| Budget Amount *help |
¥15,730,000 (Direct Cost: ¥12,100,000、Indirect Cost: ¥3,630,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2008: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
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| Research Abstract |
Genetically altered mice are very useful to analyze the molecular and cellular mechanisms of actions of general anesthetics and analgesics. Using GFP knock-in mice, we examined the effects of sevoflurane exposure to the developing brain, focusing on GABAergic neurons. In addition, we also investigated the possible influence of downregulation of vesicular GABA transporter(VGAT) on pain threshold and behavioral responses in mice. Our results provide genetic, behavioral and electrophysiological evidence that reduction of VGAT-mediated inhibitory drive in the spinal cord alters very specific forms of sensory processing : those related to pain processing.
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