Clarification for the central regulation of physical fatigue

• Project/Area Number: 20500581
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Sports science
• Research Institution: Osaka City University
• Principal Investigator: TANAKA Masaaki Osaka City University, 大学院・医学研究科, 講師 (60382199)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: スポーツ生理学 / 疲労 / 脳磁図 / 身体的疲労 / 筋電図

Research Abstract

The central mechanisms to regulate physical fatigue were examined using magnetoencephalographic (MEG), electrocardiographic (ECG), and psycho-behavioral techniques in healthy participants. By using Ramachandran's mirror box, we identified behavioral and neural evidence of an inhibitory system to limit the activation of the contralateral sensorimotor area during physical fatigue. In addition, the prefrontal area was shown to be a brain region associated with the compensation mechanisms to enhance the bilateral sensirimotor areas. Hence, we have obtained precious clues for the comprehensive understanding of the central mechanisms to regulate physical fatigue.

Research Products

• [Journal Article] Relationship between cognitive function and prevalence of decrease in intrinsic academic motivation in adolescents. (2011)
  • Author(s): Mizuno K., Tanaka M., Fukuda, S., Imai-Matsumura, K., Watanabe Y.
  • Journal Title: Behav Brain Funct 7(1) Pages: 4-4
  • Peer Reviewed
• [Journal Article] Relationship between cognitive function and prevalence of decrease in intrinsic academic motivation in adolescents. (2011)
  • Author(s): Mizuno, K., Tanaka, M., Fukuda, S., Imai-Matsumura, K., Watanabe, Y.
  • Journal Title: Behav Brain Funct Volume: 7 Pages: 4-4
  • Peer Reviewed
• [Journal Article] A new hypothesis of chronic fatigue syndrome : Co-conditioning theory. (2010)
  • Author(s): 田中雅彰, 渡辺恭良
  • Journal Title: Med Hypotheses 75 Pages: 244-249
  • Peer Reviewed
• [Journal Article] Relationship between fatigue and photosensitivity. (2010)
  • Author(s): 鴫原良仁, 田中雅彰, 渡辺恭良
  • Journal Title: Behav Med 36(4) Pages: 109-112
  • Peer Reviewed
• [Journal Article] Medial orbitofrontal cortex is associated with fatigue sensation. (2010)
  • Author(s): Tajima, S., Yamamoto, S., Tanaka M., Kataoka, Y., Iwase, M., Yoshikawa, E., Okada, H., Onoe, H., Tsukada, H., Kuratsune, H., Ouchi, Y., Watanabe Y.
  • Journal Title: Neurol Res Int 2010 Pages: 671421-671421
  • Peer Reviewed
• [Journal Article] Effort-reward imbalance for learning is associated with fatigue in school children. (2010)
  • Author(s): Fukuda, S., Yamano, E., Joudoi, T., Mizuno K., Tanaka M., Kawatani, J., Takano, M., Tomoda, A., Imai-Matsumura, K., Miike, T., Watanabe Y.
  • Journal Title: Behav Med 36(2) Pages: 53-62
  • Peer Reviewed
• [Journal Article] Personality and fatigue in medical students. (2010)
  • Author(s): Tanaka M., Mizuno K., Fukuda, S., Watanabe Y.
  • Journal Title: Psychol Rep 106(2) Pages: 567-575
  • Peer Reviewed
• [Journal Article] Temperament and character as predictors of fatigue-induced symptoms among school children in Japan : A 1-year follow-up study. (2010)
  • Author(s): Yamano, E., Fukuda, S., Joudoi, T., Mizuno K., Tanaka M., Kataoka, Y., Kawatani, J., Takano, M., Tomoda, A., Imai-Matsumura, K., Miike, T., Matsuda, F., Watanabe Y.
