed with Bulgarian Nuclear Society Annual Meeting Veliko-Turnobo
  • Place of Presentation: Bulgaria, SOFIA
  • Year and Date: 2009-11-11
• [Presentation] Clinical result and adjuvant therapy for glioblastoma with BNCT treated patients (2009)
  • Author(s): Nakai K, Ymamaoto T, Tsurubuchi T, Matsuda M, Shirakawa M, Endo K, Alexander Zabornok, Matsumura A, Kageji T
  • Organizer: Young researchers BNCT meeting
  • Place of Presentation: Mainz
  • Year and Date: 2009-09-30
• [Presentation] 初発神経膠芽腫に対する中性子捕捉療法:再開に向けて (2009)
  • Author(s): 中井啓, 山本哲哉, 遠藤聖, 柴田靖, 鶴淵隆夫, 松田真秀, 高野晋吾, 松村明, 熊田博明, 影治照喜
  • Organizer: 第6回日本ホウ素中性子捕捉療法学会
  • Place of Presentation: 大阪
  • Year and Date: 2009-09-19
• [Presentation] Boron neutron capture therapy for newly-diagnosed glioblastoma : a pilot study in Tsukuba (2008)
  • Author(s): Yamamoto T, Nakai K, Tsurubuchi T, Matsuda M, Shirakawa M, Endo K, Matsumura A
  • Organizer: 13th International Congress of Neutron Capture Therapy
  • Place of Presentation: Florence, Italy
  • Year and Date: 2008-11-03
• [Presentation] Boron neutron capture therapy for newly-diagnosed glioblastoma: a pilot study in Tsukuba (2008)
  • Author(s): Yamamoto T, Nakai K, Tsurubuchi T, Matsuda M, Shirakawa M, Endo K, Matsumura A
  • Organizer: 13th International Congress of Neutron Capture Therapy
  • Place of Presentation: Florence, Italy
  • Year and Date: 2008-11-03
• [Book] Tumors of the Central Nervous System, Vol. 21st Edition., Chapter 25 (2011)
  • Author(s): Yamamoto T, Nakai K, Kumada H
  • Publisher: Springer, Tumors of the Central Nervous System, Volume 2 Gliomas : Glioblastoma (Part 2) Series
• [Book] Tumors of the Central Nervous System, Volume 2 Gliomas : Glioblastoma (Part 2) Series : Tumors of the Central Nervous System, Vol.2 1st Edition., Chapter 25. GLIOBLASTOMA : BORON NEUTRON CAPTURE THERAPY (2011)
  • Author(s): Yamamoto T, Nakai K, Kumada H
  • Publisher: Springer