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A Molecular-epidemiological study of oral and maxillofacial disease among the residents living in Semipalatinsk nuclear test site in Kazakhstan

Research Project

Project/Area Number 20406030
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Surgical dentistry
Research InstitutionHiroshima University

Principal Investigator

OKAMOTO Tetsuji  広島大学, 大学院・医歯薬保健学研究院, 教授 (00169153)

Co-Investigator(Kenkyū-buntansha) YOSHIOKA Yukio  広島大学, 大学院・医歯薬保健学研究院, 助教 (20335665)
FUKUI Yasuto  広島大学, 大学院・医歯薬保健学研究院, 助教 (90363085)
HOSHI Masaharu  広島大学, 原爆放射線医科学研究所, 名誉教授 (50099090)
Project Period (FY) 2008 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2010: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2008: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Keywordsセミパラチンスク核実験場 / 低線量放射線被ばく / 先天異常 / 分子疫学 / 遺伝子多型 / 口腔疾患罹患率 / 唇顎口蓋裂発症率 / 顎口腔顔面疾患 / 低線量被ばく / インターロイキン1 / 歯周病 / 顎顔面口腔疾患 / 口腔常在菌 / ヘリコバクターピロリ菌 / 低線量被曝 / 先天奇形 / Tie-2 / 唇顎口蓋裂 / 歯周疾患 / 口唇口蓋裂 / 放射線影響 / 核実験 / カザフスタン共和国 / 放射能被爆 / IL-1α(889)遺伝子多型 / IL-1β(-511)遺伝子多型 / 喪失歯数
Research Abstract

From1949 to 1989, 30 surface, 88 atmospheric and 340 underground nuclear and thermonuclear explosions of nuclear weapons were carried out by former Soviet Union at the Semipalatinsk Nuclear Test Site (SNTS) in Kazakhstan that resulted in high local fallout affecting the residents in the villages adjacent to the SNTS. The radiation effect on predisposition of oral and maxillofacial disorders among the exposed people from the SNTS areas remains unknown. The purpose of this study is to investigate a possible relationship between long-term radiation exposure by nuclear testing and predisposition of Oral maxillofacial anomalies such as Cleft lip & Palate (CLP) and oral diseases such as periodontitis. In conclusion, this study strongly suggests that the inhabitants in exposed villages adjacent to SNTS might be considered a population at risk for high prevalence oforal & maxillofacial lesions. It is possible that this heightened risk resulted from long-term radiation exposure.

Report

(7 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report   Self-evaluation Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (85 results)

All 2013 2012 2011 2010 2009 2008

All Journal Article (44 results) (of which Peer Reviewed: 44 results) Presentation (39 results) (of which Invited: 1 results) Book (2 results)

  • [Journal Article] Ectomesenchymal chondromyxoid tumor of the tongue: insights on histogenesis.2013

    • Author(s)
      Yoshioka Y, Fukui Y, Okamoto T. 他6名
    • Journal Title

      Oral Surg Oral Med Oral Pathol Oral Radiol

      Volume: 115(2) Pages: 233-40

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ameloblastic carcinoma, secondary type, of the mandible: a case report.2013

    • Author(s)
      Yoshioka Y, Toratani S, Ogawa I, Okamoto T.
    • Journal Title

      J Oral Maxillofac Surg

      Volume: 71(1) Pages: 58-62

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Long-term serial cultivation of mouse induced pluripotent stem cells in serum-free and feeder-free defined medium2013

    • Author(s)
      S. Yamasaki, K. Nabeshima, Y.Sotomaru, Y. Taguchi, H. Mukasa, MK. Furue, J. Denry Sato, T. Okamoto
    • Journal Title

      International Journal of Developmental Biology

      Volume: 未定

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Review Paper: Biomedical advances from tissue culture,2013

    • Author(s)
      T.Okamoto, J. Denry Sato, David W. Barnes, and Gordon H. Sato,
    • Journal Title

      Cytotechnology

      Volume: 未定

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ectomesenchymal chondromyxoid tumor of the tongue: insights on histogenesis.2013

    • Author(s)
      Yoshioka Y, , Toratani S, Okamoto T. 他3名
    • Journal Title

      Oral Surg Oral Med Oral Pathol Oral Radiol.

