| Budget Amount *help |
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2010: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2009: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2008: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Research Abstract |
When heat shock protein 70(HSP70), a molecular chaperone, was induced in chondrocytes as a stress response mechanism under hypoxic condition, the expression of extracellular matrix gene were increased, and the chondrocytes were protected. We developed the efficiently and safe methods that supplementation of glutamine in combination with moderate heat treatment using a microwave applicator induced sufficient increased of HSP70 for therapeutic purposes in vivo. These findings showed that controlling HSP70 expression in the cartilage using supplementation of glutamine in combination with thermotherapy might offer a novel strategy for suppressing cartilage degeneration in osteoarthritis.
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