Molecular basis and clinical significance of moderately low temperature environment in the mammalian testis
| Project/Area Number |
20390424
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Kyoto University |
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Principal Investigator |
FUJITA Jun Kyoto University, 医学研究科, 教授 (50173430)
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| Co-Investigator(Kenkyū-buntansha) |
NISHIYAMA Hiroyuki 京都大学, 医学研究科, 准教授 (20324642)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2010: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2009: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2008: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
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| Keywords | 精巣 / ストレス / 低温環境 / 遺伝子発現 / ノックアウトマウス / 遺伝子 / 環境 / 細胞・組織 / 低温 / 不妊 |
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| Research Abstract |
Although the cell growth and gene expression are generally suppressed at lower temperatures, mammalian male germ cells proliferate and differentiate better at moderately low temperatures such as 32 degree C than body cavity temperature. The reasons for and biological significance of this phenomenon is unknown. We clarified in this study the molecular mechanism that regulates the expression of Cirp, the cold shock protein specifically induced at moderately low temperatures. We further produced cirp-knockout mice, and demonstrated the involvement of Cirp in spermatogenesis.
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Report
(4 results)
Research Products
(25 results)
