| Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2010: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2009: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2008: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
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| Research Abstract |
We have carried out the genomic epidemiology and immunological cohort study on amoebiasis in Bangladesh and found that Entamoeba moshkovskii was prevalent in Bangladesh. E. moshkovskii is morphologically indistinguishable from pathogenic E. histolytica and non-pathogenic Entamoeba dispar. As E. moshkovskii has been considered to be a non-pathogenic or a free living amoeba, there are few studies to elucidate the pathogenicity of it. Thus, we carried out the study to clarify the pathogenicity of E. moshkovskii. The prevalence of each Entamoeba spp. in diarrheal episode was examined in Bangladesh and several cases that were positive only for E. moshkovskii but negative for other conceivable diarrhea-causative microbes were found. E. moshkovskii was found to be pathogenic to mice and to well associate with diarrheal episode in Bangladeshi children. Therefore it is important to re-estimate the pathogenicity of E. moshkovskii.
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