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Development of carbon nanotube/apatite composites as new biomaterials applying biomimetic method

Research Project

Project/Area Number 20510103
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Nanomaterials/Nanobioscience
Research InstitutionShinshu University

Principal Investigator

TARUTA Seiichi  Shinshu University, 工学部, 教授 (00217209)

Co-Investigator(Kenkyū-buntansha) SAITO Naoto  信州大学, 医学部, 教授 (80283258)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsカーボンナノチューブ / アパタイト / バイオミメティック / 生体材料 / 複合体 / 低温合成
Research Abstract

Carbon nanotubes (CNTs) were soaked in 1.5 SBF in which inorganic ion concentrations are 1.5 times as high as those in body fluid. The deposition of apatite on the CNTs was investigated. So it is concluded that to make apatite deposit uniformly on the CNTs biomimeticaly in a short time, a small amount of the CNTs pre-treated with phosphoric acid or CaCl_2 solutions should be dispersed uniformly in 1.5SBF. On the other hand, fabrication of CNTs/apatite composites by sintering was investigated. Dense composites in which the CNTs were dispersed uniformly were obtained. The fracture toughness of the composites was higher, but the bending strength was lower due to the cracks inducing during firing, compared with those of conventional apatite ceramics.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (63 results)

All 2011 2010 2009 2008 Other

All Journal Article (10 results) (of which Peer Reviewed: 8 results) Presentation (53 results)

  • [Journal Article] Fabrication and mechanical properties of high-disoersion-treated carbon nanofiber/alumina composites2010

    • Author(s)
      Ueda N, Yamakami T, Yamaguchi T, Kitajima K, Usui Y, Aoki K, Nakanishi T, Miyaji F, Endo M, Saito N, Taruta S
    • Journal Title

      J.Ceram.Soc.Japan 118[9]

      Pages: 847-854

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fabrication and mechanical properties of high-disoersion-treated carbon nanofiber/alumina composites2010

    • Author(s)
      Ueda Naoki, et al.
    • Journal Title

      Journal of the Ceramic Society of Japan

      Volume: 118(9) Pages: 847-854

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Carbon nanotubes : biomaterial applications2009

    • Author(s)
      Saito N, Usui Y, Aoki K, Narita N, Shimizu M, Hara K, Ogihara N, Nakamura K, Ishigaki N, Kato H, Taruta S, Endo M
    • Journal Title

      Chem.Soc.Rev. 38[7]

      Pages: 1897-1903

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A thin carbon fiber web as a scaffold for bone tissue regeneration2009

    • Author(s)
      Aoki K, Usui Y, Narita N, Ogiwara N, Ishigaki N, Nakamura K, Kato H, Sano K, Ogiwara N, Kametani K, Kim C, Taruta S, Kim YA, Endo M, Saito N
    • Journal Title

      Small 5[13]

      Pages: 1540-1546

    • Related Report
      2010 Final Research Report
  • [Journal Article] Multi-walled carbon nanotubes specifically inhibit osteoclast differentiation and function2009

    • Author(s)
      Narita N, Kobayashi Y, Nakamura H, Maeda K, Ishihara A, Mizoguchi T, Usui Y, Aoki K, Shimizu M, Kato H, Ozawa H, Udagawa N, Endo M, Takahashi N, Saito N
    • Journal Title

      Nano Lett. 9(4)

      Pages: 1406-1413

    • Related Report
      2010 Final Research Report
  • [Journal Article] A Thin Carbon-Fiber Web as a Scaffold for Bone-Tissue Regeneration2009

    • Author(s)
      K.Aoki, et al.
    • Journal Title

      Small 5

      Pages: 1540-1546

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Carbon nanotubes : biomaterial applications2009

    • Author(s)
      N.Saito, et al.
    • Journal Title

      Chemical Society Reviews 38

      Pages: 1879-1903

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multi-walled carbon nanotubes specifically inhibit osteoclast differentiation and function.2009

    • Author(s)
      Narita N, et al.
    • Journal Title

      Nano Lett 9(4)

      Pages: 1406-1413

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Application of carbon fibers to biomaterials : new era of nano-level control of carbon fibers after 30-years of development

    • Author(s)
      Saito N, Aoki K, Usui Y, Shimizu M, Hara K, Narita N, Ogihara N, Nakamura K, Ishigaki N, Kato H, Haniu H, Taruta S, Kim YA, Endo M
    • Journal Title

      Chem.Soc.Rev. in press.