      Volume: Feb;115(2) Issue: 2 Pages: 233-240

    • DOI

      10.1016/j.oooo.2012.11.008

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ameloblastic carcinoma, secondary type, of the mandible: a case report.2013

    • Author(s)
      Yoshioka Y, Toratani S, Ogawa I, Okamoto T.
    • Journal Title

      J Oral Maxillofac Surg.

      Volume: Jan;71(1) Issue: 1 Pages: 58-62

    • DOI

      10.1016/j.joms.2012.09.005

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 1α,25(OH)2D3down-regulatesHBp17/FGFBP-1 expression via NF-κBpathway2012

    • Author(s)
      Rosli SN, Shintani T, Hayashido Y, Toratani S, Usui E, Okamoto T
    • Journal Title

      J Steroid Biochem Mol Biol.

      Volume: 12 Pages: 212-9

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel cytotoxic polyoxygenated steroids from an Okinawan sponge Dysidea sp.2012

    • Author(s)
      Yoshioka Y, Okamoto T, Ojika M. 他4名
    • Journal Title

      Biosci Biotechnol Biochem.

      Volume: 76(5) Pages: 999-1002

    • NAID

      10030753103

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cyclolobatriene, a novel prenylated germacrene diterpene, from the soft coral Lobophytum pauciflorum.2012

    • Author(s)
      Yoshioka Y, Okamoto T, Ojika M. 他3名
    • Journal Title

      Bioorg Med Chem

      Volume: 20(2) Pages: 687-92

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 1α,25(OH)2D3 down-regulates HBp17/FGFBP-1 expression via NF-κBpathway.2012

    • Author(s)
      Rosli SN, Shintani T, Hayashido Y, Toratani S, Usui E, Okamoto T.
    • Journal Title

      J Steroid Biochem Mol Biol.

      Volume: Oct 24.(12) Pages: 212-219

    • DOI

      10.1016/j.jsbmb.2012.10.011

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cyclolobatriene, a novel prenylated germacrene diterpene, from the soft coral Lobophytum pauciflorum.2012

    • Author(s)
      Govindam SV, Yoshioka Y, Kanamoto A, Fujiwara T, Okamoto T, Ojika M.
    • Journal Title

      Bioorg Med Chem.

      Volume: 15;20(2) Issue: 2 Pages: 2687-692

    • DOI

      10.1016/j.bmc.2011.12.012

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 鎖骨頭蓋異形成症患者歯髄由来細胞を用いた疾患特異的ヒト人工多能性幹細胞 (iPS細胞)の樹立2012

    • Author(s)
      向笠英恵、山崎佐知子、田口有紀、嶋本顕、田原 栄俊、岡本哲治
    • Journal Title

      本口腔組織培養学会誌

      Volume: 第22巻 Pages: 15-16

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Influence Of The Lop Nor Nuclear Weapons Test Base To The Population Of The Republic Of Kazakhstan2011

    • Author(s)
      Zhumadilov K., Okamoto, T., Hoshi-M., 他3名
    • Journal Title

      Radiation Measurements

      Volume: 46 Pages: 425-429

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] FGFR1 abrogates inhibitory effect of androgen receptor concurrent with induction of androgen-receptor variants in androgen receptor-negative prostate tumor epithelial cells.2011

    • Author(s)
      Kobayashi M, Okamoto T, Wang F, McKeehan WL. 他3名
    • Journal Title

      Prostate

      Volume: 71(15) Pages: 1691-700

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Growth factor-defined culture medium for human mesenchymal stem cells.2011

    • Author(s)
      Mimura S, Okamoto T, Furue MK. 他7名
    • Journal Title

      Int J Dev Biol

      Volume: 55(2) Pages: 181-187

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Influence of the Lop Nor Nuclear Weapons Test Base to the Population of the Republic of Kazakhstan2011

    • Author(s)
      Zhumadilov, K., Okamoto, T., Hoshi-M., et al.
    • Journal Title

      Radiation Measurements

      Volume: 46 Pages: 425-429

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FGFR1 abrogates inhibitory effect of androgen receptor concurrent with induction of androgen-receptor variants in androgen receptor-negative prostate tumor epithelial cells2011

