Functional analysis of adhesins and colonization factors produced by human pathogenic streptococci

• Project/Area Number: 20390465
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Morphological basic dentistry
• Research Institution: Osaka University
• Principal Investigator: KAWABATA Shigetada Osaka University, 大学院・歯学研究科, 教授 (50273694)
• Co-Investigator(Kenkyū-buntansha): TERAO Yutaka 大阪大学, 大学院・歯学研究科, 准教授 (50397717) ; NAKATA Masanobu 大阪大学, 大学院・歯学研究科, 助教 (90444497) ; SUMITOMO Tomoko 大阪大学, 大学院・歯学研究科, 助教 (50423421)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000); Fiscal Year 2010: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2009: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2008: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
• Keywords: レンサ球菌 / 線毛 / 付着因子 / 定着因子 / 組織指向性

Research Abstract

The human pathogen Streptococcus pyogenes produces diverse pili depending on the serotype. In a serotype M49 S. pyogenes strain, we demonstrate that FctA is the pilus backbone protein, and FctB and Cpa, a collagen-binding adhesin, are ancillary proteins. We also found that both Cpa and FctA are trypsin-resistant T antigens. Mutagenesis assays and eukaryotic cell adherence tests revealed that FctB and housekeeping sortase SrtA contribute to the cell wall anchoring of pili, whereas Cpa functions as a pilus adhesin to human keratinocytes. Sortase C2 and putative signal peptidase LepA enzymes were crucial for polymerization of FctA. The pilus expression increased with lower temperature. The ability to form biofilms was not affected by the mutation of the pilus genes. In contrast to the M49 pili, pili of a serotype M6 S. pyogenes strain were found to be assembled from two proteins, i.e. the backbone protein T6 and ancillary protein FctX, in a manner that requires both SrtA and pilus-associated sortase SrtB. We found that T6 pili contribute to biofilm formation, but not to adherence to human keratinocytes under the condition used in this study. These data suggest the serotype-dependent pilus assembly mechanism and contribution of S. pyogenes pili to the tissue tropism.

Research Products

• [Journal Article] Biofilm formation or internalization into epithelial cells enable Streptococcus pyogenes to evade antibiotic eradication in patients with pharyngitis. (2011)
  • Author(s): Ogawa T, Terao Y, Okuni H, Ninomiya K, Sakata H, Ikebe K, Maeda Y, Kawabata S.
  • Journal Title: Microb Pathog 51(1-2) Pages: 58-68
  • Peer Reviewed
• [Journal Article] Epidemiological characterization of Streptococcus pyogenes isolated from patients with multiple onsets of pharyngitis. (2011)
  • Author(s): Ogawa T, Terao Y, Sakata H, Ohkuni H, Ninomiya K, Ikebe K, Maeda Y, Kawabata S.
  • Journal Title: FEMS Microb Lett 318(2) Pages: 143-151
  • Peer Reviewed
• [Journal Article] Pili of oral Streptococcus sanguinis bind to salivary amylase and promote the biofilm formation. (2011)
  • Author(s): Okahashi N, Nakata M, Terao Y, Isoda R, Sakurai A, Sumitomo T, Yamaguchi M, Kimura RK, Oiki E, Kawabata S, Ooshima T.
  • Journal Title: Microb Pathog 50(3-4) Pages: 148-154
  • Peer Reviewed
• [Journal Article] Streptolysin S contributes to group A streptococcal translocation across an epithelial barrier. (2011)
  • Author(s): Sumitomo T, Nakata M, Higashino M, Jin Y, Terao Y, Fujinaga Y, Kawabata S.
  • Journal Title: J Biol Chem 286(4) Pages: 2750-2761
  • Peer Reviewed
• [Journal Article] Streptolysin S contributes to group A streptococcal translocation across an epithelial barrier (2011)
  • Author(s): Sumitomo, T., Nakata, M., Higashino, M., Jin, Y., Terao, Y., Fujinaga, Y., Kawabata, S.
  • Journal Title: Journal of Biological Chemistry Volume: 286 Pages: 2750-2761
  • Peer Reviewed
• [Journal Article] Pili of oral Streptococcus sanguinis bind to salivary amylase and promote the biofilm formation (2011)
  • Author(s): Okahashi, N., Nakata, M., Terao, Y., Isoda, R., Sakurai, A., Sumitomo, T., Yamaguchi, M., Kimura, R.K., Oiki, E., Kawabata, S., Ooshima, T.
