Development of early-diagnosis and made-to-order immunotherapy fororal cancers by using cancer-specific peptides

• Project/Area Number: 20390518
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Kyushu University
• Principal Investigator: NAKAMURA Seiji 九州大学, 歯学研究院, 教授 (60189040)
• Co-Investigator(Kenkyū-buntansha): YOSHIDA Hiroki 佐賀大学, 医学部, 教授 (40260715) ; YAMADA Akira 久留米大学, 先端癌治療センター, 教授 (50158177)
• Project Period (FY): 2008 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000); Fiscal Year 2011: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2010: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2009: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2008: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
• Keywords: 癌 / 口腔癌 / 免疫療法 / T細胞 / ペプチド / 治療 / 診断 / 臨床

Research Abstract

Fully understanding of immune surveillance and regulation against cancers is needed to develop early-diagnosis and made-to-order immunotherapy for cancers by using cancer-specific peptides. In this study, SART-1 was identified to have strongest antigenicity among various cancer-specific peptides expressed on oral cancersand to play a central part in immune surveillance against oral cancers, indicating that SART-1 is most promisingly applicable to the treatment and diagnosis of oral cancers.In contrast, it was revealed that a tumor-associated antigen, RCAS1, was expressed on and secreted from oral cancers, induced apoptosis of activated T cells, and thussuppressed immune surveillance against oral cancers. To augment immune surveillance against oral cancers, it was strongly suggested that functional regulation of RCAS1, as well as inoculation of SART-1, should be achieved.