  • Journal Title: Compr Psychiat 51(3) Pages: 256-265
  • Peer Reviewed
• [Journal Article] Mapping of regional brain activation in response to fatigue-load and recovery in rats with c-Fos immunohistochemistry. (2010)
  • Author(s): Akazawa, K., Cui, Y., Tanaka, M., Kataoka, Y., Yoneda, Y., Watanabe Y.
  • Journal Title: Neurosci Res 66(4) Pages: 372-379
  • Peer Reviewed
• [Journal Article] Hazardous nature of high-temporal-frequency strobe light stimulation : neural mechanisms revealed by magnetoencephalography. (2010)
  • Author(s): Shigihara Y., Tanaka M., Tsuyuguchi, N., Tanaka, H., Watanabe Y.
  • Journal Title: Neuroscience 166(2) Pages: 482-490
  • Peer Reviewed
• [Journal Article] Effects of mild-stream bathing on recovery from mental fatigue. (2010)
  • Author(s): Mizuno K., Tanaka M., Tajima, K., Okada, N., Rokushima, K., Watanabe Y.
  • Journal Title: Medical Science Monitor 16(1) Pages: 8-14
  • Peer Reviewed
• [Journal Article] 疲労動物モデルによる医薬品・食品成分の評価 (2010)
  • Author(s): 田中雅彰
  • Journal Title: Functional Food Vol.4(3) Pages: 324-329
• [Journal Article] Relationship between fatigue and photosensitivity. (2010)
  • Author(s): Shigihara, Y., Tanaka, M., Watanabe, Y.
  • Journal Title: Behav Med Volume: 36 Pages: 109-112
  • Peer Reviewed
• [Journal Article] Medial orbitofrontal cortex is associated with fatigue sensation. (2010)
  • Author(s): Tajima, S., Yamamoto, S., Tanaka M., Kataoka, Y., Iwase, M., Yoshikawa, E., Okada, H., Onoe, H., Tsukada, H., Kuratsune, H., Ouchi, Y., Watanabe, Y.
  • Journal Title: Neurol Res Int Volume: 2010 Pages: 671421-671421
  • Peer Reviewed
• [Journal Article] Effort-reward imbalance for learning is associated with fatigue in school children. (2010)
  • Author(s): Fukuda, S., Yamano, E., Joudoi, T., Mizuno, K., Tanaka, M., Kawatani, J., Takano, M., Tomoda, A., Imai-Matsumura, K., Miike, T., Watanabe, Y.
  • Journal Title: Behav Med Volume: 36 Pages: 53-62
  • Peer Reviewed
• [Journal Article] Personality and fatigue in medical students. (2010)
  • Author(s): Tanaka, M., Mizuno, K., Fukuda, S., Watanabe, Y.
  • Journal Title: Psychol Rep Volume: 106 Pages: 567-575
  • Peer Reviewed
• [Journal Article] Temperament and character as predictors of fatigue-induced symptoms among school children in Japan : A 1-year follow-up study. (2010)
  • Author(s): Yamano, E., Fukuda, S., Joudoi, T., Mizuno, K., Tanaka, M., Kataoka, Y., Kawatani, J., Takano, M., Tomoda, A., Imai-Matsumura, K., Miike, T., Matsuda, F., Watanabe, Y.
  • Journal Title: Compr Psychiat Volume: 51 Pages: 256-265
  • Peer Reviewed
• [Journal Article] Mapping of regional brain activation in response to fatigue-load and recovery in rats with c-Fos immunohistochemistry. (2010)
  • Author(s): Akazawa, K., Cui, Y., Tanaka, M., Kataoka, Y., Yoneda, Y., Watanabe, Y.