  • Journal Title: Microbial Pathogenesis Volume: 50 Pages: 148-154
  • Peer Reviewed
• [Journal Article] Inhibitory effects of oenothera biennis (evering primrose) seed extract on Streptococcus mutans and S.mutans-induced dental caries in rats. (2011)
  • Author(s): Matsumoto-Nakano, M., Nagayama, K., Kitagori, H., Fujita, K., Inagaki, S., Takashima, Y., Tamesada, M., Kawabata, S., Ooshima, T.
  • Journal Title: Caries Research Volume: 45 Pages: 56-63
  • Peer Reviewed
• [Journal Article] Epidemiological characterization of Streptococcus pyogenes isolated from patients with multiple onsets of pharyngitis. (2011)
  • Author(s): Ogawa, T., Terao, Y., Sakata, H., Ohkuni, H., Ninomiya, K., Ikebe, K., Maeda, Y., Kawabata, S.
  • Journal Title: FEMS Microbiology Letters Volume: (未定)
  • Peer Reviewed
• [Journal Article] Pili of oral Streptococcus sanguinis bind to fibronectin and contribute to cell adhesion. (2010)
  • Author(s): Okahashi N, Nakata M, Sakurai A, Terao Y, Hoshino T, Yamaguchi M, Isoda R, Sumitomo T, Nakano K, Kawabata S, Ooshima T.
  • Journal Title: Biochem Biophys Res Commun 391(2) Pages: 1192-1196
  • Peer Reviewed
• [Journal Article] Molecular and biological characterization of gtf regulation-associated genes in Streptococcus mutans. (2009)
  • Author(s): Terao Y, Isoda R, Murakami J, Hamada S, Kawabata S.
  • Journal Title: Oral Microbiol Immunol 24(3) Pages: 211-217
  • Peer Reviewed
• [Journal Article] Mode of expression and functional characterization of FCT-3 pilus region encoded proteins in the Streptococcus pyogenes serotype M49. (2009)
  • Author(s): Nakata M, Koller T, Moritz K, Ribardo D, Jonas L, McIver KS, Sumitomo T, Terao Y, Kawabata S, Podbielski A, Kreikemeyer B.
  • Journal Title: Infect Immun 77(1) Pages: 32-44
  • Peer Reviewed
• [Journal Article] Pili of oral Streptococcus sanguinis bind to fibronectin and contribute to cell adhesion. (2009)
  • Author(s): Okahashi, N.
  • Journal Title: Biochemical and Biophysical Research Communications 391 Pages: 1192-1196
  • Peer Reviewed
• [Journal Article] Nrc of Streptococcus pneumoniae suppresses capsule expression and enhances anti-phagocytosis. (2009)
  • Author(s): Yamaguchi, M.
  • Journal Title: Biochemical and Biophysical Research Communications 390 Pages: 155-160
  • Peer Reviewed
• [Journal Article] Comparative genomic analyses of Streptococcus mutans provide insights into chromosomal shuffling and species-specific content. (2009)
  • Author(s): Maruyama, F.
  • Journal Title: BMC Genomics 10 Pages: 358-358
  • Peer Reviewed
• [Journal Article] Molecular and biological characterization of gtf regulation-associated genes in Streptococcus mutans. (2009)
  • Author(s): Terao, Y.
  • Journal Title: Oral Microbiology and Immunology 24 Pages: 211-217
  • Peer Reviewed
• [Journal Article] Mode of expression and functional characterization of FCT 3 pilus region encoded proteins in the Streptococcus pyogenes serotype M49. (2009)
  • Author(s): Nakata, M.
  • Journal Title: Infection and Immunity 77 Pages: 32-34
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): 寺尾豊
  • Journal Title: 蛋白質核酸酵素増刊号-感染現象その理解の深化から疾患制御への展望-(共立出版) Pages: 982-9
• [Journal Article] Molecular and biological characterization of gtf regulation-associated genes inStreptococcus mutans. (2009)
  • Author(s): Terao, Y.
  • Journal Title: Oral Microbiology and Immunology 24 Pages: 211-217
  • Peer Reviewed
• [Journal Article] Mode of expression and functional characterization of FCT-3 pilus region encoded proteins in the Streptococcus pyogenes serotype M49. (2009)
  • Author(s): Nakata, M.
  • Journal Title: Infection and Immunity 77 Pages: 32-34
  • Peer Reviewed
• [Journal Article] A novel streptococcal leucine zipper protein (Lzp) binds to human immunoglobulins. (2008)
  • Author(s): Okamoto S, Terao Y, Hasuike K, Hamada S, Kawabata S.
  • Journal Title: Biochem Biophys Res Commun 377(4) Pages: 1128-1134
  • Peer Reviewed
• [Journal Article] PfbA, a novel plasminand fibronectin-binding protein of Streptococcus pneumoniae, contributes to fibronectin-dependent adhesion and antiphagocytosis. (2008)
  • Author(s): Yamaguchi M, Terao Y, Mori Y, Hamada S, Kawabata S.