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Application of carbon fibers to biomaterials: new era of nano-level control of carbon fibers after 30-years of development

    • Author(s)
      Saito Naoto, et al.
    • Journal Title

      Chemical Society Reviews

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] カップスタック型カーボンナノファイバー複合アパタイトセラミックスの作製2011

    • Author(s)
      苗承呈, 山口朋浩, 北島圀夫, 遠藤守信, 齋藤直人, 樽田誠一
    • Organizer
      日本セラミックス協会2011年年会
    • Place of Presentation
      浜松市
    • Related Report
      2010 Final Research Report
  • [Presentation] カーボンナノファイバー複合アルミナセラミックスの微構造変化および機械的性質2011

    • Author(s)
      植田直樹, 山上朋彦, 山口朋浩, 北島圀夫, 遠藤守信, 齋藤直人, 樽田誠一
    • Organizer
      第49回セラミックス基礎科学討論会
    • Place of Presentation
      岡山市
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Application of carbon nanofiber as scaffolds in regenerative medicine2011

    • Author(s)
      Saito Naoto, et al.
    • Organizer
      3rd International Conference on Drug Discovery and Therapy
    • Place of Presentation
      Dobai, UAE
    • Related Report
      2010 Annual Research Report
  • [Presentation] Potential as the bone regeneration scaffold of carbon nanotubes2011

    • Author(s)
      Usui Yuki, et al.
    • Organizer
      3rd International Conference on Drug Discovery and Therapy
    • Place of Presentation
      Dobai, UAE
    • Related Report
      2010 Annual Research Report
  • [Presentation] カップスタック型カーボンナノファイバー複合アパタイトセラミックスの作製2011

    • Author(s)
      苗承〓, 他
    • Organizer
      公益社団法人日本セラミックス協会2011年年会
    • Place of Presentation
      浜松市
    • Related Report
      2010 Annual Research Report
  • [Presentation] 擬似体液中のカーボンナノファイバーからのアパタイト析出挙動2010

    • Author(s)
      樽田誠一, 木所和樹, 山口朋浩, 北島圀夫, 遠藤守信, 齋藤直人
    • Place of Presentation
      長野市
    • Year and Date
      2010-12-30
    • Related Report
      2010 Final Research Report
  • [Presentation] 擬似体液中のカップスタック型カーボンナノチューブからのアパタイト析出-ポリビニルアルコール添加の影響-2010

    • Author(s)
      藤田大河, 他
    • Organizer
      第5回日本フラックス成長研究発表会
    • Place of Presentation
      長野市
    • Year and Date
      2010-12-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 擬似体液中のカーボンナノファイバーからのアパタイト析出挙動2010

    • Author(s)
      樽田誠一, 他
    • Organizer
      第5回日本フラックス成長研究発表会
    • Place of Presentation
      長野市
    • Year and Date
      2010-12-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 酸処理したカーボンナノファイバー複合アルミナセラミックスの作製と機械的性質2010

    • Author(s)
      植田直樹, 他
    • Organizer
      日本セラミックス協会2010年年会
    • Place of Presentation
      東京都小金井市
    • Year and Date
      2010-03-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] Carbon nanotubes : Biomaterial applications and safety2010

    • Author(s)
      Saito N, et al
    • Organizer
      3rd International Workshop on CNT's Toxicology and Safety
    • Place of Presentation
      Nagano
    • Year and Date
      2010-02-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] Microstructure and Mechanical Properties of Acid-Treated Carbon Nanofiber/Alumina Composites2010

    • Author(s)
      Ueda N, Yamakami T, Yamaguchi T, Kitajima K, Usui Y, Aoki K, Nakanishi T, Miyaji F, Endo M, Saito N, Taruta S
    • Organizer
      Third International Congress on Ceramics
    • Place of Presentation
      Osaka
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Precipitation of apatite on carbon nanofiber in simulated body fluid2010

    • Author(s)
      樽田誠一, 木所和樹, 山上朋彦, 山口朋浩, 北島圀夫, 齋藤直人, 遠藤守信
    • Organizer
      Fourth International Conference on Science and Technology of Advanced Ceramics
    • Place of Presentation
      Yokohama
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 酸処理したカーボンナノファイバー複合アルミナセラミソクスの作製と機械的性質2010

