| Project/Area Number |
20500318
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Tokyo Metropolitan Organization for Medical Research |
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Principal Investigator |
KAWANO Hitoshi Tokyo Metropolitan Organization for Medical Research, 東京都神経科学総合研究所, 副参事研究員 (20161341)
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| Co-Investigator(Kenkyū-buntansha) |
KURODA Junko 財団法人東京都医学研究機構, 東京都神経科学総合研究所, 研究員 (20142151)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 中枢神経系 / 損傷 / 細胞移植 / 神経再生 / グリア瘢痕 / 線維性瘢痕 / プロテオグリカン / 線維芽細胞 / アストロサイト / TGF-β / 脳 / ドーパミン神経路 / 嗅球グリア / 瘢痕 / コラーゲン |
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| Research Abstract |
Transplantation of olfactory ensheathing cells (OEC) into the lesion site of the CNS suppressed the formation of the fibrotic scar (Teng et al., 2008 ; Teng et al., 2010). Receptors for transforming growth factor-ss (TGF-ss) were expressed in meningeal fibroblasts which formed the fibrotic scar after brain injury (Komuta et al., 2010), and an inhibitor of TGF-ss suppressed the fibrotic scar formation (Yoshioka et al., 2011). When TGF-ss was added to coculute of astrocytes and fibroblasts, cell clusters which resembled the fibrotic scar were formed (Kimura-Kuroda et al., 2010). These results suggests that TGF-ss which increases after CNS injury is involved in the fibrotic scar formation.
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