  • Journal Title: J Biol Chem 283(52) Pages: 36272-36279
  • Peer Reviewed
• [Journal Article] Molecular and biological characterization of histidine triad protein in group A streptococci. (2008)
  • Author(s): Kunitomo E, Terao Y, Okamoto S, Rikimaru T, Hamada S, Kawabata S.
  • Journal Title: Microbes Infect 10(4) Pages: 414-423
  • Peer Reviewed
• [Journal Article] Group A streptococcal cysteine protease degrades C3 (C3b) and contributes to evasion of innate immunity. (2008)
  • Author(s): Terao Y, Mori Y, Yamaguchi M, Shimizu Y, Ooe K, Hamada S, Kawabata S.
  • Journal Title: J Biol Chem 283(10) Pages: 6253-6260
  • Peer Reviewed
• [Journal Article] A novel streptococcal leucine zipper protein (Lzp)binds to humanimmunoglobulins. (2008)
  • Author(s): Okamoto, S.
  • Journal Title: Biochemical and Biophysical Research Communications 377 Pages: 1128-1134
  • Peer Reviewed
• [Journal Article] PfbA, a nobel plasmin- and fibronectin-binding protein of Streptococcuspneumoniae, contributes to fibronectin-dependent adhesion and antiphagocytosis. (2008)
  • Author(s): Yamaguchi, M.
  • Journal Title: Journal of Biological Chemistry 283 Pages: 36272-36279
  • Peer Reviewed
• [Journal Article] Molecular cloning of novel Monad binding protein containing tetratricopeptiderepeat domains. (2008)
  • Author(s): Itsuki, Y.
  • Journal Title: FEBS Letters 582 Pages: 2365-2370
  • Peer Reviewed
• [Journal Article] Molecular and biological characterization of histidine triad protein ingroup A streptococci. (2008)
  • Author(s): Kunitomo, E.
  • Journal Title: Microbes and Infection 10 Pages: 414-423
  • Peer Reviewed
• [Journal Article] Group A streptococcal cysteine protease degrades C3 (C3b) and contributes toevasion of innate immunity. (2008)
  • Author(s): Terao, Y.
  • Journal Title: Journal of Biological Chemistry 283 Pages: 6253-6260
  • Peer Reviewed
• [Journal Article] Streptococcal immunoglobulin-binding protein Sib35 exerts stimulatory andmitogenic effects toward mouse B lymphocytes. (2008)
  • Author(s): Okamoto, S.
  • Journal Title: FEMS Microbiology Letters 281 Pages: 73-80
  • Peer Reviewed
• [Presentation] M6型A群レンサ球菌が産生する線毛の形成機構と機能の解析 (2010)
  • Author(s): 木村敬次リチャード, 中田匡宣, 住友倫子, 寺尾豊, 磯田竜太朗, 川端重忠
  • Organizer: 第63回日本細菌学会関西支部総会
  • Place of Presentation: 関西医科大学
  • Year and Date: 2010-11-20
• [Presentation] M6型A群レンサ球菌が産生する線毛の形成機構と機能の解析 (2010)
  • Author(s): 木村敬次リチャード, 中田匡宣, 住友倫子, 寺尾豊, 磯田竜太朗, 川端重忠
  • Organizer: 第63回日本細菌学会関西支部総会
  • Place of Presentation: 関西医科大学(大阪府)
  • Year and Date: 2010-11-20
• [Presentation] A群レンサ球菌の上皮バリア突破機構に関与する宿主プロテアーゼの検索 (2010)
  • Author(s): 住友倫子, 中田匡宣, 東野美晴, 寺尾豊, 川端重忠
  • Organizer: 第8回感染症沖縄フォーラム
  • Place of Presentation: 沖縄国民年金健康センター
  • Year and Date: 2010-02-12
• [Presentation] 病態観察とゲノム情報から展開するA群レンサ球菌の分子解析 (2010)
  • Author(s): 寺尾豊, 川端重忠
  • Organizer: 第52回歯科基礎医学会学術大会
  • Place of Presentation: タワーホール船堀
• [Presentation] Streptolysin S contributes to group A streptococcal paracellular translocation across epithelial cells. (2010)
  • Author(s): Sumitomo T, Nakata M, Terao Y, Kawabata S
  • Organizer: The 10th Awaji International Forum on Infection and Immunity.
  • Place of Presentation: Awaji, Hyogo, Japan
• [Presentation] Characterization of Streptococcus pyogenes isolated from patients with recurrent pharyngitis. (2010)
  • Author(s): Ogawa T, Terao Y, Ohkuni H, Ninomiya K, Sakata H, Ikebe K, Maeda Y, Kawabata S
  • Organizer: 88th General Session & Exhibition of the International Association for Dental Research.
