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Development of automated medical system to support management of circulation

Research Project

Project/Area Number 20390462
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Emergency medicine
Research InstitutionNational Cardiovascular Center Research Institute

Principal Investigator

KAMIYA Atsunori  National Cardiovascular Center Research Institute, 循環動態制御部, 研究員 (30324370)

Co-Investigator(Kenkyū-buntansha) SUGIMACHI Masaru  独立行政法人国立循環器病研究センター, 循環動態制御部, 部長 (40250261)
上村 和紀  国立循環器病センター(研究所), 循環動態機能部, 室員 (10344350)
Co-Investigator(Renkei-kenkyūsha) SUGIMACHI Masaru  独立行政法人国立循環器病研究センター, 循環動態制御部, 部長 (40250261)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2010: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2009: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2008: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Keywords集中治療医学 / 循環 / 心不全 / 左心房圧 / 肺動脈圧 / 右心房圧 / 自動治療 / 医工学
Research Abstract

Management of circulation in intensive care medicine is important and high quality specialized medical treatment, that directly determines vital prognosis of patients. However, physicians have great physical stress in background of their insufficiency in recent days, that lead human errors in medical treatment that are widely recognized as social problems. The present study, as a challenge to resolve the problems by technology-driven automated medical system, developed multiple drug-delivery system that makes a diagnosis about cardiovascular dynamics and deliver four drugs simultaneously in treatment, with particularly changing open-chest limited to closed-chest applicable system. It actually restored cardiovascular dynamics of animals (i.e., dogs) with circulatory failure.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (22 results)

All 2011 2010 2009 2008

All Journal Article (16 results) (of which Peer Reviewed: 16 results) Presentation (6 results)

  • [Journal Article] Closed-loop spontaneous baroreflex transfer function is inappropriate for system identification of neural arc but partly accurate for peripheral arc : predictability analysis.2011

    • Author(s)
      Kamiya A, Kawada T, Shimizu S, Sugimachi M.
    • Journal Title

      J Physiol.(PMID : 21486839) 589(Pt7)

      Pages: 1769-90

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Closed-loop spontaneous baroreflex transfer function is inappropriate for system identification of neural arc but partly accurate for peripheral arc : predictability analysis.2011

    • Author(s)
      Kamiya A, Kawada T, Shimizu S, Sugimachi M.
    • Journal Title

      J Physiol

      Volume: 589 Pages: 1769-90

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Parallel resetting of arterial baroreflex control of renal and cardiac sympathetic nerve activities during upright tilt in rabbits.2010

    • Author(s)
      Kamiya A, Kawada T, Mizuno M, Shimizu S, Sugimachi M.
    • Journal Title

      Am J Physiol Heart Circ Physiol.(PMID : 20348221) 298(6)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Both skeletonized and pedicled internal thoracic arteries supply adequate graft flow after coronary artery bypass grafting even during intense sympathoexcitation.2010

    • Author(s)
      Une D, Shimizu S, Kamiya A, Kawada T, Shishido T, Sugimachi M.
    • Journal Title

      J Physiol Sci.(PMID : 20839081) 60(6)(Epub2010 Sep 14)

      Pages: 407-13

    • NAID

      10027712249

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Right Ventricular Stiffness Constant as a Predictor of Postoperative Hemodynamics in Patients with Hypoplastic Right Ventricle : A Theoretical Analysis.2010

    • Author(s)
      Shimizu S, Shishido T, Une D, Kamiya A, Kawada T, Sano S, Sugimachi M.
    • Journal Title

      J Physiol Sci.(PMID : 20131025) 60(3)

      Pages: 205-12

    • NAID

      10027711824

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] In vivo direct monitoring of interstitial norepinephrine levels at the sinoatrial node.2010

    • Author(s)
      Shimizu S, Akiyama T, Kawada T, Shishido T, Mizuno M, Kamiya A, Yamazaki T, Sano S, Sugimachi M.
    • Journal Title

      Auton Neurosci.(PMID : 19767249) 152(1-2)(Epub2009 Sep 19)

      Pages: 115-8

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Both skeletonized and pedicled internal thoracic arteries supply adequate graft flow after coronary artery bypass grafting even during intense sympathoexcitation2010

    • Author(s)
      Une D, Shimizu S, Kamiya A, Kawada T, Shishido T, Sugimachi M.
    • Journal Title

      J Physiol Sci.

      Volume: 60 Pages: 407-13

    • NAID

      10027712249

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Parallel resetting of arterial baroreflex control of renal and cardiac sympathetic nerve activities during upright tilt in rabbits.2010

    • Author(s)
      Kamiya A, Kawada T, Mizuno M, Shimizu S, Sugimachi M.
    • Journal Title

      Am J Physiol Heart Circ Physiol.

