Molecular neurobiological studies on the functions of α-Synuclein
| Project/Area Number |
20500303
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | Tokyo Metropolitan Organization for Medical Research |
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Principal Investigator |
UEDA Kenji Tokyo Metropolitan Organization for Medical Research, 東京都精神医学総合研究所, 主任研究員 (90261180)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | シヌクレイン / ミトコンドリア / α-synuclein / ラット脳 / 膜電位 / ドーパミン作動性ニューロン / リン酸化 / MN9D細胞 / ドーパミン / チロシン水酸酵素 / 免疫電顕 / 複合体I |
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| Research Abstract |
After the biochemical examination of SDS-insoluble materials of the brains with Alzheimer's disease, we identified human α-Synuclein by cDNA cloning. Later, some missense mutations of the gene of α-Synuclein were found in the cases with familial Parkinson's disease. α-Synuclein turned out to be the major component of Lewy bodies. In the present studies, we identified that α-Synuclein is localized in the inner membrane of neuronal mitochondria.
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Report
(4 results)
Research Products
(27 results)