  • Place of Presentation: Barcelona, Spain
• [Presentation] Streptococcus pneumoniae evades neutrophil phagocytosis through its surface protein PfbA. (2010)
  • Author(s): Yamaguchi M, Terao Y, Nishino K, Yamaguchi A, Hamada S, Kawabata S
  • Organizer: 110th General Meeting of American Society for Microbiology.
  • Place of Presentation: San Diego, USA
• [Presentation] Streptolysin S contributes to group Astreptococcal paracellular translocation acrossepithelial cells. (2010)
  • Author(s): 住友倫子, 中田匡宣, 寺尾豊, 川端重忠
  • Organizer: 第62回日本細胞生物学会大会
  • Place of Presentation: 大阪国際会議場
• [Presentation] 口腔レンサ球菌S. sanguinis線毛piliの機能 (2010)
  • Author(s): 岡橋暢夫, 中田匡宣, 桜井敦朗, 寺尾豊, 山口雅也, 星野倫範, 川端重忠, 大嶋隆
  • Organizer: 第83回日本細菌学会総会
  • Place of Presentation: パシフィコ横浜
• [Presentation] 宿主細胞間接着分子の破壊に関与するA 群レンサ球菌プロテアーゼの検索 (2010)
  • Author(s): 東野美晴, 住友倫子, 中田匡宣, 寺尾豊, 川端重忠
  • Organizer: 第83回日本細菌学会総会
  • Place of Presentation: パシフィコ横浜
• [Presentation] A群レンサ球菌の上皮バリア突破機構に関与する宿主プロテアーゼの解析 (2010)
  • Author(s): 住友倫子, 中田匡宣, 東野美晴, 寺尾豊, 川端重忠
  • Organizer: 第83回日本細菌学会総会
  • Place of Presentation: パシフィコ横浜
• [Presentation] A群レンサ球菌が産生する線毛の細胞壁架橋機構の解析 (2010)
  • Author(s): 中田匡宣, 住友倫子, 磯田竜太朗, 寺尾豊, 川端重忠
  • Organizer: 第83回日本細菌学会総会
  • Place of Presentation: パシフィコ横浜
• [Presentation] Streptococcus pyogenesの補体C6結合タンパクの同定と機能解析 (2010)
  • Author(s): 寺尾豊, 浜田茂幸, 川端重忠
  • Organizer: 第83回日本細菌学会総会
  • Place of Presentation: パシフィコ横浜
• [Presentation] Streptolysin S contributes to group A streptococcal paracellular translocation across epithelial cells. (2010)
  • Author(s): 住友倫子, 中田匡宣, 寺尾豊, 川端重忠
  • Organizer: 第62回日本細胞生物学会大会
  • Place of Presentation: 大阪国際会議場(大阪市)
• [Presentation] Streptococcus pneumoniae evades neutrophil phagocytosis through its surface protein PfbA. (2010)
  • Author(s): Yamaguchi, M., Terao, Y., Nishino, K., Yamaguchi, A., Hamada, S., Kawabata, S.
  • Organizer: 110th General Meeting of American Society for Microbiology
  • Place of Presentation: San Diego Convention Center(USA)
• [Presentation] 再発性咽頭炎患者より分離されたA群レンサ球菌の分子解析に基づく新規治療法の提案 (2010)
  • Author(s): 小川泰治, 寺尾豊, 大国壽士, 二宮恵子, 坂田宏, 入江正寛, 本間信夫, 中野正大, 明貝路子, 浜田茂幸, 川端重忠
  • Organizer: 第19回Lancefieldレンサ球菌研究会/第42回レンサ球菌感染症研究会合同開催
  • Place of Presentation: 国立国際医療センター研究所(東京都)
• [Presentation] Characterization of Streptococcus pyogenes isolated from patients with recurrent pharyngitis. (2010)
  • Author(s): Ogawa, T., Terao, Y., Ohkuni, H., Ninomiya, K., Sakata, H., Ikebe, K., Maeda, Y., Kawabata., S.
  • Organizer: 88th General Session & Exhibition of the International Association for Dental Research
  • Place of Presentation: Centre Convencions Internacional Barcelona(Spain)
• [Presentation] Streptolysin S contributes to group A streptococcal paracellular translocation across epithelial cells. (2010)
  • Author(s): Sumitomo, T., Nakata, M., Terao, Y., Kawabata., S.