    • Author(s)
      Kobayashi M, Huang Y, Jin C, Luo Y, Okamoto, T, Wang F, McKeehan WL
    • Journal Title

      Prostate. : 2011

      Volume: Nov ; 71(15) Pages: 1691-1700

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Growth factor-defined culture medium for human mesenchymal stem cells2011

    • Author(s)
      Mimura S, Kimura N, Okamoto, T, et al.
    • Journal Title

      Int J Dev Biol

      Volume: 55(2) Pages: 181-187

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FGFRI abrogates inhibitory effect of androgen receptor concurrent with induction of androgen-receptor variants in androgen receptor-negative prostate tumor epithelial cells.2011

    • Author(s)
      Kobayashi M, Huang Y, Okamoto T Wang, F, McKeehan WL., et al.
    • Journal Title

      Prostate,doi : 10.1002/pros.21386 (Epub ahead of print)

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Growth factor-defined culture medium for human mesenchymal stem cells.2011

    • Author(s)
      Mimura S, Kimura N, Okamoto T, et al.
    • Journal Title

      Int J Dev Biol (Epub ahead of print)

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] The Influence of The Lop Nor Nuclear Weapons Test Base To The Population of The Republic of Kazakhstan2011

    • Author(s)
      Zhumadilov K., Okamoto, T., Hoshi-M., et al.
    • Journal Title

      Radiation Measurements. Measurements 46

      Pages: 425-429

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] FGFR1 abrogates inhibitory effect of androgen receptor concurrent with induction of androgen-receptor variants in androgen receptor-negative prostate tumor epithelial cells.2011

    • Author(s)
      Kobayashi M, Huang Y, Jin C, Luo Y, Okamoto T, Wang F, McKeehan WL.
    • Journal Title

      Prostate, doi:10.1002/pros.21386.

      Volume: Mar 28(印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Growth factor-defined culture medium for human mesenchymal stem cells.2011

    • Author(s)
      Mimura S, Kimura N, Okamoto T, et al.
    • Journal Title

      Int J Dev Biol.

      Volume: Feb 3(印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Influence Of The Lop Nor Nuclear Weapons Test Base To The Population Of The Republic Of Kazakhstan2011

    • Author(s)
      Zhumadilov K., Okamoto, T., Hoshi-M., et al.
    • Journal Title

      Radiation Measurements.

      Volume: 46 Pages: 425-429

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tissue culture: the unlimited potential2010

    • Author(s)
      Sato GH, Sato JD, Okamoto T, McKeehan WL, Barnes DW
    • Journal Title

      In Vitro Cell Dev Biol Anim.

      Volume: 46(7) Pages: 590-4

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Advantages and difficulties in culturing human pluripotent stem cells in growth factor-defined serum-free medium.2010

    • Author(s)
      Furue MK, Okamoto T, Sato JD. 他3名
    • Journal Title

      In Vitro Cell Dev Biol Anim

      Volume: 46(7) Pages: 573-6

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Binding of APC and dishevelled mediates Wnt5a-regulated focal adhesion dynamics in migrating cells.2010

    • Author(s)
      Matsumoto S, Fumoto K, Okamoto T, Kaibuchi K, Kikuchi A
    • Journal Title

      EMBO J

      Volume: 29(7) Pages: 1192-204

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Binding of APC and dishevelled mediates Wnt5a-regulated focal adhesion dynamics in migrating cells.2010

    • Author(s)
      Matsumoto, S., Okamoto, T., Kikuchi, A., et al.
    • Journal Title

      The EMBO Journal 29

      Pages: 1192-1204

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Tissue culture : the unlimited potential.2010

    • Author(s)
      Sato GH, Sato JD, Okamoto T, McKeehan WL, Barnes DW.
    • Journal Title

      In Vitro Cell Dev Biol Anim.

      Volume: Jul 46(7) Pages: 590-594

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Advantages and difficulties in culturing human pluripotent stem cells in growth factor-defined serum-free medium.2010

    • Author(s)
      Kusuda Furue M, Tateyama D, Okamoto T, Sato JD., et al.
    • Journal Title

      In Vitro Cell Dev Biol Anim.

