| Project/Area Number |
20390386
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Okayama University |
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Principal Investigator |
DATE Isao Okayama University, 大学院・医歯薬学総合研究科, 教授 (70236785)
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| Co-Investigator(Kenkyū-buntansha) |
MIYOSHI Yasuyuki 岡山大学, 大学院・医歯薬学総合研究科, 講師 (00362997)
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| Co-Investigator(Renkei-kenkyūsha) |
SUGIU Kenji 岡山大学, 病院, 講師 (40325105)
TOKUNAGA Koji 岡山大学, 病院, 講師 (40294467)
ONO Shigeki 岡山大学, 大学院・医歯薬学総合研究科, 助教 (40335625)
ICHIKAWA Tomotsugu 岡山大学, 大学院・医歯薬学総合研究科, 助教 (10362964)
KAMEDA Masahiro 岡山大学, 病院, 医員 (50586427)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2010: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2009: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2008: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Keywords | 脳血管障害学 / 脳卒中 / カプセル化細胞 / 細胞移植 / 栄養因子 / 角細胞移植 / 細胞療法 / 脳梗塞 / カプセル化細胞移植 / 神経幹細胞 / 骨髄幹細胞 / 神経栄養因子 / 前臨床試験 |
|---|
| Research Abstract |
We produced encapsulated neural stem cells with the scaffold using collagen type-I. We could find the survival of the neural stem cells in this capsule and could not find any tumor formations. We transplanted encapsulated neural stem cells into the middle cerebral artery occlusion model of rats. The transplanted rats could show better behavioral recovery and had smaller infarct area compared to the control rats. We also found that ischemic damage to the donor cells in transplantation could be reduced by pre-treatment with Glial cell line-derived neurotrophic factor (GDNF).
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