Functional analysis of muscle regeneration using gene-targeting and transgenic technologies
| Project/Area Number |
20500367
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | Kitasato University |
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Principal Investigator |
HANAOKA Kazunori Kitasato University, 理学部, 教授 (40189577)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Daisuke 北里大学, 理学部, 講師 (00260175)
KITAMOTO Takero 北里大学, 理学部, 助教 (20453516)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 筋再生 / サテライト細胞 / Lbx1 / Notch3 / マウス / Dp71 / 筋肉 / 幹細胞 / 筋ジストロフィー |
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| Research Abstract |
The results of present study demonstrate Notch3 as an important regulator for muscle repair. The data indicate Notch3 negatively regulate both proliferation and self-renewal of activated satellite cells after muscle injury. These results provide insight into the mechanisms of self-renewal and homeostatic regulation of satellite cells during muscle regeneration.
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Report
(4 results)
Research Products
(24 results)