      Volume: Jul 46(7) Pages: 573-576

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Binding of APC and dishevelled mediates Wnt5a-regulated focal adhesion dynamics in migrating cells2010

    • Author(s)
      Matsumoto, S., et al
    • Journal Title

      The EMBO Journal 29

      Pages: 1192-1204

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ESR dosimetry study on population of settlements nearby Ust-Kamenogorsk city, Kazakhstan2009

    • Author(s)
      Zhumadilov K, Ivannikov A, Zharlyganova D, Zhumadilov Z, Stepanenko V, Apsalikov K, Ali MR, Zhumadilova A, Toyoda S, Endo S, Tanaka K, Okamoto T, Hoshi M
    • Journal Title

      Radiat Environ Biophys.

      Volume: 48(4) Pages: 419-25

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] ESR dosimetry study on population of settlements nearby Ust-Kamenogorsk city, Kazakhstan.2009

    • Author(s)
      Zhumadilov K, Okamoto T., Hoshi, M., et al.
    • Journal Title

      Radiat Environ Biophys Nov:48(4)

      Pages: 419-425

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] β-Catenin-independent Wnt signaling regulates cell migration, polarity, and morphogenesis2009

    • Author(s)
      Matsumoto, S., et al.
    • Journal Title

      Tissue Culture Research Communications Vol.28

      Pages: 117-128

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ESR dosimetry study on population of settlements nearby Ust-Kamenogorsk city, Kazakhstan2009

    • Author(s)
      Zhumadilov K, et al.
    • Journal Title

      Radiat Environ Biophys. Nov.48(4)

      Pages: 419-425

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heparin promotes the growth of human embryonic stem cells in a defined serum-free medium2008

    • Author(s)
      Furue MK, Okamoto T, Sato JD, Andrews PW. 他6名
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 105(36) Pages: 13409-14

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] High prevalence of cleft lip and palate deformities among the residents of the Semipalatinsk nuclear test site area in Kazakhstan.2008

    • Author(s)
      Zhumadilova, A., Hoshi, M., Okamoto, T. 他9名
    • Journal Title

      Indian Journal of Radiation Research (IJRR)

      Volume: Volume: 5, No.1 Pages: 1-6

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Coincident two mutations and one single nucleotide polymorphism of the PTCH1 gene in a family with naevoid basal cell carcinoma syndrome.2008

    • Author(s)
      Yan Z, Okamoto T,Tokura Y. 他4名
    • Journal Title

      Acta Derm Venereol.

      Volume: 88(6) Pages: 635-6

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] High prevalence of cleft lip and palate deformities among the residents of the Semipalatinsk nuclear test site area in Kazakhstan.2008

    • Author(s)
      Zhumadilova A., Sakamoto A., Yoshioka Y., Hoshi M., Okamoto, T., et al.
    • Journal Title

      Indian Journal of Radiation Research (IJRR), ISSN : 0449-3060 Volume:5,No. : 1-2

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Heparin promotes the growth of human embryonic stem cells in a defined serum-free medium.2008

    • Author(s)
      Furue, MK., Na J., Jackson JP, Okamoto, T., et al.
    • Journal Title

      Proc Natl Acad Sci USA 105(36)

      Pages: 13409-13414

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Coincident two mutations and one single nucleotide polymorphism of the PTCHl gene in a family with naevoid basal cell carcinoma syndrome.2008

    • Author(s)
      Abe S, Kabashima K, Sakabe J, Shimauchi T, Yan Z, Okamoto T, Tokura Y.
    • Journal Title

      Acta Derm Venereol 88(6)

      Pages: 635-636

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Heparin promotes the growth of human embryonic stem cells in a defined serum-free medium.2008

    • Author(s)
      Fume MK, Na J, Jackson JP, Okamoto T, Jones M, Baker D, Hata R, Moore HD, Sato JD, Andrews PW.
    • Journal Title

      Proc Natl Acad Sci USA. Sep9 ; 105(36)

      Pages: 13409-13414

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Review article : Chemically defined serum-free culture for mouse embryonic stemcells2008

    • Author(s)
      Y. Hayashi, MK Furue, Y. Myoishi. T. Okamoto
    • Journal Title

