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Establishment of a new method to induce differentiation from human ES cells into neural stem cells and neurons

Research Project

Project/Area Number 20500339
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurochemistry/Neuropharmacology
Research InstitutionTokyo Metropolitan University

Principal Investigator

INOUE Nobuo  Tokyo Metropolitan University, 人間健康科学研究科, 教授 (50159985)

Co-Investigator(Kenkyū-buntansha) NAKAYAMA Takashi  横浜市立大学, 医学部, 准教授 (90150060)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords幹細胞生物学 / 再生 / 修復 / ES細胞 / 胚性幹細胞 / 神経分化 / 神経幹細胞 / 神経細胞 / アストロサイト
Research Abstract

We have developed a new method to induce uni-directional differentiation from human ES cells into neural cells and to prepare a large amount of homogeneous neural stem cells. The neural stem cells could be selectively induced to differentiate into neurons, mainly dopaminergic neurons, or astrocytes. We have also opened the possibility that human ES cells can be differentiated into many different types of neural cells by simply modifying the basic culture conditions of the method.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (102 results)

All 2011 2010 2009 2008 Other

All Journal Article (36 results) (of which Peer Reviewed: 15 results) Presentation (59 results) Book (4 results) Remarks (3 results)

  • [Journal Article] Uni-directional Differentiation of Mouse Embryonic Stem Cells into Neurons by the Neural Stem Sphere Method.2011

    • Author(s)
      Otsu M, Sai T, Nakayama T, Murakami T, Inoue N
    • Journal Title

      Neurosci Res 69

      Pages: 314-321

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Proteomic identification of differentially expressed genes in neural stem cells and neurons differentiated from embryonic stem cells of cynomolgus monkey (Macaca fascicularis) in vitro.2011

    • Author(s)
      Akama K, Horikoshi T, Nakayama T, Otsu M, Imaizumi N, Nakamura M, Toda T, Inuma M, Hirano H, Kondo Y, Suzuki Y, Inoue N
    • Journal Title

      Biochim Biophys Acta 1814

      Pages: 265-276

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Proteomic identification of differentially expressed genes in neural stem cells and neurons differentiated from embryonic stem cells of cynomolgus monkey (Macaca fascicularis) in vitro.2011

    • Author(s)
      Akama K
    • Journal Title

      Biochim Biophys Acta

      Volume: 1814 Pages: 265-276

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Uni-directional Differentiation of Mouse Embryonic Stem Cells into Neurons by the Neural Stem Sphere Method.2011

    • Author(s)
      Otsu M
    • Journal Title

      Neurosci Res

      Volume: 69 Pages: 314-321

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differentiation of embryonic stem cells into the neuronal cells.2010

    • Author(s)
      Inoue N, Otsu M, Nakayama T
    • Journal Title

      J Neurochem 115(Suppl.1)

      Pages: 62-62

    • Related Report
      2010 Final Research Report
  • [Journal Article] Analysis on the expression and function of BRINP family genes during neuronal differentiation of mouse embryonic stem cell-derived neural stem cells.2010

    • Author(s)
      Terashima M, Kobayashi M, Motomiya M, Inoue N, Yoshida T, Okano H, Iwasaki N, Minami A, Matsuoka I
    • Journal Title

      J Neurosci Res 15

      Pages: 1387-1393

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 骨中コラーゲン高親和性タンパク質の骨芽細胞様細胞株MC3T3-E1細胞の骨形成過程に及ぼす影響2010

    • Author(s)
      村上拡冶, 細川健太郎, 祭友昭, 笠井久隆, 井上順雄
    • Journal Title

      日本保健科学学会誌 12

      Pages: 237-244

    • NAID

      110007593174

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] トリペプチドアルデヒドZ-Leu-Leu-Leu-HはマウスES細胞由来の神経幹細胞をニューロンへ分化誘導する2010

    • Author(s)
      祭友昭, 岩山賢一, 大津昌弘, 井上順雄, 笠井久隆
    • Journal Title

      日本保健科学学会誌 12

      Pages: 230-236

    • NAID

      110007593173

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analysis on the expression and function of BRINP family genes during neuronal differentiation of mouse embryonic stem cell-derived neural stem cells.2010

