| Budget Amount *help |
¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2010: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2009: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2008: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
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| Research Abstract |
Although the cell growth and gene expression are generally suppressed at lower temperatures, mammalian male germ cells proliferate and differentiate better at moderately low temperatures such as 32 degree C than body cavity temperature. The reasons for and biological significance of this phenomenon is unknown. We clarified in this study the molecular mechanism that regulates the expression of Cirp, the cold shock protein specifically induced at moderately low temperatures. We further produced cirp-knockout mice, and demonstrated the involvement of Cirp in spermatogenesis.
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