Exploration of biological marker of insomnia

• Project/Area Number: 20406006
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 海外学術
• Research Field: Environmental pharmacy
• Research Institution: Osaka Bioscience Institute
• Principal Investigator: ARITAKE Kosuke Osaka Bioscience Institute, 研究員 (70390804)
• Co-Investigator(Kenkyū-buntansha): KAMAUCHI Shinya 財団法人大阪バイオサイエンス研究所, 分子行動生物学部門, 研究員 (00397564) ; MARUYAMA Toshihiko 財団法人大阪バイオサイエンス研究所, 分子行動生物学部門, 研究員 (70414133) ; HOSHIKAWA Yumiko 財団法人大阪バイオサイエンス研究所, 分子行動生物学部門, 研究員 (10390808) ; HAYAISHI OSAMU 財団法人大阪バイオサイエンス研究所, 分子行動生物学部門, 研究員 (40025507) ; NAGATA Nanae 財団法人大阪バイオサイエンス研究所, 分子行動生物学部門, 研究員 (80390805)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥13,780,000 (Direct Cost: ¥10,600,000、Indirect Cost: ¥3,180,000); Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2009: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2008: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
• Keywords: 睡眠障害 / リポカリン / プロスタグランジンD合成酵素 / オレキシン / ヒスタミン / アデノシン / 等電点電気泳動

Research Abstract

We evaluated the changes of sleep-wake promoting substances in the cerebrospinal fluid (CSF) and serum of patients with sleep disorders carry out with the sleep research group at Zurich University. Lipocalin-type prostaglandin D synthase (L-PGDS) levels in CSF of narcoleptic patients were significantly lower than those of the control, while those from patients with Parkinson's disease were significantly higher as compared with those of the control. As compared with the CSF of the controls, histamine levels in CSF of patients with multiple sclerosis were significantly higher and so as the inosine level in CSF of patients with sleep disorders. These results indicated that L-PGDS, histamine and inosine are new biological marker of sleep disorders.