    • Author(s)
      Terashima M
    • Journal Title

      J Neurosci Res

      Volume: 15 Pages: 1387-1393

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differentiation of embryonic stem cells into the neuronal cells.2010

    • Author(s)
      Inoue N
    • Journal Title

      J Neurochem

      Volume: 115 Pages: 62-62

    • Related Report
      2010 Annual Research Report
  • [Journal Article] トリペプチドアルデヒドZ-Leu-Leu-Leu-HはマウスES細胞由来の神経幹細胞をニューロンヘ分化誘導する2010

    • Author(s)
      祭友昭
    • Journal Title

      日本保健科学学会誌 12

      Pages: 230-236

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 骨中コラーゲン高親和性タンパク質の骨芽細胞様細胞株MC3T3-E1細胞の骨形成過程に及ぼす影響2010

    • Author(s)
      村上拡冶
    • Journal Title

      日本保健科学学会誌 12

      Pages: 237-244

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ES細胞から神経系細胞への分化誘導2009

    • Author(s)
      井上順雄
    • Journal Title

      日仏工業技術 55

      Pages: 27-31

    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Journal Article] Proteomic characterization during neural differentiation from monkey embryonic stem cells into neurons in vitro.2009

    • Author(s)
      Akama K, Horikoshi T, Nakayama T, Otsu M, Imaizumi N, Nakamura M, Toda T, Kondo Y, Suzuki Y, Inoue N
    • Journal Title

      J Neurochem 110(Suppl.2)

      Pages: 232-232

    • Related Report
      2010 Final Research Report
  • [Journal Article] Effects of Methylmercury on proliferation of mouse and monkey ES cell-derived neural stem cells.2009

    • Author(s)
      Kume N, Otsu M,, Kobayashi H, Inada D, Yoshie T, Nakayama T, Suzuki Y, Kondo Y, Inoue N
    • Journal Title

      J Neurochem 110(Suppl.2)

      Pages: 52-52

    • Related Report
      2010 Final Research Report
  • [Journal Article] Effects of heat shock on proliferation and differentiation of mouse ES cell-derived neural stem cells.2009

    • Author(s)
      Omori H, Otsu M, Isono M, Kume N, Shinya F, Yoshie T, Nakayama T, Inoue N
    • Journal Title

      J Neurochem 110(Suppl.2)

      Pages: 29-29

    • Related Report
      2010 Final Research Report
  • [Journal Article] Effects of X-irradiation on embryonic stem cells-derived neural stem cells.2009

    • Author(s)
      Isono M, Otsu M, 2, Konishi T, Nakayama T, Inoue N
    • Journal Title

      J Neurochem 110(Suppl.2)

      Pages: 25-25

    • Related Report
      2010 Final Research Report
  • [Journal Article] Unidirectional differentiation from human embryonic stem cells into neurons.2009

    • Author(s)
      Inoue N, Otsu M, Kume N, Isono M, Shibata M, Sai T, Nakayama T, Momoki-Soga T, Kasai H
    • Journal Title

      J Neurochem 110(Suppl.2)

      Pages: 25-25

    • Related Report
      2010 Final Research Report
  • [Journal Article] Self-contained induction of neurons from human embryonic stem cells2009

    • Author(s)
      Okuno T, Nakayama T, Konishi N, Michibata H, Wakimoto K, Suzuki Y, Nito S, Inaba T, Nakano I, Muramatsu S, Takano M, Kondo Y, Inoue N
    • Journal Title

      PLoS One

      Volume: 4巻 Issue: 7 Pages: e6318-e6318

    • DOI

      10.1371/journal.pone.0006318

    • Related Report
      2010 Final Research Report 2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multi-tracer assessment of dopamine function after transplantation of embryonic stem cell-derived neural stem cells in a primate model of Parkinson's disease.2009

    • Author(s)
      Muramatsu S, Okuno T, Suzuki Y, Nakayama T, Kakiuchi T, Takino N, Iida A, Ono F, Terao K, Inoue N, Nakano I, Kondo Y, Tsukada H
    • Journal Title

