Establishment of a new method to induce differentiation from human ES cells into neural stem cells and neurons
| Project/Area Number |
20500339
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Tokyo Metropolitan University |
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Principal Investigator |
INOUE Nobuo Tokyo Metropolitan University, 人間健康科学研究科, 教授 (50159985)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAYAMA Takashi 横浜市立大学, 医学部, 准教授 (90150060)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 幹細胞生物学 / 再生 / 修復 / ES細胞 / 胚性幹細胞 / 神経分化 / 神経幹細胞 / 神経細胞 / アストロサイト |
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| Research Abstract |
We have developed a new method to induce uni-directional differentiation from human ES cells into neural cells and to prepare a large amount of homogeneous neural stem cells. The neural stem cells could be selectively induced to differentiate into neurons, mainly dopaminergic neurons, or astrocytes. We have also opened the possibility that human ES cells can be differentiated into many different types of neural cells by simply modifying the basic culture conditions of the method.
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Report
(4 results)
Research Products
(102 results)
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[Journal Article] Proteomic identification of differentially expressed genes in neural stem cells and neurons differentiated from embryonic stem cells of cynomolgus monkey (Macaca fascicularis) in vitro.2011
Author(s)
Akama K, Horikoshi T, Nakayama T, Otsu M, Imaizumi N, Nakamura M, Toda T, Inuma M, Hirano H, Kondo Y, Suzuki Y, Inoue N
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Journal Title
Biochim Biophys Acta 1814
Pages: 265-276
Related Report
Peer Reviewed
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[Journal Article] Self-contained induction of neurons from human embryonic stem cells2009
Author(s)
Okuno T, Nakayama T, Konishi N, Michibata H, Wakimoto K, Suzuki Y, Nito S, Inaba T, Nakano I, Muramatsu S, Takano M, Kondo Y, Inoue N
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Journal Title
PLoS One
Volume: 4巻
Issue: 7
Pages: e6318-e6318
DOI
Related Report
Peer Reviewed
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[Journal Article] Multi-tracer assessment of dopamine function after transplantation of embryonic stem cell-derived neural stem cells in a primate model of Parkinson's disease.2009
Author(s)
Muramatsu S, Okuno T, Suzuki Y, Nakayama T, Kakiuchi T, Takino N, Iida A, Ono F, Terao K, Inoue N, Nakano I, Kondo Y, Tsukada H
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Journal Title
Synapse 63
Pages: 541-548
Related Report
Peer Reviewed
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