Titanium implant surface modification and tissue regeneration by phosphorylated pullulan

• Project/Area Number: 20390498
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Dental engineering/Regenerative dentistry
• Research Institution: Okayama University
• Principal Investigator: SUZUKI Kazuomi Okayama University, 大学院・医歯薬学総合研究科, 教授 (30050058)
• Co-Investigator(Kenkyū-buntansha): IRIE Masao 岡山大学, 大学院・医歯薬学総合研究科, 助教 (90105594) ; TANAKA Jiro 岡山大学, 大学院・医歯薬学総合研究科, 助教 (40171764)
• Co-Investigator(Renkei-kenkyūsha): YAMAMOTO Toshio 岡山大学, 大学院・医歯薬学総合研究科, 教授 (30107776)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000); Fiscal Year 2010: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000); Fiscal Year 2009: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2008: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
• Keywords: インプラント / チタン / 表面処理 / 骨伝導 / 上部構造体 / 適合性 / 接着材 / 被膜強さ / 被膜厚さ

Research Abstract

The improvement of bone formation-inducing activity for dental implant treatment and the newly developed adhesive for superstructure (crown, bridge, etc) were investigated. At 2 weeks after the implant surgery in rat tibia, the enhanced new bone formation was showed on the titanium surface treated with phosphorylated pullulan. The bone strength to Ag-Au-Pt-Cu alloys of 15-20% derivatized amino acid (cystine) containing urethane dimethacrylate polymers was 22.4MPa(SD:1.8),and the degradation of the bone strength was only 10% after thermal cycling with 20.000 cycles at 5-55℃.

Research Products

• [Journal Article] Determinants of early interfacial-gap performance of indirect composite restoration. (2010)
  • Author(s): Irie, M., Maruo, Y., Nishigawa, G., Suzuki, K., Watts, D.C.
  • Journal Title: Dental Materials 26 Pages: 608-615
  • Peer Reviewed
• [Journal Article] Nano-controlled molecular interaction at adhesive interfaces for hard-tissue reconstruction. (2010)
  • Author(s): Yoshohara, K., Yoshida, Y., Nagaoka, N., Fukegawa, D., Hayakawa, S., Mine, A., Nakamura, M., Minagi, S., Osaka, A., Suzuki, K., van Meerbeek, B.
  • Journal Title: Acta Biomaterialia 6 Pages: 3573-3582
  • Peer Reviewed
• [Journal Article] Mechanical properties of resin-modified glass ionomer cements for luting : Effect of adding spherical silica filler. (2010)
  • Author(s): Lihua, E., Irie, M., Nagaoka, N., Yamashiro, T., Suzuki, K.
  • Journal Title: Dental Materials Journal 29 Pages: 253-261
  • NAID: 10026470095
  • Peer Reviewed
• [Journal Article] Determinants of early interfacial-gap performance of Indirect composite restorations. (2010)
  • Author(s): Irie, M., Suzuki, K., et al
  • Journal Title: Dental Materials Volume: 26 Pages: 608-615
  • Peer Reviewed
• [Journal Article] Nano-controlled molecular interaction at adhesive interfaces for hard tissue reconstruction (2010)
  • Author(s): Yoshihara, K., Suzuki, K., et al.
  • Journal Title: Acta Biomaterialia Volume: 6 Pages: 3573-3582
  • Peer Reviewed
• [Journal Article] Mechanical properties of Resin-modified glass ionomer cements for luting (2010)
  • Author(s): Lihua, E., Suzuki, K., et al.
  • Journal Title: Dental Materials Journal Volume: 29 Pages: 253-261
  • Peer Reviewed
• [Journal Article] Delayed polishing technique on glass-ionomer restorations. (2009)
  • Author(s): Irie, M., Suzuki, K., Watts, D.C.
  • Journal Title: The Japanese Dental Science Review 45 Pages: 14-22
  • NAID: 10025820344
  • Peer Reviewed
• [Journal Article] Antibacterial effect of bactericide immobilized in resin matrix. (2009)
  • Author(s): Nanba, N., Yoshida, Y., Nagaoka, N., Takashiba, S., Matsuura-Yoshimoto, K., Maeda, H., Van Meerbeek, B., Suzuki, K.
  • Journal Title: Dental Materials 25 Pages: 424-430
  • Peer Reviewed
• [Journal Article] Delayed polishing technique on glass-ionomer restorations. (2009)
  • Author(s): Irie, M., Suzuki, S., et al.
  • Journal Title: The Japanese Dental Science Review 45 Pages: 14-22
  • NAID: 10025820344
  • Peer Reviewed
• [Journal Article] Antibacterial effect of bactericide immobilized in resin matrix. (2009)
  • Author(s): Nanba, N., Suzuki, S., et al.
  • Journal Title: Dental Materials 45 Pages: 424-430
  • Peer Reviewed
• [Journal Article] Flexral performance of flowable versus conventional light-cured composite resin in long-term in vitro study. (2008)
  • Author(s): Irie, M., Tjandrawinata, R., Lihua, E., Suzuki, K.
  • Journal Title: Dental Materials Journal 27 Pages: 300-309
  • Peer Reviewed
• [Journal Article] Fiexral Performance of Flowable versus Conventional Light-cured Composite Resins in a Long-term in vitro Study (2008)
  • Author(s): Irie, M., et al.
  • Journal Title: Dental Materials Journal 27 Pages: 300-309
  • Peer Reviewed
• [Presentation] Early no interfacial-gap incidence vs. Flexual Modulus with injectable composites (2011)
  • Author(s): Irie, M., Tamada, Y., Maruo, Y., Nishigawa, G., Oka, M., Minagi, S., Suzuki K., Watts, D.C.
  • Organizer: Annual Meeting of the IADR
  • Place of Presentation: San Diego, USA
  • Year and Date: 2011-03-19
• [Presentation] Early No Interfacial-Gap Incidence vs.Flexural Modulus with Injectable Composites (2011)
  • Author(s): Masao Irie
  • Organizer: International Association for Dental Research
  • Place of Presentation: San Diego (USA)
  • Year and Date: 2011-03-19
• [Presentation] 接着界面の最前線:界面の形成メカニズムと機能について (2010)
  • Author(s): 鈴木一臣
  • Organizer: 第28回日本接着歯学会学術大会(招待講演)
  • Place of Presentation: 松江市くにびきメッセ
  • Year and Date: 2010-01-23
• [Presentation] 接着界面の最前線 : 界面の形成メカニズムと機能について (2010)
  • Author(s): 鈴木一臣
  • Organizer: 第28回 日本接着歯学会学術大会
  • Place of Presentation: 松江市くにびきメッセ
  • Year and Date: 2010-01-23