  • Organizer: The 10th Awaji International Forum on Infection and Immunity
  • Place of Presentation: 淡路夢舞台国際会議場(兵庫県)
• [Presentation] Streptococcus pyogenes C6結合タンパクのナノスケール・バイオイメージング解析 (2010)
  • Author(s): 寺尾豊, 浜田茂幸, 川端重忠
  • Organizer: 第47回補体シンポジウム
  • Place of Presentation: コラッセふくしま(福島県)
• [Presentation] 病態観察とゲノム情報から展開するA群レンサ球菌の分子解析 (2010)
  • Author(s): 寺尾豊, 川端重忠
  • Organizer: 第52回歯科基礎医学会学術大会
  • Place of Presentation: タワーホール船堀(東京都)
• [Presentation] 難治性咽頭炎の発症メカニズム解析と再発防止へのアプローチ (2010)
  • Author(s): 小川泰治, 寺尾豊, 坂田宏, 川端重忠
  • Organizer: 第80回日本感染症学会西日本地方会学術集会
  • Place of Presentation: 松山市総合コミュニティーセンター(愛媛県)
• [Presentation] Streptococcus pneumoniaeは赤血球に侵入し好中球免疫を回避する (2010)
  • Author(s): 山口雅也, 寺尾豊, 八木哲也, 西野邦彦, 山口明人, 川端重忠
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
  • Place of Presentation: 神戸ポートアイランド(兵庫県)
• [Presentation] 新規免疫システムNETsを誘導する肺炎レンサ球菌タンパクの同定 (2010)
  • Author(s): 森有可, 寺尾豊, 山口雅也, 浜田茂幸, 大嶋隆, 川端重忠
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
  • Place of Presentation: 神戸ポートアイランド(兵庫県)
• [Presentation] Streptococcus pyogenesの補体C6結合タンパクの同定と機能解析 (2010)
  • Author(s): 寺尾豊
  • Organizer: 第83回日本細菌学会総会
  • Place of Presentation: パシフィコ横浜(横浜市)
• [Presentation] A群レンサ球菌が産生する線毛の細胞壁架橋機構の解析 (2010)
  • Author(s): 中田匡宣
  • Organizer: 第83回日本細菌学会総会
  • Place of Presentation: パシフィコ横浜(横浜市)
• [Presentation] A群レンサ球菌の上皮バリア突破機構に関与する宿主プロテアーゼの解析 (2010)
  • Author(s): 住友倫子
  • Organizer: 第83回日本細菌学会総会
  • Place of Presentation: パシフィコ横浜(横浜市)
• [Presentation] Streptococcus pneumoniaeと赤血球の相互作用の解析 (2010)
  • Author(s): 山口雅也
  • Organizer: 第83回日本細菌学会総会
  • Place of Presentation: パシフィコ横浜(横浜市)
• [Presentation] Streptococcus pneumoniaeの自然免疫回避におけるEnolaseの役割 (2010)
  • Author(s): 森有可
  • Organizer: 第83回日本細菌学会総会
  • Place of Presentation: パシフィコ横浜(横浜市)
• [Presentation] Aへ群レンサ球菌性咽頭炎の再発メカニズムの解析 (2010)
  • Author(s): 小川泰治
  • Organizer: 第83回日本細菌学会総会
  • Place of Presentation: パシフィコ横浜(横浜市)
• [Presentation] 宿主細胞間接着分子の破壊に関与するA群レンサ球菌プロテアーゼの検索 (2010)
  • Author(s): 東野美晴
  • Organizer: 第83回日本細菌学会総会
  • Place of Presentation: パシフィコ横浜(横浜市)
• [Presentation] 口腔レンサ球菌S.sanguinis線毛piliの機能 (2010)
  • Author(s): 岡橋暢夫
  • Organizer: 第83回日本細菌学会総会
  • Place of Presentation: パシフィコ横浜(横浜市)
• [Presentation] Molecular analysis of Streptococcus pyogenes isolated from patients with recurrent streptococcal pharyngitis. (2009)
  • Author(s): Ogawa, T.
