Microvascular Angina in Postmenopausal Women and Effect of Kampo Medicine

Research Project

Project/Area Number	20510248
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Gender
Research Institution	Oita University
Principal Investigator	NAKAGAWA MIKIKO Oita University, 医学部, 助教 (50244182)
Project Period (FY)	2008 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000) Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	漢方薬 / 更年期 / 微小血管性狭心症 / 女性 / 性差医療 / 血管内皮機能 / 東洋医学 / 冠血流予備能
Research Abstract	Microvascular angina is a condition characterized by angina-like chest pain with normal coronary angiography and mostly observed in the postmenopausal women. Keishibukuryougan (KBG) is a traditional Kampo medicine and improves microcirculation in peripheral vessel. However, its effect on the coronary microcirculation has not been evaluated. We measured the coronary flow velocity by echo-cardiography and determined the coronary flow velocity reserve before and after oral administration of KBG in young healthy volunteers. KBG significantly improved CFVR, suggested the potential therapeutic usefulness of KBG for coronary microvascular angina.