    • Author(s)
      植田直樹, 山上朋彦, 山口朋浩, 北島圀夫, 中西健文, 宮路史明, 遠藤守信, 齋藤直人, 樽田誠一
    • Organizer
      日本セラミックス協会2010年年会
    • Place of Presentation
      小金井市
    • Related Report
      2010 Final Research Report
  • [Presentation] 酸処理したカーボンナノファイバー/アルミナ複合体の作製と機械的性質2010

    • Author(s)
      植田直樹, 他
    • Organizer
      第26回日本セラミックス協会関東支部研究発表会
    • Place of Presentation
      茨城県日立市
    • Related Report
      2010 Annual Research Report
  • [Presentation] ポロヒドロキシソA1複合ゲルを用いるカーボンナノファイバー/αアルミナ複合粉末低温合成2010

    • Author(s)
      宮澤賢, 他
    • Organizer
      第26回日本セラミックス協会関東支部研究発表会
    • Place of Presentation
      茨城県日立市
    • Related Report
      2010 Annual Research Report
  • [Presentation] 密封下におけるハイドロキシアパタイトセラミックスの焼結挙動とその機械的性質2010

    • Author(s)
      森口悠平, 他
    • Organizer
      第26回日本セラミックス協会関東支部研究発表会
    • Place of Presentation
      茨城県日立市
    • Related Report
      2010 Annual Research Report
  • [Presentation] Development of multi-walled carbon nanotube composite ceramic biomaterial2010

    • Author(s)
      Usui Yuki, et al.
    • Organizer
      23rd European Conference on Biomaterials
    • Place of Presentation
      Tampere, Finland
    • Related Report
      2010 Annual Research Report
  • [Presentation] Enhanced functions of osteoblasts on alumina ceramics-carbon nanotubes composite material2010

    • Author(s)
      Ogihara Nobuhide, et al.
    • Organizer
      7th Combined Meeting of the Orthopaedic Research Societies
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2010 Annual Research Report
  • [Presentation] Muliti-walled carbon nanotubes promote osteoblastic mineralization2010

    • Author(s)
      Shimizu Masayuki, et al.
    • Organizer
      7th Combined Meeting of the Orthopaedic Research Societies
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2010 Annual Research Report
  • [Presentation] Development of multi-walled carbon nanotube composite ceramic biomaterial2010

    • Author(s)
      Usui Yuki, et al.
    • Organizer
      7th Combined Meeting of the Orthopaedic Research Societies
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2010 Annual Research Report
  • [Presentation] Basic safety properties of multi-walled carbon nanotubes for biomaterials2010

    • Author(s)
      Hara Kazuo, et al.
    • Organizer
      7th Combined Meeting of the Orthopaedic Research Societies
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2010 Annual Research Report
  • [Presentation] 金属アルコキシドを用いたカーボンナノファイバー表面へのアルミナコーティング2009

    • Author(s)
      井本雄三, 他
    • Organizer
      第40回中部化学関係協会支部連合秋季大会
    • Place of Presentation
      岐阜県岐阜市
    • Year and Date
      2009-11-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] 高分散処理したカーボンナノファイバー複合アルミナセラミックスの微構造と機械的性質2009

    • Author(s)
      植田直樹, 他
    • Organizer
      日本セラミックス協会第22回秋季シンポジウム
    • Place of Presentation
      愛媛県松山市
    • Year and Date
      2009-09-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] 擬似体液中におけるカップスタック型カーボンナノチューブからのアパタイトの析出2009

    • Author(s)
      藤田大河, 他
    • Organizer
      第25回日本セラミックス協会関東支部研究発表会
    • Place of Presentation
      群馬県利根郡みなかみ町
    • Year and Date
      2009-07-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] 酸処理したカーボンナノファイバー複合アルミナセラミックスの作製2009

    • Author(s)
      岩松健一, 他
    • Organizer
      第25回日本セラミックス協会関東支部研究発表会
    • Place of Presentation
      群馬県利根郡みなかみ町
    • Year and Date
      2009-07-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] 高分散処理したカーボンナノファイバー/アルミナ複合体のプラズマ焼結による作製2009