  • Organizer: Kyungpook-Osaka University International Symposium
  • Place of Presentation: Daegu, Korea
  • Year and Date: 2009-12-11
• [Presentation] Streptococcus pneumoniaeの好中球に対する抗貪食能のバイオイメージング解析 (2009)
  • Author(s): 山口雅也
  • Organizer: 第62回日本細菌学会開西支部総会
  • Place of Presentation: 大阪府立大学りんくうキャンパス多目的ホール(泉佐野市)
  • Year and Date: 2009-11-14
• [Presentation] 肺炎球菌表層タンパク質PfbAの機能解析 (2009)
  • Author(s): 川端重忠
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2009-10-23
• [Presentation] 肺炎球菌表層タンパク質PfbAの機能解析 (2009)
  • Author(s): 川端重忠
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド(神戸市)
  • Year and Date: 2009-10-23
• [Presentation] A群レンサ球菌の上皮バリア突破機構に関する解析 (2009)
  • Author(s): 住友倫子, 中田匡宣, 寺尾豊, 川端重忠
  • Organizer: 第7回感染症沖縄フォーラム
  • Place of Presentation: 沖縄県青年会館
  • Year and Date: 2009-02-12
• [Presentation] A群レンサ球菌の上皮バリア突破機構に関する解析 (2009)
  • Author(s): 住友倫子
  • Organizer: 第7回感染症沖縄フォーラム
  • Place of Presentation: 那覇市
  • Year and Date: 2009-02-12
• [Presentation] カルボシステインによるヒト肺胞上皮細胞への肺炎レンサ球菌の付着抑制効果 (2009)
  • Author(s): 住友倫子, 川端重忠
  • Organizer: 第52回日本感染症学会中日本地方会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] A群レンサ球菌が産生する線毛の発現機構の解析 (2009)
  • Author(s): 中田匡宣, 寺尾豊, 川端重忠
  • Organizer: 第51回歯科基礎医学会学術大会
  • Place of Presentation: 朱鷺メッセ,新潟市
• [Presentation] Role of Streptococcus pneumoniae PfbA in adhesion to human epithelial cells and resistance to neutrophil phagocytosis. (2009)
  • Author(s): Yamaguchi M, Terao Y, Hamada S, Kawabata S
  • Organizer: The 9th Awaji International Forum on Infection and Immunity.
  • Place of Presentation: Awaji, Hyogo, Japan
• [Presentation] Group A Streptococci translocates across epithelial barrier via intercellular junction cleavage. (2009)
  • Author(s): Sumitomo T, Nakata M, Terao Y, Kawabata S
  • Organizer: 109th General Meeting of American Society for Microbiology.
  • Place of Presentation: Philadelphia, USA
• [Presentation] Streptococcus pneumoniaeに対する感染防御抗原の検索 (2009)
  • Author(s): 山口雅也, 南出由希, 小川泰治, 森有可, 寺尾豊, 浜田茂幸, 川端重忠
  • Organizer: 第82回日本細菌学会総会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] A群レンサ球菌の上皮バリア突破機構に関する解析 (2009)
  • Author(s): 住友倫子, 中田匡宣, 寺尾豊, 川端重忠
  • Organizer: 第82回日本細菌学会総会
  • Place of Presentation: ,名古屋国際会議場
• [Presentation] A群レンサ球菌線毛の温度感受性発現機構の解析 (2009)
  • Author(s): 中田匡宣, 住友倫子, 寺尾豊, 川端重忠
  • Organizer: 第82回日本細菌学会総会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] Group A Streptococci translocates across epithelial barrier via intercellular junction cleavage. (2009)
  • Author(s): Sumitomo, T.
  • Organizer: 109th General Meeting of American Society for Microbiology
  • Place of Presentation: Philadelphia, USA
• [Presentation] Cysteine protease SpeB enables Streptococcus pyogenes to evade neutrophil immunity. (2009)
  • Author(s): Terao, Y.
  • Organizer: FEMS 2009 3rd Congress of European Microbiologists
  • Place of Presentation: Gothenburg, Sweden
• [Presentation] Role of Streptococcus pneumoniae PfbA in adhesion to human epithelial cells and resistance to neutrophil phagocytosis. (2009)
  • Author(s): Yamaguchi, M.
