| Co-Investigator(Kenkyū-buntansha) |
SHINDOH Masanobu 北海道大学, 大学院・歯学研究科, 教授 (20162802)
TOTSUKA Yasunori 北海道大学, 大学院・歯学研究科, 教授 (00109456)
HIGASHINO Fumihiro 北海道大学, 大学院・歯学研究科, 准教授 (50301891)
HIDA Yasuhiro 北海道大学, 北海道大学病院, 講師 (30399919)
KITAMURA Tetsuya 北海道大学, 大学院・歯学研究科, 助教 (00451451)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2010: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2009: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2008: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Research Abstract |
To develope novel anti-angiogenic therapy reflecting on tumor microenvironment more, we compared gene expression between tumor endothelial cell (TEC) and normal endothelial cell (NEC) and identified TEC specific genes by DNA microarray analysis.
We picked up these genes and analyzed the function of these molecules in TECs by knock down using siRNA.
Knock down of some genes inhibited TEC survival and some inhibited cell migration on TEC. Furthermore, inhibition of several TEC markers showed tumor growth suppression in vivo. These results suggested that it enabled us to develope novel anti-angiogenic therapy targeting TEC specifically.
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