      Tissue Culture Research Communications Vol. 27, No. 3

      Pages: 107-115

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Coincident two mutations and one single nucleotide polymorphism of the PTCH1 gene in a family with naevoid basal cell carcinoma syndrome.2008

    • Author(s)
      Abe S, Kabashima K, Sakabe J, Shimauchi T, Yan Z, Okamoto T, Tokura Y.
    • Journal Title

      Acta Derm Venereol 88(6)

      Pages: 635-646

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Analysis of binding site of ubiquitin ligase, human double minute 2 in integrin β8 in Oral Squamous Cell Carcinoma cell lines2013

    • Author(s)
      Sakaue T., Hayashido Y., Hamana T., Fujii T., Okamoto T.
    • Organizer
      The 2th International Symposium Suggestion for the Renaissance from Radiation Disaster
    • Place of Presentation
      Hiroshima
    • Year and Date
      2013-02-11
    • Related Report
      2012 Final Research Report
  • [Presentation] 1α,25(OH)2D3down-regulates FGF-BP expression through NFκBpathway2013

    • Author(s)
      Rosli S.N.Z., Shintani T., Hayashido Y., Toratani S., Usui E., Okamoto T.
    • Organizer
      The 2th International Symposium Suggestion for the Renaissance from Radiation Disaster
    • Place of Presentation
      Hiroshima
    • Year and Date
      2013-02-11
    • Related Report
      2012 Final Research Report
  • [Presentation] Generation of disease-specific human induced pluripotent stem (iPS) cells fromdental pulp cells of a patient with Cleidocranial dysplasia in serum-and feeder-free culture2013

    • Author(s)
      Mukasa H., Yamasaki S., Okamoto T.
    • Organizer
      The 2th International Symposium Suggestion for the Renaissance from Radiation DisasterThe 2th International Symposium Suggestion for the Renaissance from Radiation Disaster
    • Place of Presentation
      Hiroshima
    • Year and Date
      2013-02-11
    • Related Report
      2012 Final Research Report
  • [Presentation] Generation of induced pluripotent stem cells from dental pulp cells in serum-free and feeder-free culture condition2013

    • Author(s)
      Taguchi Y., Yamasaki S., ShimamotoA., Tahara H.,Okamoto T.
    • Organizer
      The 2th International Symposium Suggestion for the Renaissance from Radiation Disaster
    • Place of Presentation
      Hiroshima
    • Year and Date
      2013-02-11
    • Related Report
      2012 Final Research Report
  • [Presentation] Participation of heterodimer formation with integrin αv subunit in the stability of integrin β8 subunit in squamous cell carcinoma cells2013

    • Author(s)
      Participation of heterodimer formation with integrin αv subunit in the stability of integrin β8 subunit in squamous cell carcinoma cells
    • Organizer
      The 2th International Symposium Suggestion for the Renaissance from Radiation Disaster
    • Place of Presentation
      Hiroshima
    • Year and Date
      2013-02-11
    • Related Report
      2012 Final Research Report
  • [Presentation] Analysis of binding site of ubiquitin ligase, human double minute 2 in integrin β8 in Oral Squamous Cell Carcinoma cell lines2013

    • Author(s)
      Sakaue T., Hayashido Y., Hamana T., Fujii T. and Okamoto T
    • Organizer
      The 2nd International Symposium Suggestion for the Renaissance from Radiation Disaster
    • Place of Presentation
      Hiroshima
    • Related Report
      2012 Annual Research Report
  • [Presentation] Generation of disease-specific human induced pluripotent stem (iPS) cells from dental pulp cells of a patient with Cleidocranial dysplasia in serum-and feeder-free culture2013

    • Author(s)
      Mukasa H., Yamasaki S. and Okamoto T.
    • Organizer
      The 2nd International Symposium Suggestion for the Renaissance from Radiation Disaster
    • Place of Presentation
      Hiroshima
    • Related Report
      2012 Annual Research Report
  • [Presentation] Generation of induced pluripotent stem cells from dental pulp cells in serum-free and feeder-free culture condition2013