  • Organizer: The 9th Awaji International Forum on Infection and Immunity
  • Place of Presentation: Hyogo, Japan
• [Presentation] 菌体表層タンパクPfbAによるStreptococcus pneumoniaeの上皮細胞定着と抗貪食機構のバイオイメージング解析 (2009)
  • Author(s): 山口雅也
  • Organizer: 第18回Lancefieldレンサ球菌研究会
  • Place of Presentation: 九州大学コラボステーション(福岡市)
• [Presentation] 再発性咽頭炎患者より分離されたA群レンサ球菌の分子生物学的解析 (2009)
  • Author(s): 小川泰治
  • Organizer: 第18回Lancefieldレンサ球菌研究会
  • Place of Presentation: 九州大学コラボステーション(福岡市)
• [Presentation] 口腔領域レンサ球菌による宿主上皮細胞への付着侵入と炎症の誘導 (2009)
  • Author(s): 桜井敦朗
  • Organizer: 第18回Lancefieldレンサ球菌研究会
  • Place of Presentation: 九州大学コラボステーション(福岡市)
• [Presentation] A群レンサ球菌が産生する線毛の発現機構の解析 (2009)
  • Author(s): 中田匡宣
  • Organizer: 第51回歯科基礎医学会学術大会
  • Place of Presentation: 朱鷺メッセ(新潟市)
• [Presentation] ターメリックはStreptococcus mutansの生育を阻害する (2009)
  • Author(s): 泉井秀介
  • Organizer: 第51回歯科基礎医学会学術大会
  • Place of Presentation: 朱鷺メッセ(新潟市)
• [Presentation] カルボシステインによるヒト肺胞上皮細胞への肺炎レンサ球菌の付着抑制効果 (2009)
  • Author(s): 住友倫子
  • Organizer: 第52回日本感染症学会中日本地方会
  • Place of Presentation: 名古屋国際会議場(名古屋市)
• [Presentation] A群レンサ球菌の上皮バリア突破機構に関与する宿主プロテアーゼの検索 (2009)
  • Author(s): 住友倫子
  • Organizer: 第7回感染症沖縄フォーラム
  • Place of Presentation: 沖縄国民年金健康センター(那覇市)
• [Presentation] A群レンサ球菌の好中球免疫阻害機構に関するバイオイメージング解析 (2009)
  • Author(s): 寺尾豊
  • Organizer: 第82回日本細菌学会総会
  • Place of Presentation: 名古屋市
• [Presentation] A群レンサ球菌線毛の温度感受性発現機構の解析 (2009)
  • Author(s): 中田匡宣
  • Organizer: 第82回日本細菌学会総会
  • Place of Presentation: 名古屋市
• [Presentation] A群レンサ球菌の上皮バリア突破機構に関する解析 (2009)
  • Author(s): 住友倫子
  • Organizer: 第82回日本細菌学会総会
  • Place of Presentation: 名古屋市
• [Presentation] Streptococcus pneumoniaeに対する感染防御抗原の検索 (2009)
  • Author(s): 山口雅也
  • Organizer: 第82回日本細菌学会総会
  • Place of Presentation: 名古屋市
• [Presentation] Streptococcus pneumoniae enolaseは好中球の細胞死を誘導する (2009)
  • Author(s): 森有可
  • Organizer: 第82回日本細菌学会総会
  • Place of Presentation: 名古屋市
• [Presentation] 細胞侵入と細胞内増殖におけるサルモネラ異物排出トランスポーターの役割 (2009)
  • Author(s): 坂田博樹
  • Organizer: 第82回日本細菌学会総会
  • Place of Presentation: 名古屋市
• [Presentation] Streptococcus pneumoniaeによる好中球細胞死の解析 (2008)
  • Author(s): 森有可
  • Organizer: 第61回日本細菌学会関西支部総会
  • Place of Presentation: 京都市
  • Year and Date: 2008-11-08
• [Presentation] The Nra-Ralp3 transcriptional regulatory network of Streptococcus pyogenesserotype M49 : control of the novel ERES pathogenicity region. (2008)
  • Author(s): Fiedler, T.
  • Organizer: 17th Lancefield International Symposium on Streptococciand Streptococcal Diseases.
  • Place of Presentation: Porto Heli, Greece
  • Year and Date: 2008-06-25
• [Presentation] A群レンサ球菌が産生する線毛の機能解析 (2008)
  • Author(s): 中田匡宣, 寺尾豊, 川端重忠
  • Organizer: 第50回歯科基礎医学会学術大会
  • Place of Presentation: TOC有明コンベンションホール,東京都
• [Presentation] Impact of novel multi-functional protein PfbA on adherence, invasion, and antiphagocytosis by Streptococcus pneumoniae. (2008)
  • Author(s): Yamaguchi M, Terao Y, Mori Y, Hamada S, Kawabata S
  • Organizer: The International Union of Microbiological Societies 2008.
  • Place of Presentation: Istanbul, Turkey
• [Presentation] A群レンサ球菌の上皮バリア突破機構に関する解析 (2008)
  • Author(s): 住友倫子, 中田匡宣, 寺尾豊, 川端重忠
  • Organizer: 第17回Lancefieldレンサ球菌研究会
  • Place of Presentation: 徳島大学
• [Presentation] The Nra-Ralp3 transcriptional regulatory network of Streptococcus pyogenes serotype M49 : control of the novel ERES pathogenicity region. (2008)
  • Author(s): Nakata M, Fiedler T, Koller T, Stander K, Kawabata S, Podbielski A, Kreikemeyer B.
  • Organizer: 17th Lancefield International Symposium on Streptococci and Streptococcal Diseases.
  • Place of Presentation: Porto Heli, Greece
• [Presentation] Role of the Streptococcus pyogenes serotype M49 FCT-3 region encoded pilus in virulence. (2008)
  • Author(s): Nakata M, Koller T, McIver KS, Kawabata S, Podbielski A, Kreikemeyer B.
