Molecular basis of mouse olfactory system

• Project/Area Number: 20500280
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neuroscience in general
• Research Institution: The University of Tokyo
• Principal Investigator: NISHIZUMI Hirofumi The University of Tokyo, 大学院・理学系研究科, 助教 (30292832)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 嗅覚受容体 / 遺伝子発現 / 神経回路形成 / 軸索投射 / 遺伝子改変マウス / マウス

Research Abstract

In the mouse olfactory system, each olfactory sensory neuron expresses only one functioned odorant receptor (OR) gene in a mutually exclusive and mono-allelic manner. In this study, we analyzed how single OR gene is chosen by one of locus control regions and what kind of signals via a functional OR molecule suppress the expression of additional OR genes.

Research Products

• [Journal Article] Neuropilin-2 is required for the proper targeting of ventral glomeruli in the mouse olfactory bulb. (2010)
  • Author(s): Takahashi H, Yoshihara S, Nishizumi H, Tsuboi A
  • Journal Title: Molecular and Cellular Neuroscience 44 Pages: 233-245
  • Peer Reviewed
• [Journal Article] Regulation of antigen-receptor gene assembly in hagfish. (2010)
  • Author(s): Kishishita N, Matsuno T, Takahashi Y, Takaba H, Nishizumi H, Nagawa F
  • Journal Title: EMBO Report 11 Pages: 126-132
  • Peer Reviewed
• [Journal Article] Neuropilin-2 is required for the proper targeting of ventral glomeruli in the mouse olfactory bulb. (2010)
  • Author(s): Takahashi H, Yoshihara S, Nishizumi H, Tsuboi A.
  • Journal Title: Molecular and Cellular Neuroscience Volume: Vol.44 Pages: 233-245
  • Peer Reviewed
• [Journal Article] Regulation of antigen-receptor gene assembly in hagfish. (2010)
  • Author(s): Kishishita N, Matsuno T, Takahashi Y, Takaba H, Nishizumi H, Nagawa F.
  • Journal Title: EMBO Report Volume: Vol.11 Pages: 126-132
  • Peer Reviewed
• [Journal Article] Regulation of antigen-receptor gene assembly in hagfish (2010)
  • Author(s): 岸下奈津子
  • Journal Title: EMBO Report 11 Pages: 126-132
  • Peer Reviewed
• [Journal Article] Neuropilin-2 is required for the proper targeting of ventral glomeruli in the mouse olfactory bulb. (2010)
  • Author(s): 高橋弘雄
  • Journal Title: Molecular and Cellular Neuroscience (印刷中)
  • Peer Reviewed
• [Presentation] Synapse formation of OSN axons with M/T cell dendrites in mutant mice that have defects in glomerular map formation (2010)
  • Author(s): Nishizumi H, Miyashita A, Inoue N, Sakano H
  • Organizer: Cold Spring Harbor Laboratory Meeting "Axon Guidance, Synaptic Plasticity & Regeneration"
  • Place of Presentation: Cold Spring Harbor Laboratory, New York, USA
  • Year and Date: 2010-09-23
• [Presentation] Synapse formation of OSN axons with M/T cell dendrites in mutant mice that have defects in glomerular map formation (2010)
  • Author(s): Nishizumi H, Miyashita A, Inoue N, Sakano H
  • Organizer: Cold Spring Harbor Laboratory Meeting "Axon Guidance, Synaptic Plasticity & Regeneration"
  • Place of Presentation: Cold Spring Harbor Laboratory (New York, USA)
  • Year and Date: 2010-09-23
• [Presentation] マウス嗅覚受容体遺伝子の単一発現制御 (2009)
  • Author(s): 西住裕文、中山博文、坂野仁
  • Organizer: 日本分子生物学会
  • Place of Presentation: 神奈川・パシフィコ横浜
  • Year and Date: 2009-12-10
• [Presentation] マウス嗅覚受容体遺伝子の単一発現制御 (2009)
  • Author(s): 西住裕文
  • Organizer: 日本分子生物学会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-10
• [Presentation] Odorant receptor gene choice in the mouse olfactory system (2008)
  • Author(s): 西住裕文、中山博文、海老原章記、坂野仁
  • Organizer: Neuroscience2008 (第31回日本神経科学会大会)
  • Place of Presentation: 東京・東京国際フォーラム(口頭発表)
  • Year and Date: 2008-07-09
• [Presentation] Ddorant receptor gene choice in the mouse olfactory system(口頭発表) (2008)
  • Author(s): 西住裕文
  • Organizer: Neuroscience2008(第31回日本神経科学会大会)
  • Place of Presentation: 東京(東京国際フオーラム)
  • Year and Date: 2008-07-09
• [Remarks] ホームページ等