    • Author(s)
      Taguchi Y., Yamasaki S., ShimamotoA., Tahara H. and Okamoto T.
    • Organizer
      The 2nd International Symposium Suggestion for the Renaissance from Radiation Disaster
    • Place of Presentation
      Hiroshima
    • Related Report
      2012 Annual Research Report
  • [Presentation] Participation of heterodimer formation with integrin αv subunit in the stability of integrin β8 subunit in squamous cell carcinoma cells2013

    • Author(s)
      Fujii T., Hayashido Y., Hamana T., Sakaue T. and Okamoto T.
    • Organizer
      The 2nd International Symposium Suggestion for the Renaissance from Radiation Disaster
    • Place of Presentation
      Hiroshima
    • Related Report
      2012 Annual Research Report
  • [Presentation] 1α,25(OH)2D3down-regulates HBp17/FGFBP-1 by inhibiting NF κ B activity2012

    • Author(s)
      Rosli S.N.Z.、新谷智章、笛吹恵美子、岡本哲治
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-15
    • Related Report
      2012 Final Research Report
  • [Presentation] インテグリンβ8 におけるユビキチンリガーゼ human double minute 2 (hdm2) 結合部位の探索2012

    • Author(s)
      藤井隆彦,林堂安貴,坂上泰士,浜名智昭,岡本哲治
    • Organizer
      第49回日本口腔組織培養学会
    • Place of Presentation
      広島
    • Year and Date
      2012-11-12
    • Related Report
      2012 Final Research Report
  • [Presentation] 鎖骨頭蓋異形成症患者歯髄由来細胞を用いた疾患特異的ヒト人工多能性幹細胞 (iPS 細胞)の樹立2012

    • Author(s)
      向笠英恵、山崎佐知子、田口有紀、嶋本顕、田原栄俊、岡本哲治
    • Organizer
      第49回日本口腔組織培養学会
    • Place of Presentation
      広島
    • Year and Date
      2012-11-12
    • Related Report
      2012 Final Research Report
  • [Presentation] 1α,25(OH)2D3suppresses HBp17/FGFBP-1 expression via NFκB pathway in oral squamous cell carcinoma2012

    • Author(s)
      Rosli S.N.Z.、新谷智章、林堂安貴、笛吹恵美子、 岡本哲治
    • Organizer
      第49回日本口腔組織培養学会
    • Place of Presentation
      広島
    • Year and Date
      2012-11-12
    • Related Report
      2012 Final Research Report
  • [Presentation] 広島大学の現状と産学連携の取組み2012

    • Author(s)
      岡本哲治
    • Organizer
      広島中央サイエンスパーク施設20周年記念講演会
    • Place of Presentation
      広島中央サイエンスパーク、東広島市
    • Year and Date
      2012-10-19
    • Related Report
      2012 Final Research Report
  • [Presentation] 広島大学の現状および放射線災害復興を推進するフェニックリーダー育成プログラム2012

    • Author(s)
      岡本哲治
    • Place of Presentation
      サンパウロ広島文化センター、サンパウロ市、ブラジル
    • Year and Date
      2012-10-08
    • Related Report
      2012 Final Research Report
  • [Presentation] Analysis of binding site of ubiquitin ligase, human double minute 2 in integrin β82012

    • Author(s)
      坂上泰士、林堂安貴、浜名智昭、藤井隆彦、岡本哲治
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Year and Date
      2012-09-20
    • Related Report
      2012 Final Research Report
  • [Presentation] Generation of human induced pluripotent stem (iPS) cells in serum- and feeder-free defined culture from fetal lung fibroblasts and dental pulp2012

    • Author(s)
      YamasakiS., ShimamotoA., TaharaH. Okamoto T.
    • Organizer
      2012 World congress on In Vitro Biology
    • Place of Presentation
      Bellevue, Washington, USA
    • Year and Date
      2012-06-25
    • Related Report
      2012 Final Research Report
  • [Presentation] 1α,25(OH)2D3down-regulates FGF-BP expression through NFκBpathway2012

    • Author(s)
      Rosli S.N.Z., Shintani T., Hayashido Y., Toratani S., Usui E., Okamoto T.
    • Organizer
      15th Workshop on Vitamin D
    • Place of Presentation
      Houston,Texas,USA
    • Year and Date
      2012-06-21
    • Related Report
      2012 Final Research Report
  • [Presentation] 鎖骨頭蓋異形成症患者歯髄由来細胞を用いた疾患特異的ヒト人工多能性幹細胞(iPS 細胞)の樹立2012

