A basic study on utilization of ghrelin-induced anabolic effect to improve skeletal muscle metabolism
| Project/Area Number |
20500580
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | University of Miyazaki |
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Principal Investigator |
TOSHINAI Koji University of Miyazaki, 医学部, 講師 (80381101)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | エネルギー代謝 / QOL / 筋肥大 / 生理活性物質 / 肥満 / 老化 / 内分泌機能 / 生活習慣 / 運動 / 廃用性筋萎縮 / グレリン / 成長ホルモン / インスリンシグナル / インスリン様成長因子-1 / STAT5 |
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| Research Abstract |
Ghrelin, a peptide produced in the stomach, stimulates feeding and growth hormone secretion. I studied here whether ghrelin improved muscle atrophy, metabolic syndrome, and bedridden. Ghrelin treatment in mice exposed to hindlimb suspension-induced muscle atrophy increased insulin signal (anabolic function), and decreased expressions of atrophy-related E3 ubiquitin ligases (catabolic function). These anti-atrophic functions by ghrelin were indirectly effect in mice skeletal muscle. To exert ghrelin-induced anti-atrophic functions was necessary for increases of growth hormone secretion and food intake. Ghrelin treatment was effective for the prevention and improvement of muscle atrophy.
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Report
(4 results)
Research Products
(39 results)
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[Journal Article] Significant lowering of plasma ghrelin but not des-acylghrelin in response to acute exercise in men2011
Author(s)
Shiiya T, Ueno H, Toshinai K, Kawagoe T, Naito S, Tobina T, Nishida Y, Shindo M, Kangawa K, Tanaka H, Nakazato M
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Journal Title
Endocr J
Volume: (in press)
NAID
Related Report
Peer Reviewed
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[Journal Article] Significant lowering of plasma ghrelin but not des-acyl ghrelin in response to acute exercise in men.
Author(s)
Shiiya T, Ueno H, Toshinai K, Kawagoe T, Naito S, Tobina T, Nishida Y, Shindo M, Kangawa K, Tanaka H, Nakazato M
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Journal Title
NAID
Related Report
Peer Reviewed
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[Presentation] A novel hypothalamic peptide, neuroendocrine regulatory peptide-2, regulates feeding behavior via the orexin system in the hypothalamus.2010
Author(s)
Toshinai K, Yamaguchi H, Kageyama H, Matsuo T, Koshinaka K, Sasaki K, Shioda S, Minamino N, Nakazato M
Organizer
5th International Peptide Symposium
Place of Presentation
Kyoto, Japan
Year and Date
2010-12-05
Related Report
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[Presentation] A novel hypothalamic peptide, neuroendocrine regulatory peptide-2, regulates feeding behavior via the orexin system in the hypothalamus2010
Author(s)
Toshinai K, Yamaguchi H, Kageyama H, Matsuo T, Koshinaka K, Sasaki K, Shioda S, Minamino N, Nakazato M
Organizer
5th International Peptide Symposium
Place of Presentation
国立京都国際会館(京都府)
Year and Date
2010-12-05
Related Report
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