      Synapse 63

      Pages: 541-548

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Unidirectional differentiation from human embryonic stem cells into neurons.2009

    • Author(s)
      Inoue N
    • Journal Title

      J Neurochem 110

      Pages: 25-25

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Effects of X-irradiation on embryonic stem cells-derived neural stem cells.2009

    • Author(s)
      Isono M
    • Journal Title

      J Neurochem 110

      Pages: 25-25

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Effects of heat shock on proliferation and differentiation of mouse ES cell-derived neural stem cells.2009

    • Author(s)
      Omori H
    • Journal Title

      J Neurochem 110

      Pages: 27-27

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Effects of Methylmercury on proliferation of mouse and monkey ES cell-derived neural stem cells.2009

    • Author(s)
      Kume N
    • Journal Title

      J Neurochem 110

      Pages: 52-52

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Proteomic characterization during neural differentiation from monkey embryonic stem cells into neurons in vitro.2009

    • Author(s)
      Akama K
    • Journal Title

      J Neurochem 110

      Pages: 232-232

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Multi-tracer assessment of dopamine function after transplantation of embryonic stem cell-derived neural stem cells in a primate model of Parkinson' s disease.2009

    • Author(s)
      Muramatsu S
    • Journal Title

      Synapse 63

      Pages: 541-548

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of methyl-mercury on growth of mouse embryonic stem cell-derived neural stem cells.2008

    • Author(s)
      Otsu M, Kobayashi H, Inada D, Nakayama T, Inoue N
    • Journal Title

      Neurosci Res 61(Suppl.1)

    • Related Report
      2010 Final Research Report
  • [Journal Article] Effects of X-irradiation on neural differentiation from mouse embryonic stem cells.2008

    • Author(s)
      Nagano H, Shinya F, Otsu M, Ohtani H, Fukushi M, Nakayama T, Inoue N
    • Journal Title

      Neurosci Res 61(Suppl.1)

    • Related Report
      2010 Final Research Report
  • [Journal Article] A proteomic approach to differentiation from monkey ES cells to neural stem sphere.2008

    • Author(s)
      Horikoshi T, Nakayama T, Akama K, Otsu M, Nakamura M, Toda T, Inoue N
    • Journal Title

      Neurosci Res 61(Suppl.1)

    • Related Report
      2010 Final Research Report
  • [Journal Article] Effects of X-irradiation on proliferation and maintenance of mouse embryonic stem cell-derived neural stem cells.2008

    • Author(s)
      Isono M, Tanabe T, Otsu M, Ohtani H, Fukushi M, Nakayama T, Inoue N
    • Journal Title

      Neurosci Res 61(Suppl.1)

    • Related Report
      2010 Final Research Report
  • [Journal Article] Proteomic identification of differentially expressed genes in mouse neural stem cells and neurons differentiated from embryonic stem cells in vitro.2008

    • Author(s)
      Akama K, Tatsuno R, Otsu M, Horikoshi T, Nakayama T, Nakamura M, Toda T, Inoue N
    • Journal Title

      Biochim Biophys Acta 1784

      Pages: 773-782

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Proteomic identification of differentially expressed genes in mouse neural stem cells and neurons differentiated from embryonic stem cells in vitro.2008

    • Author(s)
      Akama K
    • Journal Title

      Biochim Biophys Acta 1784

      Pages: 773-782

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of X-irradiation on proliferation and maintenance of mouse embryonic stem eell-derived neural stem cells.2008

    • Author(s)
      Isono M
    • Journal Title

      Neurosci Res 61

    • Related Report
      2008 Annual Research Report
  • [Journal Article] A proteomic approach to differentiation from monkey ES cells to neural stem sphere.2008

    • Author(s)
      Horikoshi T
    • Journal Title

      Neurosci Res 61

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Effects of. X-irradiation on neural differentiation from mouse embryonic stem cells.2008

    • Author(s)
      Nagano H
    • Journal Title

      Neurosci Res 61

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Effects of methylmercury on growth of mouse embryonic stem cell-derived neural stem cells.2008

    • Author(s)
      Otsu M
    • Journal Title

      Neurosci Res 61

    • Related Report
      2008 Annual Research Report
  • [Presentation] マウス胚性幹細胞由来の神経幹細胞の性質と細胞増殖因子の関係2011