Research Products

• [Journal Article] (2011)
  • Author(s): Inaka K, Takahashi S, Aritake K, Tsurumura T, Furubayashi N, Yan B, Hirota E, Sano S, Sato M, Kobayashi T, Yoshimura Y, Tanaka H
  • Journal Title: Cryst Growth Des. Jun1;11(6) Pages: 2107-2111
• [Journal Article] Improvement in the quality of hematopoietic prostaglandin D synthase crystals in a microgravity environment (2011)
  • Author(s): Tanaka H, Tsurumura T, Aritake K, et al.
  • Journal Title: J Synchrotron Radiat 18(1)
• [Journal Article] High-quality crystals of human haematopoietic prostaglandin D synthase with novel inhibitors. (2011)
  • Author(s): Takahashi S, Tsurumura T, Aritake K, et al.
  • Journal Title: Acta Crystallogr Sect F Struct Biol CrystCommun Volume: 66(Pt7) Pages: 846-850
  • Peer Reviewed
• [Journal Article] Increased expression of lipocalin-type-prostaglandin D synthase in ulcerative colitis and exacerbating role in murine colitis. (2011)
  • Author(s): Hokari R, Kurihara C, Nagata N, et al.
  • Journal Title: Am J Physiol Gastroin test Liver Rbysiol. Volume: 300(3)
  • Peer Reviewed
• [Journal Article] Improvement in the quality of hematopoietic prostaglandin D synthase crystals in a microgravity environment. (2011)
  • Author(s): Tanaka H, Tsurumura T, Aritake K, et al.
  • Journal Title: J Synchrotron Radiat Volume: 18(1) Pages: 88-91
  • Peer Reviewed
• [Journal Article] A novel and comprehensive mouse model of human non-alcoholic steatohepatitis with the full range of dysmetabolic and histological abnormalities induced by gold thioglucose and a high-fat diet. (2011)
  • Author(s): Ogasawara M, Hirose A, Ono M, Aritake K, et al.
  • Journal Title: Liver Int. Volume: 31(4) Pages: 542-551
  • Peer Reviewed
• [Journal Article] Pronounced adipogenesis and increased insulin sensitivity caused by overproduction of prostaglandin D_2 in vivo (2010)
  • Author(s): Fujitani Y, Aritake K, Kanaoka Y, Goto T, Takahashi N, Fujimori K, Kawada T
  • Journal Title: FEBS J. 277(6) Pages: 1410-9
• [Journal Article] Suppression of Adipocyte differentiation by aldo-keto reductase 1B3 acting as prostaglandin F_<2α> synthase (2010)
  • Author(s): Fujimori K, Ueno T, Nagata N, Kashiwagi K, Aritake K, Amano F, Urade Y
  • Journal Title: J Biol Chem. 285(12) Pages: 8880-6
• [Journal Article] Effects of human recombinant-interferon β in experimental autoimmune encephalomyelitis in guinea pigs. (2010)
  • Author(s): Aritake K, Koh CS, et al.
  • Journal Title: Pharm Biol. Volume: 48(11) Pages: 1273-1279
  • Peer Reviewed
• [Journal Article] Pronounced adipogenesis and increased insulin sensitivity caused by overproduction of prostaglandin D_2 in vivo (2010)
  • Author(s): Fujitani Y, Aritake K, et al.
  • Journal Title: FEBS J. 277 Pages: 1410-1419
  • Peer Reviewed
• [Journal Article] Suppression of adipocyte differentiation by aldo-keto reductase 1B3 acting as prostaglandin F2alpha synthase (2010)
  • Author(s): Fujimori K, Ueno T, et al.
  • Journal Title: J Biol Chem. 285 Pages: 8880-8886
  • Peer Reviewed
• [Journal Article] Structural basis of the catalytic mechanism operating in open-closed conformers of lipocalin type prostaglandin D synthase (2009)
  • Author(s): Kumasaka T, Aritake K, Ago H, Irikura D, Tsurumura T, Yamamoto M, Miyano M, Urade Y, Hayaishi O
  • Journal Title: J Biol Chem. 284(33) Pages: 22344-52
• [Journal Article] he PGD_2 pathway, independently of FGF9, amplifies SOX9 activity in Sertoli cells during male sexual differentiation (2009)
  • Author(s): Moniot B, Declosmenil F, Barrionuevo F, Scherer G, Aritake K, Malki S, Marzi L, Cohen-Solal A, Georg I, Klattig J, Englert C, Kim Y, Capel B, Eguchi N, Urade Y, Boizet-Bonhoure B, Poulat F
  • Journal Title: Development 136(11) Pages: 1813-21
• [Journal Article] Biochemical, functional and pharmacological characterization of AT-56, an orally active and selective inhibitor of lipocalin-type prostaglandin d synthase (2009)
  • Author(s): Irikura D, Aritake K, Nagata N, Maruyama T, Shimamoto S, Urade Y
  • Journal Title: J Biol Chem. 284(12) Pages: 7623-30
• [Journal Article] Structural basis of the catalytic mechanism operating in open-closed conformers of lipocalin type prostaglandin D synthase (2009)
  • Author(s): Kumasaka T, Aritake K, et al.
  • Journal Title: J Biol Chem. 284 Pages: 22344-22352
  • Peer Reviewed
• [Journal Article] Sessa, WC. R Role of prostaglandin D_2 receptor DP as a suppressor of tumor hyperpermeability and angiogenesis in vivo (2008)
  • Author(s): Murata, T, Lin, MI, Aritake K, Matsumoto, S, Narumiya, S, Ozaki, H, Urade, Y, Hori, M
  • Journal Title: Proc Natl Acad Sci USA 105 Pages: 20009-20014
• [Journal Article] Enhancement of prostaglandin D2 production through cyclooxygenase-2 and lipocalin-type prostaglandin D synthase by upstream stimulatory factor 1 in human brain-derived TE671 cells under serum starvation (2008)
  • Author(s): Fujimori, K, Aritake, K. Urade, Y
  • Journal Title: Gene 426 Pages: 72-80
• [Presentation] Endogenous Sleep-promoting Substances (2010)
  • Author(s): Kosuke Aritake
  • Organizer: 2010 Beijing Sleep Medicine Forum
  • Place of Presentation: 北京(中国)
  • Year and Date: 2010-04-18
• [Presentation] Endogenous Sleep-promoting Substances (2010)
  • Author(s): Kosuke Aritake
  • Organizer: 2010Beijing Sleep Medicine Forum
  • Place of Presentation: 北京(中国)
  • Year and Date: 2010-04-18
• [Presentation] Lipocalin-type prostaglandin D synthase : a transporter of prostaglandin D_2 and scavenger of prostaglandin D2-degraded products (2009)
  • Author(s): Kosuke Aritake
  • Organizer: 34th FEBS Congress
  • Place of Presentation: プラハ(チェコ)
  • Year and Date: 2009-07-06
• [Presentation] リポカリン型PGD合成酵素のPGD_2の輸送と結合に関する解析 (2008)
  • Author(s): 有竹浩介
  • Organizer: 第81回日本生化学会大会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2008-12-12
• [Presentation] Lipocalin-type prostaglandin D synthase is a transporter and a scavenger of prostaglandin D_2 (2008)
  • Author(s): Kosuke Aritake
  • Organizer: 33^<rd> FEBS Congress&11^<th> IUBMB Conference
  • Place of Presentation: アテネ(ギリシャ)
  • Year and Date: 2008-07-03
• [Remarks] ホームページ等