    • Author(s)
      山崎佐知子、嶋本顕、田原栄俊、 岡本哲治
    • Organizer
      第66回NPO法人日本口科学会
    • Place of Presentation
      広島
    • Year and Date
      2012-05-17
    • Related Report
      2012 Final Research Report
  • [Presentation] ヒト人工多能性幹細胞 (iPS 細胞)の単層無血清培養系の確立2012

    • Author(s)
      田口有紀、山崎佐知子、嶋本顕、田原栄俊、岡本哲治
    • Organizer
      第66回NPO法人日本口科学会
    • Place of Presentation
      広島
    • Year and Date
      2012-05-17
    • Related Report
      2012 Final Research Report
  • [Presentation] インテグリンβ8 におけるユビキチンリガーゼ human double minute 2 (hdm2) 結合部位の探索2012

    • Author(s)
      藤井隆彦、林堂安貴、浜名智昭、坂上泰士、岡本哲治
    • Organizer
      第66回NPO法人日本口科学会
    • Place of Presentation
      広島
    • Year and Date
      2012-05-17
    • Related Report
      2012 Final Research Report
  • [Presentation] インテグリンαv サブユニットとの二量体形成がβ8 サブユニットの安定化に与える影響2012

    • Author(s)
      坂上泰士、林堂安貴、浜名智昭、藤井隆彦、岡本哲治
    • Organizer
      第66回NPO法人日本口科学会
    • Place of Presentation
      広島
    • Year and Date
      2012-05-17
    • Related Report
      2012 Final Research Report
  • [Presentation] 口腔扁平上皮癌細胞における SP 細胞群の癌幹細胞としての細胞・分子生物学的特性の検討2012

    • Author(s)
      伊藤翼、藤井良典、岡本哲治
    • Organizer
      第66回NPO法人日本口科学会
    • Place of Presentation
      広島
    • Year and Date
      2012-05-17
    • Related Report
      2012 Final Research Report
  • [Presentation] 口腔扁平上皮癌細胞株を用いた活性型ビタミン D3 による FGFBP/HBp17 蛋白発現の検討2012

    • Author(s)
      Rosli S.N.Z.、新谷智章、林堂安貴、笛吹恵美子、岡本哲治
    • Organizer
      第66回NPO法人日本口科学会
    • Place of Presentation
      広島
    • Year and Date
      2012-05-17
    • Related Report
      2012 Final Research Report
  • [Presentation] サンパウロ広島文化センター、サンパウロ市、ブラジル2012

    • Author(s)
      岡本哲治
    • Organizer
      日中歯科医学大会
    • Place of Presentation
      成都医科大学、四川省成都、中国
    • Year and Date
      2012-04-27
    • Related Report
      2012 Final Research Report
  • [Presentation] Consultants' Meeting, Global Radiation Medicine: Educational Challenges for Academia2012

    • Author(s)
      Vienna, Austria, Tetsuji Okamoto
    • Organizer
      Phoenix Leader Education Program (Hiroshima Initiative) for Renaissance from Radiation Disaster, Consultants' Meeting
    • Place of Presentation
      Venue: IAEA Headquarters
    • Related Report
      2012 Final Research Report
  • [Presentation] 口腔がんに対する細胞治療2012

    • Author(s)
      岡本哲治
    • Organizer
      日中歯科医学大会(招待講演)
    • Place of Presentation
      中国・四川省・成都
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Generation of human induced pluripotent stem (iPS) cells in serum- and feeder-free defined culture from fetal lung fibroblasts and dental pulp2012

    • Author(s)
      YamasakiS., ShimamotoA., TaharaH. and Okamoto T.
    • Organizer
      World congress on In Vitro Biology
    • Place of Presentation
      Bellevue,Washington,USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] 1α,25(OH)2D3down-regulates FGF-BP expression through NFκB pathway2012

    • Author(s)
      Rosli S.N.Z., Shintani T., Hayashido Y., Toratani S., Usui E. and Okamoto T.
    • Organizer
      15th Workshop on Vitamin D
    • Place of Presentation
      Houston, Texas, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] ヒト人工多能性幹細胞 (iPS細胞)の単層無血清培養系の確立2012