  • Journal Title: Neurosci Res Volume: 66 Pages: 372-379
  • Peer Reviewed
• [Journal Article] 疲労動物モデルによる医薬品・食品成分の評価 (2010)
  • Author(s): 田中雅彰
  • Journal Title: Functional Food Volume: 4 Pages: 324-329
• [Journal Article] Thiamine tetrahydrofurfuryl disulfide improves energy metabolism and physical performance during physical-fatigue loading in rats. (2009)
  • Author(s): Nozaki, S., Mizuma, H., Tanaka M., Jin, G., Tanaka M., Mizuno K., Yamato, M., Okuyama, K., Eguchi, A., Akimoto, K., Kitayoshi, T., Mochizuki-Oda, N., Kataoka, Y., Watanabe Y.
  • Journal Title: Nutr Res 29(12) Pages: 867-87
  • Peer Reviewed
• [Journal Article] Stress and coping style are associated with severe fatigue in medical students. (2009)
  • Author(s): Tanaka M., Fukuda, S., Mizuno K., Kuratsune, H., Watanabe Y.
  • Journal Title: Behav Med 35(3) Pages: 87-92
  • Peer Reviewed
• [Journal Article] Chronic stress elicits prolonged activation of α-MSH secretion and subsequent degeneration of melanotropha. (2009)
  • Author(s): Ogawa, T., Shishioh-Ikejima, N., Konishi, H., Makino, T., Sei, H., Kiryu-Seo, S., Tanaka M., Watanabe Y., Kiyama, H.
  • Journal Title: J Neurochem 109(5) Pages: 1389-1399
  • Peer Reviewed
• [Journal Article] Daily oral administration of crocetin attenuates physical fatigue in human. (2009)
  • Author(s): Mizuma, H., Tanaka M., Nozaki, S., Mizuno K., Tahara, T., Ataka, S., Sugino, T., Shirai, T., Kajimoto, Y., Kuratsune, H., Kajimoto, O., Watanabe Y.
  • Journal Title: Nutr Res 29(3) Pages: 145-150
  • Peer Reviewed
• [Journal Article] Central nervous system fatigue alters autonomic nerve activity. (2009)
  • Author(s): Tanaka M., Mizuno K., Tajima, S., Sasabe, T., Watanabe Y.
  • Journal Title: Life Sci 84(7-8) Pages: 235-239
  • Peer Reviewed
• [Journal Article] Changes in plasma and tissue amino acid levels in an animal model of complex fatigue. (2009)
  • Author(s): Jin, G., Kataoka, Y., Tanaka M., Mizuma, H., Nozaki, S., Tahara, T., Mizuno K., Yamato, M., Watanabe Y.
  • Journal Title: Nutrition 25(5) Pages: 597-607
  • Peer Reviewed
• [Journal Article] Personality traits associated with intrinsic academic motivation in medical students. (2009)
  • Author(s): Tanaka M., Mizuno K., Fukuda, S., Tajima, S., Watanabe Y.
  • Journal Title: Med Educ 43(3) Pages: 384-387
  • Peer Reviewed
• [Journal Article] Mental and physical fatigue-related biochemical alterations. (2009)
  • Author(s): Nozaki, S., Tanaka M., Mizuno K., Ataka, S., Mizuma, H., Tahara, T., Sugino, T., Shirai, T., Eguchi, A., Okuyama, K., Yoshida, K., Kajimoto, Y., Kuratsune, H., Kajimoto, O., Watanabe Y.
  • Journal Title: Nutrition 5(1) Pages: 51-57
  • Peer Reviewed
• [Journal Article] 過労モデル動物を用いた研究からわかってきた疲労のメカニズム (2009)
  • Author(s): 田中雅彰
  • Journal Title: 医学のあゆみ Vol.228(6) Pages: 610-614
• [Journal Article] ヒト脳疲労 (2009)
  • Author(s): 田中雅彰
  • Journal Title: 医学のあゆみ Vol.228(6) Pages: 621-625
• [Journal Article] Effects of bathing in micro-bubbles on recovery from moderate mental fatigue. (2008)
  • Author(s): Tajima, K., Tanaka M., Mizuno K., Okada, N., Rokushima, K., Watanabe Y.