    • Author(s)
      植田直樹, 他
    • Organizer
      第25回日本セラミックス協会関東支部研究発表会
    • Place of Presentation
      群馬県利根郡みなかみ町
    • Year and Date
      2009-07-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] 分散性を高めたカーボンナノファイバー/廃ガラス焼結体の作製と機械的性質2009

    • Author(s)
      齋藤英人, 他
    • Organizer
      第25回日本セラミックス協会関東支部研究発表会
    • Place of Presentation
      群馬県利根郡みなかみ町
    • Year and Date
      2009-07-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] Bone Tissue Compatibility of Carbon Nanotubes2009

    • Author(s)
      Aoki K, et al
    • Organizer
      2nd International Workshop on CNT's Toxicology and Safety
    • Place of Presentation
      Nagano
    • Year and Date
      2009-06-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] 高分散処理したカーボンナノファイバー複合アルミナセラミックスの微構造と機械的性質2009

    • Author(s)
      植田直樹, 山口朋浩, 北島圀夫, 中西健文, 宮路史明, 遠藤守信, 齋藤直人, 樽田誠一
    • Organizer
      日本セラミックス協会第22回秋季シンポジウム
    • Place of Presentation
      松山市
    • Related Report
      2010 Final Research Report
  • [Presentation] 高分散処理したカーボンナノファイバー複合アルミナセラミックスの作製と機械的性質2009

    • Author(s)
      植田直樹, 山口朋浩, 北島圀夫, 中西健文, 宮路史明, 遠藤守信, 齋藤直人, 樽田誠一
    • Organizer
      日本セラミックス協会2009年年会
    • Place of Presentation
      野田市
    • Related Report
      2010 Final Research Report
  • [Presentation] 表面処理したカップスタック型カーボンナノチューブの擬似体液中でのアパタイト析出2009

    • Author(s)
      藤田大河, 山口朋浩, 北島圀夫, 遠藤守信, 齋藤直人, 樽田誠一
    • Organizer
      日本セラミックス協会2009年年会
    • Place of Presentation
      野田市
    • Related Report
      2010 Final Research Report
  • [Presentation] 酸,アルカリおよびカルシウム含有溶液処理したカーボンナノファイバーからのアパタイトの析出2009

    • Author(s)
      木所一樹, 山口朋浩, 北島圀夫, 遠藤守信, 齋藤直人, 樽田誠一
    • Organizer
      日本セラミックス協会2009年年会
    • Place of Presentation
      野田市
    • Related Report
      2010 Final Research Report
  • [Presentation] Biocompatibility of thin carbon fiber web as a scaffold for bone regeneration2009

    • Author(s)
      Aoki K, et al
    • Organizer
      4th International Conference on Nanotechnology-Occupational and Environmental Health
    • Place of Presentation
      Helsinki
    • Related Report
      2009 Annual Research Report
  • [Presentation] Multi-walled Carbon nanotubes show high bone tissue compatibility2009

    • Author(s)
      Usui Y, et al
    • Organizer
      4th International Conference on Nanotechnology-Occupational and Environmental Health
    • Place of Presentation
      Helsinki
    • Related Report
      2009 Annual Research Report
  • [Presentation] Carbon Nanotubes Show High Bone Tissue Compatibility2009

    • Author(s)
      Usui Y, et al
    • Organizer
      22nd European Conference on Biomaterials
    • Place of Presentation
      Lausanne
    • Related Report
      2009 Annual Research Report
  • [Presentation] Mechanidal Properties and Bone Tissue Compatibility of Polyethylene/Multi-Walled Carbon Nanotube Composite2009

    • Author(s)
      Aoki K, et al
    • Organizer
      22nd European Conference on Biomaterials
    • Place of Presentation
      Lausanne
    • Related Report
      2009 Annual Research Report
  • [Presentation] 多層カーボンナノチューブ複合セラミックスの開発2009

    • Author(s)
      薄井雄企, 他
    • Organizer
      第24回日本整形外科学会基礎学術集
    • Place of Presentation
      横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] 多層カーボンナノチューブの骨芽細胞に対する効果2009

    • Author(s)
      清水政幸, 他
    • Organizer
      第24回日本整形外科学会基礎学術集
    • Place of Presentation
      横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] 高分散処理しかカーボンナノファイバー複合アルミナセラミックスの作製と機械的性質2009

