| Project/Area Number |
20390401
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | The University of Tokushima |
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Principal Investigator |
YASUI Natsuo The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 教授 (00157984)
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| Co-Investigator(Kenkyū-buntansha) |
TAKATA Shinjiro 徳島大学, 病院, 准教授 (20284292)
MATSUURA Tetsuya 徳島大学, 病院, 講師 (30359913)
NIKAWA Takeshi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (20263824)
TAKAHASHI Mitsuhiko 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 講師 (10372715)
SAIRYO Koichi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 講師 (10304528)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2009: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2008: ¥11,960,000 (Direct Cost: ¥9,200,000、Indirect Cost: ¥2,760,000)
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| Keywords | 仮骨延長 / 骨成長因子 / 持続投与 / distraction / osteogenesis / osteoenesis |
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| Research Abstract |
Rabbit tibial lengthening was achieved to examine the effect of local infusion of the growth factors and bisphosphonate into the lengthened segment. When FGF-2 and bisphosphonate were infused simultaneously during consolidation phase, bone healing was dramatically enhanced. FGF-2 stimulated bone formation while bisphosphonate inhibited bone resorption. We believe this method is valid to shorten the treatment time of limb lengthening and is applicable in the clinical field as a new drug delivery system.
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