  • Journal Title: Ergonomia IJE&HF 30(2) Pages: 137-147
  • Peer Reviewed
• [Journal Article] Reliability and validity of the Japanese version of the Chalder Fatigue Scale among youth in Japan. (2008)
  • Author(s): Tanaka M., Fukuda, S., Mizuno K., Imai-Matsumura, K., Jodoi, T., Kawatani, J., Takano, M., Tomoda, A., Miike, T., Watanabe Y.
  • Journal Title: Psychol Rep 103(3) Pages: 82-690
  • Peer Reviewed
• [Journal Article] Factors influencing the academic motivation of individual college students. (2008)
  • Author(s): Yoshida, M., Tanaka M., Mizuno K., Ishii, A., Nozaki, K., Urakawa, A., Cho, Y., Kataoka, Y., Watanabe Y.
  • Journal Title: Int J Neurosci 118(10) Pages: 1400-1411
  • Peer Reviewed
• [Journal Article] Relationships between dietary habits and the prevalence of fatigue in medical students. (2008)
  • Author(s): Tanaka M., Mizuno K., Fukuda, S., Shigihara Y., Watanabe Y.
  • Journal Title: Nutrition 24(10) Pages: 985-989
  • Peer Reviewed
• [Journal Article] The neural basis of academic achievement motivation. (2008)
  • Author(s): Mizuno K., Tanaka M., Ishii, A., Tanabe, H.C., Onoe, H., Sadato, N., Watanabe Y.
  • Journal Title: NeuroImage 42(1) Pages: 369-378
  • Peer Reviewed
• [Journal Article] Effects of (-)-epigallocatechin gallate in liver of an animal model of combined (physical and mental) fatigue. (2008)
  • Author(s): Tanaka M., Baba, Y., Kataoka, Y., Kinbara, N., Sagesaka, Y.M., Kakuda, T., Watanabe Y.
  • Journal Title: Nutrition 24(6) Pages: 599-603
  • Peer Reviewed
• [Journal Article] Reduced energy utilization in the brain is a feature of an animal model of fatigue. (2008)
  • Author(s): 田中雅彰, 渡辺恭良
  • Journal Title: Int J Neurosci 118(5) Pages: 683-692
  • Peer Reviewed
• [Journal Article] Anti-fatigue effects of coenzyme Q10 during physical fatigue. (2008)
  • Author(s): Mizuno K., Tanaka M., Nozaki, S., Mizuma, H., Ataka, S., Tahara, T., Sugino, T., Shirai, T., Kajimoto, Y., Kuratsune, H., Kajimoto, O., Watanabe Y.
  • Journal Title: Nutrition 24(4) Pages: 293-299
  • Peer Reviewed
• [Journal Article] Effects of oral administration of caffeine and D-ribose on mental fatigue. (2008)
  • Author(s): Ataka, S., Tanaka M., Nozaki, S., Mizuma, H., Mizuno K., Tahara, T., Sugino, T., Shirai, T., Kajimoto, Y., Kuratsune, H., Kajimoto, O., Watanabe Y.