    • Author(s)
      吉江拓也
    • Organizer
      第10回日本再生医療学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-03-01
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] ES細胞からドーパミン作動性神経細胞への分化過程における脳領域形成関連遺伝子の発現解析2011

    • Author(s)
      上田理沙
    • Organizer
      第10回日本再生医療学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-03-01
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Role of neural cell adhesion nolecule (NCAM) during the epileptogenesis in the hippocampus of epileptic mutant EL.2010

    • Author(s)
      Murashima
    • Organizer
      8th Asian & Oceanian Epilepsy Congress
    • Place of Presentation
      Melbourne, Australia
    • Year and Date
      2010-10-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] Differentiation of embryonic stem cells into the neuronal cells.2010

    • Author(s)
      井上順雄
    • Organizer
      10th Biennial Meeting of the Asia-Pacific Society for Neurochemistry (APSN 2010)
    • Place of Presentation
      Phuket Island, Thailand
    • Year and Date
      2010-10-20
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 神経細胞認識タンパクの発達過程特異的発現がELのてんかん原性に関与している2010

    • Author(s)
      村島善也
    • Organizer
      第44回日本てんかん学会
    • Place of Presentation
      岡山
    • Year and Date
      2010-10-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒトES細胞・iPS細胞から神経系細胞への分化過程の解析と分化した神経系細胞の特徴付け2010

    • Author(s)
      上田理沙
    • Organizer
      第20回日本保健科学学術集会
    • Place of Presentation
      東京
    • Year and Date
      2010-10-09
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] パーキンソン病の移植治療を目指すES細胞から神経細胞の分化誘導2010

    • Author(s)
      井上順雄
    • Organizer
      第20回日本保健科学学術集会
    • Place of Presentation
      東京
    • Year and Date
      2010-10-09
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] メチル水銀はサル胚性幹細胞由来神経幹細胞の分化にどのような影響を及ぼすか2010

    • Author(s)
      柴田雅祥
    • Organizer
      第20回日本保健科学学術集会
    • Place of Presentation
      東京
    • Year and Date
      2010-10-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] 温熱刺激によるマウスES細胞由来神経幹細胞の増殖および遺伝子発現変化の検討2010

    • Author(s)
      大森啓之
    • Organizer
      第20回日本保健科学学術集会
    • Place of Presentation
      東京
    • Year and Date
      2010-10-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] ES細胞由来神経幹細胞の増殖と分化におけるX線照射の影響2010

    • Author(s)
      磯野真由
    • Organizer
      第20回日本保健科学学術集会
    • Place of Presentation
      東京
    • Year and Date
      2010-10-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] ES細胞から神経細胞への分化誘導系を用いる神経幹細胞への放射線照射の影響の解析2010

    • Author(s)
      新屋冬美
    • Organizer
      第20回日本保健科学学術集会
    • Place of Presentation
      東京
    • Year and Date
      2010-10-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] マウスES細胞由来の神経幹細胞の増殖に対する細胞増殖因子の効果2010

    • Author(s)
      吉江拓也
    • Organizer
      第20回日本保健科学学術集会
    • Place of Presentation
      東京
    • Year and Date
      2010-10-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Effects of methyl mercury on the differentiation of monkey ES cell-derived neural stem cells.2010

    • Author(s)
      Shibata M
    • Organizer
      Neuro2010
    • Place of Presentation
      神戸
    • Year and Date
      2010-09-04
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Effects of FGF-2 and EGF on proliferation of mouse embryonic stem cell-derived neural stem cells.2010

    • Author(s)
      吉江拓也
    • Organizer
      Neuro2010
    • Place of Presentation
      神戸
    • Year and Date
      2010-09-03
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Proteomic characterization of monkey initial neurogenesis from embryonic stem cells to neural stem cells by neural stem sphere method.2010

    • Author(s)
      Akama K
    • Organizer
      Neuro2010
    • Place of Presentation
      神戸
    • Year and Date
      2010-09-03
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Proliferation and differentiation of X-irradiated neural stem cells derived from mouse embryonic stem cells.2010

