Effects of antioxidant on muscular atrophy accompanied by type II diabetes
| Project/Area Number |
20500628
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAITO Hisashi 順天堂大学, スポーツ健康科学部, 教授 (70188861)
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| Project Period (FY) |
2008 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | 生活習慣病 / 抗酸化食品 / アスタキサンチン / インスリン抵抗性 / 筋萎縮 / Akt / 糖尿病 / 酸化ストレス / 2型糖尿病 / 抗酸化物質 / 酸化傷害 / 抗酸化剤 |
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| Research Abstract |
There was no significant difference in body weight and food intake between D group and A group till 52 weeks. GTT at 25 weeks showed that blood glucose at fasting and 30 minutes in D group were significantly increased and insulin level at 30 and 60 minutes were also significantly increased, but not in A group. Hindlimb muscles in D group at 25 weeks showed siginificant decrease of muscle weight and reduction of Akt phosphorylation, but not those in A group. The body weight of D group decreased at 98 weeks, but that of A group was maintained. GTT at 98 weeks showed that the insulin level in A group was maintained, but not in D group.
From these results, Asx supplementation of before onset of type 2 diabetes transiently improves insulin resistance and attenuates atrophy, and that maintains Akt phosphorylation in muscles. Long term Asx supplementation conserved insulin secretory function for OLEF rats.
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Report
(6 results)
Research Products
(14 results)
