Roles of odorant receptor signaling in axonal projection of olfactory sensory neurons
Project/Area Number |
20509002
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Neuroscience in general
|
Research Institution | The University of Tokyo |
Principal Investigator |
IMAI Takeshi The University of Tokyo, 大学院・理学系研究科, 客員共同研究員 (70509851)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥3,890,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,200,000 (Direct Cost: ¥2,200,000)
|
Keywords | シグナル伝達 / 発生・再生 / 神経科学 / 脳・神経 |
Research Abstract |
In this study, we found that odorant receptors control axonal projection of olfactory sensory neurons via Gs and Golf, each controlling distinct phase of axon guidance. We also analyzed the pre-target axon sorting for olfactory map formation in mice, and found that pre-target axon sorting plays an important role in establishing the topographic order based on the relative levels of guidance molecules expressed by axons.
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Report
(4 results)
Research Products
(28 results)