The influence and action of antioxidant vitamin supplementation on thermoregulatory vasomotion in human skin
| Project/Area Number |
20500589
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
YAMAZAKI Fumio University of Occupational and Environmental Health, Japan, 産業保健学部, 講師 (80269050)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKAHARA Kazuo 産業医科大学, 産業保健学部, 教授 (30163306)
SEKI Meikan 産業医科大学, 産業保健学部, 教授 (40163092)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2008: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Keywords | アスコルビン酸 / 皮膚血流量 / 暑熱負荷 / 寒冷負荷 / 活性酸素 / 皮膚血流調節 / ビタミンC / 全身冷却 / 局所冷却 / 体温調節 |
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| Research Abstract |
To elucidate the influence and action mechanism of antioxidant vitamin supplementation on thermoregulatory vasomotor function in human skin, we administered vasoactive agents with and without vitamin C in forearm skin and examined the vasomotor responses at the treated skin sites during thermal stress. The present study suggests that antioxidant vitamin supplementation increases the vasodilator response during whole-body heating but does not alter the vasoconstrictor response during whole-body cooling, while it inhibits the vasoconstrictor response to local skin cooling through adrenoceptor-dependent mechanism.
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Report
(4 results)
Research Products
(9 results)