    • Author(s)
      田口有紀、山崎佐知子、嶋本顕、田原栄俊、岡本 哲治
    • Organizer
      第66回NPO法人日本口腔科学会学術集会
    • Place of Presentation
      広島
    • Related Report
      2012 Annual Research Report
  • [Presentation] 鎖骨頭蓋異形成症患者歯髄由来細胞を用いた疾患特異的ヒト人工多能性幹細胞(iPS細胞)の樹立2012

    • Author(s)
      山崎佐知子、嶋本顕、田原栄俊、岡本哲治
    • Organizer
      第66回NPO法人日本口腔科学会学術集会
    • Place of Presentation
      広島
    • Related Report
      2012 Annual Research Report
  • [Presentation] Data of ESR dosimetry study of population in the vicinity of Semipalatinsk Nuclear Test Site2012

    • Author(s)
      K.Zhumadilov, T.Okamoto, M.Hoshi, et al.
    • Organizer
      The 17th Hiroshima International Symposium
    • Place of Presentation
      Hiroshima, Japan(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Long term serial cultivation of mouse induced pluripotent stem cells in serum free- and feeder-free growth factor defined culture.2011

    • Author(s)
      Tetsuji Okamoto
    • Organizer
      Annual Meeting of Association for Dental Sciences of the Republic of China
    • Place of Presentation
      Taichung
    • Year and Date
      2011-08-27
    • Related Report
      2012 Final Research Report
  • [Presentation] Developmental Signaling Disorders in Craniofacial Anomalies and Cancers2009

    • Author(s)
      Tetsuji Okamoto
    • Organizer
      Annual Meeting of Association for Dental Sciences of the Republic of China
    • Place of Presentation
      Kaohsiung
    • Year and Date
      2009-11-28
    • Related Report
      2012 Final Research Report
  • [Presentation] Neuroectodermal Differentiation from embryonic stem cells in Xenopus, Mouse, and Human in serum-free defined culture2009

    • Author(s)
      Okamoto T.
    • Organizer
      The 32nd Annual Scientific Meeting of Association for Dental Sciences of the Republic of China (ADS-ROC)
    • Place of Presentation
      Kaohsiung, Taiwan, Invited Speaker
    • Year and Date
      2009-11-28
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Neuroectodermal Differentiation from embryonic stem cells in Xenopus, Mouse, and Human in serum-free defined culture2009

    • Author(s)
      Okamoto, T.
    • Organizer
      The 32nd Annual Scientific Meeting of Association for Dental Sciences of the Republic of China (ADS-ROC)
    • Place of Presentation
      Kaohsiung, Taiwan
    • Year and Date
      2009-11-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] 口腔癌に対する細胞治療:基礎研九・っ赫木研究へ2008

    • Author(s)
      岡本折治
    • Organizer
      台湾歯科医学会総会招待講演
    • Place of Presentation
      台北市
    • Year and Date
      2008-11-30
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] 口腔癌に対する細胞治療 : 基礎研究から臨床研究へ2008

    • Author(s)
      岡本哲治
    • Organizer
      台湾歯科医学会総会 招待講演
    • Place of Presentation
      台北市(台湾)
    • Year and Date
      2008-11-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] An Innovative Therapy for Oral Cancer: Research-based Clinical Application of Cell Therapy2008

    • Author(s)
      Tetsuji Okamoto
    • Organizer
      Annual Meeting of Dental Science
    • Place of Presentation
      Taipei
    • Year and Date
      2008-11-17
    • Related Report
      2012 Final Research Report
  • [Book] 口腔外科学2010

    • Author(s)
      白砂兼光, 古郷幹彦, 他
    • Total Pages
      815
    • Publisher
      医歯薬出版
    • Related Report
      2009 Annual Research Report
  • [Book] 口腔外科学2008

    • Author(s)
      白砂兼光,占郷幹彦, 他
    • Total Pages
      815
    • Publisher
      医歯薬出版
    • Related Report
      2012 Final Research Report 2010 Self-evaluation Report

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Published: 2008-04-01   Modified: 2019-07-29  

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