  • Organizer: 17th Lancefield International Symposium on Streptococci and Streptococcal Diseases.
  • Place of Presentation: Porto Heli, Greece
• [Presentation] Group A streptococcal cysteine protease degrades complement C3 and contributesto evasion of innate immunity in severe streptococcal infections. (2008)
  • Author(s): Terao, Y.
  • Organizer: 108th General Meeting of American Society for Microbiology.
  • Place of Presentation: Boston, USA
• [Presentation] Role of the Streptococcus pyogenes serotype M49 FCT-3 region encoded pilus invirulence. (2008)
  • Author(s): Nakata, M.
  • Organizer: 17th Lancefield International Symposium on Streptococciand Streptococcal Diseases.
  • Place of Presentation: Porto Heli, Greece
• [Presentation] Impact of novel multi-functional protein PfbA on adherence, invasion, andantiphagocytosis by Streptococcus pneumoniae. (2008)
  • Author(s): Yamaguchi, M.
  • Organizer: The International Union of Microbiological Societies 2008
  • Place of Presentation: Istanbul, Turkey
• [Presentation] Streptococcus pyogenes degrades complements C3 and C3b to evade of innateimmune system. (2008)
  • Author(s): Terao, Y.
  • Organizer: The 8th Awaji International Forum on Infection and Immunity
  • Place of Presentation: Hyogo, Japan
• [Presentation] 肺炎レンサ球菌ならびに黄色ブドウ球菌感染症に対するキメラ免疫グロブリンの構築 (2008)
  • Author(s): 寺尾豊
  • Organizer: 第82回日本感染症学会総会
  • Place of Presentation: 松江市
• [Presentation] A群レンサ球菌の上皮バリア突破機構に関する解析 (2008)
  • Author(s): 住友倫子
  • Organizer: 第17回Lancefieldレンサ球菌研究会
  • Place of Presentation: 徳島市
• [Presentation] 補体分解によるA群レンサ球菌の免疫回避機構 (2008)
  • Author(s): 寺尾豊
  • Organizer: 第2回細菌学若手コロッセウム
  • Place of Presentation: 神奈川県三浦郡
• [Presentation] A群レンサ球菌が産生する線毛の機能解析 (2008)
  • Author(s): 中田匡宣
  • Organizer: 第50回歯科基礎医学会学術大会
  • Place of Presentation: 東京都
• [Presentation] 経鼻投与コレラトキシンによる活性化樹状細胞はIgAクラススイッチングB1 B細胞を誘導する (2008)
  • Author(s): 片岡宏介
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都市
• [Book] 炎症と免疫, 18(6)(A群レンサ球菌-インフルエンザウイルスとの複合感染による重症化-) (2010)
  • Author(s): 岡本成史, 川端重忠
  • Publisher: 先端医学社
• [Book] 口腔微生物学・免疫学 第3版(グラム陽性球菌と感染症) (2010)
  • Author(s): 川端重忠
  • Publisher: 医歯薬出版
• [Book] グラム陽性球菌と感染症,口腔微生物学・免疫学 第3版 (2010)
  • Author(s): 川端重忠
  • Publisher: 医歯薬出版
• [Book] A群レンサ球菌-インフルエンザウイルスとの複合感染による重症化-.炎症と免疫.18(6) (2010)
  • Author(s): 岡本成史, 川端重忠
  • Publisher: 先端医学社
• [Book] 蛋白質核酸酵素2009年6月増刊号,54(8)(感染現象その理解の深化から疾患制御への展望,A群連鎖球菌のサバイバル・ストラテジー) (2009)
  • Author(s): 寺尾豊, 川端重忠
  • Publisher: 共立出版
• [Book] 蛋白質核酸酵素増刊号 (2009)
  • Author(s): 寺尾豊
  • Total Pages: 6
  • Publisher: A群レンサ球菌のサバイバル・ストラテジー
• [Book] 生命歯科医学のカッティング・エッジ(病原性レンサ球菌の病原因子の機能解析) (2008)
  • Author(s): 寺尾豊, 住友倫子, 中田匡宣, 磯田竜太朗, 川端重忠
  • Publisher: 大阪大学出版会
• [Book] 感染・炎症・免疫,38(1)(A群レンサ球菌の病原性発現に関する分子機構) (2008)
  • Author(s): 川端重忠, 寺尾豊, 中田匡宣
  • Publisher: 医薬の門社
• [Book] 生命歯科医学のカッティング・エッジ, 米田俊之編 (2008)
  • Author(s): 寺尾豊
  • Total Pages: 11
  • Publisher: 病原性レンサ球菌の病原因子の機能解析
• [Remarks] ホームページ等
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