| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Research Abstract |
Rats treated neonatally with an NMDA antagonist (MK-801), which are supposed as a putative animal model of schizophrenia, were tested for behavioral or cognitive deficits. Rats were treated with MK-801 from postnatal days 7 to 20. Sensorimotor gating and working memory was tested in adulthood, using prepulse inhibition (PPI) and spontaneous alternation (SA), respectively. As results, MK-801 induced a marginally significant impairment in PPI, but not in SA. MK-801 treatment in a short period (5 days) did not have any behavioral effects.
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