      Volume: 298 Pages: 1966-75

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Right Ventricular Stiffness Constant as a Predictor of Postope rative Hemodynamics in Patients with Hypoplastic Right Ventricle : A Theoretical Analysis.2010

    • Author(s)
      Shimizu S, Shishido T, Une D, Kamiya A, Kawada T, Sano S, Sugimachi M.
    • Journal Title

      J Physiol Sci (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Slow head-up tilt causes lower activation of muscle sympathetic nerve activity : loading speed-dependence of orthostatic sympathetic activation in humans.2009

    • Author(s)
      Kamiya A, Kawada T, Shimizu S, Iwase S, Sugimachi M, Tadaaki Mano T.
    • Journal Title

      Am J Physiol Heart Circ Physiol.(PMID : 19448145) 297(1)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Slow head-up tilt causes lower activation of muscle sympathetis nerve activity : loading speed-dependence of orthostatic sympathetic activation in humans.2009

    • Author(s)
      Kamiya A, Kawada T, Shimizu S, Iwase S, Sugimachi M, Tadaaki Mano T.
    • Journal Title

      Am J Physiol Heart Circ Physiol. 297(1)

      Pages: 53-58

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vivo direct monitoring of interstitial norepinephrine levels at the sinoatrial node.2009

    • Author(s)
      Shimizu S, Akiyama T, Kawada T, Shishido T, Mizuno M, Kamiya A, Yamazaki T, Sano S, Sugimachi M.
    • Journal Title

      Auton Neurosci. 152(1-2)

      Pages: 115-118

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decoding rule from vasoconstrictor skin sympathetic nerve activity to nonglabrous skin blood flow in humans at normothermic rest.2008

    • Author(s)
      Kamiya A, Michikami D, Iwase S, Mano T.
    • Journal Title

      Neurosci Lett.(PMID : 18502048) 439(1)(Epub2008 Apr 10)

      Pages: 13-7

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Upright tilt resets dynamic transfer function of baroreflex neural arc to minify the pressure disturbance in total baroreflex control.2008

    • Author(s)
      Kamiya A, Kawada T, Yamamoto K, Mizuno M, Shimizu S, Sugimachi M.
    • Journal Title

      J Physiol Sci.(PMID : 18471343) 58(3)(Epub2008 May 13)

      Pages: 189-98

    • NAID

      10022598243

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Upright tilt resets dynamic transfer function of barore flex neural arc to minify the pressure disturbance in total baroreflex control2008

    • Author(s)
      Kamiya A, Kawada T, Yamamoto K, Mizuno M, Shimizu S, Sugimachi M.
    • Journal Title

      J Physiol Sci. 58(3)

      Pages: 189-198

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decoding rule from vasoconstrictor skin sympathetic nerve activity to nonglabrous skin blood flow in humans at normothermic rest2008

    • Author(s)
      Kamiya A, Michikami D, Iwase S, Mano T.
    • Journal Title

      Neurosci Lett 439(1)

      Pages: 13-17

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Estimated venous return surface and cardiac output curve precisely predicts new hemodynamics after volume change.2010

    • Author(s)
      Sugimachi M, Sunagawa K, Uemura K, Kamiya A, Shimizu S, Inagaki M, Shishido T.
    • Organizer
      Conf Proc IEEE Eng Med Biol Soc.
    • Place of Presentation
      Argentina
    • Related Report
      2010 Final Research Report
  • [Presentation] Estimated venous return surface and cardiac output curve precisely predicts new hemodynamics after volume change.2010

    • Author(s)
      Sugimachi M, Sunagawa K, Uemura K, Kamiya A, Shimizu S, Inagaki M, Shishido T.
    • Organizer
      Conf Proc IEEE Eng Med Biol Soc.
    • Place of Presentation
      32nd Annual International IEEE EMBS Conference (ブエノスアイレス,アルゼンチン)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Feedback control of multiple hemodynamic variables with multiple cardiovascular drugs.2009

    • Author(s)
      Sugimachi M, Uemura K, Kamiya A, Shimizu S, Inagaki M, Shishido T.
    • Organizer
      Conf Proc IEEE Eng Med Biol Soc.
    • Place of Presentation
      Minneapolis, Minnesota, USA
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Macroscopic two-pump two-vasculature cardiovascular model to support treatment of acute heart failure.2009

    • Author(s)
      Sugimachi M, Sunagawa K, Uemura K, Kamiya A, Shimizu S, Inagaki M, Shishido T.
    • Organizer
      Conf Proc IEEE Eng Med Biol Soc.
    • Place of Presentation
      Minneapolis, Minnesota, USA
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Theoretical and experimental demonstration of minumizing O2 consumption under preserved hemodynamics in heart failure.2008

    • Author(s)
      Sugimachi M, Uemura K, Shishido T, Kamiya A, Shimizu S, Sunagawa K.
    • Organizer
      XVIIIth Cardiovascular System Dynamics Society.
    • Place of Presentation
      St.Louis, Missouri, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] Theoretical and experimental demonstration of minumizing 02 consumption under preserved hemodynamics in heart failure2008

    • Author(s)
      M. Sugimachi, K. Uemura, T. Shishido, A. Kamiya, S. Shimizu, K. Sunagawa
    • Organizer
      XVIIIth Cardiovascular System Dynamics Society
    • Place of Presentation
      St. Louis, Missouri, USA
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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