Research Products

• [Journal Article] In vitro induction of specific CD8(+) T lymphocytes by tumorassociated antigenic peptides in patients with oral squamous cell carcinoma (2012)
  • Author(s): Toyoshima, T., Kumamaru, W., Hayashida, J.-N., Moriyama, M., Kitamura, R., Tanaka, H., Yamada, A., Itoh, K., and Nakamura, S.
  • Journal Title: Cancer Lett Volume: 322 Issue: 1 Pages: 86-91
  • DOI: 10.1016/j.canlet.2012.02.016
  • Peer Reviewed
• [Journal Article] In vitro induction of specific CD8+ T lymphocytes by tumor-associated antigenic peptides in patients with oral squamous cell carcinoma (2012)
  • Author(s): Toyoshima T, Kumamaru W, Hayashida J-N, Moriyama M, Kitamura R, Tanaka H, Yamada A, Itoh K, Nakamura S
  • Journal Title: Cancer Letter Volume: (In press)
  • Peer Reviewed
• [Journal Article] Increased ΔNp63 expression is predictive of malignant transformation in oral epithelial dysplasia and poor prognosis in oral squamous cell carcinoma (2011)
  • Author(s): Matsubara, R., Kawano, S., Kiyosue, T., Goto, Y., Hirano, M., Jinno, T.,Toyoshima, T., Kitamura, R., Oobu, K., and Nakamura S
  • Journal Title: Int. J. Oncol Volume: 39 Pages: 1391-9
  • DOI: 10.3892/ijo.2011.1151
• [Journal Article] Association of T cell regulatory gene polymorphisms with oral squamous cell carcinoma (2010)
  • Author(s): Toyoshima, et al.
  • Journal Title: Oral Oncology (In press)
  • Peer Reviewed
• [Presentation] 口腔扁平上皮癌由来細胞株における腫瘍関連抗原RCAS1(receptor-binding caner antigen expressed on SiSo cells)の発現と機能についての検討 (2013)
  • Author(s): 田中秀明、豊嶋健史、園田顕三、北村亮二、川野真太郎、平野充広、神野哲平、笹栗正明、大部一成、中村誠司
  • Organizer: 第31回日本口腔腫瘍学会学術大会
  • Place of Presentation: 東京
  • Year and Date: 2013-01-24
• [Presentation] 口腔扁平上皮癌における CTLA-4 遺伝子多型の発現 (2011)
  • Author(s): 豊嶋健史、北村亮二、川野真太郎、新井伸作、清末崇裕、松原良太、後藤雄一、久保慶朗、田中秀明、大部一成、中村誠司
  • Organizer: 第29回日本口腔腫瘍学会学術大会
  • Place of Presentation: 熊本
  • Year and Date: 2011-01-27
• [Presentation] 口腔癌に対する癌ワクチン療法の現状と展望(シンポジウム) (2011)
  • Author(s): 中村誠司
  • Organizer: 第29回日本口腔腫瘍学会学術大会
  • Place of Presentation: 熊本
  • Year and Date: 2011-01-27
• [Presentation] 口腔癌に対する癌ワクチン療法の現状と展望 (2011)
  • Author(s): 中村誠司
  • Organizer: 第29回日本口腔腫瘍学会学術大会
  • Place of Presentation: 崇城大学市民ホール(熊本)
  • Year and Date: 2011-01-27
• [Presentation] 口腔扁平上皮癌に対するCTLA-4遺伝子多型の発現 (2011)
  • Author(s): 豊嶋健史、北村亮二、川野真太郎、新井伸作、清末崇裕、松原良太、後藤雄一、久保慶朗、田中秀明、大部一成、中村誠司
  • Organizer: 第29回日本口腔腫瘍学会学術大会
  • Place of Presentation: 崇城大学市民ホール(熊本)
  • Year and Date: 2011-01-27
• [Presentation] 口腔癌に対する癌ワクチン療法の現状と展望(シンポジウム) (2011)
  • Author(s): 中村誠司(座長)
  • Organizer: 第29回日本口腔腫瘍学会学術大会
  • Place of Presentation: 崇城大学市民ホール
  • Year and Date: 2011-01-27
• [Presentation] 口腔扁平上皮癌におけるCTLA-4遺伝子多型の発現 (2011)
  • Author(s): 豊嶋健史, 他
  • Organizer: 第29回日本口腔腫瘍学会学術大会
  • Place of Presentation: 崇城大学市民ホール
  • Year and Date: 2011-01-27
• [Presentation] 口腔扁平上皮癌におけるΔNp63 の発現と機能 (2010)
  • Author(s): 松原良太、川野真太郎、清末崇裕、後藤雄一、中尾 祐、豊嶋健史、梯 裕恵、吉賀大午、北村亮二、大部一成、中村誠司
  • Organizer: 第55回日本口腔外科学会総会 ・学術大会
  • Place of Presentation: 千葉
  • Year and Date: 2010-10-16
• [Presentation] Possible involvement of ΔNp63 in proliferation and differentiation of OSCC (2010)
  • Author(s): Matsubara, R., Kawano, S., Kiyosue, T., Goto, Y., Nakao, Y., Yoshiga, D., Oobu, K., and Nakamura S
  • Organizer: 10thBiennial Congress of the European Association of Oral Medicine
  • Place of Presentation: London
  • Year and Date: 2010-09-23
• [Presentation] 口腔扁平上皮癌におけるΔNp63 の発現と機能 (2010)
  • Author(s): 松原良太、川野真太郎、清末崇裕、後藤雄一、中尾祐、豊嶋健史、梯 裕恵、吉賀大午、北村亮二、大部一成、中村誠司
  • Organizer: 第64回日本口腔科学会・学術集会
  • Place of Presentation: 札幌
  • Year and Date: 2010-06-25
• [Presentation] 口腔扁平上皮癌における上皮幹細胞マーカー(p63、p75NTR)に関する研究 (2009)
  • Author(s): 松原良太、川野真太郎、清末崇裕、後藤雄一、吉賀大午、豊嶋健史、梯 裕恵、大部一成、中村誠司
  • Organizer: 第54回日本口腔外科学会総会 ・学術大会
  • Place of Presentation: 札幌
  • Year and Date: 2009-10-09