  • Journal Title: Nutrition 24(3) Pages: 233-238
  • Peer Reviewed
• [Journal Article] 疲労の分子神経メカニズム 脳機能イメージングを用いて (2008)
  • Author(s): 田中雅彰、渡辺恭良
  • Journal Title: メディカルバイオ Vol.5(4) Pages: 36-41
• [Journal Article] 疲労の脳内機序 (2008)
  • Author(s): 渡辺恭良、田中雅彰、水野敬
  • Journal Title: 精神医学 Vol.50(6) Pages: 527-532
• [Journal Article] 慢性疲労状態の脳機能・分子イメージング (2008)
  • Author(s): 田中雅彰、渡辺恭良
  • Journal Title: 治療 Vol.90(3) Pages: 473-479
• [Journal Article] 疲れのメカニズムはどこまでわかったか? (2008)
  • Author(s): 田中雅彰、渡辺恭良
  • Journal Title: 現代化学 Vol.444(3) Pages: 24-28
• [Journal Article] 乳酸疲労原因物質は誤り! (2008)
  • Author(s): 田中雅彰、渡辺恭良
  • Journal Title: 現代化学 Vol.444(3) Pages: 29-29
• [Journal Article] 乳酸は疲労原因物質でないというのは本当か? (2008)
  • Author(s): 田中雅彰、渡辺恭良
  • Journal Title: Clinical Neuroscience Vol.26(1) Pages: 108-108
• [Journal Article] CBEX-Dr配合飲料の健常者における抗疲労効果 (2008)
  • Author(s): 田中雅彰、鴫原良仁、藤井比佐子、平山佳伸、渡辺恭良
  • Journal Title: 薬理と治療 Vol.36(3) Pages: 199-212
• [Journal Article] Academic and family conditions associated with intrinsic academic motivation in Japanese medical students : a pilot study.
  • Author(s): 田中雅彰, 渡辺恭良
  • Journal Title: Health Educ J in press
  • Peer Reviewed
• [Journal Article] Association between lifestyle and school attendance in Japanese medical students : a pilot study.
  • Author(s): 田中雅彰, 渡辺恭良
  • Journal Title: Health Educ J in press
  • Peer Reviewed
• [Journal Article] Relationship between cognitive functions and prevalence of fatigue in elementary and junior high school students.
  • Author(s): Mizuno K., Tanaka M., Fukuda, S., Imai-Matsumura, K., Watanabe Y.
  • Journal Title: Brain Dev in press
  • NAID: 10029561992
  • Peer Reviewed
• [Journal Article] Changes in cognitive functions of students in the transitional period from elementary school to junior high school.
  • Author(s): Mizuno K., Tanaka M., Fukuda, S., Sasabe, T., Imai-Matsumura, K., Watanabe Y.
  • Journal Title: Brain Dev in press
  • NAID: 10029561733
  • Peer Reviewed
• [Journal Article] Central regulation of physical fatigue via mirror visual feedback.
  • Author(s): Tsutsumi, K., Tanaka M., Shigihara Y., Watanabe Y.
  • Journal Title: Eur J Sport Sci in press
  • Peer Reviewed
• [Journal Article] Central regulation of physical fatigue via mirror visual feedback.
  • Author(s): Tsutsumi, K., Tanaka, M., Shigihara, Y., Watanabe, Y.
  • Journal Title: Eur J Sport Sci Volume: (In press)
  • Peer Reviewed
• [Journal Article] Academic and family conditions associated with intrinsic academic motivation in Japanese medical students : a pilot study.
  • Author(s): Tanaka, M., Watanabe, Y.
  • Journal Title: Health Educ J Volume: (In press)
  • Peer Reviewed
• [Journal Article] Association between lifestyle and school attendance in Japanese medical students : a pilot study.
  • Author(s): Tanaka, M., Watanabe, Y.
  • Journal Title: Health Educ J Volume: (In press)
  • Peer Reviewed
• [Journal Article] Relationship between cognitive functions and prevalence of fatigue in elementary and junior high school students.
  • Author(s): Mizuno, K., Tanaka, M., Fukuda, S., Imai-Matsumura, K., Watanabe, Y.
  • Journal Title: Brain Dev Volume: (In press)
  • NAID: 10029561992
  • Peer Reviewed
• [Journal Article] Changes in cognitive functions of students in the transitional period from elementary school to junior high school.
  • Author(s): Mizuno, K., Tanaka, M., Fukuda, S., Sasabe, T., Imai-Matsumura, K., Watanabe, Y.
