Pharmaco-physiological studies related to the deterrence factor of activities during development
Project/Area Number |
20500246
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Cognitive science
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Research Institution | Tokyo Metropolitan Organization for Medical Research |
Principal Investigator |
HONDA Yoshiko Tokyo Metropolitan Organization for Medical Research, 東京都神経科学総合研究所, 主任研究員 (50142154)
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Co-Investigator(Kenkyū-buntansha) |
USUI Setsuo 財団法人医学研究機構, 東京都神経科学総合研究所, 主任研究員 (30160253)
KODAMA Tohru 財団法人医学研究機構, 東京都神経科学総合研究所, 副参事研究員 (20195746)
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Project Period (FY) |
2008 – 2010
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Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 感情 / 情緒 / 行動 / ドーパミン / 多動 / 光環境 / 発達 / 多動性 / 発育 |
Research Abstract |
The rats grown under the condition of LD1:1 (repeated light-dark period every hour) show the hyperactivity in the unfamiliar place. This hyperactivity is related to the high amount of dopamine in the brain. Methylphenidate administration is effective for reduction of hyperactivities. D5 mRNA expression decreased significantly in the caudate nucleus of 6 week old LD1:1 rats. Furthermore, DAT mRNA expression showed abnormal in the frontal cortex of 3 week old LD1:1 rats.
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Report
(4 results)
Research Products
(52 results)
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[Journal Article] Transcriptional regulation of the hypocretin/orexin gene by NR6A1.2010
Author(s)
Tanaka, S., Kodama, T., Nonaka, T., Toyoda, H., Arai, M., Fukazawa, M., Honda, Y., Honda, M., Mignot, E.
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Journal Title
Biochem Biophys Res Commun
Volume: 403
Pages: 178-183
Related Report
Peer Reviewed
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[Presentation] 海洋性哺乳類の半球睡眠に関係する神経伝達物質2008
Author(s)
Kodama T., Lapierre JL., Kosenko PO., Lyamin OI., Mukhametov LM., Siegel JM.
Organizer
第33回日本睡眠学会定期学術会議
Place of Presentation
福島
Year and Date
2008-06-25
Related Report
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