    • Author(s)
      植田直樹, 他
    • Organizer
      日本セラミックス協会2009年年会
    • Place of Presentation
      千葉県野田市
    • Related Report
      2008 Annual Research Report
  • [Presentation] 酸, アルカリおよびカルシウム含有溶液処理したカーボンナノファイバーからのアパタイトの析出2009

    • Author(s)
      木所和樹, 他
    • Organizer
      日本セラミックス協会2009年年会
    • Place of Presentation
      千葉県野田市
    • Related Report
      2008 Annual Research Report
  • [Presentation] 表面処理したカップスタック型カーボンナノチューブの擬似体液中でのアパタイト析出2009

    • Author(s)
      藤田大河, 他
    • Organizer
      日本セラミックス協会2009年年会
    • Place of Presentation
      千葉県野田市
    • Related Report
      2008 Annual Research Report
  • [Presentation] PVBを分散剤として用いたアルミナ/カーボンナノファイバー複合体の作製と性質2008

    • Author(s)
      湯本慎也, 山口朋浩, 北島圀夫, 遠藤守信, 齋藤直人, 樽田誠一
    • Organizer
      日本セラミックス協会第21回秋季シンポジウム
    • Place of Presentation
      北九州市
    • Related Report
      2010 Final Research Report
  • [Presentation] Carbon nanotube compatibility with Bone Tissue.2008

    • Author(s)
      Saito N
    • Organizer
      INNO. 08
    • Place of Presentation
      Montreal
    • Related Report
      2008 Annual Research Report
  • [Presentation] Fabrication of carbon nano-fiber/almina composites by vacuum sintering and hot isostatic pressing.2008

    • Author(s)
      Taruta S, et al.
    • Organizer
      Carbon 2008
    • Place of Presentation
      Nagano
    • Related Report
      2008 Annual Research Report
  • [Presentation] Multi-walled carbon nanotubes specifically inhibit osteoclast differentiation and function.2008

    • Author(s)
      Narita N, et al.
    • Organizer
      Carbon 2008
    • Place of Presentation
      Nagano
    • Related Report
      2008 Annual Research Report
  • [Presentation] Carbon nanotubes show high bone tissue compatibility and accelerate bone formation.2008

    • Author(s)
      Usui Y, et al.
    • Organizer
      Carbon 2008
    • Place of Presentation
      Nagano
    • Related Report
      2008 Annual Research Report
  • [Presentation] A thin carbon fiber web as a scaffold for bone tissue regeneration.2008

    • Author(s)
      Aoki K, et al.
    • Organizer
      Carbon 2008
    • Place of Presentation
      Nagano
    • Related Report
      2008 Annual Research Report
  • [Presentation] Multi-walled carbon nanotubes specifically inhibit osteoclast differentiation and function.2008

    • Author(s)
      Narita N, et al.
    • Organizer
      NanoEurope 2008
    • Place of Presentation
      St. Gallen, Switzerland
    • Related Report
      2008 Annual Research Report
  • [Presentation] 酸およびアルカリ処理したカーボンナノフアイバーからのアパタイトの析出.2008

    • Author(s)
      木所和樹, 他
    • Organizer
      日本セラミックス協会第24回関東支部研究発表会
    • Place of Presentation
      神奈川
    • Related Report
      2008 Annual Research Report
  • [Presentation] PVBを分散剤として用いたアルミナ/カーボンナノフアイバー複合体の作製と性質.2008

    • Author(s)
      湯本慎也, 他
    • Organizer
      日本セラミックス協会第21回秋季シンポジウム
    • Place of Presentation
      北九州市
    • Related Report
      2008 Annual Research Report
  • [Presentation] 多層カーボンナノチューブの骨形成に対する影響.2008

    • Author(s)
      薄井雄企, 他
    • Organizer
      第23回日本整形外科学会基礎学術集会
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report
  • [Presentation] 新規カーボンファイバーシートをscaffoldとして用いたラット骨髄細胞移植による骨形成.2008

    • Author(s)
      青木薫, 他
    • Organizer
      第23回日本整形外科学会基礎学術集会
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report
  • [Presentation] 多層カーボンナノチューブはNFATclの核移行を阻害することにより破骨細胞分化を抑制する.2008

    • Author(s)
      成田伸代, 他
    • Organizer
      第23回日本整形外科学会基礎学術集会
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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