  • Journal Title: Brain Dev Volume: (In press)
  • NAID: 10029561733
  • Peer Reviewed
• [Presentation] シンポジウム「疲労の脳科学～ウイルス、サイトカイン、イメージングからの新しい視点～」(座長:渡辺恭良、田中雅彰)、脳神経回路の周波数分析と疲労～Human MEG study～ (2010)
  • Author(s): 田中雅彰、鴫原良仁、渡辺恭良
  • Organizer: 第33回日本神経科学会大会(Neuro2010)
  • Place of Presentation: 神戸コンベンションセンター
  • Year and Date: 2010-09-04
• [Presentation] シンポジウム「疲労の脳科学～ウイルス、サイトカイン、イメージングからの新しい視点～」脳神経回路の周波数分析と疲労～Human MEG study～ (2010)
  • Author(s): 田中雅彰、鴫原良仁、渡辺恭良
  • Organizer: 第33回日本神経科学会大会(Neuro2010)
  • Place of Presentation: 神戸コンベンションセンター(神戸市)(招待講演)
  • Year and Date: 2010-09-04
• [Presentation] ポスター発表、脳磁図を用いて明らかになった疲労による中枢神経系周波数特性の変化 (2010)
  • Author(s): 田中雅彰、鴫原良仁、船倉正三、金井江都子、渡辺恭良
  • Organizer: 第6回日本疲労学会総会・学術集会
  • Place of Presentation: 大阪産業創造館
  • Year and Date: 2010-06-26
• [Presentation] シンポジウム「疲労の基礎研究」(座長:岩井一宏、近藤一博)、脳磁図を用いて明らかになった疲労の脳神経学的メカニズム (2009)
  • Author(s): 田中雅彰、鴫原良仁、水野敬、渡辺恭良
  • Organizer: 第5回日本疲労学会総会・学術集会
  • Place of Presentation: 九州大学
  • Year and Date: 2009-05-15
• [Presentation] 脳磁図を用いて明らかになった疲労の脳神経学的メカニズム (2009)
  • Author(s): 田中雅彰、鴫原良仁、水野敬、渡辺恭良
  • Organizer: 第5回日本疲労学会総会・学術集会
  • Place of Presentation: 九州大学
  • Year and Date: 2009-05-15
• [Presentation] シンポジウム「疲労と意欲の脳科学/Brain Science on Fatigue and Motivation」(座長:定藤規弘、田中雅彰)、疲労と意欲のニューロイメージング (2008)
  • Author(s): 田中雅彰、水野敬、渡辺恭良
  • Organizer: 第51回日本神経化学会大会
  • Place of Presentation: 富山国際会議場
  • Year and Date: 2008-09-13
• [Presentation] Anti-fatigue effects of imidazole dipeptides. (2008)
  • Author(s): Tanaka M., Luncheon Seminar (Chair : Yosky Kataoka)
  • Organizer: International Conference on Fatigue Science 2008.
  • Place of Presentation: Okinawa, Japan
  • Year and Date: 2008-09-04
• [Presentation] Neural mechanisms underlying chronic fatigue. (2008)
  • Author(s): Tanaka M., Mizuno K., Watanabe Y., Symposium (Chairs : Kenny L. De Meirleir, Hirohiko Kuratsune)
  • Organizer: International Conference on Fatigue Science 2008.
  • Place of Presentation: Okinawa, Japan
  • Year and Date: 2008-09-03
• [Patent(Industrial Property Rights)] 生体疲労評価装置 (2009)
  • Inventor(s): 金井江都子、船倉正三、渡辺恭良、田中雅彰、鴫原良仁、水野敬
  • Industrial Property Rights Holder: パナソニック株式会社
  • Industrial Property Number: 2009-235689
  • Filing Date: 2009-10-09
• [Patent(Industrial Property Rights)] 生体疲労評価装置 (2009)
  • Inventor(s): 金井江都子、船倉正三、渡辺恭良、田中雅彰、鴫原良仁
  • Industrial Property Rights Holder: パナソニック株式会社
  • Industrial Property Number: 2009-249537
  • Filing Date: 2009-10-09