    • Author(s)
      Isono M
    • Organizer
      Neuro2010
    • Place of Presentation
      神戸
    • Year and Date
      2010-09-03
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Changes in proliferation and gene expression of mouse ES cell-derived neural stem cells after heat shock.2010

    • Author(s)
      Omori H
    • Organizer
      Neuro2010
    • Place of Presentation
      神戸
    • Year and Date
      2010-09-03
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Cell recognition Molecules may trigger the epileptogenesis during development in the hippocampus of the epileptic mutant EL2010

    • Author(s)
      Murashima YL
    • Organizer
      9th European Congress on Epileptology
    • Place of Presentation
      Rhodos, Greece
    • Year and Date
      2010-06-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] マウス胚性幹細胞由来神経幹細胞に対する有用な温熱刺激条件の検討2010

    • Author(s)
      大森啓之
    • Organizer
      第45回日本理学療法学術大会
    • Place of Presentation
      岐阜
    • Year and Date
      2010-05-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] 神経幹細胞の増殖能と分化能に対するX線照射の影響2010

    • Author(s)
      磯野真由
    • Organizer
      日本放射線影響学会第53回大会
    • Place of Presentation
      京都
    • Related Report
      2010 Annual Research Report
  • [Presentation] ES細胞から神経系細胞への分化誘導法の開発とその応用2009

    • Author(s)
      井上順雄
    • Organizer
      荒川キャンパス産学交流会2009
    • Place of Presentation
      東京
    • Year and Date
      2009-12-09
    • Related Report
      2010 Final Research Report
  • [Presentation] 初期神経発生過程で発現する新規神経分化マーカー遺伝子の探索2009

    • Author(s)
      大津昌弘
    • Organizer
      第19回日本保健科学学術集会
    • Place of Presentation
      東京
    • Year and Date
      2009-09-19
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] ES細胞由来の神経幹細胞に対する増殖因子の影響2009

    • Author(s)
      吉江拓也
    • Organizer
      第19回日本保健科学学術集会
    • Place of Presentation
      東京
    • Year and Date
      2009-09-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] サルES細胞由来神経幹細胞に対するメチル水銀の影響2009

    • Author(s)
      久米伸恵
    • Organizer
      第19回日本保健科学学術集会
    • Place of Presentation
      東京
    • Year and Date
      2009-09-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] Proteomic characterization of monkey neural stem cells, neurons and astrocyte precursors differentiated by neural stem sphere method.2009

    • Author(s)
      Akama K
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] Effects of heat shock on proliferation and differentiation of mouse ES cell-derived neural stem cells.2009

    • Author(s)
      Omori H
    • Organizer
      22nd Biennial Meeting of the International Society for Neurochemistry
    • Place of Presentation
      Busan
    • Year and Date
      2009-08-24
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Effects of Methylmercury on proliferation of mouse and monkey ES cell-derived neural stem cells.2009

    • Author(s)
      Kume N
    • Organizer
      22nd Biennial Meeting of the International Society for Neurochemistry
    • Place of Presentation
      Busan
    • Year and Date
      2009-08-24
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Unidirectional differentiation from human embryonic stem cells into neurons.2009

    • Author(s)
      井上順雄
    • Organizer
      22nd Biennial Meeting of the International Society for Neurochemistry
    • Place of Presentation
      Busan
    • Year and Date
      2009-08-24
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Effects of X-irradiation on embryonic stem cells-derived neural stem cells.2009

    • Author(s)
      Isono M
    • Organizer
      22nd Biennial Meeting of the International Society for Neurochemistry
    • Place of Presentation
      Busan
    • Year and Date
      2009-08-24
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Proteomic characterization during neural differentiation from monkey embryonic stem cells into neurons in vitro.2009

    • Author(s)
      Akama K
    • Organizer
      22nd Biennial Meeting of the International Society for Neurochemistry
    • Place of Presentation
      Busan
    • Year and Date
      2009-08-24
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Biological effects of radiation on mouse embryonic stem cell-derived neural stem cells.2009

