Role of the parafascicular-striatal projection in the anti-depressive effect of vagal nerve stimulation
| Project/Area Number |
20390385
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Shimane University |
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Principal Investigator |
ITO Shin-Ichi Shimane University, 医学部, 准教授 (10145295)
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| Co-Investigator(Kenkyū-buntansha) |
TAKADA Kohji 帝京大学, 文学部, 教授 (70100930)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2010: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2009: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2008: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
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| Keywords | 迷走神経刺激 / カフ電極 / 視床束傍核 / 強制水泳 / 恐怖条件付け / 抗うつ効果 / 抗不安効果 / 逆行性標識 / 破壊実験 / 迷走神経求心線維 / 強制水泳試験 / 学習性無力 / 社会性ストレス / 抗うつ作用 / 大脳基底核 / 埋め込み電極 |
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| Research Abstract |
A new implantable cuff electrode for vagus nerve stimulation (VNS) was developed. VNS was found to be effective to the treatment-resistant depression model based on fear conditioning. It was found that vagus input to the thalamic parafascicular nucleus was transmitted via medial subnucleus of the ipsilateral parabrachial nucleus. Effects of parafascicular lesion on the anti-depressant VNS effect is under investigation.
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Report
(4 results)
Research Products
(12 results)