    • Author(s)
      Isono M
    • Organizer
      第52回日本神経化学会大会
    • Place of Presentation
      群馬
    • Year and Date
      2009-06-23
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 胚性幹細胞から分化誘導・調製した神経幹細胞の増殖・分化に対する温熱刺激の影響2009

    • Author(s)
      大森啓之
    • Organizer
      第44回日本理学療法学術大会
    • Place of Presentation
      東京
    • Year and Date
      2009-05-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] ES細胞から神経細胞への一方向的分化誘導法を用いる発達神経毒性試験研究2009

    • Author(s)
      井上順雄
    • Organizer
      第8回国際医薬品原料・中間体展.TLO/大学知的財産本部 技術移転セミナー
    • Place of Presentation
      東京
    • Year and Date
      2009-04-22
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Effects of X-irradiation on differentiation from mouse embryonic stem cells into neuron.2009

    • Author(s)
      Shinya F
    • Organizer
      第52回日本神経化学会大会
    • Place of Presentation
      群馬
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Effects of methyl mercury on proliferation of monkey ES cell-derived neural stem cells.2009

    • Author(s)
      Kume N
    • Organizer
      第52回日本神経化学会大会
    • Place of Presentation
      群馬
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Effects of heat shock on proliferation and differentiation of mouse ES cell-derived neural stem cells.2009

    • Author(s)
      Omori H
    • Organizer
      第52回日本神経化学会大会
    • Place of Presentation
      群馬
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Dramatically different effects of methyl mercury on uni-directional differentiation from embryonic stem cells into neurons by Neural Stem Sphere method.2009

    • Author(s)
      大津昌弘
    • Organizer
      第52回日本神経化学会大会
    • Place of Presentation
      群馬
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] ES細胞から神経細胞への一方向的分化誘導法を用いる発達神経毒性試験研究.2009

    • Author(s)
      井上順雄
    • Organizer
      第8回産学官連携推進会議
    • Place of Presentation
      京都
    • Related Report
      2010 Final Research Report
  • [Presentation] Neural Stem Sphere形成を介したヒト胚性幹細胞の神経分化2009

    • Author(s)
      大津昌弘
    • Organizer
      第8回日本再生医療学会総会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] Neural Stem Sphere法を用いたサルES細胞から神経への分化における発現比較解析2009

    • Author(s)
      今泉紀明
    • Organizer
      日本ヒトプロテオーム機構第7回大会
    • Place of Presentation
      東京
    • Related Report
      2009 Annual Research Report
  • [Presentation] Neural Stem Sphere法を用いたサルES細胞から神経幹細胞への分化過程における発現量変化解析2009

    • Author(s)
      今泉紀明
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      広島
    • Related Report
      2009 Annual Research Report
  • [Presentation] 放医研マイクロビーム細胞照射装置の現状2009

    • Author(s)
      磯野真由
    • Organizer
      日本放射線影響学会第52回大会
    • Place of Presentation
      広島
    • Related Report
      2009 Annual Research Report
  • [Presentation] 線維芽細胞による微笑環境がマウスES細胞の増殖と分化に与える影響.2009

    • Author(s)
      北沢啓子
    • Organizer
      第8回日本再生医療学会総会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] ES細胞を用いた神経毒性試験法の基礎検討2008

    • Author(s)
      井上順雄
    • Organizer
      第7回日本化学工業協会LRI研究報告会
    • Place of Presentation
      東京
    • Year and Date
      2008-08-01
    • Related Report
      2010 Final Research Report
  • [Presentation] Neural Stem Sphere法によるサル胚性幹細胞からの神経分化誘導過程のプロテオーム解析から得られた新知見2008

    • Author(s)
      堀越朋恵
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会 合同大会(BMB2008)
    • Place of Presentation
      神戸
    • Related Report
      2010 Final Research Report
  • [Presentation] Effects of methyl mercury on neural differentiation from mouse embryonic stem cells by Neural Stem Sphere method.2008

    • Author(s)
      Inada D
    • Organizer
      第51回日本神経化学会大会
    • Place of Presentation
      富山
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] Uni-directional neural differentiation from human embryonic stem cells by Neural Stem Sphere method.2008

    • Author(s)
      大津昌弘
    • Organizer
      第51回日本神経化学会大会
    • Place of Presentation
      富山
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] A proteomic approach to differentiation from monkey ES cells to neural stem sphere.2008

    • Author(s)
      Horikoshi T, Nakayama T, Akama K, 大津昌弘, Nakamura M, Toda T, Inoue N
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] Effects of X-irradiation on proliferation and maintenance of mouse embryonic stem cell-derived neural stem cells.2008

    • Author(s)
      Isono M
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] Effects of X-irradiation on neural differentiation from mouse embryonic stem cells.2008

    • Author(s)
      Nagano H
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] Effects of methylmercury on growth of mouse embryonic stem cellderived neural stem cells.2008

    • Author(s)
      大津昌弘
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] Effects of methylmercury on growth of mouse embryonic stem cell-derived neural stem cells.2008

    • Author(s)
      Otsu M
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] サル胚性幹細胞からNeural Stem Spheresへの分化誘導初期過程のプロテオーム解析から得られた新知見.2008

    • Author(s)
      堀越 朋恵
    • Organizer
      日本ヒトプロテオーム機構第6回大会
    • Place of Presentation
      大阪
    • Related Report
      2008 Annual Research Report
  • [Presentation] ES細胞を用いた神経毒性試験法の基礎検討.2008

    • Author(s)
      井上順雄
    • Organizer
      第7回日本化学工業協会LRI研究報告会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] マウス胚性幹細胞由来神経幹細胞の増殖、分化に対する温熱刺激の影響.2008

    • Author(s)
      大森啓之
    • Organizer
      第18回日本保健科学学術集会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] Neural Stem Sphere法を用いた神経系発達初期におけるメチル水銀の影響評価.2008

    • Author(s)
      大津昌弘
    • Organizer
      第18回日本保健科学学術集会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] Analysis on the expression and function of BRINP family genes during neuronal differentiation of mouse embryonic stem cell-derived neural stem cells.2008

    • Author(s)
      Terashima M
    • Organizer
      第51回日本神経化学会大会
    • Place of Presentation
      富山
    • Related Report
      2008 Annual Research Report
  • [Presentation] Effects on proliferation and differentiation of ES cells by culture conditions of mouse embryonic fibroblast.2008

    • Author(s)
      Yamanoha B
    • Organizer
      第51回日本神経化学会大会
    • Place of Presentation
      富山
    • Related Report
      2008 Annual Research Report
  • [Presentation] Neural Stem Sphere法によるサル胚性幹細胞からの神経分化誘導過程のプロテオーム解析から得られた新知見.2008

    • Author(s)
      堀越 朋恵
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会 合同大会
    • Place of Presentation
      神戸
    • Related Report
      2008 Annual Research Report
  • [Book] ES細胞からの神経幹細胞・神経細胞の分化誘導-自給型分化誘導法によるヒト細胞の安定供給-幹細胞の分化誘導と応用2009

    • Author(s)
      大津昌弘, 中山孝, 井上順雄
    • Publisher
      エヌ・ティー・エス
    • Related Report
      2010 Final Research Report
  • [Book] ES細胞からの神経幹細胞・神経細胞の分化誘導-自給型分化誘導法によるヒト細胞の安定供給-. 幹細胞の分化誘導と応用2009

    • Author(s)
      大津昌弘
    • Publisher
      エヌ・ティー・エス
    • Related Report
      2008 Annual Research Report
  • [Book] Neural Stem Sphere method. Stem Cell Application in Diseases Research, Ed Sorensen ML. NY, USA2008

    • Author(s)
      中山孝, 大津昌弘, 井上順雄
    • Publisher
      Nova Science Publishers Inc
    • Related Report
      2010 Final Research Report
  • [Book] Neural Stem Sphere method. in Stem Cell Application in Diseases Research2008

    • Author(s)
      Nakayama T
    • Publisher
      Nova Science Publishers Inc. NY, USA.
    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.metro-hs.ac.jp/pt/shinkeisaisei/

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.metro-hs.ac.jp/pt/shinkeisaisei/

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.metro-hs.ac.jp/pt/shinkeisaisei/

    • Related Report
      2008 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2023-03-16  

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